Libri, cataloghi, stampe, spillette. Tutti i prodotti realizzati per le serate Renape a portata di click! Grandi autoproduzioni e nuove idee

An excerpt from Columbus and Other Cannibals: The Wetiko Disease of Exploitation, Imperialism, and Terrorism by Jack D. Forbes: It is quite clear that in modern times we have witnessed the ...

Background Treatment of peritoneal metastasis (PM) from appendicular adenocarcinoma consists of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). No specific recommendation exists in case of acute appendicular syndrome (AAS) with perforated tumor. Patients and Methods Data from 12 expert centers from the BIG-RENAPE network were collected. We analyzed 5-year overall survival (OS), 5-year disease-free survival (DFS), and 5-year peritoneal-free survival (PFS) between carcinologic right colectomy (CRC) and prophylactic CRS with HIPEC (pCRS + HIPEC) groups. Survival analysis was also performed between CRC, pCRS + HIPEC, and curative CRS with HIPEC (cCRS + HIPEC) groups. Results Carcinologic surgery was performed in 130 patients: 11 in CRC, 44 in pCRS + HIPEC, and 75 in cCRS + HIPEC groups. OS was 96.9% (95% confidence interval [CI]: 91.0–100%) in the pCRS + HIPEC group compared with 51.9% (95% CI 21.6–100%) in the CRC group (p < 0.001). The 5-year DFS was 75.2% (95% CI 60.5–93.5%) in the pCRS + HIPEC group compared with 34.3% (95% CI 11.2–100 %) in the CRC group (p = 0.003). The 5-year PFS was 77.6% (95% CI 63.0–95.6%) in the pCRS + HIPEC group compared with the CRC group 34.3% (95% CI 11.2–100 %) (p = 0.001). When comparing all three groups, OS and DFS were significantly better in the pCRS + HIPEC group compared with the CRC and cCRS + HIPEC groups. There were no significant differences in postoperative morbidity between the three groups. Conclusions Performing pCRS + HIPEC in the case of perforated appendiceal adenocarcinoma discovered during AAS seems to be associated with better OS compared with performing CRC. This therapeutic option should systematically be discussed in cases of perforated appendiceal adenocarcinoma discovered during acute appendicitis.

Más de 200.000 documentos emitidos en los últimos años podrían estar comprometidos por un defecto invisible. RENAPE habilitó un chatbot en WhatsApp para verificarlos.

As part of the national 2009-2013 Cancer Plan, and with t...

This document is a summary of the French intergroup guidelines for the management of liver and peritoneal metastases developed within the « cancer of unknown primary » (CUP) syndrome, published in Apr...