If your cell isn't discussing polyol nitration, spall mechanics, hygroscopicity, long term chemical compatibility, [REDACTED], [REDACTED], [REDACTED] or [REDACTED], what are they doing? Your network is your net effect
November 6, 2025 at 11:11 AM
If your cell isn't discussing polyol nitration, spall mechanics, hygroscopicity, long term chemical compatibility, [REDACTED], [REDACTED], [REDACTED] or [REDACTED], what are they doing? Your network is your net effect
Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer 🧪https://www.nature.com/articles/s41418-024-01415-1
Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer - Cell Death & Differentiation
Cell Death & Differentiation - Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer
www.nature.com
November 21, 2024 at 9:31 AM
Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer 🧪https://www.nature.com/articles/s41418-024-01415-1
Being CANCELLED by @jtp.bsky.social because of my innocent academic interest in polyol nitrations
November 14, 2025 at 10:04 PM
Being CANCELLED by @jtp.bsky.social because of my innocent academic interest in polyol nitrations
"Quantifying the Systematic Catalytic Surface Chemistry of Non-Noble Metal Intermetallic Compounds to Achieve Diol and Olefin Production in Polyol Deoxygenation Reactions": hiring students for the summer while "support[ing] the inclusivity of these experiences"
February 11, 2025 at 10:54 PM
"Quantifying the Systematic Catalytic Surface Chemistry of Non-Noble Metal Intermetallic Compounds to Achieve Diol and Olefin Production in Polyol Deoxygenation Reactions": hiring students for the summer while "support[ing] the inclusivity of these experiences"
Solasonine Modulates Aldose Reductase Activity in Galleria mellonella (Lepidoptera): Implications for the Polyol Pathway
#galleria #mellonella
www.mdpi.com/2072-6651/18...
#galleria #mellonella
www.mdpi.com/2072-6651/18...
www.mdpi.com
September 29, 2026 at 8:32 AM
Solasonine Modulates Aldose Reductase Activity in Galleria mellonella (Lepidoptera): Implications for the Polyol Pathway
#galleria #mellonella
www.mdpi.com/2072-6651/18...
#galleria #mellonella
www.mdpi.com/2072-6651/18...
Mechano-dependent sorbitol accumulation supports biomolecular condensate
🧪
www.cell.com/cell/abstrac...
🧪
www.cell.com/cell/abstrac...
Mechano-dependent sorbitol accumulation supports biomolecular condensate
Torrino et al. identify the mechanosensitive polyol pathway as a natural mediator
of cytoplasmic and nuclear protein condensates through tightly controlled intracellular
sorbitol accumulation. Extrace...
www.cell.com
December 1, 2024 at 6:28 AM
Mechano-dependent sorbitol accumulation supports biomolecular condensate
🧪
www.cell.com/cell/abstrac...
🧪
www.cell.com/cell/abstrac...
The 2026 World Cup has kicked off! This edition's ball has fewer polyurethane panels than previous World Cup balls. Learn more about the ball's materials chemistry in this graphic: wp.me/p4aPLT-8VK
#ChemSky 🧪
#ChemSky 🧪
June 13, 2026 at 8:12 PM
The 2026 World Cup has kicked off! This edition's ball has fewer polyurethane panels than previous World Cup balls. Learn more about the ball's materials chemistry in this graphic: wp.me/p4aPLT-8VK
#ChemSky 🧪
#ChemSky 🧪
So basically those people were likely covered in fucking napalm as the foam converted to polyol
January 3, 2026 at 4:39 AM
So basically those people were likely covered in fucking napalm as the foam converted to polyol
The last part of the mask is the horn.
It is 16 cm long, and if it were made from a chunk of cast material, one side would weigh over 180 g. In total, it weighs 360 g, which is fatal for a mask.
The FRP with felt and polyol filler I used earlier only weighs 25g.
It is 16 cm long, and if it were made from a chunk of cast material, one side would weigh over 180 g. In total, it weighs 360 g, which is fatal for a mask.
The FRP with felt and polyol filler I used earlier only weighs 25g.
January 21, 2025 at 8:50 AM
The last part of the mask is the horn.
It is 16 cm long, and if it were made from a chunk of cast material, one side would weigh over 180 g. In total, it weighs 360 g, which is fatal for a mask.
The FRP with felt and polyol filler I used earlier only weighs 25g.
It is 16 cm long, and if it were made from a chunk of cast material, one side would weigh over 180 g. In total, it weighs 360 g, which is fatal for a mask.
The FRP with felt and polyol filler I used earlier only weighs 25g.
We’re excited to share our work describing the role of mechano-dependent sorbitol in biomolecular condensate formation, published @cellcellpress.bsky.social
cell.com/cell/abstrac...
cell.com/cell/abstrac...
