Can cellular life be created in the lab? We are not yet there, but clearly getting closer! Check this paper where a new scenario for protocell replication is presented by Job Boekhoven and co-workers @manlius.bsky.social www.cell.com/chem/pdf/S24...
August 30, 2025 at 1:06 PM
Can cellular life be created in the lab? We are not yet there, but clearly getting closer! Check this paper where a new scenario for protocell replication is presented by Job Boekhoven and co-workers @manlius.bsky.social www.cell.com/chem/pdf/S24...
Next, @danielcooney1.bsky.social presents a multilevel selection model of protocell and chromosome evolution #MMEE2026
July 23, 2026 at 10:29 AM
Next, @danielcooney1.bsky.social presents a multilevel selection model of protocell and chromosome evolution #MMEE2026
Membraneless protocell confined by a heat flow
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Membraneless protocell confined by a heat flow - Nature Physics
It is unclear how cell compartmentalization emerged in prebiotic conditions. Now it is shown that a temperature gradient in a confined space can bring the core components of a cell together.
doi.org
June 29, 2025 at 8:36 AM
Membraneless protocell confined by a heat flow
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Protocell Formation On Micrometeorites
astrobiology.com/2025/04/prot... #astrobiology #originoflife #meteorite
astrobiology.com/2025/04/prot... #astrobiology #originoflife #meteorite
Protocell Formation On Micrometeorites - Astrobiology
We report on the formation of membranous protocells by self-assembly of lipids on micrometeorites
astrobiology.com
April 14, 2025 at 4:05 PM
Protocell Formation On Micrometeorites
astrobiology.com/2025/04/prot... #astrobiology #originoflife #meteorite
astrobiology.com/2025/04/prot... #astrobiology #originoflife #meteorite
New paper: "Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies"
Happy to have participated in this work!
royalsocietypublishing.org/doi/10.1098/...
Happy to have participated in this work!
royalsocietypublishing.org/doi/10.1098/...
Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies | Philosophical Transactions of the Royal Society B: Biological Sciences
How and why did natural systems develop the first mechanisms of regulation? How could they turn into adaptive agents in a minimal (though deeply meaningful) biological sense? A novel simulation platform, Araudia, has been implemented to address these ...
royalsocietypublishing.org
October 2, 2025 at 12:37 PM
New paper: "Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies"
Happy to have participated in this work!
royalsocietypublishing.org/doi/10.1098/...
Happy to have participated in this work!
royalsocietypublishing.org/doi/10.1098/...
January 28, 2026 at 11:52 AM
How Life's Building Blocks Took Shape On Early Earth: The Limits of Membraneless Polyester Protocell Formation
astrobiology.com/2025/02/how-... #astrobiology #evolution #genomics #originoflife
astrobiology.com/2025/02/how-... #astrobiology #evolution #genomics #originoflife
How Life's Building Blocks Took Shape On Early Earth: The Limits of Membraneless Polyester Protocell Formation - Astrobiology
One leading theory on the origins of life on Earth proposes that simple chemical molecules gradually became more complex
astrobiology.com
February 6, 2025 at 8:12 PM
How Life's Building Blocks Took Shape On Early Earth: The Limits of Membraneless Polyester Protocell Formation
astrobiology.com/2025/02/how-... #astrobiology #evolution #genomics #originoflife
astrobiology.com/2025/02/how-... #astrobiology #evolution #genomics #originoflife
Moe Yabuta is now speaking about self-growing protocell models in aqueous two-phase system induced by internal DNA replication reaction. Beautiful talk by a PhD student... one to watch! #japanuksynbio
February 4, 2025 at 6:56 AM
Moe Yabuta is now speaking about self-growing protocell models in aqueous two-phase system induced by internal DNA replication reaction. Beautiful talk by a PhD student... one to watch! #japanuksynbio
Protocell Effects on RNA Folding, Function, and Evolution
astrobiology.com/2025/01/prot... #astrobiology #genomics #evolution
astrobiology.com/2025/01/prot... #astrobiology #genomics #evolution
Protocell Effects on RNA Folding, Function, and Evolution - Astrobiology
Creating a living system from nonliving matter is a great challenge in chemistry and biophysics.
astrobiology.com
January 7, 2025 at 5:52 PM
Protocell Effects on RNA Folding, Function, and Evolution
astrobiology.com/2025/01/prot... #astrobiology #genomics #evolution
astrobiology.com/2025/01/prot... #astrobiology #genomics #evolution
[🎀] this isn't even a single-celled organism at this rate that's a protocell
December 13, 2025 at 12:41 AM
[🎀] this isn't even a single-celled organism at this rate that's a protocell
"On the silica surface, the cysteine and thioesters spontaneously reacted to form lipids, generating protocell-like membrane vesicles stable enough to sustain biochemical reactions" 🧪⚒️
astrobiology.com/2024/11/how-...
astrobiology.com/2024/11/how-...
