To translate this concept into reality, a chemical tool that combines circulatory stability with rapid, proximity-triggered cleavage is essential. Although sulfur(VI) fluoride exchange (SuFEx) chemistry offers a promising balance of stability and reactivity27,28, we initially sought to integrate a self-immolative phenol-based scaffold—a structure widely used to mediate efficient drug release29—by developing a sulfur–phenol exchange (SuPEx) system. However, unlike SuFEx, SuPEx—even with p-nitrophenol as the leaving group—showed negligible tyrosine reactivity in tubes (Extended Data Fig. 1a). Inspired by the review in ref. 30, we substituted sulfur (S) with phosphorus (P) as the central electrophilic atom and developed the phosphorus(V)–phenol exchange (PhoPEx) reaction (Fig. 1c), and this replacement enhanced the tyrosine reaction rate in vitro. Therefore, we engineered the first-generation PhoPEx linker, using p-hydroxybenzyl alcohol as the leaving group and conjugated it to a FAP-targeting ligand (FAPI) to evaluate its BTR ability. This design was based on molecular docking predictions indicating the proximity of reactive nucleophilic residues to the FAPI binding pocket within FAP (Fig. 1d). In vitro, PhoPEx-based BTR conjugates bearing caged fluorescent reporters (coumarin or MeRho) demonstrated FAP-dependent payload release after 24 h of co-incubation, a response absent in SuPEx-based conjugates and phosphate-buffered saline (PBS) controls (Fig. 1e,f). This specificity...

국민의힘이 내년 4·10총선을 앞두고 인재영입의 첫 신호탄을 쏜다. 국민의힘은 20일 오전 국회에서 ‘국민을 위한 도전정신’ 입당 환영식을 갖는다. 이날 환영식에는 춘천 출신 박영춘 전 SK그룹 수펙스(SUPEX) 추구협의회 부사장과 시대전환 대표인 조정훈 국회의원, 더불어민주당 출신 조광한 전 경기 남양주시장, 문재인 정부 당시 국세청장과 한

[포인트경제] 최태원 SK그룹 회장이 7일 오전 서울 중구 SK텔레콤 T타워 SUPEX홀에서 SK텔레콤의 해킹 사고와 관련해 국민들에 사과했다. "SKT 위약금 면제와 관련해 이사회가 좋은 해결방안을 낼 것""SKT 정보보호혁신위, 수펙스추구협의회서 운영될 듯""SKT 해킹, 보안 넘

▲한덕수 대통령 권한대행 국무총리가 31일 경기도 SK하이닉스 이천캠퍼스 수펙스(SUPEX)센터에서 '반도체산업 현장 간담회'를 마치고 곽노정 SK하이닉

Photo : YONHAP News SK Group Chairman Chey Tae-won issued an apology on Monday after a court ordered him to pay his estranged wife a record divorce settlement. In a statement, the chairman apologized for the 'distress' that his personal matter has caused to SK employees and stakeholders, adding that he will continue to do his part to ensure there's no negative impact on both SK and the South Korean economy. The statement was made during an emergency meeting of the SK Supex Council, the group's highest decision-making body, to discuss ways to deal with the aftermath of the court