Retour sur la journée du samedi 20 juin 2026 en direct du Hellfest. L'équipe de Radio Metal couvre l'évenement : photos, reports et vidéos.

DOTA Chelator GMP Grade Radiometal Coordination Therapy Global DOTA Chelator GMP Grade Radiometal market is projected to grow from USD 268 million in 2026 to USD 512 million by 2034, exhibiting a CA...

89Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical...

Abstract. The development of peptide-based, radiometal-labeled PET imaging agents has seen an increase in attention due to the favorable properties the pep

A covalent adduct of DFOB and DOTA separated by a l-lysine residue (DFOB-l-Lys-N6-DOTA) exhibited remarkable regioselective metal binding, with {1H}-13C NMR spectral shifts supporting Zr(iv) coordinating to the DFOB unit, and Lu(iii) coordinating to the DOTA unit. This first-in-class, dual-chelator theranost

Adarulatide tetraxetan is a chelator-conjugated peptide compound used for radiolabeling and diagnostic imaging. It enables site-specific radiometal binding, particularly with copper isotopes, to visualize tumor targets in molecular imaging research.

DOTA-NOC is a GMP-grade, high-purity ligand selective for somatostatin receptor subtypes 2, 3, and 5. Designed for radiometal labeling and radiopeptide imaging, it supports both wholesale and retail with research-use-only compliance.（For wholesale prices, other specifications and uses, please consult our staff）

Read the full paper: Ultra-Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal-Labeling Platform for Cancer Radioembolization

Troisième épisode de la deuxième saison pour l'émission qui lie le metal, les Comics et la BD !

El CICA es el Centro Interdisciplinar de Química e Bioloxía. Se encarga del desarrollo de proyectos de investigación.

Comme tous les ans l'émission Noise Pollution s'associe avec Metal Brigade de radiometal pour un best of en 2 émissions. Cette année ce sera les 3 et 10 janviers à 20h sur radio Canut et plus tard sur radio Metal. Le blog de Noise pollution :…

Conjugated poly(imide dioxime)-based microspheres establish a radiometal coordination-driven conformational interlocked network with ultra-high radiostability. This platform enables low-temperature, multi-radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in vivo studies demonstrate effective tumor targeting, supporting clinical translation for liver cancer theranostics. ABSTRACT Transcatheter arterial embolization (TARE) has emerged as a highly effective locoregional treatment for advanced liver cancer, which represents a significant advancement in clinical practice. Nonetheless, the utilization of traditional radioactive microspheres in TARE is hindered by various material and technical challenges that necessitate resolution. Herein, we present, for the first time, well-designed and synthesized conjugated poly(imide dioxime) ligand-based microspheres (PID-Ms) with a remarkable radiometal coordinate covalent conformational interlocked network. PID-Ms can be radiolabeled with various radionuclides, including 177 Lu, 90 Y, 188 Re, 68 Ga, and 99m Tc, can be achieved at low temperatures (40°C), and for diagnostic imaging and radiotherapy applications. The combined strategy of extended x-ray absorption fine structure spectroscopy (EXAFS), DFT calculations, and in vitro and in vivo radiostability experiments collectively confirmed that radiometal-PID complexes exhibit ultra-high radiostability. 177 Lu-PID-Ms were employed to accurately predict normal organ shunts and radiotherapy in rat and rabbit VX2 orthotopic live tumor models, demonstrating their ultra-radiostability and remarkable anti-tumor efficacy. Furthermore, Radiometals-PID-Ms have an adjustable shelf life, enabling on-demand radiolabeling for drug preparation, achieving rapid ‘on-demand’ capability. This innovative approach has the potential to inspire the synthesis of numerous coordination polymeric materials for various applications in PET/SPECT-mediated radiopharmaceutical therapy, alpha-nucleophile-targeted radiotherapy, and MRI contrast agents.