#PaperoftheDay
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aging-us.bsky.social
#PaperoftheDay: "Could social relationships be key to reaching healthy longevity?"

DOI ⬇️
https://doi.org/10.18632/aging.204871

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Could social relationships be key to reaching healthy longevity? | Aging
doi.org
November 13, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Advances in cancer therapy: clinical benefit of new cancer drugs"

DOI ⬇️
https://doi.org/10.18632/aging.204839

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Advances in cancer therapy: clinical benefit of new cancer drugs | Aging
doi.org
November 11, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Advancing screening for cognitive impairment: the memtrax continuous recognition test"

DOI ⬇️
https://doi.org/10.18632/aging.204828

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Advancing screening for cognitive impairment: the memtrax continuous recognition test | Aging
doi.org
November 10, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Comprehensive healthspan assessments and influence of sex as a biological variable in aging rats"

DOI ⬇️
https://doi.org/10.18632/aging.206438

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Comprehensive healthspan assessments and influence of sex as a biological variable in aging rats | Aging
Rats have significant genetic and physiological similarity with humans. Many biological processes and pathways are conserved between rats and humans, making rats a suitable model for studying aspects
doi.org
November 12, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Predicting lifespan-extending chemical compounds for C. elegans with machine learning and biologically interpretable features"

DOI ⬇️
https://doi.org/10.18632/aging.204866

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Predicting lifespan-extending chemical compounds for C. elegans with machine learning and biologically interpretable features | Aging
Recently, there has been a growing interest in the development of pharmacological interventions targeting ageing, as well as in the use of machine learning for analysing ageing-related data. In this w
doi.org
November 9, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan"

DOI ⬇️
https://doi.org/10.18632/aging.204833

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan | Aging
Positive experiences, such as social interaction, cognitive training and physical exercise, have been shown to ameliorate some of the harms to cognition associated with ageing. Animal models of positi
doi.org
November 6, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Age-dependent albumin post-translational modification landscape reveals a critical midlife transition window"

DOI ⬇️
https://doi.org/10.18632/aging.206435

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Age-dependent albumin post-translational modification landscape reveals a critical midlife transition window | Aging
Albumin, the most abundant plasma protein, maintains osmotic pressure, transporting diverse substances, and provides antioxidant defense. To screen aging-related proteins, we performed quantitative p
doi.org
November 5, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Brain glucose metabolism and blood brain barrier permeability in Alzheimer’s disease continuum"

DOI ⬇️
https://doi.org/10.18632/aging.206393

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Brain glucose metabolism and blood brain barrier permeability in Alzheimer’s disease continuum | Aging
Background: Within the ATN framework of Alzheimer’s disease (AD), patients are classified according to the presence of amyloid pathology (A), tau pathology (T), and neurodegeneration (N). While the A
doi.org
November 4, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Cognitive reserve, neuropathology, and progression towards Alzheimer’s disease"

DOI ⬇️
https://doi.org/10.18632/aging.204909

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Cognitive reserve, neuropathology, and progression towards Alzheimer’s disease | Aging
doi.org
November 2, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Chemically induced reprogramming to reverse cellular aging"

DOI ⬇️
https://doi.org/10.18632/aging.204896

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Chemically induced reprogramming to reverse cellular aging | Aging
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OS
doi.org
November 3, 2026 at 1:00 PM
aging-us.bsky.social
#PaperoftheDay: "Remote cognitive assessment to early detection of cognitive decline"

DOI ⬇️
https://doi.org/10.18632/aging.204908

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Remote cognitive assessment to early detection of cognitive decline | Aging
doi.org
October 30, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Failure of current Alzheimer’s disease hypotheses"

DOI ⬇️
https://doi.org/10.18632/aging.204880

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Failure of current Alzheimer’s disease hypotheses | Aging
doi.org
October 29, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Investigating the efficacy and toxicity of partial in vivo reprogramming as a rejuvenation intervention"

DOI ⬇️
https://doi.org/10.18632/aging.206431

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Investigating the efficacy and toxicity of partial in vivo reprogramming as a rejuvenation intervention | Aging
Partial reprogramming by cyclic expression of Yamanaka factors has been proposed as a rejuvenation strategy, yet evaluating tissue-specific responses and potential risks remains challenging. Here, we
doi.org
October 28, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span"

DOI ⬇️
https://doi.org/10.18632/aging.204897

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span | Aging
The decrease in the podocyte’s lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse these
doi.org
October 27, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Human senescent fibroblasts trigger progressive lung fibrosis in mice"

DOI ⬇️
https://doi.org/10.18632/aging.204825

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Human senescent fibroblasts trigger progressive lung fibrosis in mice | Aging
Cell senescence has recently emerged as a potentially relevant pathogenic mechanism in fibrosing interstitial lung diseases (f-ILDs), particularly in idiopathic pulmonary fibrosis. We hypothesized tha
doi.org
October 26, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?"

