February 1, 2025 at 4:28 PM
I am once again crying on the floor. we must kill archives with hammers. also the image sunday in his suit and welt's tie makes my head spib
October 30, 2025 at 10:04 AM
I am once again crying on the floor. we must kill archives with hammers. also the image sunday in his suit and welt's tie makes my head spib
2/2 Exploring the sea of immune cell diversity, our work successfully maps future lanes for dendritic cell reprogramming and cancer immunotherapy!
Illustration by @azuravesta.bsky.social (azuravesta.com)
Read the full paper here: pereiralab.com/publication/...
Illustration by @azuravesta.bsky.social (azuravesta.com)
Read the full paper here: pereiralab.com/publication/...
Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity - Pereira Lab
Highlights Anchored screening identifies ETS-IRF pairs and a third factor specifying DC subsets PU.1, IRF4, and PRDM1 induce a pro-inflammatory cDC2B-like identity SPIB, IRF8, and IKZF2 drive an i...
pereiralab.com
October 14, 2025 at 3:45 PM
2/2 Exploring the sea of immune cell diversity, our work successfully maps future lanes for dendritic cell reprogramming and cancer immunotherapy!
Illustration by @azuravesta.bsky.social (azuravesta.com)
Read the full paper here: pereiralab.com/publication/...
Illustration by @azuravesta.bsky.social (azuravesta.com)
Read the full paper here: pereiralab.com/publication/...
5/17 🔀 Both combinations rely on an ETS + IRF pair (PU.1/IRF4 or SPIB/IRF8) to prime DC identity. The third factor (PRDM1 or IKZF2) directs the subtype-specific program in induced dendritic cells (iDCs).
August 29, 2025 at 4:15 PM
5/17 🔀 Both combinations rely on an ETS + IRF pair (PU.1/IRF4 or SPIB/IRF8) to prime DC identity. The third factor (PRDM1 or IKZF2) directs the subtype-specific program in induced dendritic cells (iDCs).
4/17 Screening in mouse embryonic fibroblasts revealed 2 key combos: PIP (PU.1, IRF4, PRDM1) activated Clec9a reporter & CD11b expression showing cDC2-like cell programming; SII (SPIB, IRF8, IKZF2) activated the Clec9a & hCD2 lymphoid reporters & BST2 expression- pDC-like cell
August 29, 2025 at 4:14 PM
4/17 Screening in mouse embryonic fibroblasts revealed 2 key combos: PIP (PU.1, IRF4, PRDM1) activated Clec9a reporter & CD11b expression showing cDC2-like cell programming; SII (SPIB, IRF8, IKZF2) activated the Clec9a & hCD2 lymphoid reporters & BST2 expression- pDC-like cell
5/17 🔀 Both combinations rely on an ETS + IRF pair (PU.1/IRF4 or SPIB/IRF8) to prime DC identity. The third factor (PRDM1 or IKZF2) directs the subtype-specific program in induced dendritic cells (iDCs).
August 29, 2025 at 3:23 PM
5/17 🔀 Both combinations rely on an ETS + IRF pair (PU.1/IRF4 or SPIB/IRF8) to prime DC identity. The third factor (PRDM1 or IKZF2) directs the subtype-specific program in induced dendritic cells (iDCs).
4/17 Screening in mouse embryonic fibroblasts revealed 2 key combos: PIP (PU.1, IRF4, & PRDM1) activated Clec9a reporter & CD11b expression showing cDC2-like cell programming; SII (SPIB, IRF8, & IKZF2) activated Clec9a & hCD2 lymphoid reporters & BST2 expression- pDC-like cell
August 29, 2025 at 3:22 PM
4/17 Screening in mouse embryonic fibroblasts revealed 2 key combos: PIP (PU.1, IRF4, & PRDM1) activated Clec9a reporter & CD11b expression showing cDC2-like cell programming; SII (SPIB, IRF8, & IKZF2) activated Clec9a & hCD2 lymphoid reporters & BST2 expression- pDC-like cell
Helpful and thorough review of Kagi 📺
It covers domain ranking, lenses, quick access from results to the @archive.org's Wayback Machine, keyboard shortcuts, bang shortcuts, sorting search results, and an overview of the iOS app:
www.youtube.com/watch?v=spiB...
