#RelapsingBrainDisease
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neurotorium.org
#SubstanceUseDisorders are characterized by the compulsion to take a substance or engage in certain behaviours. Addiction is a #RelapsingBrainDisease that can have a progressive disease course, characterized by the development of tolerance over time.

🔗 neurotorium.org/substance-us...
Diagram showing brain changes from chronic substance use. On the left, a non-addicted brain displays balanced signals between "go" and "no-go" pathways, involving the PFC (prefrontal cortex), ACG (anterior cingulate gyrus), OFC (orbitofrontal cortex), NAcc (nucleus accumbens), VP (ventral pallidum), HIP (hippocampus), and Amyg (amygdala). On the right, the addicted brain shows disrupted circuits: increased "go" signals and reduced "no-go" inhibition. Right-side notes explain how drug use affects dopamine and stress pathways, alters circuits linked to self-control, and impacts reward, cognition, motivation, and memory.
June 12, 2025 at 7:53 AM