Mechano-dependent sorbitol accumulation supports biomolecular condensate
Torrino et al. identify the mechanosensitive polyol pathway as a natural mediator
of cytoplasmic and nuclear protein condensates through tightly controlled intracellular
sorbitol accumulation. Extrace...
cell.com
January 15, 2025 at 8:28 AM
We’re excited to share our work describing the role of mechano-dependent sorbitol in biomolecular condensate formation, published @cellcellpress.bsky.social
cell.com/cell/abstrac...
cell.com/cell/abstrac...
Uh coming from the org Chem 1001 side... is there something special about erythritol in this setup? Because nitration should work the same for any polyol? (Yeah and the results are also all variations on the same 💥 theme)
March 18, 2026 at 12:58 AM
Uh coming from the org Chem 1001 side... is there something special about erythritol in this setup? Because nitration should work the same for any polyol? (Yeah and the results are also all variations on the same 💥 theme)
Fascinating new slant on biomolecular condensate formation, suggesting it can be under mechanical control. Stiffening of the extracellular matrix can promote conversion of glucose to sorbitol, which then acts as a crowding agent to promote aggregation and BC formation.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Mechano-dependent sorbitol accumulation supports biomolecular condensate
Torrino et al. identify the mechanosensitive polyol pathway as a natural mediator
of cytoplasmic and nuclear protein condensates through tightly controlled intracellular
sorbitol accumulation. Extrace...
www.cell.com
January 23, 2025 at 10:34 PM
Fascinating new slant on biomolecular condensate formation, suggesting it can be under mechanical control. Stiffening of the extracellular matrix can promote conversion of glucose to sorbitol, which then acts as a crowding agent to promote aggregation and BC formation.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
The pathology is complicated and not really the point, but it’s a combination of free radical damage via the polyol pathway, RAGE pathway, inflammation and other things).
There was a study in japan that should an a1c average around 3 yrs raised risk for peripheral neuropathy. So, that “why” is easy
There was a study in japan that should an a1c average around 3 yrs raised risk for peripheral neuropathy. So, that “why” is easy
January 9, 2025 at 2:57 PM
The pathology is complicated and not really the point, but it’s a combination of free radical damage via the polyol pathway, RAGE pathway, inflammation and other things).
There was a study in japan that should an a1c average around 3 yrs raised risk for peripheral neuropathy. So, that “why” is easy
There was a study in japan that should an a1c average around 3 yrs raised risk for peripheral neuropathy. So, that “why” is easy
Now online & open access:
Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A
www.nature.com/articles/s44...
#ChemSky
Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A
www.nature.com/articles/s44...
#ChemSky
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A - Nature Synthesis
The structures of 1,5-polyol-containing polyketide-derived natural products are notoriously difficult to determine using spectroscopic techniques due to spectral overlap and chemical shift degeneracy....
www.nature.com
March 13, 2025 at 11:23 AM
Now online & open access:
Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A
www.nature.com/articles/s44...
#ChemSky
Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers
The combination of synthesis and ultra-high-resolution NMR spectroscopy reveals the correct structure of caylobolide A
www.nature.com/articles/s44...
#ChemSky
He linked me this NIST page and said “You can see how the foam converts to polyol and pools before igniting in this video. And at 7 seconds the melt pool ignites. This could be the explosion reported.
B4-1
Fire Barrier: Glass B4, Cover Fabric: Polypropylene (3kg) Filling Material: Polyethalene (6kg) and Polyester (4 kg)
www.nist.gov
January 3, 2026 at 4:38 AM
He linked me this NIST page and said “You can see how the foam converts to polyol and pools before igniting in this video. And at 7 seconds the melt pool ignites. This could be the explosion reported.
Delighted to have contributed to this work revealing ECM stiffness as a key regulator of biomolecular condensate formation in vivo via mechanical stress-dependent control of polyol metabolism. Check it out while I try to get the authors over here!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Mechano-dependent sorbitol accumulation supports biomolecular condensate
Condensed droplets of protein regulate many cellular functions, yet the physiological conditions regulating their formation remain largely unexplored.…
www.sciencedirect.com
November 25, 2024 at 4:26 PM
Delighted to have contributed to this work revealing ECM stiffness as a key regulator of biomolecular condensate formation in vivo via mechanical stress-dependent control of polyol metabolism. Check it out while I try to get the authors over here!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Congratulations to newly minted Dr. Christopher LaSalle from the Reineke Group on the successful defense of his PhD thesis entitled "Modular mRNA Delivery Vehicles via Renewable Polyol Carbonates". Best wishes on your future career Chris!!
April 25, 2025 at 6:18 PM
Congratulations to newly minted Dr. Christopher LaSalle from the Reineke Group on the successful defense of his PhD thesis entitled "Modular mRNA Delivery Vehicles via Renewable Polyol Carbonates". Best wishes on your future career Chris!!
Polyurethanes are made from 2 components – a polyol and a diisocyanate. Bio-based polyols are now commonplace, but now Algenesis has set up a pilot plant for its process to make bio-based diisocyanates, leading to fully bio-based and biodegradeable polyurethanes.