It covers domain ranking, lenses, quick access from results to the @archive.org's Wayback Machine, keyboard shortcuts, bang shortcuts, sorting search results, and an overview of the iOS app:
www.youtube.com/watch?v=spiB...
Kagi is the best Google alternative I've ever used
YouTube video by A Better Computer
www.youtube.com
September 15, 2024 at 12:30 PM
Helpful and thorough review of Kagi 📺
It covers domain ranking, lenses, quick access from results to the @archive.org's Wayback Machine, keyboard shortcuts, bang shortcuts, sorting search results, and an overview of the iOS app:
www.youtube.com/watch?v=spiB...
It covers domain ranking, lenses, quick access from results to the @archive.org's Wayback Machine, keyboard shortcuts, bang shortcuts, sorting search results, and an overview of the iOS app:
www.youtube.com/watch?v=spiB...
I AM LIVE TO BRING SPIB HOME www.twitch.tv/kirasatina
KiraSatina - Twitch
[18+ Monster Vtuber] YAPPING TO BRING SPIB HOME
www.twitch.tv
November 4, 2025 at 11:15 PM
I AM LIVE TO BRING SPIB HOME www.twitch.tv/kirasatina
I seriously want to stop doing donothons and asking for money, I fucking seriously do.. but Spib still owes 1.1k to his landlords and I don’t know what to do. So I am asking for help.. if you would like to donate please just dm me for the PayPal or do it at my donations page. I’m so sorry yall.
November 4, 2025 at 7:13 PM
I seriously want to stop doing donothons and asking for money, I fucking seriously do.. but Spib still owes 1.1k to his landlords and I don’t know what to do. So I am asking for help.. if you would like to donate please just dm me for the PayPal or do it at my donations page. I’m so sorry yall.
A study identifies two distinct Waldenström macroglobulinemia subtypes with unique differentiation capacities and potential treatment implications.
by Gagler DC, Ghamlouch H (...) Morgan GJ et 22 al. in Blood #MedSky
👉 get more here
📖 read the article:
by Gagler DC, Ghamlouch H (...) Morgan GJ et 22 al. in Blood #MedSky
👉 get more here
📖 read the article:
A multiomic analysis of Waldenström macroglobulinemia defines distinct disease subtypes
Key Points. Single-cell multiome analysis identifies two subtypes of WM with variable differentiation capacity and SPI1, SPIB, and XBP1 activity.The MBC-li
ashpublications.org
May 16, 2025 at 10:36 AM
Butterball spib-off sequel: when?
Butterball is such a good character. Like, I fully believe he does his own thing and only hangs out with Pinhead sometimes. Other times he's having fun, doing his torture stuff that he likes, that is different than Pinhead's stuff.
April 15, 2024 at 10:23 PM
Butterball spib-off sequel: when?
Happy 100 to Miles Davis! 30 tracks i particularly love
#25
Black Comedy / Miles in the Sky (w. Wayne Shorter, Herbie Hancock, Ron Carter, Tony Williams)
www.youtube.com/watch?v=SPIb....
#25
Black Comedy / Miles in the Sky (w. Wayne Shorter, Herbie Hancock, Ron Carter, Tony Williams)
www.youtube.com/watch?v=SPIb....
June 21, 2026 at 8:04 AM
Happy 100 to Miles Davis! 30 tracks i particularly love
#25
Black Comedy / Miles in the Sky (w. Wayne Shorter, Herbie Hancock, Ron Carter, Tony Williams)
www.youtube.com/watch?v=SPIb....
#25
Black Comedy / Miles in the Sky (w. Wayne Shorter, Herbie Hancock, Ron Carter, Tony Williams)
www.youtube.com/watch?v=SPIb....
