Its always amazing when collaborative projects come to fruition 💚💚
Had two such collaborations published this month!
1. With Melissa Kelley and @joshuabenoit.bsky.social .
links.springernature.com/f/a/gDGfwNr_...
2. With Kat Daly and @samerhattar.bsky.social !
www.cell.com/cell-reports...
Had two such collaborations published this month!
1. With Melissa Kelley and @joshuabenoit.bsky.social .
links.springernature.com/f/a/gDGfwNr_...
2. With Kat Daly and @samerhattar.bsky.social !
www.cell.com/cell-reports...
Microbiome-derived queuine vitamers underlie tyrosine metabolism and predator avoidance in mosquito larvae - Communications Biology
Microbiome-derived queuosine (Q) shapes mosquito larval development, behavior, and cuticle formation. Q deficiency disrupts tyrosine pathways, impairs predator evasion, and increases larval mortality.
links.springernature.com
July 14, 2026 at 6:00 PM
Its always amazing when collaborative projects come to fruition 💚💚
Had two such collaborations published this month!
1. With Melissa Kelley and @joshuabenoit.bsky.social .
links.springernature.com/f/a/gDGfwNr_...
2. With Kat Daly and @samerhattar.bsky.social !
www.cell.com/cell-reports...
Had two such collaborations published this month!
1. With Melissa Kelley and @joshuabenoit.bsky.social .
links.springernature.com/f/a/gDGfwNr_...
2. With Kat Daly and @samerhattar.bsky.social !
www.cell.com/cell-reports...
Das Gen SLC35F2 soll ein spezifischer Transporter für die Queuine und Queuosine sein, die essenziell für die tRNA-Modifikation und eine präzise Proteinbiosynthese sind.
Ein Queuine-Mangel könnte Krebs zum Beispiel begünstigen.
pure.qub.ac.uk/en/publicati...
Ein Queuine-Mangel könnte Krebs zum Beispiel begünstigen.
pure.qub.ac.uk/en/publicati...
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine
pure.qub.ac.uk
July 26, 2025 at 3:03 PM
Das Gen SLC35F2 soll ein spezifischer Transporter für die Queuine und Queuosine sein, die essenziell für die tRNA-Modifikation und eine präzise Proteinbiosynthese sind.
Ein Queuine-Mangel könnte Krebs zum Beispiel begünstigen.
pure.qub.ac.uk/en/publicati...
Ein Queuine-Mangel könnte Krebs zum Beispiel begünstigen.
pure.qub.ac.uk/en/publicati...
UChicago researchers have discovered how two competing molecules made by your gut bacteria—queuine (promotes growth) and preQ1 (halts growth)—reach deep inside your cells to control their protein-building machinery.
Read the fascinating study: biologicalsciences.uchicago.edu/news/how-mic...
Read the fascinating study: biologicalsciences.uchicago.edu/news/how-mic...
How microbes control mammalian cell growth
UChicago researchers identify two small molecules made by gut bacteria that compete to control our cells’ protein building machinery.
biologicalsciences.uchicago.edu
October 28, 2025 at 3:56 PM
UChicago researchers have discovered how two competing molecules made by your gut bacteria—queuine (promotes growth) and preQ1 (halts growth)—reach deep inside your cells to control their protein-building machinery.
Read the fascinating study: biologicalsciences.uchicago.edu/news/how-mic...
Read the fascinating study: biologicalsciences.uchicago.edu/news/how-mic...
腸内細菌叢由来の代謝物による細胞運命制御
腸内微生物叢由来の代謝産物であるpreQ1が細胞増殖を抑制することを報告。preQ1はtRNAを修飾してハウスキーピング遺伝子の翻訳速度を低下させるらしい。腫瘍モデルマウスにおいて腫瘍増殖を抑制する効果も
メカニズム面白いです
www.nature.com/articles/s41...
腸内微生物叢由来の代謝産物であるpreQ1が細胞増殖を抑制することを報告。preQ1はtRNAを修飾してハウスキーピング遺伝子の翻訳速度を低下させるらしい。腫瘍モデルマウスにおいて腫瘍増殖を抑制する効果も
メカニズム面白いです
www.nature.com/articles/s41...