Algenesis cracks diisocyanate problem to make fully bio-based polyurethane
Process combines algal fermentation with flow chemistry and avoids hazardous phosgene
www.chemistryworld.com
October 23, 2025 at 9:10 AM
Polyurethanes are made from 2 components – a polyol and a diisocyanate. Bio-based polyols are now commonplace, but now Algenesis has set up a pilot plant for its process to make bio-based diisocyanates, leading to fully bio-based and biodegradeable polyurethanes.
The project asks how you can get freeze tolerance *without* accumulating large quantities of sugar and polyol cryoprotectants. It focuses on intertidal species, where freeze tolerance is common. Some of the hypotheses are here in @jexpbiol.bsky.social : journals.biologists.com/jeb/article/...
Ice in the intertidal: patterns and processes of freeze tolerance in intertidal invertebrates
Summary: We review our current understanding of intertidal invertebrate freeze tolerance, highlighting knowledge gaps, proposed physiological mechanisms behind this trait and potential future directio...
journals.biologists.com
April 3, 2025 at 2:38 PM
The project asks how you can get freeze tolerance *without* accumulating large quantities of sugar and polyol cryoprotectants. It focuses on intertidal species, where freeze tolerance is common. Some of the hypotheses are here in @jexpbiol.bsky.social : journals.biologists.com/jeb/article/...
I have polyol issues, I was kind of bummed that sorbitol is in broccoli! I love broccoli
June 20, 2025 at 3:54 PM
I have polyol issues, I was kind of bummed that sorbitol is in broccoli! I love broccoli
🧪🍎📃 #medsky
Excess sugar intake plays a key role in primary hypertension:
-Fructose from added sugars affects kidney function.
-This leads to blood vessel tightening.
-Over time, inflammation keeps vessels constricted.
-Result? Persistent high BP.
Salt amplifies this process.
🔗 shorturl.at/gdFYI
Excess sugar intake plays a key role in primary hypertension:
-Fructose from added sugars affects kidney function.
-This leads to blood vessel tightening.
-Over time, inflammation keeps vessels constricted.
-Result? Persistent high BP.
Salt amplifies this process.
🔗 shorturl.at/gdFYI
January 24, 2025 at 7:09 PM
🧪🍎📃 #medsky
Excess sugar intake plays a key role in primary hypertension:
-Fructose from added sugars affects kidney function.
-This leads to blood vessel tightening.
-Over time, inflammation keeps vessels constricted.
-Result? Persistent high BP.
Salt amplifies this process.
🔗 shorturl.at/gdFYI
Excess sugar intake plays a key role in primary hypertension:
-Fructose from added sugars affects kidney function.
-This leads to blood vessel tightening.
-Over time, inflammation keeps vessels constricted.
-Result? Persistent high BP.
Salt amplifies this process.
🔗 shorturl.at/gdFYI
MOF-Modified Biobased Polyol Derived from a Castor-Coated Fertilizer for Precise Controlled Release of Nutrients http://dx.doi.org/10.1021/acsapm.5c00612
May 23, 2025 at 1:21 PM
MOF-Modified Biobased Polyol Derived from a Castor-Coated Fertilizer for Precise Controlled Release of Nutrients http://dx.doi.org/10.1021/acsapm.5c00612
📰Mechano-dependent sorbitol accumulation supports biomolecular condensate
📌Extracellular matrix stiffness links mechanical cues with the control of glucose metabolism to sorbitol & biomolecular condensates in a breast cancer cell model.
www.cell.com/cell/abstrac...
📌Extracellular matrix stiffness links mechanical cues with the control of glucose metabolism to sorbitol & biomolecular condensates in a breast cancer cell model.
www.cell.com/cell/abstrac...
Mechano-dependent sorbitol accumulation supports biomolecular condensate
Torrino et al. identify the mechanosensitive polyol pathway as a natural mediator
of cytoplasmic and nuclear protein condensates through tightly controlled intracellular
sorbitol accumulation. Extrace...
www.cell.com
November 26, 2024 at 9:08 AM
📰Mechano-dependent sorbitol accumulation supports biomolecular condensate
📌Extracellular matrix stiffness links mechanical cues with the control of glucose metabolism to sorbitol & biomolecular condensates in a breast cancer cell model.
www.cell.com/cell/abstrac...
📌Extracellular matrix stiffness links mechanical cues with the control of glucose metabolism to sorbitol & biomolecular condensates in a breast cancer cell model.
www.cell.com/cell/abstrac...
That's polyurethane foam. Made by reacting a polyol, a diisocyanate and water. It releases CO2 as it solidifies. Probably the most widely used insulating material in the World.
April 20, 2025 at 10:35 PM
That's polyurethane foam. Made by reacting a polyol, a diisocyanate and water. It releases CO2 as it solidifies. Probably the most widely used insulating material in the World.