#PREFUL
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In this issue:
🆕COVID, Flu, H5N1, Measles updates
🧒Long COVID kids have lung injury seen only on PREFUL MRI
🧪IFN-γ as possible Long COVID biomarker
💉Pancreatic cancer vaccine works

& much more drruth.substack.com/p/covid-and-...

#medsky #pedsky #IDsky 🛟😷
COVID & Health News 3/2/25
Respiratory illnesses are MODERATE across the country as levels of COVID decrease.
drruth.substack.com
March 3, 2025 at 7:34 PM
elhopkins.bsky.social
Also from February this year..

Children and teens with #Longcovid show significant lung abnormalities detected on MRIs
timesofindia.indiatimes.com/life-style/h...
Surprising study uncovers serious lung damage in children and teens with Long Covid - The Times of India
A new study utilizing PREFUL MRI has identified significant lung abnormalities in children suffering from long Covid without using radiation or contra
timesofindia.indiatimes.com
August 18, 2025 at 2:40 PM
davidjoffe64.bsky.social
www.sciencedirect.com/science/arti...
November 20, 2025 at 2:45 AM
elhopkins.bsky.social
timesofindia.indiatimes.com/life-style/h...
There have been studies showing this for years.
Surprising study uncovers serious lung damage in children and teens with Long Covid - The Times of India
A new study utilizing PREFUL MRI has identified significant lung abnormalities in children suffering from long Covid without using radiation or contra
timesofindia.indiatimes.com
March 3, 2025 at 8:17 PM
bhanlon15.bsky.social
Health Day: 'PREFUL MRI Reveals Distinct Lung Phenotype in Children With Long COVID'

'Children and adolescents with post-COVID-19 condition have lower regional ventilation and quantified perfusion'

www.healthday.com/healthpro-ne...
PREFUL MRI Reveals Distinct Lung Phenotype in Children With Long COVID
THURSDAY, Feb. 27, 2025 (HealthDay News) -- Free-breathing phase-resolved functional lung (PREFUL) magnetic resonance imaging (MRI)-derived parameters can ident
www.healthday.com
February 27, 2025 at 7:33 PM
tomkindlon.bsky.social
From China

Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #Covidlung
Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID: A one-year study using phase-resolved functional lung (PREFUL) MRI — Ouyang et al. "We found ventilation defects normalizing by six months, while perfusion defects persisted for up to one year. Severe perfusion defects at the acute phase were associated with a higher risk of long COVID, persistent dyspnea, and fatigue."
November 27, 2025 at 1:48 AM
apresj20.bsky.social
❓Pourquoi est-ce important ?

- Cette étude apporte la première preuve biologique mesurable des anomalies pulmonaires chez les enfants atteints de #CovidLong.
- L'IRM PREFUL n'utilise ni radiation ni produit de contraste, idéale pour les jeunes patients.
February 25, 2025 at 7:05 PM
apresj20.bsky.social
Les chercheurs recommandent une surveillance régulière de ces anomalies pour mieux guider les traitements futurs.

L'IRM pulmonaire PREFUL pourrait devenir un outil clé pour le diagnostic et le suivi du #CovidLongPediatrique
February 25, 2025 at 7:05 PM
thedoctoreditor.bsky.social
A special MRI can track lung function in kids and teens with long COVID without radiation. Their symptoms often go undiagnosed and untreated. www.thedoctorwillseeyounow.com/content/kids... #longcovid #kids #ChronicFatigue #chronicfatiguesyndrome #respiratoryhealth #tiredkids #COVID19 #lungs #PREFUL
Help for Kids and Teens with Long COVID
A PREFUL MRI can track lung function in kids and teens with long COVID without radiation. Their symptoms often go undiagnosed and untreated.
www.thedoctorwillseeyounow.com
March 3, 2025 at 2:34 PM
ygjumi.bsky.social
Long COVID患児における著しい肺傷害が画像で明らかに

Long COVIDの小児および10代の若者
位相分解機能性肺(PREFUL)MRIと呼ばれる
先進的な磁気共鳴画像法（MRI）により肺の重大な異常が検出

Imaging shows significant lung injury in kids with long COVID www.cidrap.umn.edu/covid-19/ima...
Imaging shows significant lung injury in kids with long COVID
www.cidrap.umn.edu
February 27, 2025 at 10:55 AM
acute-tomato.bsky.social
Surprising study uncovers serious lung damage in children and teens with Long Covid ~
Surprising study uncovers serious lung damage in children and teens with Long Covid - The Times of India
A new study utilizing PREFUL MRI has identified significant lung abnormalities in children suffering from long Covid without using radiation or contra
buff.ly
March 2, 2025 at 7:10 PM
apresj20.bsky.social
🔬🩻Des chercheurs ont utilisé une IRM pulmonaire avancée (PREFUL) pour analyser la ventilation et la perfusion (flux sanguin pulmonaire) chez 54 enfants (11-17 ans), dont la moitié souffrait de #CovidLong.