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control - Nature Cell Biology
Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth, decreases the translation of…
www.nature.com
September 17, 2025 at 10:00 AM
腸内細菌叢由来の代謝物による細胞運命制御
腸内微生物叢由来の代謝産物であるpreQ1が細胞増殖を抑制することを報告。preQ1はtRNAを修飾してハウスキーピング遺伝子の翻訳速度を低下させるらしい。腫瘍モデルマウスにおいて腫瘍増殖を抑制する効果も
メカニズム面白いです
www.nature.com/articles/s41...
腸内微生物叢由来の代謝産物であるpreQ1が細胞増殖を抑制することを報告。preQ1はtRNAを修飾してハウスキーピング遺伝子の翻訳速度を低下させるらしい。腫瘍モデルマウスにおいて腫瘍増殖を抑制する効果も
メカニズム面白いです
www.nature.com/articles/s41...
🚨 New study out @natcellbio.nature.com!
We show how the microbial metabolite preQ1 shapes host physiology through tRNA modification and regulating translation.
Check it out 👉 nature.com/articles/s41...
👏 Huge congrats to the whole team!
#Translation #Queuine #MicrobialMetabolites #RNAmodifications
We show how the microbial metabolite preQ1 shapes host physiology through tRNA modification and regulating translation.
Check it out 👉 nature.com/articles/s41...
👏 Huge congrats to the whole team!
#Translation #Queuine #MicrobialMetabolites #RNAmodifications
September 17, 2025 at 6:41 PM
🚨 New study out @natcellbio.nature.com!
We show how the microbial metabolite preQ1 shapes host physiology through tRNA modification and regulating translation.
Check it out 👉 nature.com/articles/s41...
👏 Huge congrats to the whole team!
#Translation #Queuine #MicrobialMetabolites #RNAmodifications
We show how the microbial metabolite preQ1 shapes host physiology through tRNA modification and regulating translation.
Check it out 👉 nature.com/articles/s41...
👏 Huge congrats to the whole team!
#Translation #Queuine #MicrobialMetabolites #RNAmodifications
After a 15 year search: The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine biorxiv.org/cgi/content/short/2024.12.03.625470v1 (it's fission yeast SPCC320.08). Congrats to Valerie Crecy-Lagard @annehrenhofer.bsky.social & Co.
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine
The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria that are acquired from the gut microbiome and/or diet in humans. Following cellular uptake, Q is in...
biorxiv.org
December 5, 2024 at 12:34 PM
After a 15 year search: The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine biorxiv.org/cgi/content/short/2024.12.03.625470v1 (it's fission yeast SPCC320.08). Congrats to Valerie Crecy-Lagard @annehrenhofer.bsky.social & Co.
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine pubmed.ncbi.nlm.nih.gov/40526720/
June 18, 2025 at 7:16 AM
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine pubmed.ncbi.nlm.nih.gov/40526720/
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine biorxiv.org/cgi/content/short/2024.12.03.625470v1
December 5, 2024 at 8:15 AM
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine biorxiv.org/cgi/content/short/2024.12.03.625470v1
Queuosine is a modified nucleoside that is present in certain tRNAs in bacteria and eukaryotes.[1][2] It contains the nucleobase queuine
en.wikipedia.org/wiki/Queuosine
en.wikipedia.org/wiki/Queuosine
Queuosine - Wikipedia
en.wikipedia.org
June 26, 2025 at 4:12 AM
Queuosine is a modified nucleoside that is present in certain tRNAs in bacteria and eukaryotes.[1][2] It contains the nucleobase queuine
en.wikipedia.org/wiki/Queuosine
en.wikipedia.org/wiki/Queuosine
Two gut microbiome metabolites, queuine and preQ1, compete to regulate mammalian cell growth by modifying tRNAs, with potential implications for cancer therapy and immune function. doi.org/g9426f
Two microbiome metabolites compete for control of mammalian cell growth, study reveals
The microbiome—the trillions of bacteria, viruses, and fungi that live quietly in our body—plays a crucial role in shaping human health by providing a variety of micronutrients necessary for vital functions.
phys.org
October 29, 2025 at 2:12 PM
Two gut microbiome metabolites, queuine and preQ1, compete to regulate mammalian cell growth by modifying tRNAs, with potential implications for cancer therapy and immune function. doi.org/g9426f
tRNA modifications have become a hot topic that touches many fields of life & health sciences. Queuosine tRNA modification has been of special interest for me as well as many scientists. I wrote a short review summarizing 4 decades of research on queuosine onlinelibrary.wiley.com/doi/full/10....
