Background: Collecting duct carcinoma (CDC; Bellini duct carcinoma) is a rare, aggressive renal cancer with no established standard of care, and evidence for immune checkpoint inhibitor (ICI)-based therapy in CDC remains emer... | Find, read and cite all the research you need on Tech Science Press

Colorectal cancer does not develop in a single way, and different tumor types may interact differently with bacteria living on the bowel lining. This study examined both tissue-associated bacteria and DNA methylation, an epigenetic mark that helps regulate genes, in paired tumor and nearby non-tumor...

Background Donation after brain death (DBD) has declined in Spain despite sustained transplantation activity and marked growth in donation after circulatory death (DCD). We examined whether this tra...

Burnout is recognized in the ICD-11 as an occupational phenomenon resulting from chronic work-related stress. In educational settings, psychosocial risks—particularly high job demands and insufficient resources—have been associated with burnout, depressive symptoms, and physiological stress dysregulation. This longitudinal quasi-experimental study examined changes associated with participation in a multicomponent cognitive–behavioral intervention among teachers. The sample comprised 66 primary and secondary school teachers (30 training, 36 non-training), further stratified according to high or low baseline levels of stress-related health problems. Measures included resource availability, self-efficacy, interpersonal conflicts, work overload, burnout, depressive symptoms, and salivary cortisol, assessed as total morning cortisol output using the area under the curve with respect to ground (AUCg), at baseline (T1), post-intervention (T2), and four-month follow-up (T3). The clearest pattern of statistically significant within-group changes was observed among trained teachers with high baseline stress-related health problems (TG-HHP; n = 13). From T1 to T2, this subgroup showed increased resource availability and self-efficacy and reductions in burnout (1.63 to 1.33; p = 0.013, d = 0.81), depressive symptoms (46.92 to 42.40; p = 0.032, d = 0.67), and morning cortisol AUCg (410.01 to 306.50; p = 0.018, d = 0.78). At T3, statistically significant changes relative to baseline were observed across all study variables. These findings provide preliminary evidence that participation in a structured cognitive–behavioral intervention may be associated with psychosocial, psychological, and physiological improvements, particularly among teachers with elevated baseline stress-related health problems.

Purpose To evaluate whether early vascular susceptibility, reflected by first-trimester lipoprotein(a), together with longitudinal renal biomarker trajectories across pregnancy, is associated with the subsequent development of preeclampsia. Methods Retrospective analysis of prospectively collected data from a high-risk pregnancy cohort. Maternal serum inflammatory (interleukin-6, C-reactive protein), lipid (lipoprotein(a), triglycerides, total cholesterol), and renal (uric acid, cystatin C) biomarkers were measured at 11–13, 19–22, and 32 weeks of gestation. Longitudinal changes were assessed using population-averaged models including trimester, preeclampsia status, and their interaction, adjusted for maternal age and body mass index. First-trimester lipoprotein(a) was evaluated using adjusted logistic regression. Results Among 119 women, 20 developed preeclampsia. First-trimester lipoprotein(a) concentrations were higher in women who later developed preeclampsia and were independently associated with increased risk (OR 2.38; p < 0.001). Longitudinal analyses showed significant trimester-by-preeclampsia interactions for uric acid and cystatin C (both p = 0.03), indicating progressive divergence across pregnancy. Inflammatory biomarkers showed early between-group differences without significant longitudinal divergence. Conclusions Our findings suggest that preeclampsia may be associated with both early maternal vascular susceptibility and progressive alterations in renal biomarkers during pregnancy. Elevated first-trimester lipoprotein(a) may reflect an underlying vascular phenotype, while divergent renal biomarker trajectories highlight the dynamic evolution of the disease before clinical onset, although these findings require validation in larger prospective studies.

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