Dr. Kunzhe Dong talks about the $3.8 million grant his lab was awarded by the National Institutes of Health (NIH) to investigate how a molecule in blood vessels, PRDM16-DT, may help protect against atherosclerosis.
youtu.be/sYeQnhZ89hQ?...
#CardiovascularResearch #Atherosclerosis #Immunology #NIH
youtu.be/sYeQnhZ89hQ?...
#CardiovascularResearch #Atherosclerosis #Immunology #NIH
Can a Molecule in Blood Vessels Help Prevent Heart Disease? | Kunzhe Dong, PhD
YouTube video by Medical College of Georgia
youtu.be
November 6, 2026 at 2:38 PM
Dr. Kunzhe Dong talks about the $3.8 million grant his lab was awarded by the National Institutes of Health (NIH) to investigate how a molecule in blood vessels, PRDM16-DT, may help protect against atherosclerosis.
youtu.be/sYeQnhZ89hQ?...
#CardiovascularResearch #Atherosclerosis #Immunology #NIH
youtu.be/sYeQnhZ89hQ?...
#CardiovascularResearch #Atherosclerosis #Immunology #NIH
Could a molecule in our blood vessels help protect against heart disease? 🩸🔬
Kunzhe Dong, PhD, has received a $3.8M NIH grant to investigate how PRDM16-DT may help protect against atherosclerosis.
Read more:
jagwire.augusta.edu/immcg-resear...
#Immunology #AugustaUniversity #atherosclerosis
Kunzhe Dong, PhD, has received a $3.8M NIH grant to investigate how PRDM16-DT may help protect against atherosclerosis.
Read more:
jagwire.augusta.edu/immcg-resear...
#Immunology #AugustaUniversity #atherosclerosis
November 2, 2026 at 2:13 PM
Could a molecule in our blood vessels help protect against heart disease? 🩸🔬
Kunzhe Dong, PhD, has received a $3.8M NIH grant to investigate how PRDM16-DT may help protect against atherosclerosis.
Read more:
jagwire.augusta.edu/immcg-resear...
#Immunology #AugustaUniversity #atherosclerosis
Kunzhe Dong, PhD, has received a $3.8M NIH grant to investigate how PRDM16-DT may help protect against atherosclerosis.
Read more:
jagwire.augusta.edu/immcg-resear...
#Immunology #AugustaUniversity #atherosclerosis
GUSB-enriched sympathetic neurons promote thermogenic recruitment through extracellular matrix remodelling in male mice
->Nature | More on "Sympathetic neurons and thermogenic fat" at BigEarthData.ai
->Nature | More on "Sympathetic neurons and thermogenic fat" at BigEarthData.ai
GUSB-enriched sympathetic neurons promote thermogenic recruitment through extracellular matrix remodelling in male mice
Meyer, C. W. et al. Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299, R1396–R1406 (2010). Cohen, P. et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156, 304–316 (2014). Hanssen, M. J. et al. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat. Med. 21, 863–865 (2015). Hanssen, M. J. W. et al. Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 65, 1179–1189 (2016). Zhu, Y. et al. Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat. Nature 634, 243–250 (2024). Li, E. et al. Control of lipolysis by a population of oxytocinergic sympathetic neurons. Nature 625, 175–180 (2024). DeBari, M. K. & Abbott, R. D. Adipose tissue fibrosis: mechanisms, models, and importance. Int. J. Mol. Sci. 21, 6030 (2020). Marcelin, G., Silveira, A. L. M., Martins, L. B., Ferreira, A. V. & Clément, K. Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis. J. Clin. Invest. 129, 4032–4040 (2019). Lawler, H. M. et al. Adipose tissue hypoxia, inflammation, and fibrosis in obese insulin-sensitive and obese insulin-resistant subjects. J. Clin. Endocrinol...
www.nature.com
November 7, 2026 at 1:05 AM
The authors included RRIDs in their in Developmental Dynamics paper! We value the author's support of reproducibility. #methodsmatter #ReproducibleResearch #BetterScience
<fc>PRDM16</fc> is necessary for sensory neuronal development and differentiation in the trigeminal ganglion
Read the full paper: <fc>PRDM16</fc> is necessary for sensory neuronal development and differentiation in the trigeminal ganglion
doi.org
October 30, 2026 at 7:07 AM
The authors included RRIDs in their in Developmental Dynamics paper! We value the author's support of reproducibility. #methodsmatter #ReproducibleResearch #BetterScience
In zebrafish, disrupting five HoxA/D9–10 genes led to complete loss of pelvic fins.