Queuosine tRNA Modification: Connecting the Microbiome to the Translatome
tRNA queuosine modifications in mammalian cells are dependent on queuine produced by gut microbiome or from the diet. This gut-tRNA axis provides an interesting link between gut health and tissue tra...
onlinelibrary.wiley.com
December 4, 2024 at 12:28 PM
tRNA modifications have become a hot topic that touches many fields of life & health sciences. Queuosine tRNA modification has been of special interest for me as well as many scientists. I wrote a short review summarizing 4 decades of research on queuosine onlinelibrary.wiley.com/doi/full/10....
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine https://www.biorxiv.org/content/10.1101/2024.12.03.625470v1
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine https://www.biorxiv.org/content/10.1101/2024.12.03.625470v1
The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria
www.biorxiv.org
December 5, 2024 at 2:45 AM
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine https://www.biorxiv.org/content/10.1101/2024.12.03.625470v1
Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach https://www.biorxiv.org/content/10.1101/2024.06.24.600019v1
Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach https://www.biorxiv.org/content/10.1101/2024.06.24.600019v1
Queuosine (Q) is a hypermodified 7-deaza-guanosine nucleoside exclusively synthesized by bacteria. T
www.biorxiv.org
June 25, 2024 at 5:46 AM
Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach https://www.biorxiv.org/content/10.1101/2024.06.24.600019v1
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control #rnasky www.nature.com/articles/s41...
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control - Nature Cell Biology
Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth, decreases the translation of r...
www.nature.com
September 16, 2025 at 11:26 AM
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control #rnasky www.nature.com/articles/s41...
Queuine: A Bacterial Nucleobase Shaping Translation in Eukaryotes #rnasky #rnabiology review by Ann Ehrenhofer Murray www.sciencedirect.com/science/arti...
Queuine: A Bacterial Nucleobase Shaping Translation in Eukaryotes
Queuosine (Q), a 7-deazaguanosine derivative, is among the most intricate tRNA modifications, and is located at position 34 (the Wobble position) of t…
www.sciencedirect.com
February 18, 2025 at 2:18 PM
Queuine: A Bacterial Nucleobase Shaping Translation in Eukaryotes #rnasky #rnabiology review by Ann Ehrenhofer Murray www.sciencedirect.com/science/arti...
Latest paper from the de Crecy lab is out!
A finding that answers a ~40 year old question: a eukaryotic high-specificity transporter for Q/q
A finding that answers a ~40 year old question: a eukaryotic high-specificity transporter for Q/q
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine | PNAS
The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived
from bacteria that are acquired from the gut microbiome and/...
doi.org
June 17, 2025 at 6:37 PM
Latest paper from the de Crecy lab is out!
A finding that answers a ~40 year old question: a eukaryotic high-specificity transporter for Q/q
A finding that answers a ~40 year old question: a eukaryotic high-specificity transporter for Q/q
Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine https://www.biorxiv.org/content/10.64898/2026.03.22.713446v1
March 25, 2026 at 1:02 AM
Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine https://www.biorxiv.org/content/10.64898/2026.03.22.713446v1
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine https://www.biorxiv.org/content/10.1101/2024.12.03.625470v1
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine https://www.biorxiv.org/content/10.1101/2024.12.03.625470v1
The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria
www.biorxiv.org
December 5, 2024 at 2:45 AM
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine https://www.biorxiv.org/content/10.1101/2024.12.03.625470v1
Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach https://www.biorxiv.org/content/10.1101/2024.06.24.600019v1
Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach https://www.biorxiv.org/content/10.1101/2024.06.24.600019v1
Queuosine (Q) is a hypermodified 7-deaza-guanosine nucleoside exclusively synthesized by bacteria. T
www.biorxiv.org
June 25, 2024 at 5:46 AM
Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach https://www.biorxiv.org/content/10.1101/2024.06.24.600019v1
TL;DR: A 2025 study in PNAS found that sLC35F2 emerged as the high-specificity transporter for queuine and queuosine, linking gut-derived micronutrients to tRNA modification and the cell's protein-translation machinery.
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June 23, 2026 at 1:11 PM
TL;DR: A 2025 study in PNAS found that sLC35F2 emerged as the high-specificity transporter for queuine and queuosine, linking gut-derived micronutrients to tRNA modification and the cell's protein-translation machinery.
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