Forgot to share that I replayed a real Sonic game on Saturday (it gets really really bad in the second half). I played Sonic 1 for the Game Gear a bunch as a kid, loved the first 3 zones. Played it through SADX on the GameCube, it's the first GG game you unlock.
October 6, 2026 at 2:24 PM
Forgot to share that I replayed a real Sonic game on Saturday (it gets really really bad in the second half). I played Sonic 1 for the Game Gear a bunch as a kid, loved the first 3 zones. Played it through SADX on the GameCube, it's the first GG game you unlock.
Lesse...
* The Dreamcastify blog in 2017. Before that, opinions were more split on SADX. After, DX became so hated that it started getting blamed as the entire reason people thought they didn't like SA1.
* The Dreamcastify blog in 2017. Before that, opinions were more split on SADX. After, DX became so hated that it started getting blamed as the entire reason people thought they didn't like SA1.
October 4, 2026 at 2:37 PM
Lesse...
* The Dreamcastify blog in 2017. Before that, opinions were more split on SADX. After, DX became so hated that it started getting blamed as the entire reason people thought they didn't like SA1.
* The Dreamcastify blog in 2017. Before that, opinions were more split on SADX. After, DX became so hated that it started getting blamed as the entire reason people thought they didn't like SA1.
The machine learning model has to account for different meanings of binned activity per directed evolution round and the binned, ordinal labels. We use ordinal regression with a evolutionary score as an additional feature. That model nominates new SadX mutations that we test. 3/
October 2, 2026 at 3:45 PM
The machine learning model has to account for different meanings of binned activity per directed evolution round and the binned, ordinal labels. We use ordinal regression with a evolutionary score as an additional feature. That model nominates new SadX mutations that we test. 3/
The main idea is to rearray the existing sequence variants from each round of directed evolution based on enzyme activity bins. Then use long read sequencing to map sequences to function bins per round. That gives a training dataset for machine learning. 2/
October 2, 2026 at 3:45 PM
The main idea is to rearray the existing sequence variants from each round of directed evolution based on enzyme activity bins. Then use long read sequencing to map sequences to function bins per round. That gives a training dataset for machine learning. 2/
Our new preprint with the @philromero.bsky.social and @jclewislab.bsky.social labs explores how to extract additional information for protein engineering from a previous directed evolution campaign. We test it with SadX for site-selective C-H azidation. 1/
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Extracting Latent Sequence-Function Information from Directed Evolution to Design Improved C-H Azidases | ChemRxiv
Directed evolution is a powerful approach for enzyme engineering, but conventional
workflows use only a fraction of the information generated during experimental screening.
Typically, only top-perform...
chemrxiv.org
October 2, 2026 at 3:45 PM
Our new preprint with the @philromero.bsky.social and @jclewislab.bsky.social labs explores how to extract additional information for protein engineering from a previous directed evolution campaign. We test it with SadX for site-selective C-H azidation. 1/
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
the only correct way to play sa1 on pc is sadx with dreamcast conversion
October 1, 2026 at 8:10 PM
the only correct way to play sa1 on pc is sadx with dreamcast conversion
need to find a new game for individual level speedruns. been continuing the sadx knuckles grind quietly in the background but it's getting tedious as my single go-to speedrun thing without anything else to mix things up
September 27, 2026 at 1:20 PM
need to find a new game for individual level speedruns. been continuing the sadx knuckles grind quietly in the background but it's getting tedious as my single go-to speedrun thing without anything else to mix things up
Honourable mentions that did not make the list: firstly, Sonic 2, which I played a bit as a child but did not really grab me til a lot later - so I kind of have SADX representing the Sonix slot. Saying that, if we were talking game *soundtracks*, Sonic 2 would easily be here.
September 27, 2026 at 9:28 AM
Honourable mentions that did not make the list: firstly, Sonic 2, which I played a bit as a child but did not really grab me til a lot later - so I kind of have SADX representing the Sonix slot. Saying that, if we were talking game *soundtracks*, Sonic 2 would easily be here.
Some delays occur, so these Sonic SFM toys (main Tails Doll not included) will be released for download somewhere on my birthday. They'll be in my SFM prop pack, and they're posable too. 🥰
September 22, 2026 at 4:55 PM
Some delays occur, so these Sonic SFM toys (main Tails Doll not included) will be released for download somewhere on my birthday. They'll be in my SFM prop pack, and they're posable too. 🥰
Вже 12 років фанат соніка... аж самому не віриться. Так чи інакше, я став фанатом побачивши ігролад Sonic Generations, але першою грою була Sonic Megamix v3.0, далі грав у Sonic Advance а за ним і SADX та Heroes (SA2B чогось не вийшло встановити тоді), навіть до Riders у мене тоді руки добрались.
