This exciting role offers the opportunity to contribute to major EU-funded research programmes, including PrecisionTox and PARC (Partnership for the Assessment of Risks from Chemicals), in close colla...

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

🥳It’s a big day! We’ve 💥extended registration for the Final #ASPIS Open Symposium so even more of you can 🤝join the discussion shaping sustainable, ❌🐇animal-free, and ✅️reliable chemical risk assessme...

Current regulations aimed at safeguarding human health and the environment from chemical risks require toxicity testing, while regulatory bodies worldwide are phasing out the use of protected animals. Here, we systematically produced toxicity data from five alternative nonmammalian model organisms and a human cell line to demonstrate similarities and differences among distantly related species in their responses to chemical exposure (concentration range 1.8 pM to 2.1 M). We show that Daphnia magna and Danio rerio embryos are affected by more chemicals than Xenopus laevis embryos, Drosophila melanogaster and Caenorhabditis elegans. Lethality/immotility data assembled 72 diverse chemicals into 11 clusters, revealing species-specific outcomes and showing differential enrichment of the clusters for certain chemical structures and modes of action. The ranked relative toxicities of chemicals across the model organisms were highly correlated (Spearman’s correlation, maximum rho = 0.86, p-value = 0; minimum rho = 0.57, p-value = 0.000312), and their average toxicity values closely matched published values for rodents (rat: rho = 0.88, p = 2.8e-06; mouse: rho = 0.88, p = 2.7e-06). Our findings suggest that chemical toxicity under standardized experimental conditions is broadly conserved across a phylogenetically diverse set of model organisms, providing a conservative estimate of mammalian toxicity.

EVENT DATES: - ASPIS training (open to ASPIS cluster members + invited stakeholders) - Mon 26 Jan + Tue 27 Jan 2026 - RISK-HUNT3R General Assembly (project members only) - Tue 27 Jan + Wed 28 Jan...

EVENT DETAILS Date: 17-18 September 2025 Location: Athens, Greece Venue: Golden Age Hotel There is no attendance fee for any of the days. Registration for the ASPIS Open Symposium (OS) 2025 will be op...

The 2024 EURL ECVAM Status Report highlights progress in advancing non-animal methods for science and regulation. Driven by EU-funded collaborations, research focuses on chemical safety assessment, en...