Nature research paper: Expanding the human proteome with microproteins and peptideins
go.nature.com/4ttILbi
go.nature.com/4ttILbi
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
go.nature.com
May 6, 2026 at 6:49 PM
Nature research paper: Expanding the human proteome with microproteins and peptideins
go.nature.com/4ttILbi
go.nature.com/4ttILbi
Major new work by the #TransCODE Consortium out today in @nature.com.
Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome
This was a huge global collaboration, in part funded via #NIH
www.nature.com/articles/s41...
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Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome
This was a huge global collaboration, in part funded via #NIH
www.nature.com/articles/s41...
1/
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
www.nature.com
May 6, 2026 at 7:18 PM
Major new work by the #TransCODE Consortium out today in @nature.com.
Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome
This was a huge global collaboration, in part funded via #NIH
www.nature.com/articles/s41...
1/
Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome
This was a huge global collaboration, in part funded via #NIH
www.nature.com/articles/s41...
1/
Fascinating new @nature.com paper: a Pluto moment for biology.
It introduces the concept of 'peptideins' - a new category for dark translated ORFs that produce detectable microprotein-like products with unknown biological roles.
It introduces the concept of 'peptideins' - a new category for dark translated ORFs that produce detectable microprotein-like products with unknown biological roles.
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of ‘dark proteins’ have been reclassified as peptideins and added to databases as a new category.
www.nature.com
May 7, 2026 at 7:55 AM
Fascinating new @nature.com paper: a Pluto moment for biology.
It introduces the concept of 'peptideins' - a new category for dark translated ORFs that produce detectable microprotein-like products with unknown biological roles.
It introduces the concept of 'peptideins' - a new category for dark translated ORFs that produce detectable microprotein-like products with unknown biological roles.
Bei solchen Bangern macht mein Wissenschaftsherz immer einen kleinen Sprung
May 14, 2026 at 6:27 PM
Bei solchen Bangern macht mein Wissenschaftsherz immer einen kleinen Sprung
The code for these proteins was excluded from official genome and protein counts
go.nature.com/4tkbGOH
go.nature.com/4tkbGOH
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Nature - Thousands of ‘dark proteins’ have been reclassified as peptideins and added to databases as a new category.
go.nature.com
May 9, 2026 at 2:14 PM
The code for these proteins was excluded from official genome and protein counts
go.nature.com/4tkbGOH
go.nature.com/4tkbGOH
Some stretches of our genome encode mysterious peptide sequences of very short amino acid length that lack matching versions in other organisms, so are omitted from proteome databases. In a new @nature.com paper, the TransCODE Consortium dubs these ‘peptideins’ & provides a framework to study them.🧪
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of ‘dark proteins’ have been reclassified as peptideins and added to databases as a new category.
www.nature.com
May 6, 2026 at 5:14 PM
Some stretches of our genome encode mysterious peptide sequences of very short amino acid length that lack matching versions in other organisms, so are omitted from proteome databases. In a new @nature.com paper, the TransCODE Consortium dubs these ‘peptideins’ & provides a framework to study them.🧪
Link to the original article: Expanding the human proteome with microproteins and peptideins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
www.nature.com
May 7, 2026 at 7:55 AM
Link to the original article: Expanding the human proteome with microproteins and peptideins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The code for these proteins was excluded from official genome and protein counts
go.nature.com/4uppKYi
go.nature.com/4uppKYi
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of ‘dark proteins’ have been reclassified as peptideins and added to databases as a new category.
go.nature.com
May 6, 2026 at 4:09 PM
The code for these proteins was excluded from official genome and protein counts
go.nature.com/4uppKYi
go.nature.com/4uppKYi
So, as translation control is getting popular, please note the newly unified nomenclatures:
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
Translon: a single term for translated regions - Nature Methods
Nature Methods - Translon: a single term for translated regions
www.nature.com
May 15, 2026 at 1:02 PM
So, as translation control is getting popular, please note the newly unified nomenclatures:
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
Translons: a single term for translated regions
www.nature.com/articles/s41...
Peptideins: translated ORFs lacking sufficient evidence for protein-coding gene status
www.nature.com/articles/s41...
Introducing peptidiens! Congratulations to the TransCODE consortium on this exciting tour-de-force in @nature.com: nature.com/articles/s41...
We look forward to seeing what’s next as lead authors Sebastiaan van Heesch and John Prensner take on our dark proteome challenge as part of team ILLUMINE!
We look forward to seeing what’s next as lead authors Sebastiaan van Heesch and John Prensner take on our dark proteome challenge as part of team ILLUMINE!
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
nature.com
May 6, 2026 at 4:18 PM
Introducing peptidiens! Congratulations to the TransCODE consortium on this exciting tour-de-force in @nature.com: nature.com/articles/s41...
We look forward to seeing what’s next as lead authors Sebastiaan van Heesch and John Prensner take on our dark proteome challenge as part of team ILLUMINE!
We look forward to seeing what’s next as lead authors Sebastiaan van Heesch and John Prensner take on our dark proteome challenge as part of team ILLUMINE!
Overall, we think that #peptideins and #microproteins can substantially advance our understanding of human biology, disease processes, and hopefully therapeutics that help patients.
5/end
5/end
May 6, 2026 at 7:18 PM
Overall, we think that #peptideins and #microproteins can substantially advance our understanding of human biology, disease processes, and hopefully therapeutics that help patients.