September 21, 2026 at 5:14 PM
Вже 12 років фанат соніка... аж самому не віриться. Так чи інакше, я став фанатом побачивши ігролад Sonic Generations, але першою грою була Sonic Megamix v3.0, далі грав у Sonic Advance а за ним і SADX та Heroes (SA2B чогось не вийшло встановити тоді), навіть до Riders у мене тоді руки добрались.
Amy art from 2023 where i forgot dreamcast x button is not blue, so you'll be playing SADX on your xbox360 instead lmao
September 20, 2026 at 9:24 PM
Amy art from 2023 where i forgot dreamcast x button is not blue, so you'll be playing SADX on your xbox360 instead lmao
why the dreamcast version?
well see below, i got 100% on the Steam version of SADX, which means i have no reason to touch it or the GC version in general ever again.
BUT if i do the Dreamcast Version, i can do retroachievements on a retroarch!!!!
well see below, i got 100% on the Steam version of SADX, which means i have no reason to touch it or the GC version in general ever again.
BUT if i do the Dreamcast Version, i can do retroachievements on a retroarch!!!!
September 17, 2026 at 4:27 PM
why the dreamcast version?
well see below, i got 100% on the Steam version of SADX, which means i have no reason to touch it or the GC version in general ever again.
BUT if i do the Dreamcast Version, i can do retroachievements on a retroarch!!!!
well see below, i got 100% on the Steam version of SADX, which means i have no reason to touch it or the GC version in general ever again.
BUT if i do the Dreamcast Version, i can do retroachievements on a retroarch!!!!
#SillyOlBearQueen
Upcoming smol clips of EPIC releasing my Top 3 Childhood Trio... In ONE. FREAKIN. SEASON/SITTING... FAAAAAAAA-
😭💸💸💸
♡♡♡
#VTuber #ENVTuber #VSky
🎮: #Fortnite #FortniteOverride (C7S4)
🎶: #Sonic Heroes Intro
🎶: SADX - Windy Valley/Hill
🎶: Crush40/Sonic - Live And Learn (Acapella)
Upcoming smol clips of EPIC releasing my Top 3 Childhood Trio... In ONE. FREAKIN. SEASON/SITTING... FAAAAAAAA-
😭💸💸💸
♡♡♡
#VTuber #ENVTuber #VSky
🎮: #Fortnite #FortniteOverride (C7S4)
🎶: #Sonic Heroes Intro
🎶: SADX - Windy Valley/Hill
🎶: Crush40/Sonic - Live And Learn (Acapella)
September 17, 2026 at 1:43 AM
#SillyOlBearQueen
Upcoming smol clips of EPIC releasing my Top 3 Childhood Trio... In ONE. FREAKIN. SEASON/SITTING... FAAAAAAAA-
😭💸💸💸
♡♡♡
#VTuber #ENVTuber #VSky
🎮: #Fortnite #FortniteOverride (C7S4)
🎶: #Sonic Heroes Intro
🎶: SADX - Windy Valley/Hill
🎶: Crush40/Sonic - Live And Learn (Acapella)
Upcoming smol clips of EPIC releasing my Top 3 Childhood Trio... In ONE. FREAKIN. SEASON/SITTING... FAAAAAAAA-
😭💸💸💸
♡♡♡
#VTuber #ENVTuber #VSky
🎮: #Fortnite #FortniteOverride (C7S4)
🎶: #Sonic Heroes Intro
🎶: SADX - Windy Valley/Hill
🎶: Crush40/Sonic - Live And Learn (Acapella)
Jennifer 'AlonWoof' Dehan, this is absolutely incredible! The way you captured that glitchy, low-fi aesthetic is just so cool. I love how the pink and white tones of the character pop against that dark, streaked background. And that 'SADX' folder notification window adds such a unique, mysterious
September 13, 2026 at 8:28 PM
Jennifer 'AlonWoof' Dehan, this is absolutely incredible! The way you captured that glitchy, low-fi aesthetic is just so cool. I love how the pink and white tones of the character pop against that dark, streaked background. And that 'SADX' folder notification window adds such a unique, mysterious
I remember as a teen playing SADX the most fun i had was running the first sonic level over and over again, not trying to go faster but trying to make it look cool, and trying to get as many animals for the chao garden as possible. I don't think I've ever wanted to beat a fastest time.