Early progenitor markers, including prdm16, were no longer detected. A hoxa10b reporter also marked the presumptive pelvic fin field before budding.
Early progenitor markers, including prdm16, were no longer detected. A hoxa10b reporter also marked the presumptive pelvic fin field before budding.
October 23, 2026 at 8:31 AM
In zebrafish, disrupting five HoxA/D9–10 genes led to complete loss of pelvic fins.
Early progenitor markers, including prdm16, were no longer detected. A hoxa10b reporter also marked the presumptive pelvic fin field before budding.
Early progenitor markers, including prdm16, were no longer detected. A hoxa10b reporter also marked the presumptive pelvic fin field before budding.
Manipulating Maturity: Protein PRDM16 regulates human iPSC-derived cardiomyocyte maturation – potential target in heart damage repair & heart tissue engineering
📷 Kanae Tani et al Kyoto University in
@stemcellreports.bsky.social
➡️ bpod.org.uk/archive/2026... with
@rooph.bsky.social
📷 Kanae Tani et al Kyoto University in
@stemcellreports.bsky.social
➡️ bpod.org.uk/archive/2026... with
@rooph.bsky.social
September 14, 2026 at 8:04 AM
Manipulating Maturity: Protein PRDM16 regulates human iPSC-derived cardiomyocyte maturation – potential target in heart damage repair & heart tissue engineering
📷 Kanae Tani et al Kyoto University in
@stemcellreports.bsky.social
➡️ bpod.org.uk/archive/2026... with
@rooph.bsky.social
📷 Kanae Tani et al Kyoto University in
@stemcellreports.bsky.social
➡️ bpod.org.uk/archive/2026... with
@rooph.bsky.social
Work from the @su2c.bsky.socialConvergence 3.1416 Research Team led by Dan Littman from NYU and a Sharp Award was published in @nature.com describing how dendritic cells are able to regulate T cell responses to food and microbes and contribute to food tolerance www.nature.com/articles/s41...
PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens - Nature
A subset of antigen-presenting cells of myeloid origin that require PRDM16 and RORγt regulates T cell function to enable immune tolerance of food and commensal gut microorganisms.
www.nature.com
May 21, 2025 at 8:58 PM
Work from the @su2c.bsky.socialConvergence 3.1416 Research Team led by Dan Littman from NYU and a Sharp Award was published in @nature.com describing how dendritic cells are able to regulate T cell responses to food and microbes and contribute to food tolerance www.nature.com/articles/s41...
migraine pathophysiology.
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
June 9, 2026 at 10:51 AM
migraine pathophysiology.
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
RESULTS: Eight EDC-related genes were identified as significantly associated with migraine risk, of which MEF2D, OSBPL10, B9D2, HTRA1 and PRDM16 were classified as high- or medium-evidence genes. (🧵 8/14)
Mechanistically, she found that PRDM16 regulates knee chondrogenesis through DNA binding and by modulating H3K4me3 deposition at promoter and enhancer regions of key chondrogenic and hypertrophic genes (e.g., MEF2C), thereby shaping chondrocyte phenotype specification and joint homeostasis.
February 7, 2026 at 4:52 PM
Mechanistically, she found that PRDM16 regulates knee chondrogenesis through DNA binding and by modulating H3K4me3 deposition at promoter and enhancer regions of key chondrogenic and hypertrophic genes (e.g., MEF2C), thereby shaping chondrocyte phenotype specification and joint homeostasis.
