#PROSPECTOR1 ⛏️double blind pilot feasibility RCT of single dose vs. multi dose challenge for #penicillinallergy fully recruited! Can’t wait for the results… and PROSPECTOR2 to commence internationally in 2025! Stay tuned… #IDSky #MedSky #AISky
November 15, 2024 at 10:18 PM
#PROSPECTOR1 ⛏️double blind pilot feasibility RCT of single dose vs. multi dose challenge for #penicillinallergy fully recruited! Can’t wait for the results… and PROSPECTOR2 to commence internationally in 2025! Stay tuned… #IDSky #MedSky #AISky
We randomised our first patients yesterday into the #PROSPECTOR2 ⛏️ study - international superioty trail of 1 dose versus day challenge for #penicillinallergy. “Is one dose ever enough….”
March 26, 2025 at 8:50 PM
We randomised our first patients yesterday into the #PROSPECTOR2 ⛏️ study - international superioty trail of 1 dose versus day challenge for #penicillinallergy. “Is one dose ever enough….”
#PROSPECTOR Trial is out in NEJM Evidence 🔥
➡️ evidence.nejm.org/doi/full/10....
✅ 1st double-blind, placebo RCT in #drugallergy
✅ Pilot feasibility RCT
✅ 1-dose vs 5-day amoxicillin challenge in delayed/unknown #penicillinallergy
We’re going to answer… Is 1 dose ever enough? 👀 #PROSPECTOR2
➡️ evidence.nejm.org/doi/full/10....
✅ 1st double-blind, placebo RCT in #drugallergy
✅ Pilot feasibility RCT
✅ 1-dose vs 5-day amoxicillin challenge in delayed/unknown #penicillinallergy
We’re going to answer… Is 1 dose ever enough? 👀 #PROSPECTOR2
Feasibility Trial of Prolonged versus Single-Dose Challenge in Penicillin Allergy
We aimed to evaluate the feasibility of conducting a multicenter, double-blind, placebo-controlled
trial of prolonged (i.e., multidose) compared with single-dose amoxicillin challenge
in patients w...
evidence.nejm.org
February 28, 2026 at 9:15 PM
#PROSPECTOR Trial is out in NEJM Evidence 🔥
➡️ evidence.nejm.org/doi/full/10....
✅ 1st double-blind, placebo RCT in #drugallergy
✅ Pilot feasibility RCT
✅ 1-dose vs 5-day amoxicillin challenge in delayed/unknown #penicillinallergy
We’re going to answer… Is 1 dose ever enough? 👀 #PROSPECTOR2
➡️ evidence.nejm.org/doi/full/10....
✅ 1st double-blind, placebo RCT in #drugallergy
✅ Pilot feasibility RCT
✅ 1-dose vs 5-day amoxicillin challenge in delayed/unknown #penicillinallergy
We’re going to answer… Is 1 dose ever enough? 👀 #PROSPECTOR2
Excuse ignorance but what study is PROSPECTOR2?
November 15, 2024 at 10:56 PM
Excuse ignorance but what study is PROSPECTOR2?
Is one dose enough?! Great talk from Dr Rose for the #PROSPECTOR #penicillinallergy #RCT at #EAACI HK Summer School. 6.7% increase in immune mediated reactions with prolonged oral challenge. Looking forward to #PROSPECTOR2 definitive phase III study to change practice!
August 28, 2025 at 1:54 PM
Is one dose enough?! Great talk from Dr Rose for the #PROSPECTOR #penicillinallergy #RCT at #EAACI HK Summer School. 6.7% increase in immune mediated reactions with prolonged oral challenge. Looking forward to #PROSPECTOR2 definitive phase III study to change practice!
Incredibly clear set of guidelines for penicillin allergy assessment and management. Currently not recommending multiple day challenges-eagerly awaiting PROSPECTOR2. @idsky.bsky.social
In this latest @escmid.bsky.social clinical guideline, a panel of 16 multidisciplinary experts provide recommendations for how to evaluate and manage patients with reported antibiotic allergies.
www.clinicalmicrobiologyandinfection.org/article/S119...
www.clinicalmicrobiologyandinfection.org/article/S119...
June 1, 2026 at 12:13 PM
Incredibly clear set of guidelines for penicillin allergy assessment and management. Currently not recommending multiple day challenges-eagerly awaiting PROSPECTOR2. @idsky.bsky.social