🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
www.nature.com
February 21, 2026 at 11:32 PM
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 11:58 PM
Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
April 25, 2025 at 5:19 AM
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
July 25, 2025 at 3:46 PM
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
Breakthrough article 😊
Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo
doi.org/10.1093/nar/...
@zarnack-group.bsky.social
@könig-lab.bsky.social
@mibinet.bsky.social
#EMBOrnaLocalization
Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo
doi.org/10.1093/nar/...
@zarnack-group.bsky.social
@könig-lab.bsky.social
@mibinet.bsky.social
#EMBOrnaLocalization
Dissecting the RNA-binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport
Abstract. RNA-binding proteins (RBPs) utilize multiple RNA-binding domains (RBDs) to engage with extensive messenger RNA (mRNA) networks. Understanding the
doi.org
April 1, 2026 at 2:25 PM
Breakthrough article 😊
Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo
doi.org/10.1093/nar/...
@zarnack-group.bsky.social
@könig-lab.bsky.social
@mibinet.bsky.social
#EMBOrnaLocalization
Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo
doi.org/10.1093/nar/...
@zarnack-group.bsky.social
@könig-lab.bsky.social
@mibinet.bsky.social
#EMBOrnaLocalization
Advances in CLIP-derived methods have enabled high-resolution mapping of individual RNA binding protein-RNA interactions as well as RNA binding protein-associated RNA–RNA interactions #RNA #CLIP @evannostrandlab.bsky.social bit.ly/4bYjAsg
February 17, 2026 at 4:25 PM
Advances in CLIP-derived methods have enabled high-resolution mapping of individual RNA binding protein-RNA interactions as well as RNA binding protein-associated RNA–RNA interactions #RNA #CLIP @evannostrandlab.bsky.social bit.ly/4bYjAsg
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
The advent of system-wide proteomic approaches has largely expanded the number of
RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming
our understanding of biolog...
www.cell.com
September 5, 2025 at 3:49 PM
Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
🧵1/
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6
Intrinsically disordered regions (IDRs) are prevalent in RNA-binding proteins (RBPs), yet their roles in RNA interactions remain poorly defined. Here, we examined the structured and disordered RNA-bin...
www.biorxiv.org
April 15, 2025 at 11:36 PM
🧵1/
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
🚨Check out our significantly updated preprint, now out on @biorxivpreprint.bsky.social. Together with Sasi Conte lab, we characterize a novel role for intrinsically disordered regions (IDRs) in promoting RNA-binding selectivity in RNA binding proteins (RBPs): www.biorxiv.org/content/10.1...
Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI
doi.org/10.1038/s443...
doi.org/10.1038/s443...
RNA-binding proteins as versatile metabolic regulators - npj Metabolic Health and Disease
npj Metabolic Health and Disease - RNA-binding proteins as versatile metabolic regulators
doi.org
January 14, 2025 at 4:16 PM
Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI
doi.org/10.1038/s443...
doi.org/10.1038/s443...
RNA-binding proteins as versatile metabolic regulators
great review from @inahuppertz.bsky.social & Ellie Koletsou
www.nature.com/articles/s44...
great review from @inahuppertz.bsky.social & Ellie Koletsou
www.nature.com/articles/s44...
RNA-binding proteins as versatile metabolic regulators - npj Metabolic Health and Disease
npj Metabolic Health and Disease - RNA-binding proteins as versatile metabolic regulators
www.nature.com
January 14, 2025 at 2:13 PM
RNA-binding proteins as versatile metabolic regulators
great review from @inahuppertz.bsky.social & Ellie Koletsou
www.nature.com/articles/s44...
great review from @inahuppertz.bsky.social & Ellie Koletsou
www.nature.com/articles/s44...
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology
RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...
www.nature.com
January 27, 2026 at 7:32 AM
Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
#paperalert!
In our new study, we ask the question: Can we predict RNA stability across conditions and protocols, based solely on experimental and/or computationally predicted RNA binding protein target sites?
Read the paper to find out !
www.biorxiv.org/content/10.1...