September 8, 2026 at 11:23 PM
I remember as a teen playing SADX the most fun i had was running the first sonic level over and over again, not trying to go faster but trying to make it look cool, and trying to get as many animals for the chao garden as possible. I don't think I've ever wanted to beat a fastest time.
I imagine they're planning on giving us SA2B and SADX on NSO.
Truthfully, I'm more surprised we haven't got an Advance collection yet with 1-3, Battle and Pinball Party. Now THAT is a no-brainer and surely the work of an afternoon to code.
Truthfully, I'm more surprised we haven't got an Advance collection yet with 1-3, Battle and Pinball Party. Now THAT is a no-brainer and surely the work of an afternoon to code.
September 8, 2026 at 8:58 PM
I imagine they're planning on giving us SA2B and SADX on NSO.
Truthfully, I'm more surprised we haven't got an Advance collection yet with 1-3, Battle and Pinball Party. Now THAT is a no-brainer and surely the work of an afternoon to code.
Truthfully, I'm more surprised we haven't got an Advance collection yet with 1-3, Battle and Pinball Party. Now THAT is a no-brainer and surely the work of an afternoon to code.
sad that we're never getting adventure remasters, since that would mean actual effort instead of adding innocuous extra features to a hedgehog engine game released 10 years ago.
or idk maybe they would repackage sadx again but with a shadow skin dlc and a $60 price tag
or idk maybe they would repackage sadx again but with a shadow skin dlc and a $60 price tag
September 8, 2026 at 8:06 PM
sad that we're never getting adventure remasters, since that would mean actual effort instead of adding innocuous extra features to a hedgehog engine game released 10 years ago.
or idk maybe they would repackage sadx again but with a shadow skin dlc and a $60 price tag
or idk maybe they would repackage sadx again but with a shadow skin dlc and a $60 price tag
SADX is done!! Great game especially with the help of the BetterSADX mod c:
Its very silly and clunky and weird but its also really charming, I'm excited to try SA2 after a lil break c:
Its very silly and clunky and weird but its also really charming, I'm excited to try SA2 after a lil break c:
September 4, 2026 at 7:46 AM
SADX is done!! Great game especially with the help of the BetterSADX mod c:
Its very silly and clunky and weird but its also really charming, I'm excited to try SA2 after a lil break c:
Its very silly and clunky and weird but its also really charming, I'm excited to try SA2 after a lil break c:
sadx is more consistently buggy i think 06 bugs are more destructive
September 3, 2026 at 8:57 PM
sadx is more consistently buggy i think 06 bugs are more destructive
I personally had a more buggy time with SADX and Heroes on Gamecube than I did with Sonic 06 I think - like bugs that actually frustrated me
Sonic 06 was predictable in it's jank
Sonic 06 was predictable in it's jank
September 3, 2026 at 8:51 PM
I personally had a more buggy time with SADX and Heroes on Gamecube than I did with Sonic 06 I think - like bugs that actually frustrated me
Sonic 06 was predictable in it's jank
Sonic 06 was predictable in it's jank
Comfort gaming to relax and vibe to {SADX}
www.twitch.tv/cheshire_jj
#sonic #SonicOC #Mobian #Furry #PNGtuber #Jackal #Twitch
www.twitch.tv/cheshire_jj
#sonic #SonicOC #Mobian #Furry #PNGtuber #Jackal #Twitch
Cheshire_JJ - Live on Twitch
Comfort gaming to relax and vibe to {SADX} | Streaming sonic adventure dx: director's cut.
www.twitch.tv
September 1, 2026 at 4:35 PM
Comfort gaming to relax and vibe to {SADX}
www.twitch.tv/cheshire_jj
#sonic #SonicOC #Mobian #Furry #PNGtuber #Jackal #Twitch
www.twitch.tv/cheshire_jj
#sonic #SonicOC #Mobian #Furry #PNGtuber #Jackal #Twitch
Cheshire_JJ - Live on Twitch
Comfort gaming to relax and vibe to {SADX} | Streaming sonic adventure dx: director's cut.
www.twitch.tv
September 1, 2026 at 3:52 PM