#PapersToRead Gasdermin-induced pyroptosis in macrophages leads to F-actin exposure for recognition by CLEC9A on dendritic cells
#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
www.nature.com
December 7, 2024 at 6:10 PM
#PapersToRead Gasdermin-induced pyroptosis in macrophages leads to F-actin exposure for recognition by CLEC9A on dendritic cells
#PapersToRead In silico designed MHC class I:peptide binders can activate CAR T cells - from the Baker lab
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1...
New from the Baker lab
New from the Baker lab
December 8, 2024 at 3:56 PM
#PapersToRead In silico designed MHC class I:peptide binders can activate CAR T cells - from the Baker lab
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...