#ProteinGuide
ProteinGuide: Predictor guidance for conditional generation with any autoregressive or discrete diffusion protein model.

@junhaobearxiong.bsky.social @hnisonoff.bsky.social @jlistgarten.bsky.social

arxiv.org/abs/2505.04823
May 14, 2025 at 1:18 PM
Protein engineers at UC Berkeley created ProteinGuide—a method using experimental data to steer generative AI models toward better, highly stable & active proteins without expensive model retraining.

Read more about this @ucberkeleyofficial.bsky.social research: bit.ly/4AlhcFC
September 17, 2026 at 7:58 PM
Check out our pre-print on ProteinGuide, a new method for conditioning protein generative models on experimental data! Thanks to the amazing team: @junhaobearxiong.bsky.social, @hnisonoff.bsky.social, Ishan, Luke, @jlistgarten.bsky.social and @davesavage.bsky.social! @savagecatsonly.bsky.social
Guide your favorite protein generative model with experimental data? Meet ProteinGuide - a method to condition pre-trained models on properties without retraining. We validated it both in silico by guiding ProteinMPNN and ESM3 on 3 tasks and in vitro by engineering base editors.
June 1, 2025 at 11:15 PM
Guide your favorite protein generative model with experimental data? Meet ProteinGuide - a method to condition pre-trained models on properties without retraining. We validated it both in silico by guiding ProteinMPNN and ESM3 on 3 tasks and in vitro by engineering base editors.
May 31, 2025 at 3:46 PM
We love generating data! But what should we do with it? We collaborated w/ the Listgarten lab on ProteinGuide - a new method for using experimental data to guide protein generative models. Congrats to @junhaobearxiong.bsky.social, @hnisonoff.bsky.social, @marialukarska.bsky.social, Ishan, & Luke! ⬇️
Guide your favorite protein generative model with experimental data? Meet ProteinGuide - a method to condition pre-trained models on properties without retraining. We validated it both in silico by guiding ProteinMPNN and ESM3 on 3 tasks and in vitro by engineering base editors.
June 1, 2025 at 10:41 AM
🥦 No Meat? No Problem! 💪 Here are the BEST protein-packed foods every vegetarian & vegan must know for strength & energy! 🌱🔥 #PlantProtein #VeganPower #VegLife #ProteinGuide #HealthyEating
Top Protein-Rich Foods for Vegetarians and Vegans: Complete Guide to Plant-Based Protein
Discover the best protein-rich foods for vegetarians and vegans in this complete guide. Learn how to meet your daily protein needs with top plant-based sources like lentils, tofu, quinoa, and more—perfect for muscle building, weight management, and overall health.
news.musicyrics.com
July 27, 2025 at 6:30 AM
In our third task, we demonstrate the generality of ProteinGuide beyond amino acid sequences, to structure tokens. In particular, we guide ESM3 to generate backbone structures (as tokens) with specified CATH fold class labels.
May 31, 2025 at 3:46 PM
To illustrate the potential of ProteinGuide, we applied it, in silico, to three tasks, using two representative, well-known protein generative models, ProteinMPNN and ESM3. Across these three tasks, we observed that guidance, as expected, led to the desired outcome.
May 31, 2025 at 3:46 PM
We didn't just validate in silico - we also synthesized & tested proteins in the lab. We used ProteinGuide to engineer an adenine base editor for high activity: generated 2,000 variants → tested in bacteria → used results to guide 2,000 new designs.
May 31, 2025 at 3:46 PM
Property guidance for protein sequence generative models with ProteinGuide
Dauparas, J. et al. Robust deep learning–based protein sequence design using ProteinMPNN. Science 378, 49–56 (2022). Watson, J. et al. De novo design of protein structure and function with RFdiffusion. Nature 620, 1089–1100 (2023). Ingraham, J. et al. Illuminating protein space with a programmable generative model. Nature 623, 1070–1078 (2023). Hsien-Wei Yeh, A. et al. De novo design of luciferases using deep learning. Nature 614, 774–780 (2023). Bennett, N. et al. Atomically accurate de novo design of antibodies with RFdiffusion. Nature 649, 183–193 (2026). Lisanza, S. et al. Multistate and functional protein design using RoseTTAFold sequence space diffusion. Nat. Biotechnol. 43, 1288–1298 (2025). Hong, L. & Kortemme, T. An integrative approach to protein sequence design through multiobjective optimization. PLoS Comput. Biol. 20, e1011953 (2024). Ziegler, D. et al. Fine-tuning language models from human preferences. Preprint at https://doi.org/10.48550/arXiv.1909.08593 (2019). Ouyang, L. et al. Training language models to follow instructions with human feedback. In Proc. 35th Conference on Advances in Neural Information Processing Systems (eds Oh, A. et al.) (ACM, 2022). Ruffolo, J. A. et al. Design of highly functional genome editors by modeling CRISPR–Cas sequences. Nature 645, 518–525 (2025). Nijkamp, E., Ruffolo, J., Weinstein, E., Naik, N. & Madani, A. ProGen2:...
www.nature.com
August 2, 2026 at 9:23 AM
Notfalls isst man einfach etwas mehr Protein, das gleicht eine schlechtere Verfügbarkeit aus.
Wenn du mehr Infos möchtest, hier gibt es einen ganz brauchbaren Protein-Guide kostenlos als Download:
nvsino.com/pages/wie-ve...
WIE VEGAN? | NVSINO
⚖️ Wie lebe ich Vegan? Wie komme ich als Veganer auf meine Proteine? Deine vegane Einkaufsliste, Ernährungsplan, Proteinguide und mehr findest du hier! ☑️
nvsino.com
September 4, 2026 at 8:37 AM
Property guidance for protein sequence generative models with ProteinGuide [new]
...is achieved via on-the-fly conditioning of pretrained models.
July 30, 2026 at 3:22 PM
Protein fuels recovery, keeps you satisfied, and supports fat loss.

