Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas. Achado abre caminho para novas abordagens em reprodução assistida. agencia.fapesp.br/59280
Falha no reparo do DNA materno compromete desenvolvimento embrionário e gera mutações pós-fecundação
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas. Acha...
agencia.fapesp.br
September 28, 2026 at 12:02 PM
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas. Achado abre caminho para novas abordagens em reprodução assistida. agencia.fapesp.br/59280
Falha no reparo do DNA materno compromete desenvolvimento embrionário e gera mutações pós-fecundação
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas.
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas.
Falha no reparo do DNA materno compromete desenvolvimento embrionário e gera mutações pós-fecundação
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas. Acha...
agencia.fapesp.br
September 28, 2026 at 10:28 AM
Falha no reparo do DNA materno compromete desenvolvimento embrionário e gera mutações pós-fecundação
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas.
Pesquisa com camundongos revela que a falta da proteína RAD51 em óvulos provoca danos no genoma do embrião, reduz o número de filhotes e favorece o surgimento de alterações genéticas espontâneas.
DNA repair filaments are assembled and capped by two distinct RAD51 paralog complexes. Each has four protein subunits, a more complex arrangement than previously assumed. doi.org/hckk3r
New findings explain how cells assemble machinery to repair damaged DNA
A cell's ability to repair its damaged DNA is one of the most fundamental processes in biology, helping protect us from diseases like cancer.
phys.org
September 24, 2026 at 8:40 PM
DNA repair filaments are assembled and capped by two distinct RAD51 paralog complexes. Each has four protein subunits, a more complex arrangement than previously assumed. doi.org/hckk3r
How to grow a filament: Lessons from the RAD51 paralogs toolbox
How to grow a filament: Lessons from the RAD51 paralogs toolbox
In this issue of Molecular Cell, Koo et al. describe how the yeast Rad55-Rad57-SHU complex dynamically nucleates Rad51 filaments on DNA. Functional coupling between Rad55-Rad57 and Rad51 on ssDNA seeds filament growth, whilst ATP hydrolysis promotes complex turnover.
dlvr.it
September 22, 2026 at 10:57 PM
How to grow a filament: Lessons from the RAD51 paralogs toolbox
It provides a simple framework to understand the regulation of Rad51 filament structure and function by RAD51 paralogs complexes and functional homologs of Srs2.
September 18, 2026 at 6:01 AM
It provides a simple framework to understand the regulation of Rad51 filament structure and function by RAD51 paralogs complexes and functional homologs of Srs2.
Through computational modeling, we show that such outcome can be achieved if Rad55-Rad57 restricts Srs2 disruption activity to individual Rad51 segments. It results in the “pruning” that allows surviving ones to grow longer. Reduced filament segmentation = increased stiffness!
September 18, 2026 at 6:01 AM
Through computational modeling, we show that such outcome can be achieved if Rad55-Rad57 restricts Srs2 disruption activity to individual Rad51 segments. It results in the “pruning” that allows surviving ones to grow longer. Reduced filament segmentation = increased stiffness!
Through in vitro reconstitution experiments, we surprisingly find that the disruption activity of Srs2 drives the assembly of long and stiff Rad51 filaments when Rad55-Rad57 is present. How can that be?
September 18, 2026 at 6:01 AM
Through in vitro reconstitution experiments, we surprisingly find that the disruption activity of Srs2 drives the assembly of long and stiff Rad51 filaments when Rad55-Rad57 is present. How can that be?
Importantly, by mapping genome-wide the contacts made by Rad51 filaments and by quantifying D-loop products, we show that the combined presence of Rad55-Rad57 and Srs2 is required for homology search to turn genome-wide; a switch that requires assembly of long and stiff Rad51 filaments.
September 18, 2026 at 6:01 AM
Importantly, by mapping genome-wide the contacts made by Rad51 filaments and by quantifying D-loop products, we show that the combined presence of Rad55-Rad57 and Srs2 is required for homology search to turn genome-wide; a switch that requires assembly of long and stiff Rad51 filaments.
Using calibrated strand-specific Rad51 ChIP-seq, we corroborate prior models about the role of Rad55-Rad57 in promoting the assembly of Rad51 filament and protecting them against disruption by Srs2.
September 18, 2026 at 6:01 AM
Using calibrated strand-specific Rad51 ChIP-seq, we corroborate prior models about the role of Rad55-Rad57 in promoting the assembly of Rad51 filament and protecting them against disruption by Srs2.
They are orchestrated by seemingly antagonistic recombination factors: the Rad51 paralogs Rad55-Rad57 and the Srs2 translocase.
September 18, 2026 at 6:01 AM
They are orchestrated by seemingly antagonistic recombination factors: the Rad51 paralogs Rad55-Rad57 and the Srs2 translocase.
