I see Forkhead, Sox9, sox4, tbx5, hand 1 & 2, Klf, some zinc fingers and nucleosomes?
February 1, 2025 at 11:10 PM
I see Forkhead, Sox9, sox4, tbx5, hand 1 & 2, Klf, some zinc fingers and nucleosomes?
SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease https://www.biorxiv.org/content/10.64898/2026.09.24.754142v1
September 28, 2026 at 7:30 AM
SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease https://www.biorxiv.org/content/10.64898/2026.09.24.754142v1
SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease https://www.biorxiv.org/content/10.64898/2026.09.24.754142v1
September 28, 2026 at 7:30 AM
SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease https://www.biorxiv.org/content/10.64898/2026.09.24.754142v1
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
#openaccess
#openaccess
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
Chronic kidney disease (CKD) is a widely prevalent health issue globally. A striking pathological feature of CKD is kidney fibrosis characterized by excessive production and deposition of…
buff.ly
October 2, 2025 at 8:01 PM
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
#openaccess
#openaccess
Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...
A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma - Nature Communications
Epigenetic causes of intra-tumoural heterogeneity are crucial in paediatric cancers with low mutation rates, such as hepatoblastoma. Here, the authors characterise transcriptional heterogeneity in hep...
www.nature.com
November 20, 2024 at 2:29 PM
Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...
Sox4 in Treg Cells Suppresses IL-10 Production via c-Maf Degradation and Exacerbates Type 2 Inflammation https://www.biorxiv.org/content/10.1101/2025.11.04.686669v1
November 6, 2025 at 8:16 PM
Sox4 in Treg Cells Suppresses IL-10 Production via c-Maf Degradation and Exacerbates Type 2 Inflammation https://www.biorxiv.org/content/10.1101/2025.11.04.686669v1
Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature
A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
www.nature.com
January 15, 2025 at 6:06 PM
Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature research paper: Specification of claustro-amygdalar and palaeocortical neurons and circuits
https://go.nature.com/4fYd8j1
https://go.nature.com/4fYd8j1
Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature
A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
go.nature.com
January 15, 2025 at 6:08 PM
Nature research paper: Specification of claustro-amygdalar and palaeocortical neurons and circuits
https://go.nature.com/4fYd8j1
https://go.nature.com/4fYd8j1
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
doi.org/10.1016/j.kint.2025.08.030
#OpenAccess #NephSky #MedSky #CKD #kidneyfibrosis
@yalepathology.bsky.social
doi.org/10.1016/j.kint.2025.08.030
#OpenAccess #NephSky #MedSky #CKD #kidneyfibrosis
@yalepathology.bsky.social
October 3, 2025 at 9:36 PM
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
doi.org/10.1016/j.kint.2025.08.030
#OpenAccess #NephSky #MedSky #CKD #kidneyfibrosis
@yalepathology.bsky.social
doi.org/10.1016/j.kint.2025.08.030
#OpenAccess #NephSky #MedSky #CKD #kidneyfibrosis
@yalepathology.bsky.social
Validating MATCHA predictions in vitro and in vivo, we showed that SOX4 was sufficient to drive cell-vs-tissue gene expression changes, increase cells’ proliferative capacity in metabolically stressful environments, and even predict human cancer risk years in the future (8/n)
December 22, 2025 at 4:35 PM
Validating MATCHA predictions in vitro and in vivo, we showed that SOX4 was sufficient to drive cell-vs-tissue gene expression changes, increase cells’ proliferative capacity in metabolically stressful environments, and even predict human cancer risk years in the future (8/n)
RRID:AB_2880093 from @proteintech.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #methodsmatter #accelerateopenscience #STMpublishing
Evaluation of the correlativity of SOX4 and epithelial-mesenchymal transition markers expression in the prognosis of oral squamous cell carcinoma
doi.org
November 30, 2025 at 8:00 AM
RRID:AB_2880093 from @proteintech.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #methodsmatter #accelerateopenscience #STMpublishing
Targeted silencing of Sox4 using AAV vectors significantly improves liver function in mouse models of Alagille syndrome.
by Fox D, Xie J (...) Jafar-Nejad H et 12 al. in Gastroenterology #MedSky
👉 get more here
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0016508525008248
by Fox D, Xie J (...) Jafar-Nejad H et 12 al. in Gastroenterology #MedSky
👉 get more here
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0016508525008248
June 6, 2025 at 10:38 AM
Targeted silencing of Sox4 using AAV vectors significantly improves liver function in mouse models of Alagille syndrome.