DOI ⬇️
https://doi.org/10.18632/aging.204920

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases? | Aging
Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately succumb to age-related diseases. However, the former, if administered disease-oriented dosages for a long
doi.org
October 23, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "A novel theory of ageing independent of damage accumulation"

DOI ⬇️
https://doi.org/10.18632/aging.204956

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
A novel theory of ageing independent of damage accumulation | Aging
doi.org
October 22, 2026 at 12:00 PM
thesocialsensei.bsky.social
#PaperOfTheDay: QLoRA (Dettmers et al., 2023)

Fine-tuning a 65B model in 16-bit needs 780GB+ of GPU memory. QLoRA freezes the base in 4-bit (NF4) and trains small LoRA adapters on top, which gets it under 48GB: one GPU, near full-precision quality.

knowyourml.com/report.php
QLoRA: Quantized Fine-Tuning — Know Your ML
QLoRA fine-tunes 65B models on one 48GB GPU by combining 4-bit quantization with LoRA adapters — nearly matching full-precision tuning.
knowyourml.com
October 23, 2026 at 2:33 AM
aging-us.bsky.social
#PaperoftheDay: "From hyperfunction to systemic amplification: reframing the logic of late-life rejuvenation"

DOI ⬇️
https://doi.org/10.18632/aging.206430

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
From hyperfunction to systemic amplification: reframing the logic of late-life rejuvenation | Aging
Aging is often modeled, and interventions prioritized, as the near-linear accumulation of cell-intrinsic lesions; yet the exponential acceleration of late-life mortality under the Gompertz law points
doi.org
October 21, 2026 at 12:00 PM
thesocialsensei.bsky.social
#PaperOfTheDay: FlashAttention (Dao et al., 2022)

Attention was slow mostly from memory traffic, not math. FlashAttention computes it in tiles inside fast on-chip SRAM and never writes the full N×N matrix to GPU memory. Same exact result, far fewer reads/writes.

knowyourml.com/report.php
FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness — Know Your ML
FlashAttention tiles exact attention in fast on-chip memory, cutting memory from quadratic to linear and making long-context transformers practical.
knowyourml.com
October 22, 2026 at 2:34 AM
aging-us.bsky.social
#PaperoftheDay: "Associations between klotho and telomere biology in high stress caregivers"

DOI ⬇️
https://doi.org/10.18632/aging.204961

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Associations between klotho and telomere biology in high stress caregivers | Aging
Aging biomarkers may be related to each other through direct co-regulation and/or through being regulated by common processes associated with chronological aging or stress. Klotho is an aging regulato
doi.org
October 20, 2026 at 12:00 PM
thesocialsensei.bsky.social
#PaperOfTheDay: Chinchilla (Hoffmann et al., 2022)

400+ models later, the finding: scale params and tokens together, ~20 tokens per parameter. A 70B model on 1.4T tokens beat the 280B Gopher on the same compute. GPT-3 was at under 2.

Plain-English report: knowyourml.com/report.php
Chinchilla: Compute-Optimal Training — Know Your ML
Chinchilla proved a 70B model on 1.4T tokens beats a 280B model on the same compute — most large models were badly undertrained on data.
knowyourml.com
October 21, 2026 at 2:40 AM
aging-us.bsky.social
#PaperoftheDay: "Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice"

DOI ⬇️
https://doi.org/10.18632/aging.204959

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice | Aging
The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, we questioned how estrogen deficiency might impact the overall skeletal muscle phosphoproteom
doi.org
October 19, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Cardiovascular events and death after catheter ablation in very old patients with nonvalvular atrial fibrillation"

DOI ⬇️
https://doi.org/10.18632/aging.204952

#Aging #Research #OpenAccess #Gerontology #PeerReviewed #Journal #Publishing
Cardiovascular events and death after catheter ablation in very old patients with nonvalvular atrial fibrillation | Aging
Background: Catheter ablation of atrial fibrillation (AF) is recommended for selected older patients. However, the preventive effects of AF ablation on cardiovascular events and death remain unclear,
doi.org
October 16, 2026 at 12:00 PM
aging-us.bsky.social
#PaperoftheDay: "Ferroptosis-related hub genes and immune infiltration characteristics in Duchenne muscular dystrophy: a molecular framework with implications for aging-related muscle degeneration"

DOI ⬇️
https://doi.org/10.18632/aging.206429

#Aging #Research #OA #Gerontology #Publishing
Ferroptosis-related hub genes and immune infiltration characteristics in Duchenne muscular dystrophy: a molecular framework with implications for aging-related muscle degeneration | Aging
Sarcopenia, the age-related loss of skeletal muscle mass and function, is a major driver of frailty in older adults, yet its molecular basis remains incompletely defined. Ferroptosis, an iron-dependen
doi.org
October 15, 2026 at 12:00 PM