Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails
from unrelated species to transfer their DNA across bacterial hosts. This tail piracy
enables broad dissemination and ...
www.cell.com
September 9, 2025 at 5:05 PM
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
These salty thieves are called PICIs (phage-inducible chromosomal islands) & they lie in wait as little bits of virus-like DNA in the genome of the bacteria, biding their time.
When a bacteriophage (virus of bacteria) invades the cell, they spring the trap, cutting themselves out of the genome...
When a bacteriophage (virus of bacteria) invades the cell, they spring the trap, cutting themselves out of the genome...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails
from unrelated species to transfer their DNA across bacterial hosts. This tail piracy
enables broad dissemination and ...
www.cell.com
September 19, 2026 at 2:13 PM
These salty thieves are called PICIs (phage-inducible chromosomal islands) & they lie in wait as little bits of virus-like DNA in the genome of the bacteria, biding their time.
When a bacteriophage (virus of bacteria) invades the cell, they spring the trap, cutting themselves out of the genome...
When a bacteriophage (virus of bacteria) invades the cell, they spring the trap, cutting themselves out of the genome...
New mechanism of gene transfer! With @tcostalab.bsky.social @imperialcollegeldn.bsky.social, we discovered that cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE
Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization
Some mobile genetic elements spread among unrelated bacterial species through unknown mechanisms. Recently, we discovered that identical capsid-forming phage-inducible chromosomal islands (cf-PICIs), ...
shorturl.at
February 12, 2025 at 1:48 PM
New mechanism of gene transfer! With @tcostalab.bsky.social @imperialcollegeldn.bsky.social, we discovered that cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
September 9, 2025 at 9:10 PM
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
The push to make non-regime media communications and access a precursor to ‘terrorism’ charges, and the push to replace all information and knowledge sources with billionaire controlled AI systems are, perhaps not exactly a circle, but there isn’t much daylight in the vesica picis.
June 24, 2026 at 2:22 AM
The push to make non-regime media communications and access a precursor to ‘terrorism’ charges, and the push to replace all information and knowledge sources with billionaire controlled AI systems are, perhaps not exactly a circle, but there isn’t much daylight in the vesica picis.
PICIs in mycobacteria!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
October 4, 2023 at 10:27 PM
PICIs in mycobacteria!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Hmmm role
Nisam 20 godina rolao, a to je nešto najbolje ikada
Ideš, a pičiš
Nisam 20 godina rolao, a to je nešto najbolje ikada
Ideš, a pičiš
naručila sam si koturaljke, bit ce padova ovo ljeto
February 16, 2026 at 5:26 PM
Hmmm role
Nisam 20 godina rolao, a to je nešto najbolje ikada
Ideš, a pičiš
Nisam 20 godina rolao, a to je nešto najbolje ikada
Ideš, a pičiš
Idk where the firsr picis from i just had it saved
April 23, 2025 at 9:50 PM
Idk where the firsr picis from i just had it saved
Very interesting paper. www.science.org/doi/10.1126/...
Bacteriophages mobilize bacterial defense systems via lateral transduction
Bacteriophages and PICIs spread bacterial defenses via lateral transduction, shaping microbial immunity and pathogen evolution.
www.science.org
January 24, 2026 at 1:24 PM
Very interesting paper. www.science.org/doi/10.1126/...
#SciArted Day 10, Elasticity
Phage Inducible Chromosomal Islands (PICIs) parasitize phages, hijacking structural proteins and assembly to package their own genomes. PICIs use a different scaffold protein to produce smaller capsids that don't fit the phage genome. #SciArt #Phagesky
Phage Inducible Chromosomal Islands (PICIs) parasitize phages, hijacking structural proteins and assembly to package their own genomes. PICIs use a different scaffold protein to produce smaller capsids that don't fit the phage genome. #SciArt #Phagesky
October 10, 2024 at 9:58 PM
Bacteriophages mobilize bacterial defense systems via lateral transduction
#phage #virus #microecoevo
www.science.org/doi/10.1126/...
#phage #virus #microecoevo
www.science.org/doi/10.1126/...