Thrilled to share our new bioRxiv preprint led by Eloise Fadial (@efadial.bsky.social) 🥳🎉! Using PRDM16 cKO mice, hiPSC models, scRNA-seq & CUT&RUN, Eloise shows that PRDM16 is a key genetic and epigenetic regulator of knee chondrogenesis and chondrocyte identity.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 7, 2026 at 4:52 PM
Thrilled to share our new bioRxiv preprint led by Eloise Fadial (@efadial.bsky.social) 🥳🎉! Using PRDM16 cKO mice, hiPSC models, scRNA-seq & CUT&RUN, Eloise shows that PRDM16 is a key genetic and epigenetic regulator of knee chondrogenesis and chondrocyte identity.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Protein PRDM16, which promotes “beiging” of white fat, protects mice against hypertension, per study in Science Magazine. 🐁 🧪
Absence of the transcription factor for PRDM16 in mice caused remodeling of adipose tissue around blood vessels, elevating blood pressure: https://ow.ly/jIcg50Yw28t
Absence of the transcription factor for PRDM16 in mice caused remodeling of adipose tissue around blood vessels, elevating blood pressure: https://ow.ly/jIcg50Yw28t
March 19, 2026 at 9:55 PM
Protein PRDM16, which promotes “beiging” of white fat, protects mice against hypertension, per study in Science Magazine. 🐁 🧪
Absence of the transcription factor for PRDM16 in mice caused remodeling of adipose tissue around blood vessels, elevating blood pressure: https://ow.ly/jIcg50Yw28t
Absence of the transcription factor for PRDM16 in mice caused remodeling of adipose tissue around blood vessels, elevating blood pressure: https://ow.ly/jIcg50Yw28t
Loss of PRDM16 Drives Nasal Septal Deviation through Dysregulated TGFβ2 Signaling #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.07.28.741259v1
https://www.biorxiv.org/content/10.64898/2026.07.28.741259v1
July 29, 2026 at 1:00 PM
Loss of PRDM16 Drives Nasal Septal Deviation through Dysregulated TGFβ2 Signaling #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.07.28.741259v1
https://www.biorxiv.org/content/10.64898/2026.07.28.741259v1
PRDM16 Coordinates Genetic and Epigenetic Programs Governing Chondrogenesis and Chondrocyte Phenotype Specification in the Knee Joint #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.01.28.701140v1
https://www.biorxiv.org/content/10.64898/2026.01.28.701140v1
February 1, 2026 at 8:00 AM
PRDM16 Coordinates Genetic and Epigenetic Programs Governing Chondrogenesis and Chondrocyte Phenotype Specification in the Knee Joint #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.01.28.701140v1
https://www.biorxiv.org/content/10.64898/2026.01.28.701140v1
PRDM16 controls smooth muscle cell fate in atherosclerosis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.02.19.639186v1
https://www.biorxiv.org/content/10.1101/2025.02.19.639186v1
February 24, 2025 at 8:38 AM
PRDM16 controls smooth muscle cell fate in atherosclerosis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.02.19.639186v1
https://www.biorxiv.org/content/10.1101/2025.02.19.639186v1
Congratulations to our colleague Dr. Annarita Di Lorenzo and team on their new Science Magazine paper "Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure."
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure
Excess adiposity is a major risk factor for hypertension and heart disease. Brown fat is associated with protection from cardiovascular pathology, but whether this relationship is causal remains unkno...
www.science.org
January 16, 2026 at 2:13 PM
Congratulations to our colleague Dr. Annarita Di Lorenzo and team on their new Science Magazine paper "Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure."
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PRDM16 emerged as a master regulator in fetal-origin NUP98::NSD1 AML. Knocking out PRDM16 halted leukemia growth and overcame therapy resistance, spotlighting PRDM16 as an exciting therapeutic target. 10/13
April 8, 2025 at 2:32 PM
PRDM16 emerged as a master regulator in fetal-origin NUP98::NSD1 AML. Knocking out PRDM16 halted leukemia growth and overcame therapy resistance, spotlighting PRDM16 as an exciting therapeutic target. 10/13
Fetal-origin leukemia stem cells uniquely rely on oxidative phosphorylation & fatty acid oxidation, driven by the transcription factor PRDM16. PRDM16 also enhances anti-apoptotic BCL2, creating powerful therapy resistance. 9/13
April 8, 2025 at 2:32 PM
Fetal-origin leukemia stem cells uniquely rely on oxidative phosphorylation & fatty acid oxidation, driven by the transcription factor PRDM16. PRDM16 also enhances anti-apoptotic BCL2, creating powerful therapy resistance. 9/13
Meet Mostafa Nasr, an SBUR Travel Award Winner from the University of South Florida, who was also selected for podium presentation!
"Induction of the transcription factor, PRDM16, in prostate cancer cells is critical for the initiation of an intrinsic dormancy program that... 1/2
"Induction of the transcription factor, PRDM16, in prostate cancer cells is critical for the initiation of an intrinsic dormancy program that... 1/2
May 23, 2025 at 2:00 PM
Meet Mostafa Nasr, an SBUR Travel Award Winner from the University of South Florida, who was also selected for podium presentation!