How The First Cell Membranes Came To Exist - Astrobiology
Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist?
astrobiology.com
November 14, 2024 at 11:07 PM
"On the silica surface, the cysteine and thioesters spontaneously reacted to form lipids, generating protocell-like membrane vesicles stable enough to sustain biochemical reactions" 🧪⚒️
astrobiology.com/2024/11/how-...
astrobiology.com/2024/11/how-...
Modelling the prebiotic origins of regulation & agency in evolving protocell ecologies https://www.biorxiv.org/content/10.1101/2024.11.20.624505v1
Modelling the prebiotic origins of regulation & agency in evolving protocell ecologies https://www.biorxiv.org/content/10.1101/2024.11.20.624505v1
How did natural systems develop the first mechanisms of regulation and what for? How could they turn
www.biorxiv.org
November 22, 2024 at 3:31 PM
Modelling the prebiotic origins of regulation & agency in evolving protocell ecologies https://www.biorxiv.org/content/10.1101/2024.11.20.624505v1
cocky overpowered hero has infinite lives but every time they die they have to physically transform themself through his evolutionary lineage from a protocell at the same pond every time, travelling through a path that takes them through each species habitat. has to start over if they die during
September 22, 2026 at 12:14 AM
cocky overpowered hero has infinite lives but every time they die they have to physically transform themself through his evolutionary lineage from a protocell at the same pond every time, travelling through a path that takes them through each species habitat. has to start over if they die during
Our paper on how protocells at the origins of life could have first evolved adaptive responses to their environment was published today in Trans. Royal Society B: royalsocietypublishing.org/doi/10.1098/... ...and what a beautiful cover the Special Issue has too! #protocell #OOL #abiogenesis
October 2, 2025 at 12:33 PM
Our paper on how protocells at the origins of life could have first evolved adaptive responses to their environment was published today in Trans. Royal Society B: royalsocietypublishing.org/doi/10.1098/... ...and what a beautiful cover the Special Issue has too! #protocell #OOL #abiogenesis
🦠 The #PROTOCELL experiment is heading into space!
The project led by @hlouchova-lab.bsky.social & @pluskal-lab.org at IOCB Prague is one of 13 Czech scientific and technological experiments supported by @esa.int that will become part of the now confirmed mission of Czech astronaut Aleš Svoboda.
The project led by @hlouchova-lab.bsky.social & @pluskal-lab.org at IOCB Prague is one of 13 Czech scientific and technological experiments supported by @esa.int that will become part of the now confirmed mission of Czech astronaut Aleš Svoboda.
June 9, 2026 at 8:18 AM
🦠 The #PROTOCELL experiment is heading into space!
The project led by @hlouchova-lab.bsky.social & @pluskal-lab.org at IOCB Prague is one of 13 Czech scientific and technological experiments supported by @esa.int that will become part of the now confirmed mission of Czech astronaut Aleš Svoboda.
The project led by @hlouchova-lab.bsky.social & @pluskal-lab.org at IOCB Prague is one of 13 Czech scientific and technological experiments supported by @esa.int that will become part of the now confirmed mission of Czech astronaut Aleš Svoboda.
Postdoc position available in our lab in DCU!
We’re looking for a computational modeller passionate about protocell membranes, origins of life, and biosignature detection to join our ERC funded project. 🧬💻
Full job details and apply here:
universityvacancies.com/dublin-city-...
#OriginsOfLife
We’re looking for a computational modeller passionate about protocell membranes, origins of life, and biosignature detection to join our ERC funded project. 🧬💻
Full job details and apply here:
universityvacancies.com/dublin-city-...
#OriginsOfLife
Postdoctoral Researcher in Computational Modelling of Protocell Membranes | University Vacancies IrelandUniversity Vacancies Logo
universityvacancies.com
December 16, 2024 at 5:30 PM
Postdoc position available in our lab in DCU!
We’re looking for a computational modeller passionate about protocell membranes, origins of life, and biosignature detection to join our ERC funded project. 🧬💻
Full job details and apply here:
universityvacancies.com/dublin-city-...
#OriginsOfLife
We’re looking for a computational modeller passionate about protocell membranes, origins of life, and biosignature detection to join our ERC funded project. 🧬💻
Full job details and apply here:
universityvacancies.com/dublin-city-...
#OriginsOfLife
🤔 The math says life shouldn’t exist?
But somehow it does!
The unreasonable likelihood of being:
Origin of life, terraforming, and AI 🧪
arxiv.org/abs/2507.18545
The origin of life on Earth via spontaneous emergence of a protocell prior to Darwinian evolution remains a fundamental open question.
But somehow it does!
The unreasonable likelihood of being:
Origin of life, terraforming, and AI 🧪
arxiv.org/abs/2507.18545
The origin of life on Earth via spontaneous emergence of a protocell prior to Darwinian evolution remains a fundamental open question.
November 6, 2025 at 3:36 PM
🤔 The math says life shouldn’t exist?
But somehow it does!
The unreasonable likelihood of being:
Origin of life, terraforming, and AI 🧪
arxiv.org/abs/2507.18545
The origin of life on Earth via spontaneous emergence of a protocell prior to Darwinian evolution remains a fundamental open question.
But somehow it does!
