Check out our selection for October's #ReactomeResearchSpotlight!

Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response"

Read more: 🔗 reactome.org/content/reac...
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An exciting #ReactomeResearchSpotlight!
In the feature article of the October 2024 issue of Drug Discovery Today titled "Chemical coverage of human biological pathways" by Kwak et al. describe the #Target2035 initiative!
Read more: reactome.org/content/reac...

Check out our selection for our latest #ReactomeResearchSpotlight! 💡

In their March 2026 Society of Toxicology paper, “A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets”.

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Check out our selection for our latest #ReactomeResearchSpotlight! 💡

🔗 reactome.org/content/reac...

🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight!

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Check out our selection for our first 2026 #ReactomeResearchSpotlight! 💡

🔗 reactome.org/content/reac...

🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us (help@reactome.org) to submit your work for our monthly spotlight!

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#ReactomeResearchSpotlight is updated monthly on our website's homepage! Our staff selects candidate articles to feature. After team discussion, the winner is posted on our home page.

Contact us at help@reactome.org with if you want to be featured as the next Spotlight!

The #ReactomeResearchSpotlight for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids
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#ReactomeResearchSpotlight is updated monthly on our website's homepage! Our staff selects candidate articles to feature. After team discussion, the winner is posted on our home page.
Contact us at help@reactome.org with if you want to be featured as the next Spotlight!

Time for #ReactomeResearchSpotlight! Bracha et al. use #Reactome expression analysis to confirm that they successfully delivered multiple large therapeutic proteins across the blood-brain barrier into target neurons in mice using engineered Toxoplasma gondii secretion systems.
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Have you seen our latest #ReactomeResearchSpotlight? This month's focused on the recent work by Chen et al.
reactome.org/content/reac...
Chen et al used data simulated based on Reactome pathways to validate their Functional Representation of Gene Signatures (FRoGS) algorithm.

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Read more about this and other #ReactomeResearchSpotlight articles. Tell us more about how you use
@Reactome
and #OpenData in your work to be showcased next month!

Have you seen our latest #ReactomeResearchSpotlight?

Zhang et al published a study in Toxicology and Applied Pharmacology (12/23) that uses the ReactomePA R package to identify enriched pathways responding to nickel-induced transcriptional memory in response to nicotine!

Read more about this and other #ReactomeResearchSpotlight articles!
Tell us about how you use @Reactome and #OpenData in your work!

Have you seen our #ReactomeResearchSpotlight? “Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation" 🖥️🧬 🧪

Read more about this and other #ReactomeResearchSpotlight ➡️  tinyurl.com/RRSAll

🧬Have you seen our new #ReactomeResearchSpotlight for October? 
This month, we are thrilled to highlight a study by Miller et al (2023) that used @Reactome to perform an epigenome-wide association study. ➡️ tinyurl.com/RRS1023 #Epigenomics #Diabetes #CardiovascularDisease
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