5/end
5/end
Expanding the human proteome with microproteins and peptideins @nature.com @themaximacenter.bsky.social @oncodeinstitute.bsky.social @umich.edu
doi.org/10.1038/s415...
doi.org/10.1038/s415...
May 6, 2026 at 8:10 PM
Expanding the human proteome with microproteins and peptideins @nature.com @themaximacenter.bsky.social @oncodeinstitute.bsky.social @umich.edu
doi.org/10.1038/s415...
doi.org/10.1038/s415...
If peptideins prove to be largely unimportant, they may soon be forgotten. But if studying them pays off, prepare to hear the name a lot more
The human genome encodes for a new category of molecule
They may be useful targets for future drugs
econ.st
May 8, 2026 at 5:20 PM
If peptideins prove to be largely unimportant, they may soon be forgotten. But if studying them pays off, prepare to hear the name a lot more
Expanding the human proteome with microproteins and peptideins www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper
May 6, 2026 at 9:00 PM
Expanding the human proteome with microproteins and peptideins www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper
Peptideins are a newly named class of molecules found within human cells that are similar to proteins but smaller and with vaguer purposes. Register for free to learn how they could shake up cell biology
The human genome encodes for a new category of molecule
They may be useful targets for future drugs
econ.st
May 12, 2026 at 11:20 AM
Peptideins are a newly named class of molecules found within human cells that are similar to proteins but smaller and with vaguer purposes. Register for free to learn how they could shake up cell biology
Could these #peptideins also be important? We think Yes. And some might be on the path to our understanding them as full proteins.
We used extensive CRISPR-based analyses to show how these can display important cellular phenotypes in a number of contexts.
4/
We used extensive CRISPR-based analyses to show how these can display important cellular phenotypes in a number of contexts.
4/
May 6, 2026 at 7:18 PM
Could these #peptideins also be important? We think Yes. And some might be on the path to our understanding them as full proteins.
We used extensive CRISPR-based analyses to show how these can display important cellular phenotypes in a number of contexts.
4/
We used extensive CRISPR-based analyses to show how these can display important cellular phenotypes in a number of contexts.
4/
Important development👇
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of dark proteins have been reclassified as peptideins and added to databases as a new category.
www.nature.com/articles/d41...
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of dark proteins have been reclassified as peptideins and added to databases as a new category.
www.nature.com/articles/d41...
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of dark proteins have been reclassified as peptideins and added to databases as a new category.
www.nature.com
May 10, 2026 at 11:18 AM
Important development👇
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of dark proteins have been reclassified as peptideins and added to databases as a new category.
www.nature.com/articles/d41...
Revealed: the mysterious ‘dark’ proteins that might play a big role in biology
Thousands of dark proteins have been reclassified as peptideins and added to databases as a new category.
www.nature.com/articles/d41...
Expanding the human proteome with microproteins and peptideins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
www.nature.com
May 8, 2026 at 6:17 PM
Expanding the human proteome with microproteins and peptideins
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A new study reveals 1,700+ protein-like molecules hiding in the human genome — expanding what we thought we knew about the proteome.
These newly identified “peptideins” could play roles in cancer, immunotherapy, and disease.
isbscience.org/news/chronic...
@nature.com
These newly identified “peptideins” could play roles in cancer, immunotherapy, and disease.
isbscience.org/news/chronic...
@nature.com
Scientists Uncover 1,700+ Protein-like Molecules in the ‘Dark Proteome’
Scientists identify 1,700+ new protein-like molecules in the human genome, revealing a hidden layer with implications for cancer and disease.
isbscience.org
May 6, 2026 at 7:34 PM
A new study reveals 1,700+ protein-like molecules hiding in the human genome — expanding what we thought we knew about the proteome.
These newly identified “peptideins” could play roles in cancer, immunotherapy, and disease.
isbscience.org/news/chronic...
@nature.com
These newly identified “peptideins” could play roles in cancer, immunotherapy, and disease.
isbscience.org/news/chronic...
@nature.com
Big picture: we find that lots of protein entities can be robustly confirmed in the human proteome. Some look like "real" proteins and we now annotate them as such. Most look like a mixed picture, with experimental evidence but not fully meeting "protein" criteria. We call these, #peptideins.
3/
3/
May 6, 2026 at 7:18 PM
Big picture: we find that lots of protein entities can be robustly confirmed in the human proteome. Some look like "real" proteins and we now annotate them as such. Most look like a mixed picture, with experimental evidence but not fully meeting "protein" criteria. We call these, #peptideins.
3/
3/
What these dark proteins--now renamed peptideins--are doing inside the body is not easy to answer. Some act like actual proteins, but others have much murkier roles, if any. But if one is closely associated with a specific cancer, for instance, we can use it as a target regardless of its role.
May 22, 2026 at 7:04 PM
What these dark proteins--now renamed peptideins--are doing inside the body is not easy to answer. Some act like actual proteins, but others have much murkier roles, if any. But if one is closely associated with a specific cancer, for instance, we can use it as a target regardless of its role.
The HGNC looks forward to working within the TransCODE Consortium to name micropeptides and peptideins, a new class of non-canonical ORFs www.nature.com/articles/s41...
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
www.nature.com
May 7, 2026 at 10:59 AM
The HGNC looks forward to working within the TransCODE Consortium to name micropeptides and peptideins, a new class of non-canonical ORFs www.nature.com/articles/s41...