Here’s your no-fluff guide to protein-rich foods 🥩🥚🐟

...
#ProteinGuide #RealNutrition #MuscleFuel #BlueskyFitness #NSHFIT #NoFluffHealth
May 10, 2025 at 10:03 AM
Protein shakes for men get a lot of claims — this guide cuts through the noise with research-informed points on what to look for and how they fit into real fitness routines: https://livegoodforlife.com/healthiest-protein-shake-for-men/ #ProteinGuide #MensHealth
HEALTHIEST Protein Shake for Men
Protein Shake for Men by LiveGood In the journey towards optimal health and fitness, protein shakes have emerged as a vital component for men who aim to build and maintain muscle. Dr. Ryan, a renowned expert in the field of health and nutrition, is passionately dedicated to helping people discover and utilize the healthiest ingredients.
livegoodforlife.com
May 10, 2026 at 10:30 PM
MyFitnessPal Guide: Protein Edition

Protein spiller en avgjørende rolle i helsen din og velvære. Enten du ønsker å utvikle muskler, understøtter beinhelsen eller bare føle deg best, forstå hva proteinet gjør og hvordan du får riktig mengde kan hjelpe deg med å nå dine mål. Her er din proteinguide…
MyFitnessPal Guide: Protein Edition
Protein spiller en avgjørende rolle i helsen din og velvære. Enten du ønsker å utvikle muskler, understøtter beinhelsen eller bare føle deg best, forstå hva proteinet gjør og hvordan du får riktig mengde kan hjelpe deg med å nå dine mål. Her er din proteinguide for å skaffe informasjon fra eksperter og MyFitnessPal -verktøy for å hjelpe deg med å navigere i ernæringsreise.
1rev.net
February 13, 2025 at 3:31 AM
present ProteinGuide, a rigorous and general framework to achieve just that: through unifying a broad class of protein generative models that includes masked language, (order-agnostic) autoregressive, diffusion and flow-matching models, we provide an [3/5 of https://arxiv.org/abs/2505.04823v1]
May 9, 2025 at 5:59 AM