Résultat : des anomalies significatives ont été détectées.
February 25, 2025 at 7:05 PM
mtnsnark.bsky.social
I’m caught in that awkward phase of looking at my 3 year old hugging my leg telling me they love me, and also feeling that smack across my balls as they throw their arms around my leg. It’s precious and painful: preful, paincious. Still workshopping that.
January 4, 2024 at 1:46 AM
tlhm-md.bsky.social
Can MRI predict CTD‑ILD progression? 🫁

PREFUL MRI shows ventilation–perfusion changes linked to 1‑yr progression. Higher perfusion defects & V/Q mismatch flagged at‑risk pts.

A promising, radiation‑free marker for ILD management 📖

#chestrad
@rsnasky.bsky.social

pubs.rsna.org/doi/10.1148/...
April 30, 2026 at 12:03 AM
ygjumi.bsky.social
”PREFULの結果から、Long COVIDの子供たちは、
特定のLong COVIDの症状や肺の血流の全体的な低下と
相関する肺の傷害を有していることが示された。”
www.cidrap.umn.edu/covid-19/ima...
Imaging shows significant lung injury in kids with long COVID
www.cidrap.umn.edu
February 27, 2025 at 12:42 PM
antjehellwich.bsky.social
Phase-Resolved Functional Lung (PREFUL) #MRI: The Next-Generation Ventilation-Perfusion Scan?
Learn more about the radiation-free alternative for lung function assessment at www.magnetomworld.siemens-healthineers.com/clinical-cor...

#MagnetomWorld #LungHealth #LungFunctionMonitoring
This article is by Andreas Voskrebenzev, Ph.D.; Filip Klimeš, Ph.D.; and Jens Vogel-Claussen, M.D. (Hannover Medical School and BREATH - Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Member of the Deutsches Zentrum für Lungenforschung (DZL), Hannover, Germany). Chronic pulmonary diseases —such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and chronic thromboembolic pulmonary hypertension (CTEPH) – require accurate and sensitive diagnostic techniques to monitor progression and therapeutic response. Traditional pulmonary function tests (PFTs), including the Tiffeneau-Pinelli index, provide global lung function parameters but lack the capacity to map region-specific changes. Imaging approaches like computed tomography (CT) or single photon emission computed tomography (SPECT) can visualize lung morphology and function but inevitably involve ionizing radiation, making repeated examinations challenging. Magnetic resonance imaging (MRI) offers a promising, radiation-free alternative for lung function assessment. PREFUL MRI provides a robust, radiation-free means of assessing ventilation and perfusion in a single free-breathing scan. Validation studies have consistently shown strong concordance with established methods like SPECT, DCE, and hyperpolarized gas MRI, underscoring its clinical potential. PREFUL technology will be available soon under the product name LungMaps as a postprocessing application for MRI scanners from Siemens Healthineers.
March 18, 2025 at 7:30 AM
thatcovidlife.bsky.social
Radiology: Phase-resolved Functional Lung MRI Reveals Distinct Lung Perfusion Phenotype in Children and Adolescents with Post–COVID-19 Condition: ABSTRACT

Background

Although measurable organic dysfunctions are frequently absent in pediatric patients with… #ThatCovidLife #CovidIsNotOver
Radiology: Phase-resolved Functional Lung MRI Reveals Distinct Lung Perfusion Phenotype in Children and Adolescents with Post–COVID-19 Condition
ABSTRACT Background Although measurable organic dysfunctions are frequently absent in pediatric patients with post–COVID-19 condition (PCC), this condition adversely affects quality of life. Free-breathing phase-resolved functional lung (PREFUL) MRI m...
thatcovid.life
March 3, 2025 at 4:00 PM
antjehellwich.bsky.social
Phase-Resolved Functional Lung Protocols: The #PREFUL research team shares their #MRI protocols for 1.5T, 3T, and 0.55T MAGNETOM systems.

www.magnetomworld.siemens-healthineers.com/clinical-cor...

#RadSky #LungMRI #Pediatrics #FunctionalImaging #LungHealth
Chronic pulmonary diseases (CPD) represent a major global health burden and are the leading cause of death among lung diseases. Each year, more than 55 million new cases are diagnosed worldwide, and approximately 10% of patients affected by CPDs are children. CPDs comprise a spectrum of diseases that require continuous surveillance. Assessing lung function, particularly perfusion (blood flow) and ventilation (airflow), is essential. Nuclear medicine is currently considered the gold standard for functional lung imaging. However, when repeated follow-up imaging is required, radiation exposure has to be taken into account, especially for vulnerable patient groups such as children. LungMaps is a proton MRI-based application that provides functional lung information without the need for tracers, contrast agents, or ionizing radiation. It is based on the PREFUL method, which has been clinically evaluated across a wide range of patient populations. Although LungMaps is a post-processing application, it relies on a 2D MRI acquisition protocol with sufficient temporal resolution to capture both respiratory- and cardiac-based signal variations in the lungs. Shout-out to Andreas Voskrebenzev, Ph.D.; Filip Klimeš, Ph.D.; and Jens Vogel-Claussen, M.D. (Department of Radiology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; Department for Diagnostic and Interventional Radiology, Hannover Medical School, Germany) for sharing their protocols. Download the protocols for: -- 0.55T MAGNETOM Free (syngo MR XA80) -- 1.5T MAGNETOM Sola (syngo MR XA61) -- 3T MAGNETOM Vida (syngo MR XA60)
June 28, 2026 at 8:24 AM
DOI: 10.1148/radiol.241596
Long COVID(新型コロナ後遺症)の17歳以下の患者を、自由呼吸位相分解機能的肺（PREFUL）MRIで調べたところ、肺の重大な異常が検出された
PREFUL MRI は造影剤や放射線を使用しない画像診断法であり、撮像例が少なかった子どもに使用できると考えられる
2022~2024に、LCと非LCの54人を撮影し、特定の長期COVIDの症状と肺の全体的な血流低下と相関する肺損傷を患っている、ことなどが判明した
より大規模なコホートの多施設縦断研究を行うべきである