Yeast Rad55-Rad57-SHU paralog complex dynamically promotes Rad51 filament formation
Yeast Rad55-Rad57-SHU paralog complex dynamically promotes Rad51 filament formation
Koo et al. show how the yeast Rad51 paralog complex Rad55-Rad57-SHU promotes homologous recombination. Cryo-EM structures reveal that Rad55-Rad57 recruits Rad51 to ssDNA to seed filament formation, while ATP hydrolysis promotes paralog complex turnover.
dlvr.it
September 17, 2026 at 7:14 PM
Yeast Rad55-Rad57-SHU paralog complex dynamically promotes Rad51 filament formation
RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair
RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair
Yeh et al. show that DNA homology-directed repair template search is constrained to proximal DNA sequences in humans. Chromatin conformation further constrains the search profile and enables distant search interactions. However, exogenous DNA sequences, such as used in genome editing, are unconstrained and efficiently searched, thereby competing with endogenous search.
dlvr.it
September 16, 2026 at 7:50 PM
RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair
💡A new study sheds light on the complex process of DNA repair. The findings reveal how chromatin remodeling and DNA replication machinery coordinate to fix broken DNA strands, helping preserve genome integrity and cellular health.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
ISWI/CHRAC orchestrates sequential chromatin-remodeling activities by mobilizing DNA polymerase ε for homologous recombination - Communications Biology
CHRAC17, a key coordinator of chromatin remoder and DNA polymerase ε (Polε), orchestrates sequential chromatin remodeling, nucleosome assembly and sliding, to promote RAD51-mediated HR and mobilize Po...
doi.org
September 16, 2026 at 3:03 PM
💡A new study sheds light on the complex process of DNA repair. The findings reveal how chromatin remodeling and DNA replication machinery coordinate to fix broken DNA strands, helping preserve genome integrity and cellular health.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
RRID:AB_2633280 from @thermofishersci.bsky.social was used by authors in their Biochemical Pharmacology paper. RRIDs improve reproducibility in scientific research. #OpenResearch #BetterScience #reproducibility
A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin
Read the full paper: A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin
doi.org
August 28, 2026 at 7:00 AM
RRID:AB_2633280 from @thermofishersci.bsky.social was used by authors in their Biochemical Pharmacology paper. RRIDs improve reproducibility in scientific research. #OpenResearch #BetterScience #reproducibility
An extraordinary new paper shows how the RAD51 recombinase, which is canonically involved in DNA repair by HR, has an additional role in generating NETS (Neutrophil extracellular traps). These highly branched DNAs are released by immune cells to trap pathogens
www.science.org/doi/full/10....
www.science.org/doi/full/10....
August 25, 2026 at 9:45 PM
An extraordinary new paper shows how the RAD51 recombinase, which is canonically involved in DNA repair by HR, has an additional role in generating NETS (Neutrophil extracellular traps). These highly branched DNAs are released by immune cells to trap pathogens
www.science.org/doi/full/10....
www.science.org/doi/full/10....
RAD51-based homologous recombination deficiency is associated with treatment response and survival in early breast cancer scientiasalut.gencat.cat/handle/11351... #ScientiaVH
Making sure you're not a bot!
scientiasalut.gencat.cat
August 25, 2026 at 3:30 PM
RAD51-based homologous recombination deficiency is associated with treatment response and survival in early breast cancer scientiasalut.gencat.cat/handle/11351... #ScientiaVH
We posted a new preprint that revises an earlier preprint. Here, we tested the hypothesis from our original preprint and propose that the two eukaryotic recombinases, Rad51 and Dmc1, specialized in distinct directions after duplication in early eukaryotes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
August 25, 2026 at 12:07 PM
We posted a new preprint that revises an earlier preprint. Here, we tested the hypothesis from our original preprint and propose that the two eukaryotic recombinases, Rad51 and Dmc1, specialized in distinct directions after duplication in early eukaryotes
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The BRCA protein works two fold. First, it signals for other proteins, like RAD51, to seek out DNA templates. Second, it temporarily links the template and DNA, allowing for repair to occur. 4/11
August 25, 2026 at 10:53 AM
The BRCA protein works two fold. First, it signals for other proteins, like RAD51, to seek out DNA templates. Second, it temporarily links the template and DNA, allowing for repair to occur. 4/11
#WeekendRead! #LocationLocationLocation! Tsansizi, Guan, @venipap.bsky.social &co show @science.org that DNA repair protein RAD51 controls branching of neutrophil extracellular traps #NETs, preventing NET spread in the bloodstream, systemic inflammation & eosinophilia during #lung aspergillosis!
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation
Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...
doi.org
August 22, 2026 at 2:27 PM
#WeekendRead! #LocationLocationLocation! Tsansizi, Guan, @venipap.bsky.social &co show @science.org that DNA repair protein RAD51 controls branching of neutrophil extracellular traps #NETs, preventing NET spread in the bloodstream, systemic inflammation & eosinophilia during #lung aspergillosis!
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation | Science
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation
Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...
www.science.org
August 22, 2026 at 4:27 AM
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation | Science
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation | Science www.science.org/doi/10.1126/...
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation
Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...
www.science.org
August 21, 2026 at 6:19 AM
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation | Science www.science.org/doi/10.1126/...
We've long wondered what gives NETs their branched architecture. We are excited to report that RAD51—a protein involved in DNA repair—promotes NET branching & stability, spatially restricting NETs to control type-2 inflammation. @crick.ac.uk www.science.org/doi/10.1126/...
RAD51 stabilizes neutrophil extracellular traps to compartmentalize inflammation
Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...
www.science.org
August 21, 2026 at 4:21 AM
We've long wondered what gives NETs their branched architecture. We are excited to report that RAD51—a protein involved in DNA repair—promotes NET branching & stability, spatially restricting NETs to control type-2 inflammation. @crick.ac.uk www.science.org/doi/10.1126/...
