ICYMI: *30* year outcomes from SPCG-4
dx.doi.org/10.1056/NEJM...
RP vs. WW for clinically detected #prostatecancer reduces CSM 48% and *ACM* by 26%. NNT down to 6. Clear benefit to treatment of clinically detectable disease if (and only if) your pt has a very long life expectancy. #pcsm
dx.doi.org/10.1056/NEJM...
RP vs. WW for clinically detected #prostatecancer reduces CSM 48% and *ACM* by 26%. NNT down to 6. Clear benefit to treatment of clinically detectable disease if (and only if) your pt has a very long life expectancy. #pcsm
November 23, 2024 at 3:04 AM
ICYMI: *30* year outcomes from SPCG-4
dx.doi.org/10.1056/NEJM...
RP vs. WW for clinically detected #prostatecancer reduces CSM 48% and *ACM* by 26%. NNT down to 6. Clear benefit to treatment of clinically detectable disease if (and only if) your pt has a very long life expectancy. #pcsm
dx.doi.org/10.1056/NEJM...
RP vs. WW for clinically detected #prostatecancer reduces CSM 48% and *ACM* by 26%. NNT down to 6. Clear benefit to treatment of clinically detectable disease if (and only if) your pt has a very long life expectancy. #pcsm
Reported this post to the SPCG
August 17, 2025 at 11:45 PM
Reported this post to the SPCG
New SPCG preprint in collaboration with the Amir lab
We solve an accumulator model of cell division with noisy threshold and memory, finding a continuum of strategies from timer to adder to sizer and that extrinsic noise is essential to explain E. coli size fluctuations.
arxiv.org/abs/2605.070...
We solve an accumulator model of cell division with noisy threshold and memory, finding a continuum of strategies from timer to adder to sizer and that extrinsic noise is essential to explain E. coli size fluctuations.
arxiv.org/abs/2605.070...
May 11, 2026 at 7:51 AM
New SPCG preprint in collaboration with the Amir lab
We solve an accumulator model of cell division with noisy threshold and memory, finding a continuum of strategies from timer to adder to sizer and that extrinsic noise is essential to explain E. coli size fluctuations.
arxiv.org/abs/2605.070...
We solve an accumulator model of cell division with noisy threshold and memory, finding a continuum of strategies from timer to adder to sizer and that extrinsic noise is essential to explain E. coli size fluctuations.
arxiv.org/abs/2605.070...
New SPCG review paper on "component systems" from genomes and ecosystems to language, cities, and software. How do we separate universal combinatorial patterns from system-specific signatures?
journals.plos.org/complexsyste...
journals.plos.org/complexsyste...
June 30, 2026 at 10:00 PM
New SPCG review paper on "component systems" from genomes and ecosystems to language, cities, and software. How do we separate universal combinatorial patterns from system-specific signatures?
journals.plos.org/complexsyste...
journals.plos.org/complexsyste...
Just out on bioRxiv - spcg collab with Piel lab: growing mammalian cells use two independent systems — one controlling volume, one driving protein synthesis — to control macromolecular density.
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
April 25, 2025 at 3:10 PM
Just out on bioRxiv - spcg collab with Piel lab: growing mammalian cells use two independent systems — one controlling volume, one driving protein synthesis — to control macromolecular density.
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
Together, they restore dry mass density homeostasis.
www.biorxiv.org/content/10.1...
Maybe a good time to mention there are SpaceX short ETFs. If I had cash to spare, I’d throw some into SNK, SPCG, etc.
Not financial advice, yadda yadda
Not financial advice, yadda yadda
oh man passing through the 180 day lockup gate is gonna be a fucking bloodbath lol
July 23, 2026 at 2:38 PM
Maybe a good time to mention there are SpaceX short ETFs. If I had cash to spare, I’d throw some into SNK, SPCG, etc.
Not financial advice, yadda yadda
Not financial advice, yadda yadda
La présence du cliché dans un fonds du SPCG (service photographique et cinématographique de guerre), enregistré en septembre 1918, confirme en tout cas un cliché pris pendant le conflit plutôt qu'après-guerre comme cela a pu être suggéré.
August 18, 2024 at 9:10 AM
La présence du cliché dans un fonds du SPCG (service photographique et cinématographique de guerre), enregistré en septembre 1918, confirme en tout cas un cliché pris pendant le conflit plutôt qu'après-guerre comme cela a pu être suggéré.
C'est finalement dans les salons attenants à la galerie des glaces que les clauses les plus intéressantes du traité de Versailles ont été discutées (noms régionaux du chocotube, interdiction du kalimotxo en Allemagne, etc.)
![Les officiers, debout sur des tabourets et guéridons, observent les négociations.
Versailles, Trianon palace. Remise aux Allemands du traité de paix. [légende d'origine]
Date de fin : 1919-05-07
Lieu(x) :
Auteur(s) : Inconnu
Origine : SPCG (service photographique et cinématographique de guerre)
Référence : SPA 230 Z 7867
Accéder à la notice](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:h4tiqxlaess3yxdmrwhqqdwh/bafkreicjxfmuvw5oh7445nhad755rpfi2s4ru5ednrisyj3c45yg62kmuu)
January 13, 2026 at 8:32 AM
C'est finalement dans les salons attenants à la galerie des glaces que les clauses les plus intéressantes du traité de Versailles ont été discutées (noms régionaux du chocotube, interdiction du kalimotxo en Allemagne, etc.)
New spcg preprint with Bokinsky lab (Milan Lacassin), by Andrea Ripamonti. We model the competition for transcriptional resources, and explain new data on E. coli’s second messengers ppGpp & cAMP reshaping gene expression globally.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 21, 2025 at 8:48 AM
New spcg preprint with Bokinsky lab (Milan Lacassin), by Andrea Ripamonti. We model the competition for transcriptional resources, and explain new data on E. coli’s second messengers ppGpp & cAMP reshaping gene expression globally.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New SPCG paper. With the Bokinsky lab (Milan Lacassin), Andrea Ripamonti modeled the competition for transcriptional resources. Our data and model jointly show how E. coli’s second messengers ppGpp & cAMP reshape gene expression globally.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Transcriptional competition biases the effects of second messengers in Escherichia coli
Cells regulate gene expression by balancing transcriptional resources across different functional groups of genes. In Escherichia coli, second messeng…
www.sciencedirect.com
May 14, 2026 at 10:56 AM
New SPCG paper. With the Bokinsky lab (Milan Lacassin), Andrea Ripamonti modeled the competition for transcriptional resources. Our data and model jointly show how E. coli’s second messengers ppGpp & cAMP reshape gene expression globally.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
they should put a spcg in a gacha
July 5, 2025 at 9:25 PM
they should put a spcg in a gacha
Spcg preprint with Bertotti lab and @litinice.bsky.social. It took >5y but proud to say it works—and we know why and how. μSeq infers mutation rates from deep sequencing of single clonal expansions, >10x faster than MALs. Validated in cancer organoids and in yeast.
tinyurl.com/4jmk3tkh
tinyurl.com/4jmk3tkh
April 23, 2025 at 9:19 AM
Spcg preprint with Bertotti lab and @litinice.bsky.social. It took >5y but proud to say it works—and we know why and how. μSeq infers mutation rates from deep sequencing of single clonal expansions, >10x faster than MALs. Validated in cancer organoids and in yeast.
tinyurl.com/4jmk3tkh
tinyurl.com/4jmk3tkh
New spcg&collabs paper, by Rossana Droghetti: Model for E. coli dynamical balance of amino acid pools, ppGpp signaling, and ribosome allocation to regulate growth, explaining observed damped oscillatory feedback in response to nutrient shifts 🧫 #GrowthLaws
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli - Nature Communications
Current theories of bacterial growth physiology often lack mechanistic detail. Here, Droghetti et al. present a theoretical framework that includes sensing and regulation of protein synthesis at the m...
www.nature.com
April 21, 2025 at 8:33 AM
New spcg&collabs paper, by Rossana Droghetti: Model for E. coli dynamical balance of amino acid pools, ppGpp signaling, and ribosome allocation to regulate growth, explaining observed damped oscillatory feedback in response to nutrient shifts 🧫 #GrowthLaws
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Late one last night from JP @atpgeo.bsky.social
Chagos, Iran, Board of Peace, Andrews, & NATO - Crazy Times 🔴 LIVE STREAM: Geopolitics News
www.youtube.com/watch?v=spcg...
Chagos, Iran, Board of Peace, Andrews, & NATO - Crazy Times 🔴 LIVE STREAM: Geopolitics News
www.youtube.com/watch?v=spcg...
Chagos, Iran, Board of Peace, Andrews, & NATO - Crazy Times 🔴 LIVE STREAM: Geopolitics News
YouTube video by ATP Geopolitics
www.youtube.com
February 20, 2026 at 11:47 AM
Late one last night from JP @atpgeo.bsky.social
Chagos, Iran, Board of Peace, Andrews, & NATO - Crazy Times 🔴 LIVE STREAM: Geopolitics News
www.youtube.com/watch?v=spcg...
Chagos, Iran, Board of Peace, Andrews, & NATO - Crazy Times 🔴 LIVE STREAM: Geopolitics News
www.youtube.com/watch?v=spcg...
Alaskans own 176,100 shares of Spcg Pcl worth $41,711. It's in the 🔌 Utilities industry, based in 🇹🇭 Thailand.
October 10, 2025 at 10:29 AM
Alaskans own 176,100 shares of Spcg Pcl worth $41,711. It's in the 🔌 Utilities industry, based in 🇹🇭 Thailand.
At SPCG, your consent matters. We’ve reset our newsletter list, so only those who actively opt in will receive updates. If you’d like to stay in the loop, sign up here: www.survivorperspectives.com/newslettersi...
We look forward to connecting with you!
#SPCG #Survivor #CAF #SA #Consent #FLW
We look forward to connecting with you!
#SPCG #Survivor #CAF #SA #Consent #FLW
September 9, 2025 at 2:37 PM
We’re watching the verdict with heavy hearts and unwavering solidarity.