www.cidrap.umn.edu/covid-19/ima...
Imaging shows significant lung injury in kids with long COVID
www.cidrap.umn.edu
February 27, 2025 at 1:48 AM
idw-online.de
Please imitate! MHH radiology offers guidance for innovative lung MRI @MHH_life...
weiterlesen
Developed the PREFUL method for regional lung imaging in MRI: Dr. Andreas Voskrebenzev, physicist (left) and Professor Dr. Jens Vogel-Claussen (right), Senior Consultant at the Institute of Diagnostic and Interventional Radiology at the MHH. - Copyright Copyright: Dr. Andreas Voskrebenzev/MHH
October 21, 2024 at 10:45 AM
idw-online.de
Bitte nachahmen! MHH-Radiologie bietet Anleitung für neuartiges Lungen-MRT
An der MHH entwickelte Aufnahmetechnik ermöglicht regionale Darstellung der Lungenfunktion ohne Strahlenbelastung und Atemstopps...
weiterlesen
Entwickelten die PREFUL Methode für die regionale Lungenbildgebung im MRT: Dr. Andreas Voskrebenzev, Physiker (links) und Professor Dr. Jens Vogel-Claussen (rechts), Leitender Oberarzt im Institut für Diagnostische und Interventionelle Radiologe der MHH. - Copyright Copyright: Dr. Andreas Voskrebenzev/MHH
October 21, 2024 at 10:44 AM
longtail-news.bsky.social
Feed: "DiscoverMedNews.com"
By: DMN on Saturday, March 8, 2025
Phase-resolved functional lung MRI revealed pulmonary perfusion abnormalities in children and adolescents with post-COVID syndrome (84% COVID-vaccinated)
Lung PREFUL MRI revealed subtle pulmonary changes in pediatric post-COVID syndrome, such as reduced regional ventilation and perfusion.
discovermednews.com
March 9, 2025 at 5:47 PM
pezlarson.bsky.social
onlinelibrary.wiley.com/doi/full/10....

uses 3D FLORET trajectory, and ventilation processing from PREFUL (phase-resolved functional lung) method

Compelling examples in CF, LAM, BOS, and Post-HSCT with HP Xe comparisons

@cincykidsrad.bsky.social
Quantifying spatial and dynamic lung abnormalities with 3D PREFUL FLORET UTE imaging: A feasibility study
Purpose Pulmonary MRI faces challenges due to low proton density, rapid transverse magnetization decay, and cardiac and respiratory motion. The fermat-looped orthogonally encoded trajectories (FLORE.....
onlinelibrary.wiley.com
April 17, 2025 at 11:03 PM
plasmapineapple.bsky.social
Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID: A one-year study using phase-resolved functional lung (PREFUL) MRI — Ouyang et al.

www.sciencedirect.com/science/arti...
Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID: A one-year study using … PREFUL MRI, 2025, Ouyang+
Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID: A one-year study using phase-resolved functional lung PREFUL MRI RATIONALE AND OBJECTIVES The long-term trajecto...
www.s4me.info
November 24, 2025 at 5:29 PM
scienmag.bsky.social
Evaluating Lung Function in Cystic Fibrosis: MRI Methods

A groundbreaking study has recently emerged in the realm of pediatric medicine, significantly enhancing our understanding of lung health in children afflicted with cystic fibrosis. This innovative research, conducted by a team of scientists…
Evaluating Lung Function in Cystic Fibrosis: MRI Methods
A groundbreaking study has recently emerged in the realm of pediatric medicine, significantly enhancing our understanding of lung health in children afflicted with cystic fibrosis. This innovative research, conducted by a team of scientists led by Munidasa, utilizes advanced imaging techniques to monitor lung function over time. The pivotal focus is on comparing two sophisticated MRI technologies: phase-resolved functional lung imaging (PREFUL) and hyperpolarized xenon-129 (hyperpolarized ^129Xe) MRI.
scienmag.com
September 12, 2025 at 8:57 AM