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cleverlyns.bsky.social
Upgrading SMB Infrastructure: Overcoming Tech Fear, Playing It Safe, and Going DIY blog.cleverly.ca/upgrading-sm...

#SMBIT #TechMigration #ITInfrastructure #BusinessTech #NiagaraBiz #SaintJohnBiz #UptownSJ
How to Upgrade SMB Tech Without Downtime or Data Loss
Avoid costly downtime and data loss during major IT upgrades. Learn how an MSP protects your business, or follow our DIY migration safety checklist.
blog.cleverly.ca
September 29, 2026 at 11:21 AM
addgene.bsky.social
We've just added 250+ more plasmids to the Promega Collection
• Human ORFs with tags like NanoLuc®, HaloTag®, SmBiT, and LgBiT
• NanoBiT® and NanoBRET® plasmids for live-cell assays
• Reporter vectors for gene expression and pathway analysis
https://twp.ai/4iriLO
Accelerate your research, no MTA required. Blugene mascot with a lightbulb, and Addgene and Promega logos.
September 30, 2025 at 2:00 PM
addgene.bsky.social
The Promega Plasmid Collection is here! It includes response element reporters, NanoLuc fusions, and more. Plasmids are available in bacterial format or as purified DNA—a new service offering you can tap into today. Visit our online catalog to order: https://twp.ai/4iowmh
Addgene: Promega Plasmid Collection
Find luciferase reporter vectors for sensitive gene expression analysis and fusion vectors containing tags such as NanoLuc, HaloTag, SmBiT, and LgBiT, useful for detecting and tracking key drug target proteins.
twp.ai
August 7, 2025 at 6:00 PM
addgene.bsky.social
The growing Promega Collection supports applications from protein-protein interactions to targeted protein degradation and bioluminescent assays. Available to both academic & industry researchers, as stabs or purified DNA. No MTA required. https://twp.ai/4is86M
@promegacorporation.bsky.social
Addgene: Promega Plasmid Collection
Find luciferase reporter vectors for sensitive gene expression analysis and fusion vectors containing tags such as NanoLuc, HaloTag, SmBiT, and LgBiT, useful for detecting and tracking key drug target proteins.
twp.ai
October 16, 2025 at 12:00 PM
clintvs.bsky.social
We have our SMBiT meetings at the Bells hotel south Melbourne, short tram ride out of the city it has a good menu and some nice dining alcoves that would seat 10,
February 1, 2026 at 11:49 PM
endocancer.bsky.social
🔬 Discovery of a novel sodium iodide symporter regulatory pathway in breast cancer cells.

Vikki L Poole et al. opens new therapeutic avenues in #BreastCancer by mapping sodium iodide symporter regulation & pinpointing targets to boost radioiodide avidity.

Read #OpenAccess: doi.org/10.1530/ERC-...
New Research: Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer in Endocrine-Related Cancer. By Vikki L Poole et al. Published by Bioscientifica. Society for Endocrinology. Figure 1. Phosphorylated PBF represses RAIU in breast cancer cells. (A) Left – schematic of the interaction between NIS and PBF proteins tagged at the C-terminus with the NanoLuc luciferase subunits LgBiT and SmBiT, respectively. In close proximity, LgBiT and SmBiT form a functional enzyme that uses the substrate furimazine to produce a high-intensity, luminescent signal. Created using Alphafold (59, 60) and BioRender. Right – NanoBiT analysis of NIS:PBF interaction in MCF-7 cells, with bar graph showing results at 20 min post-addition of Nano-Glo live cell assay substrate. (B) Co-immunoprecipitation assay showing PBF-HA and NIS-MYC interaction in MCF-7 breast cancer cells. (C) Schematic of PBF highlighting the overlapping phosphorylation site and endocytosis motif at the C-terminus, and the PBF-Y174A and E170_N172delinsAAA (PBF-EEN MUT) mutants. (D) Western blot showing the phosphorylation status of PBF-Y174A and PBF-EEN MUT compared with PBF-WT in MCF-7 cells. (E) Immunofluorescent images showing PBF-WT, PBF-Y174A and PBF-EEN MUT localisation in MCF-7 cells. (F) Immunofluorescent images showing subcellular localisation following the co-transfection of NIS-MYC (green) with VO, PBF-WT, PBF-Y174A or PBF-EEN MUT (red) in MCF-7 cells. Co-localisation is seen in yellow. (G) The effect of PBF and phosphomutants (Y174A/EEN-MUT) on RAIU in MCF-7 (i) and MDA-MB-231 (ii) cells transiently co-transfected with NIS-MYC. (H) The effect of PBF and phosphomutants (Y174A/EEN-MUT) on RAIU in MCF-7 cells treated with ATRA and dexamethasone. VO = vector only control. Bars = 10 μm. n = 3 for all experiments. Error bars = SEM. Significance shown compared with VO unless otherwise shown...Endocrine-Related Cancer 32, 8; 10.1530/ERC-24-0312
September 16, 2025 at 9:53 AM
clintvs.bsky.social
SMBiT professionals has a monthly meeting for IT professionals on the last Wednesday of the month in South Melbourne www.smbitpro.org/chapters/
Chapters – SMBiT Professionals
www.smbitpro.org
January 11, 2026 at 10:37 AM
clintvs.bsky.social
I had a great night at SMBiT Professionals Melbourne meeting tonight with an informative member presentation about a CVE found in a vendors product and the hoops to jump through to get them to fix it. #MSP #SMBiT #ITpros #Cybersecurity
An old white man talking into a microphone, while reading a PowerPoint slide, about a Cybersecurity vulnerability. That is on a large oversaturated screen
May 28, 2025 at 10:28 AM