by Fox D, Xie J (...) Jafar-Nejad H et 12 al. in Gastroenterology #MedSky
👉 get more here
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0016508525008248
by Fox D, Xie J (...) Jafar-Nejad H et 12 al. in Gastroenterology #MedSky
👉 get more here
📖 read the article: https://linkinghub.elsevier.com/retrieve/pii/S0016508525008248
AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancer https://www.biorxiv.org/content/10.64898/2026.04.27.721035v1
April 27, 2026 at 9:48 PM
AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancer https://www.biorxiv.org/content/10.64898/2026.04.27.721035v1
RRIDs were included in this in Advanced Science paper. We value the author's support of reproducibility. #BetterScience #ReproducibleResearch #methodsmatter
Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression
Read the full paper: Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression
doi.org
April 12, 2026 at 7:00 AM
RRIDs were included in this in Advanced Science paper. We value the author's support of reproducibility. #BetterScience #ReproducibleResearch #methodsmatter
Specification of claustro-amygdalar and palaeocortical neurons and circuits rdcu.be/d6qUO - nice! (in mice... mostly)
Specification of claustro-amygdalar and palaeocortical neurons and circuits
Nature - A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
rdcu.be
January 16, 2025 at 11:31 AM
Specification of claustro-amygdalar and palaeocortical neurons and circuits rdcu.be/d6qUO - nice! (in mice... mostly)
The authors included RRIDs in their in Molecular Cancer Research paper! We value the author's support of reproducibility. #OpenScience #BetterScience #ReproducibleResearch
SOX4-Mediated Post-Transcriptional suppression of PTEN via miR-106b~25 Cluster Contributes to Prostate Cancer Aggressiveness
Read the full paper: SOX4-Mediated Post-Transcriptional suppression of PTEN via miR-106b~25 Cluster Contributes to Prostate Cancer Aggressiveness
doi.org
April 24, 2026 at 7:03 AM
The authors included RRIDs in their in Molecular Cancer Research paper! We value the author's support of reproducibility. #OpenScience #BetterScience #ReproducibleResearch
@proteintech.bsky.social's resource, RRID:AB_2107436, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenScience #OpenResearch #methodsmatter
Empagliflozin Restores the Colonic Mucous Barrier by an AMPK/SOX4-Dependent Pathway in Glycogen Storage Disease Type Ib
Read the full paper: Empagliflozin Restores the Colonic Mucous Barrier by an AMPK/SOX4-Dependent Pathway in Glycogen Storage Disease Type Ib
doi.org
May 28, 2026 at 7:08 AM
@proteintech.bsky.social's resource, RRID:AB_2107436, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenScience #OpenResearch #methodsmatter
Anti-mesothelin CAR T are safe but with limited phase I efficacy in pancreatic cancer, related to a dysfunctional signature including ID3 and SOX4 upregulation
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
August 18, 2025 at 10:06 PM
Anti-mesothelin CAR T are safe but with limited phase I efficacy in pancreatic cancer, related to a dysfunctional signature including ID3 and SOX4 upregulation
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
@cp-cellrepmed.bsky.social
This review describes the role of the transcription factor SOX4 in #LiverDisease & #HCC progression, highlighting it as a promising #TherapeuticTarget to modulate #Fibrogenesis and overcome #DrugResistance.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
February 23, 2026 at 3:32 PM
This review describes the role of the transcription factor SOX4 in #LiverDisease & #HCC progression, highlighting it as a promising #TherapeuticTarget to modulate #Fibrogenesis and overcome #DrugResistance.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
A comprehensive atlas of testicular interstitium reveals Cd34+/Sox4+ mesenchymal cells as potential Leydig cell progenitors https://www.biorxiv.org/content/10.1101/2024.08.02.606288v1
A comprehensive atlas of testicular interstitium reveals Cd34+/Sox4+ mesenchymal cells as potential Leydig cell progenitors https://www.biorxiv.org/content/10.1101/2024.08.02.606288v1
The declining rates of male fertility pose a significant clinical challenge, primarily due to our li
www.biorxiv.org
August 6, 2024 at 10:30 AM
A comprehensive atlas of testicular interstitium reveals Cd34+/Sox4+ mesenchymal cells as potential Leydig cell progenitors https://www.biorxiv.org/content/10.1101/2024.08.02.606288v1
Scientists show #lncRNA AC004854.2 drives #ColorectalCancer by disrupting the PUF60–FUBP1 complex to boost #cMYC transcription; forming a SOX4/AC004854.2/PUF60/c-MYC axis that promotes #tumor growth, attenuated by c-MYC inhibition.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
March 12, 2026 at 6:00 PM
Scientists show #lncRNA AC004854.2 drives #ColorectalCancer by disrupting the PUF60–FUBP1 complex to boost #cMYC transcription; forming a SOX4/AC004854.2/PUF60/c-MYC axis that promotes #tumor growth, attenuated by c-MYC inhibition.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
RRIDs were included in this in Cell Death & Disease paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #RRID
The long noncoding RNA AC093895.1 promotes ovarian cancer formation and metastasis through a positive feedback network dependent on the transcription factor SOX4 - Cell Death & Disease
Read the full paper: The long noncoding RNA AC093895.1 promotes ovarian cancer formation and metastasis through a positive feedback network dependent on the transcription factor SOX4
doi.org
February 15, 2026 at 8:00 AM
RRIDs were included in this in Cell Death & Disease paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #RRID
Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity
Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity
Bracey et al. show that impaired antibody responses with age are primarily driven by defective T follicular helper cell maturation rather than intrinsic B cell dysfunction. They identify loss of human-specific CXCL13+ T follicular helper cells and reduced BACH2 and SOX4 as hallmarks of aging-associated humoral immune dysfunction.
dlvr.it
June 24, 2026 at 7:50 PM
Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity