We had a great first session - beautiful ET of ERES from @dr-downes.bsky.social, fantastic insight into Sec24 control of COP-II vesicle size from Xiaohan Li (@lizmillercu.bsky.social lab) fab speakers, all! #UKMT2024

🤰 ¿Cómo evoluciona el riesgo CV de la mujer? ¿Cómo mejorar el control de los FRCV 🫀? María Goya y Vicente Pallarés responden en el🎧 #CardioPODCAST #SEC24, moderado por Mercedes Rivas-Lasarte: omny.fm/shows/cardio...

🚨El viernes 29, Reunión GT Enfermedad CV de la Mujer reuniongrupoecv.es

Finally, that's only the first part of the paper! In the second part, Emma shows that a specific site in the COPII coat subunit Sec24 sequesters SNAREs and prevents them from driving fusion until the coat falls off.
/18

🚨 ¿Qué se destacó en la sesión más esperada del Congreso #SEC24? En nuestro especial #CardioPODCAST te resumimos lo más relevante de la cardiología en el último año presentado en CardioActualidad.

🎧 omny.fm/shows/cardio...

1. determinants of cellular location for many proteins are unknown
2. lipid rafts are implicated in post-Golgi traffic, but not early secretory (ER)
3. cholesterol, critical for lipid rafts, is low in ER
4. adaptors that help cargo exit ER (sec24) have four isoforms, some prefer raft proteins

2/9

Big questions:

1. Cholesterol is synthesized in the ER but then exported… is there enough remaining to make raft domains?
2. sec24, the inner coat component of COP-II machinery in charge of cargo recognition, has 4 isoforms in mammals. Do they have non-overlapping functions? How?

3/9

This line of work includes:

Privy (CHI ’26 Honorable Mention Award):
hankhplee.com/papers/privy...

AI Privacy Taxonomy (CHI ’24 Best Paper Award):
hankhplee.com/papers/chi24...

AI Practitioners’ Privacy Work Interviews (USENIX Security ’24 Distinguished Paper Award):
hankhplee.com/papers/sec24...

なんで今でもアニメは
1sec24コマなんだろ？
デジタルだし、コマ数変えないのかな？

Asgard archaeal genomes encode many eukaryotic signature proteins, previously thought to be restricted to eukaryotes. In modern eukaryotes several of these ESPs are involved in membrane traffic. But Asgard archaea lack canonical vesicle coats. So what were these proteins doing in FECA?

🫀 Environmental factors such as low temperatures and carbon monoxide levels in the air have long been underestimated as risk factors for triggering a #heartattack. The issue and its consequences for policymakers were discussed at the 🇪🇸 @secardiologia.bsky.social congress (#SEC24) in Bilbao.