Post May 2020, the failure shifted to govt ignoring SAGE advice and refusing to learn from emerging research and experience from other countries, and refusing to learn the lesson of acting early and importance of clear communication, trust & support (SpiB emphasised often!) 3/4
November 1, 2023 at 11:44 PM
Post May 2020, the failure shifted to govt ignoring SAGE advice and refusing to learn from emerging research and experience from other countries, and refusing to learn the lesson of acting early and importance of clear communication, trust & support (SpiB emphasised often!) 3/4
Interesting dark pool activity for $SPIB. Recent institutional filings indicate the average purchase price for institutions was $33.42, which means the current price represents a 0% discount to their entry. Currently, 25 institutions hold positions.
May 8, 2026 at 12:06 PM
Interesting dark pool activity for $SPIB. Recent institutional filings indicate the average purchase price for institutions was $33.42, which means the current price represents a 0% discount to their entry. Currently, 25 institutions hold positions.
🚨 Dark Pool Alert: $SPIB
• Quantity: 12.04M shares
• Price: $33.39
• Total: $402.11M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 12.04M shares
• Price: $33.39
• Total: $402.11M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
June 2, 2026 at 4:45 PM
🚨 Dark Pool Alert: $SPIB
• Quantity: 12.04M shares
• Price: $33.39
• Total: $402.11M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 12.04M shares
• Price: $33.39
• Total: $402.11M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
🚨 Dark Pool Alert: $SPIB
• Quantity: 3.05M shares
• Price: $33.42
• Total: $101.85M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 3.05M shares
• Price: $33.42
• Total: $101.85M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
March 13, 2026 at 5:39 PM
🚨 Dark Pool Alert: $SPIB
• Quantity: 3.05M shares
• Price: $33.42
• Total: $101.85M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 3.05M shares
• Price: $33.42
• Total: $101.85M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
🚨 Dark Pool Alert: $SPIB
• Quantity: 3.37M shares
• Price: $33.82
• Total: $113.97M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 3.37M shares
• Price: $33.82
• Total: $113.97M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
December 15, 2025 at 10:01 PM
🚨 Dark Pool Alert: $SPIB
• Quantity: 3.37M shares
• Price: $33.82
• Total: $113.97M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 3.37M shares
• Price: $33.82
• Total: $113.97M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
🚨 Dark Pool Alert: $SPIB
• Quantity: 3.01M shares
• Price: $33.82
• Total: $101.72M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 3.01M shares
• Price: $33.82
• Total: $101.72M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
December 15, 2025 at 6:19 PM
🚨 Dark Pool Alert: $SPIB
• Quantity: 3.01M shares
• Price: $33.82
• Total: $101.72M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 3.01M shares
• Price: $33.82
• Total: $101.72M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
🚨 Dark Pool Alert: $SPIB
• Quantity: 8.68M shares
• Price: $33.87
• Total: $293.96M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 8.68M shares
• Price: $33.87
• Total: $293.96M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
December 3, 2025 at 5:38 PM
🚨 Dark Pool Alert: $SPIB
• Quantity: 8.68M shares
• Price: $33.87
• Total: $293.96M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 8.68M shares
• Price: $33.87
• Total: $293.96M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
🚨 Dark Pool Alert: $SPIB
• Quantity: 4.4M shares
• Price: $34.0
• Total: $149.6M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 4.4M shares
• Price: $34.0
• Total: $149.6M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
November 26, 2025 at 4:54 PM
🚨 Dark Pool Alert: $SPIB
• Quantity: 4.4M shares
• Price: $34.0
• Total: $149.6M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
• Quantity: 4.4M shares
• Price: $34.0
• Total: $149.6M
Large institutional order detected away from public markets.
Track more: stocknear.com/dark-pool-flow
Bientôt la rencontre Spib/ Homer Simpson ? 😅
February 27, 2024 at 12:39 PM
Bientôt la rencontre Spib/ Homer Simpson ? 😅