In our new study, we ask the question: Can we predict RNA stability across conditions and protocols, based solely on experimental and/or computationally predicted RNA binding protein target sites?
Read the paper to find out !
www.biorxiv.org/content/10.1...
Cell-type specific prediction of RNA stability from RNA-protein interactions
RNA-binding proteins (RBPs) are important contributors to post-transcriptional regulatory processes. The combinatorial action of expressed RBPs and non-coding factors bound to the same transcript dete...
www.biorxiv.org
December 4, 2024 at 12:48 PM
#paperalert!
In our new study, we ask the question: Can we predict RNA stability across conditions and protocols, based solely on experimental and/or computationally predicted RNA binding protein target sites?
Read the paper to find out !
www.biorxiv.org/content/10.1...
In our new study, we ask the question: Can we predict RNA stability across conditions and protocols, based solely on experimental and/or computationally predicted RNA binding protein target sites?
Read the paper to find out !
www.biorxiv.org/content/10.1...
Excited to share the first pre-print from our lab!!
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
June 8, 2026 at 8:49 PM
Excited to share the first pre-print from our lab!!
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
protein may not be enough to halt cancer. Instead, the poison exon itself seems to play a larger role. This told researchers that poison-exon-containing RNA doesn’t just silence TRA2β. It likely sequesters other RNA-binding proteins, creating an even more toxic environment for cancer cells.
March 23, 2025 at 4:08 PM
protein may not be enough to halt cancer. Instead, the poison exon itself seems to play a larger role. This told researchers that poison-exon-containing RNA doesn’t just silence TRA2β. It likely sequesters other RNA-binding proteins, creating an even more toxic environment for cancer cells.
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
May 15, 2026 at 1:50 PM
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource go.nature.com/4mc1SmQ
rdcu.be/fxFp9
rdcu.be/fxFp9
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
August 6, 2026 at 4:03 AM
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource go.nature.com/4mc1SmQ
rdcu.be/fxFp9
rdcu.be/fxFp9
I am thrilled to share our paper introducing RBPscan, a novel approach to profile RNA–protein interactions in living cells. Free access link at the end ⬇️ 🧵 1/
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions
Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding
proteins engage their targets in living cells. This approach quantifies the binding
strength of protein-RNA...
www.cell.com
February 6, 2026 at 9:37 PM
I am thrilled to share our paper introducing RBPscan, a novel approach to profile RNA–protein interactions in living cells. Free access link at the end ⬇️ 🧵 1/
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...
Cell surface RNA biology: new roles for RNA binding proteins
Much of our understanding of RNA–protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking…
www.sciencedirect.com
April 25, 2025 at 12:52 PM
“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - @raflynn5.bsky.social go.nature.com/3YbT1In
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
go.nature.com
April 23, 2025 at 3:11 PM
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - @raflynn5.bsky.social go.nature.com/3YbT1In
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
www.nature.com
July 28, 2025 at 3:34 PM
New in @natbiotech.nature.com: a team led by scientists at MSK and University of Toronto have developed a new platform to facilitate the study of RNA-biding proteins (RBPs) across hundreds of species of plants, insects, and animals.
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
July 26, 2025 at 7:15 PM
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
Architecture and RNA binding properties of the trypanosome nuclear cap-binding complex - key complex in the parasite’s RNA metabolism. Final peer-reviewed version is public! #RNAsky #trypsky www.nature.com/articles/s41...
Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex - Nature Communications
Bernhard et al. reveal the architecture of the tetrameric Trypanosoma brucei nuclear cap-binding complex. Using cryo-electron microscopy and biochemical assays, the researchers characterize its bindin...
www.nature.com
January 21, 2025 at 10:14 AM
Architecture and RNA binding properties of the trypanosome nuclear cap-binding complex - key complex in the parasite’s RNA metabolism. Final peer-reviewed version is public! #RNAsky #trypsky www.nature.com/articles/s41...
📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Mitotic fidelity depends on proper chromosome alignment at the spindle equator, a process known as chromosome congression, driven by well-established protein networks. Whereas RNA-binding proteins and...
www.biorxiv.org
January 23, 2025 at 5:26 PM
📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...