with a focus on short-chain fatty acids (SCFAs), tryptophan (Trp)-related metabolites, and nitric oxide (NO)-related metabolic pathways, and their potential effects on neuroimmune signaling, intestinal barrier integrity, and trigeminovascular function. (🧵 3/5)

본 문헌 고찰은 단쇄지방산(SCFAs), 트립토판(Trp) 관련 대사산물, 일산화질소 (NO) 관련 대사 경로를 중심으로, 이들이 신경면역 신호전달, 장 장벽 무결성, 삼차신경혈관 기능에 미칠 수 있는 잠재적 영향을 다룬다. 현재의 증거에 따르면 장내 미생물 불균형과 대사 장애는 편두통과 관련이 있으며, 신경염증 경로와 중추 감작을 조절할 수 있는 것으로 보이지만, 인간을 대상으로 한 직접적인 인과 (🧵 2/3)

편두통 발병 기전에서 장내 미생물 대사산물의 역할
▶️ 논문읽기

📚 출처: Frontiers in medicine
👤 저자: Yadi Shi et al.
📅 날짜: 2026년 10월 31일

🆔 PMID: 42964618
📄 PMC: PMC13720901
🔗 DOI: 10.3389/fmed.2026.1949484

#편두통논문g/%ED%8E%B8%EB%91%90%ED%86%B5%EB%85%BC%EB%AC%B8" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#편두통논문 #편두통hashtag/%ED%8E%B8%EB%91%90%ED%86%B5" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#편두통 #펍메드hashtag/%ED%8E%8D%EB%A9%94%EB%93%9C" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#펍메드

.
Ethical healthcare AI
assesses and addresses

- affordable healthy housing,
- healthy bedding,
- nighttime endogenous melatonin amplitude and volume,
- nighttime SDNN
- pineal gland vascular health
- gut-derived SCFAs,
- causes of chronic stress,
- daily sunlight exposure (all wavelengths)

.
Ethical healthcare AI
assesses and addresses

- affordable healthy housing,
- healthy bedding,
- nighttime endogenous melatonin amplitude and volume,
- nighttime SDNN
- pineal gland vascular health
- gut-derived SCFAs,
- causes of chronic stress,
- daily sunlight exposure (all wavelengths)

We believe postbiotic are metabolites that are produced by these good bacteria. Maybe the drink contain some characterized metabolites like SCFAs and all. Could you share the ingredients?

🦠 How does the gut microbiota influence obesity and metabolic health?

Explore the role of dietary interventions, prebiotics, SCFAs, gut barrier function, GLP-1 signaling, inflammation & insulin sensitivity.

Abstract Deadline: Oct 22, 2026!
microbiomecongress.org/abstract-sub...

#GMC2027

📄New article from our division highlights differences in gut microbial diversity across the epidemiologic transition and association with T2D.
👉🏿Read the full article: www.tandfonline.com/doi/full/10....

@dshb-antibodies.bsky.social's resource, RRID:AB_528440, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #methodsmatter #reproducibility #BetterScience

Microbiota-derived SCFAs modulate Socs36E-mediated feedback to regulate intestinal stem cell proliferation upon Atg4 loss in Drosophila
#Drosophila

🔬 Scientists are uncovering fascinating links between diet, the gut microbiome, and the immune system, raising an exciting question: Could changing our diet help the gut microbiome support the body’s response to cancer immunotherapy?

Curious? Read our latest blog post: eusci.org.uk/2026/10/16/y...

Lycopene mitigates T-2 toxin-induced systemic inflammation and oxidative stress in association with gut microbiota and SCFAs regulation in mice

Saber Y. Adam, Wael Ennab ... Hao-Yu Liu & Demin Cai

link.springer.com/article/10.1...

#MycotoxinToxicity #Morphology #AnimalToxicology

Mechanisms of key gut microbial metabolites: SCFAs, BAs, and TDMs
#microbiology #microbiome #microbiota #MicroSky
@cp-trendsmicrobiol.bsky.social
www.sciencedirect.com/science/arti...

Gut microbiome needs time to adapt to fibermaxxing, experts warn

Dr Megan Rossi explains that increasing dietary fibre feeds gut bacteria and promotes short-chain fatty acids (SCFAs) such as acetate, propionate and butyrate, which support gut, metabolic and immune…

UCSF researchers review evidence that altered gut microbes in MS shift SCFAs, tryptophan metabolites and bile acids, affecting immune cells, brain barriers and glia.

Human causality remains unproven.

www.neurology.org/doi/10.1212/...

Gut dysbiosis→leaky gut→endotoxemia→inflammation→insulin resistance. TCM breaks this cascade by restoring SCFAs, tight junctions, and immune balance—while regulating bile acids, circadian rhythms, and TMAO. A holistic strategy for T2DM from the inside out.

doi.org/10.1016/S187...

On the back cover of issue 18 of Food & Function:
Excess iodine induces lipid metabolic disorders by the gut microbiota SCFAs/H2S-p-AMPKα/PPARγ/SREBP-1c pathway in female rats.
Shujian Wu et al.
pubs.rsc.org/fo/article/d...

🤔 Why do stroke patients with similar infarcts recover differently?
📌 A new FBL review introduces a phase-specific immune-metabolic framework:
1️⃣ Neuroinflammation & BBB status.
2️⃣ The Gut-Brain-Metabolic Axis.
🔗 https://www.imrpress.com/journal/FBL/31/8/10.31083/FBL54110
#Stroke #Neuroscience

At a time when inadequate dietary fibre intake is a growing #publichealth concern, this study highlights the physiological importance of SCFAs and their potential role in metabolic health and disease prevention.

#Medsky🧪@natmetabolism.nature.com Evaluate the current evidence linking SCFAs to metabolic health & disease & consider the translational potential of targeting SCFA pathways through dietary & therapeutic approaches.

www.nature.com/articles/s42...

Intact carrot fibers make it all the way to your colon, where they feed keystone microbes like *Faecalibacterium prausnitzii* and *Bifidobacteria*.

These bacteria ferment pectin into Short-Chain Fatty Acids (SCFAs):
Butyrate (powers 70%+ of colonocyte energy)
Acetate (supports metabolic regulation)

Did you know over 90% of your serotonin (5-HT) is produced in your gut mucosa by enterochromaffin cells?

Microbial Short-Chain Fatty Acids (SCFAs) activate the TPH1 enzyme:
Dietary Tryptophan ➔ Serotonin (5-HT) ➔ Melatonin

Your gut holds 400x more melatonin than your pineal gland!

Human Clostridia consortia reverse colitis via dual effects of tryptophan metabolites on microbiota & immunity.

Live biotherapeutic products ease colitis by suppressing pathobionts & activating AhR anti‑inflammatory pathways independently of SCFAs & IL‑10
www.sciencedirect.com/science/arti...

.
Gut microbiota-derived butyrate
is an excellent HDAC inhibitor.

Preventive healthcare AI
needs to monitor and improve
circulating gut microbiota-derived SCFAs.
.

REVIEW | A Dagbasi, G Frost et al. (Imperial College London)

An overview of the biology of SCFAs, highlighting their translational potential for metabolic and inflammatory diseases 🧪