"Induction of the transcription factor, PRDM16, in prostate cancer cells is critical for the initiation of an intrinsic dormancy program that... 1/2
"Induction of the transcription factor, PRDM16, in prostate cancer cells is critical for the initiation of an intrinsic dormancy program that... 1/2
Researchers at NYU found a group of #cells in the intestines lower immune responses caused by exposure to food #proteins. Tolerogenic dendritic cells, enable food to pass through without an immune reaction, unless they malfunction & cause allergies.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prdm16-dependent antigen-presenting cells induce tolerance to gut antigens - Nature
Nature - Prdm16-dependent antigen-presenting cells induce tolerance to gut antigens
www.nature.com
April 14, 2025 at 4:09 PM
Researchers at NYU found a group of #cells in the intestines lower immune responses caused by exposure to food #proteins. Tolerogenic dendritic cells, enable food to pass through without an immune reaction, unless they malfunction & cause allergies.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PRDM16 Coordinates Genetic and Epigenetic Programs Governing Chondrogenesis and Chondrocyte Phenotype Specification in the Knee Joint https://www.biorxiv.org/content/10.64898/2026.01.28.701140v1
February 1, 2026 at 5:00 AM
PRDM16 Coordinates Genetic and Epigenetic Programs Governing Chondrogenesis and Chondrocyte Phenotype Specification in the Knee Joint https://www.biorxiv.org/content/10.64898/2026.01.28.701140v1
Beige fat surrounding blood vessels actively works to keep high blood pressure in check, according to a new Science study in mice. The findings support the notion that therapeutic activation of thermogenic fat tissue could help reduce the risk of cardiovascular disease. https://scim.ag/4jGVhRe
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure
Excess adiposity is a major risk factor for hypertension and heart disease. Brown fat is associated with protection from cardiovascular pathology, but whether this relationship is causal remains unkno...
scim.ag
January 21, 2026 at 8:54 PM
Beige fat surrounding blood vessels actively works to keep high blood pressure in check, according to a new Science study in mice. The findings support the notion that therapeutic activation of thermogenic fat tissue could help reduce the risk of cardiovascular disease. https://scim.ag/4jGVhRe
🔍 Main findings:
• Tau vs Aβ → pathology-specific DNA methylation remodeling
• Larger effects in the hippocampus
• Convergence with human studies: ANK1, PRDM16, SATB1
• Accelerated epigenetic age with tau accumulation
#Tau #Amyloid #Alzheimer #EndAlz #Epigenetics
• Tau vs Aβ → pathology-specific DNA methylation remodeling
• Larger effects in the hippocampus
• Convergence with human studies: ANK1, PRDM16, SATB1
• Accelerated epigenetic age with tau accumulation
#Tau #Amyloid #Alzheimer #EndAlz #Epigenetics
August 5, 2025 at 1:12 PM
🔍 Main findings:
• Tau vs Aβ → pathology-specific DNA methylation remodeling
• Larger effects in the hippocampus
• Convergence with human studies: ANK1, PRDM16, SATB1
• Accelerated epigenetic age with tau accumulation
#Tau #Amyloid #Alzheimer #EndAlz #Epigenetics
• Tau vs Aβ → pathology-specific DNA methylation remodeling
• Larger effects in the hippocampus
• Convergence with human studies: ANK1, PRDM16, SATB1
• Accelerated epigenetic age with tau accumulation
#Tau #Amyloid #Alzheimer #EndAlz #Epigenetics
Spring 2026 NUIP Graduate highlight!
Congratulations, Dr. Omid Rouzbehani!
Dissertation: PRDM16-MEDIATED CARDIOMYOPATHY: MOLECULAR MECHANISMS AND THERAPEUTIC STRATEGIES.
#UImagineMore #UImagineThenDo #UniversityofUtah #UofUHealth
Congratulations, Dr. Omid Rouzbehani!
Dissertation: PRDM16-MEDIATED CARDIOMYOPATHY: MOLECULAR MECHANISMS AND THERAPEUTIC STRATEGIES.
#UImagineMore #UImagineThenDo #UniversityofUtah #UofUHealth
March 20, 2026 at 2:03 PM
Spring 2026 NUIP Graduate highlight!
Congratulations, Dr. Omid Rouzbehani!
Dissertation: PRDM16-MEDIATED CARDIOMYOPATHY: MOLECULAR MECHANISMS AND THERAPEUTIC STRATEGIES.
#UImagineMore #UImagineThenDo #UniversityofUtah #UofUHealth
Congratulations, Dr. Omid Rouzbehani!
Dissertation: PRDM16-MEDIATED CARDIOMYOPATHY: MOLECULAR MECHANISMS AND THERAPEUTIC STRATEGIES.
#UImagineMore #UImagineThenDo #UniversityofUtah #UofUHealth