To E.M. and all survivors: we see you. We believe you.
No verdict can undo harm. We will always call out gender-based violence and push for justice.
#BelieveSurvivors #SPCG #HockeyCanada #Trial
To E.M. and all survivors: we see you. We believe you.
No verdict can undo harm. We will always call out gender-based violence and push for justice.
#BelieveSurvivors #SPCG #HockeyCanada #Trial
July 24, 2025 at 1:20 PM
We’re watching the verdict with heavy hearts and unwavering solidarity.
To E.M. and all survivors: we see you. We believe you.
No verdict can undo harm. We will always call out gender-based violence and push for justice.
#BelieveSurvivors #SPCG #HockeyCanada #Trial
To E.M. and all survivors: we see you. We believe you.
No verdict can undo harm. We will always call out gender-based violence and push for justice.
#BelieveSurvivors #SPCG #HockeyCanada #Trial
i think it's just such a potent mind poison that the thought of it can compel people into suicide. it's a cognitihazard. like spcg
April 16, 2025 at 9:23 PM
i think it's just such a potent mind poison that the thought of it can compel people into suicide. it's a cognitihazard. like spcg
New "From Where I Stand" blog post from our CEO, Donna Van Leusden.
EM’s courage mattered.
The verdict doesn’t change what she lived through — or how many of us believe her.
#BelieveSurvivors #Defiance #HockeyCanada #SPCG
EM’s courage mattered.
The verdict doesn’t change what she lived through — or how many of us believe her.
#BelieveSurvivors #Defiance #HockeyCanada #SPCG
Hockey Canada Sexual Assault Trial
Sexual assault is still nearly impossible to prosecute — victim-blaming, trauma ignorance, and good old-fashioned misogyny are alive and well. Not guilty is not the same as innocent. EM, I am sorry th...
www.survivorperspectives.com
July 24, 2025 at 7:44 PM
New "From Where I Stand" blog post from our CEO, Donna Van Leusden.
EM’s courage mattered.
The verdict doesn’t change what she lived through — or how many of us believe her.
#BelieveSurvivors #Defiance #HockeyCanada #SPCG
EM’s courage mattered.
The verdict doesn’t change what she lived through — or how many of us believe her.
#BelieveSurvivors #Defiance #HockeyCanada #SPCG
TW: Aberglaube
Ich habe mittlerweile die reale Verschwörungstheorie/Urban Legend zum Schenkelklopfer gefunden - es ist der Solarplexus Clown Glider. Und nein, den hab ich mir weder ausgedacht, noch war ich von ihm beeinflusst.
obscurban-legend.fandom.com/wiki/Solar_P...
Ich habe mittlerweile die reale Verschwörungstheorie/Urban Legend zum Schenkelklopfer gefunden - es ist der Solarplexus Clown Glider. Und nein, den hab ich mir weder ausgedacht, noch war ich von ihm beeinflusst.
obscurban-legend.fandom.com/wiki/Solar_P...
Solar Plexus Clown Gliders
Solar Plexus Clown Glider (SPCG) is the collective name given to a broad range of paranormal phenomena attributed to a corruptive entity which infects weak and vulnerable people through the Solar Plex...
obscurban-legend.fandom.com
October 3, 2023 at 6:32 PM
TW: Aberglaube
Ich habe mittlerweile die reale Verschwörungstheorie/Urban Legend zum Schenkelklopfer gefunden - es ist der Solarplexus Clown Glider. Und nein, den hab ich mir weder ausgedacht, noch war ich von ihm beeinflusst.
obscurban-legend.fandom.com/wiki/Solar_P...
Ich habe mittlerweile die reale Verschwörungstheorie/Urban Legend zum Schenkelklopfer gefunden - es ist der Solarplexus Clown Glider. Und nein, den hab ich mir weder ausgedacht, noch war ich von ihm beeinflusst.
obscurban-legend.fandom.com/wiki/Solar_P...
30y update! of the SPCG-4 trial comparing radical prostatectomy to surveillance in treating prostate cancer (pre PSA era). RR 0.52 and mean 2.2y gained with surgery. NNT 6 to avert a PCa death, NNT 17 to avert any death.
Glorious finish to marvelous SPCG-4 trial👍
www.nejm.org/doi/full/10....
Glorious finish to marvelous SPCG-4 trial👍
www.nejm.org/doi/full/10....
Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer | NEJM
In this randomized trial, conducted between 1989 and 2022 to compare radical prostatectomy
with watchful waiting, radical prostatectomy led to a 48% lower risk of death from
prostate cancer and to ...
www.nejm.org
December 13, 2024 at 8:28 AM
30y update! of the SPCG-4 trial comparing radical prostatectomy to surveillance in treating prostate cancer (pre PSA era). RR 0.52 and mean 2.2y gained with surgery. NNT 6 to avert a PCa death, NNT 17 to avert any death.
Glorious finish to marvelous SPCG-4 trial👍
www.nejm.org/doi/full/10....
Glorious finish to marvelous SPCG-4 trial👍
www.nejm.org/doi/full/10....