Bacteriophages mobilize bacterial defense systems via lateral transduction
Bacteriophages and PICIs spread bacterial defenses via lateral transduction, shaping microbial immunity and pathogen evolution.
www.science.org
January 25, 2026 at 3:55 PM
Bacteriophages mobilize bacterial defense systems via lateral transduction
#phage #virus #microecoevo
www.science.org/doi/10.1126/...
#phage #virus #microecoevo
www.science.org/doi/10.1126/...
In the 1970s you could buy the secret of the 9th degree at a Tupperware party
March 25, 2025 at 2:51 PM
In the 1970s you could buy the secret of the 9th degree at a Tupperware party
Pamer aman esgrim 6 picis jd 10k pake kode indo10 tadi sore
June 13, 2024 at 12:04 PM
Pamer aman esgrim 6 picis jd 10k pake kode indo10 tadi sore
In the process, they block the invading phage from packaging itself, essentially 'killing' the virus, or leaving it stranded & unable to spread.
These cf-PICIs have been found in at least 200 species of bacteria, ready to plunder the genome of any phages that come into range.
These cf-PICIs have been found in at least 200 species of bacteria, ready to plunder the genome of any phages that come into range.
Phage-inducible chromosomal islands are ubiquitous within the bacterial universe - The ISME Journal
The ISME Journal - Phage-inducible chromosomal islands are ubiquitous within the bacterial universe
www.nature.com
September 19, 2026 at 2:13 PM
In the process, they block the invading phage from packaging itself, essentially 'killing' the virus, or leaving it stranded & unable to spread.
These cf-PICIs have been found in at least 200 species of bacteria, ready to plunder the genome of any phages that come into range.
These cf-PICIs have been found in at least 200 species of bacteria, ready to plunder the genome of any phages that come into range.
zato je kul dublinski aerodrom jer ima U.S. preclearance facility, obaviš sve birokracije ovdje i kad sletiš pičiš van direktno kao da si domaći
Sine moj, dva sata čekali provjeru pasoša na JFK-u 😹
April 3, 2024 at 6:29 AM
zato je kul dublinski aerodrom jer ima U.S. preclearance facility, obaviš sve birokracije ovdje i kad sletiš pičiš van direktno kao da si domaći
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization: Cell www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails
from unrelated species to transfer their DNA across bacterial hosts. This tail piracy
enables broad dissemination and ...
www.cell.com
September 9, 2025 at 3:27 PM
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization: Cell www.cell.com/cell/fulltex...
Eikö sen pitäisi olla muka-latinaa? Picis Amnia.
September 10, 2024 at 1:21 PM
Eikö sen pitäisi olla muka-latinaa? Picis Amnia.
Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
By solving a previously unsolved biological question, the AI co-scientist predicted
a complex mechanism of gene transfer and generated hypotheses that opened new research
directions, illustrating AI's...
www.cell.com
September 9, 2025 at 5:23 PM
Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
In honor of our 30th anniversary, we asked our team, “What makes Picis special to you?” #Picis #perioperative #teamwork #WeAreHarris
November 25, 2024 at 3:14 PM
In honor of our 30th anniversary, we asked our team, “What makes Picis special to you?” #Picis #perioperative #teamwork #WeAreHarris
@jonaszpatkowski.bsky.social and I pinpointed tail piracy as a new mechanism of horizontal gene transfer and explained the wide spread of cf-PICIs among different bacterial species and viromes.
New work from the lab with @jrpenades.bsky.social! We discovered a biological entity that spreads among different bacterial species by hijacking tails from various phages. This finding has major translational applications due to its broad host range. More news soon!
shorturl.at/kRJqE
shorturl.at/kRJqE
Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization
Some mobile genetic elements spread among unrelated bacterial species through unknown mechanisms. Recently, we discovered that identical capsid-forming phage-inducible chromosomal islands (cf-PICIs), ...
shorturl.at
February 13, 2025 at 2:25 PM
@jonaszpatkowski.bsky.social and I pinpointed tail piracy as a new mechanism of horizontal gene transfer and explained the wide spread of cf-PICIs among different bacterial species and viromes.
This is Frīda, also known as Frīduli, Picis, Picen, Chonkadonka or Silver Bear. She turned three today
June 5, 2023 at 4:20 PM
This is Frīda, also known as Frīduli, Picis, Picen, Chonkadonka or Silver Bear. She turned three today