The unreasonable likelihood of being:
Origin of life, terraforming, and AI 🧪
arxiv.org/abs/2507.18545
The origin of life on Earth via spontaneous emergence of a protocell prior to Darwinian evolution remains a fundamental open question.
How did regulation and agency arise before genes?
Shirt-Ediss et al. model evolving protocell ecologies with the Araudia platform—showing how simple metabolic systems can “learn” to adapt to changing environments
dialecticalsystems.eu/publications...
Shirt-Ediss et al. model evolving protocell ecologies with the Araudia platform—showing how simple metabolic systems can “learn” to adapt to changing environments
dialecticalsystems.eu/publications...
New Paper (2025): Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies - Dialectical Systems
How could the first living systems learn to regulate themselves before the emergence of genes? In their new paper, Ben Shirt-Ediss, Arián Ferrero-Fernández, Daniele De Martino, Leonardo Bich, Álvaro M...
dialecticalsystems.eu
October 15, 2025 at 9:05 AM
How did regulation and agency arise before genes?
Shirt-Ediss et al. model evolving protocell ecologies with the Araudia platform—showing how simple metabolic systems can “learn” to adapt to changing environments
dialecticalsystems.eu/publications...
Shirt-Ediss et al. model evolving protocell ecologies with the Araudia platform—showing how simple metabolic systems can “learn” to adapt to changing environments
dialecticalsystems.eu/publications...
PROTOCELL is one of 13 Czech scientific and technological experiments supported by @esa that will be included in the planned mission of Czech astronaut-in-training @astro_ales to the #ISS, as announced in October 2025 ► www.uochb.cz/en/news/742 2/2
The origin of life on Earth – and possibly elsewhere in the universe – studied by the PROTOCELL…
Is life in the universe rare, or might it occur almost everywhere? The PROTOCELL project led by Dr. Klára Hlouchová at IOCB Prague aims to find out. PROTOCELL is one of thirteen Czech scientific and…
www.uochb.cz
January 5, 2026 at 8:07 PM
PROTOCELL is one of 13 Czech scientific and technological experiments supported by @esa that will be included in the planned mission of Czech astronaut-in-training @astro_ales to the #ISS, as announced in October 2025 ► www.uochb.cz/en/news/742 2/2
Mutation is evolution.
A lab cell broke containment. You move, it kills on its own — every upgrade drags you closer to meltdown.
PROTOCELL — out November 10.
▶ www.youtube.com/watch?v=yRjd...
🧬 store.steampowered.com/app/4870510/
A lab cell broke containment. You move, it kills on its own — every upgrade drags you closer to meltdown.
PROTOCELL — out November 10.
▶ www.youtube.com/watch?v=yRjd...
🧬 store.steampowered.com/app/4870510/
PROTOCELL — Official Trailer | Mutate. Adapt. Survive.
YouTube video by lejiww
www.youtube.com
August 31, 2026 at 10:33 PM
Mutation is evolution.
A lab cell broke containment. You move, it kills on its own — every upgrade drags you closer to meltdown.
PROTOCELL — out November 10.
▶ www.youtube.com/watch?v=yRjd...
🧬 store.steampowered.com/app/4870510/
A lab cell broke containment. You move, it kills on its own — every upgrade drags you closer to meltdown.
PROTOCELL — out November 10.
▶ www.youtube.com/watch?v=yRjd...
🧬 store.steampowered.com/app/4870510/
10/23 Can between-protocell selection rescue this? Only under restrictive conditions. Within-cell dynamics drive all protocells toward similarly degraded states, eroding the variation that selection needs to act on.
May 13, 2026 at 2:17 PM
10/23 Can between-protocell selection rescue this? Only under restrictive conditions. Within-cell dynamics drive all protocells toward similarly degraded states, eroding the variation that selection needs to act on.
A Gene-Free Minimal System for Synthetic Quorum Sensing in Protocell Communities
astrobiology.com/2026/01/a-ge... #astrobiology #originoflife #microbiology
astrobiology.com/2026/01/a-ge... #astrobiology #originoflife #microbiology
A Gene-Free Minimal System for Synthetic Quorum Sensing in Protocell Communities - Astrobiology
Synthetic communication networks are key to engineering life-like behaviors in artificial cells. I
astrobiology.com
January 24, 2026 at 7:12 PM
A Gene-Free Minimal System for Synthetic Quorum Sensing in Protocell Communities
astrobiology.com/2026/01/a-ge... #astrobiology #originoflife #microbiology
astrobiology.com/2026/01/a-ge... #astrobiology #originoflife #microbiology
You can read more about @danielcooney1.bsky.social’s work here: link.springer.com/article/10.1...
A PDE Model for Protocell Evolution and the Origin of Chromosomes via Multilevel Selection - Bulletin of Mathematical Biology
The evolution of complex cellular life involved two major transitions: the encapsulation of self-replicating genetic entities into cellular units and the aggregation of individual genes into a collect...
link.springer.com
July 23, 2026 at 10:31 AM
You can read more about @danielcooney1.bsky.social’s work here: link.springer.com/article/10.1...