#SABCS22
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oncbrothers.bsky.social
2. #PADMA: Ph III, HR+ metastatic breast cancer, chemo vs ET + Palbociclib.

- #SABCS22 in #RightChoice study, we knew CDK4/6i upfront is better.

- Time to treatment failure and PFS better in PADMA. CDK4/6i remain 1L SoC for these pts

3/5
December 11, 2024 at 2:26 AM
stage4kelly.bsky.social
Want to get #SABCS22 updates from some of the best breast oncologists on the planet? For free! DM me for the link to the Bay Area Great Cancer Forum featuring Drs. @hoperugo, Michelle Melisko, and Jo Chien. TONIGHT (Wed 1/25) at 6 PM PACIFIC
November 17, 2024 at 4:54 AM
stage4kelly.bsky.social
.@SABCSSanAntonio how can those of us who were at #SABCS22 in person watch sessions we missed because cloning isn’t a thing yet?
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
After 3.5 weeks 🤿 🐠 in Cozumel and another 5 days at #SABCS22, I’m glad to be home with my boys, even if it is 🌨 ❄️ 💨. Going to light a 🔥, make some homemade 🍲 and find a good 📖 to read.
Tomorrow it’ll be snow shoveling and DoD grant critique writing.
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
Saw so many wonderful folks at #SABCS22 but 😢 I didn’t get to talk to @DrSGraff - we have to make a date for #SABCS23 if not sooner
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
😞 to be leaving #sabcs22 in hopes of beating a major ❄️ storm at home. Seeing #advocate, oncologist, & researcher friends recharged me. This is the ⭐️ breast cancer conference & while the science is incredible, I really come for the people 💙💚💗 🏨 for #sabcs23 already booked!
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
Dr @AngieDemichele on RCT vs RWE - and immediately comments it really should be RCT and RWE; randomized trials plus real world evidence is an example of #StrongerTogether #sabcs22 #bcsm
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
There are alternatives to a MTD approach. CDK4/6 inhibitors are as effective at lower doses - but do people who tolerate the higher dose NEED the higher dose for efficacy?? With alpelisib lower doses don’t work as well as higher doses. #sabcs22 #bcsm
November 17, 2024 at 9:58 AM
stage4kelly.bsky.social
Why study a dose if people can’t tolerate it and drop out of the trial or over 50% need a dose reduction. #sabcs22 #bcsm
November 17, 2024 at 9:58 AM
stage4kelly.bsky.social
And it’s not the only drug where MTD/recommended starting dose got thrown out PDQ. #sabcs22 #bcsm
November 17, 2024 at 9:58 AM
stage4kelly.bsky.social
Capecitabine (Xeloda) is a good example of a drug where no one uses MTD, which is the recommended starting dose, because it’s intolerable #sabcs22 #bcsm
November 17, 2024 at 5:40 AM
stage4kelly.bsky.social
Maximum tolerated dose (MTD) is kinda whatever doesn’t kill you makes you better 🤷‍♀️ #sabcs22 #bcsm
November 17, 2024 at 5:40 AM
stage4kelly.bsky.social
So Dr @hoperugo how come YOU don’t have slides on RIP MTD in the app 😂#sabcs22 #bcsm
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
Always love and learn so much from these @abreastcancer sessions with the @FDAOncology breast team Drs @tmprowell @pre_ryan Bindu Libyan and Asma Dilawari #sabcs22 #bcsm
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
One thing not up for debate: a CDK 4/6 inhibitor (specifically ribociclib) + endocrine therapy is better than chemo in first line aggressive disease. #sabcs22 #bcsm
November 17, 2024 at 11:05 AM
stage4kelly.bsky.social
Dr Ruth O’Regan takes the “nope, they’re different” side, structurally and in side effects, but also in OS #SABCS22 #bcsm
November 17, 2024 at 10:44 AM
stage4kelly.bsky.social
Dr Pratt: “we’re really lucky to have all 3 agents”. This can allow matching the right drug to the right patient.
#SABCS22 #bcsm
November 17, 2024 at 10:44 AM
stage4kelly.bsky.social
There are differences in OS but there are limitations in the palbo trials in that a high % of people dropped out when palbo was approved in 2015 (and therefore could get without being on a trial). RWE has shown palbo does have an OS benefit (no slide available) #sabcs22 #bcsm
November 17, 2024 at 9:58 AM
stage4kelly.bsky.social
Dr Debra Pratt, taking the “yes, all CDK 4/6 inhibitors are the same” is having technical difficulties with updated slides 😝 so for now I’ll just share what’s in the app. Original trials all showed very similar PFS but side effects are different #sabcs22 #bcsm
November 17, 2024 at 5:41 AM
stage4kelly.bsky.social
Now up: debate on whether all CDK4/6 inhibitors are the same #sabcs22 #bcsm
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
.@SABCSSanAntonionext year can you PLEASE make sure 1 exhibitor has that yummy Mexican hot chocolate?? #sabcs22
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
No slides for this talk about PROTAC ARV471 😢 and I’m too far back in the room to get good projected slide 📸. Will find and retweet others’ take on this trial. #sabcs22
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
Will have to tweet additional slides from this general session later - seems like the app is overloaded as everything froze! #sabcs22 #bcsm
November 17, 2024 at 5:17 AM
stage4kelly.bsky.social
An oral pill rather than a 💉 in the 🍑 every month would be a welcome option but there are GI side effects 🤢, although very few people stopped therapy due to side effects. #sabcs22 #bcsm
November 17, 2024 at 5:41 AM
stage4kelly.bsky.social
Promising data on elacestrant from the EMERLAD trial. Elacestrant is an oral SERD. Everyone has been on a CDK 4/6 inhibitor and it worked well in people with an ESR1 mutation #sabcs22 #bcsm
November 17, 2024 at 5:18 AM