There's a new #RDKit blog post introducing some new functionality that I'm really excited about: doing efficient substructure and similarity searches in very large chemical libraries:
greglandrum.github.io/rdkit-blog/p...
#ChemSky
greglandrum.github.io/rdkit-blog/p...
#ChemSky
Introducing Synthon Searching – RDKit blog
Searching unreasonably large chemical spaces in reasonable amounts of time.
greglandrum.github.io
December 3, 2024 at 7:21 AM
There's a new #RDKit blog post introducing some new functionality that I'm really excited about: doing efficient substructure and similarity searches in very large chemical libraries:
greglandrum.github.io/rdkit-blog/p...
#ChemSky
greglandrum.github.io/rdkit-blog/p...
#ChemSky
Goldman Sachs’ investment arm agrees €2bn deal for drugmaker Synthon
https://www.ft.com/content/8d01e20d-ecff-4611-9730-45a0038845ce
https://www.ft.com/content/8d01e20d-ecff-4611-9730-45a0038845ce
Goldman Sachs’ investment arm agrees €2bn deal for drugmaker Synthon
Deal with BC Partners aims to capitalise on rising demand for off-patent versions of complex drugs
www.ft.com
December 16, 2024 at 11:26 AM
Goldman Sachs’ investment arm agrees €2bn deal for drugmaker Synthon
https://www.ft.com/content/8d01e20d-ecff-4611-9730-45a0038845ce
https://www.ft.com/content/8d01e20d-ecff-4611-9730-45a0038845ce
A Ca(I) synthon with bridging N2 is key to the synthesis of homometallic Ca peroxide and oxide complexes. In solution, the Ca oxide complex decomposes even at -80 C. It can only be prepared in the solid state. @ChemCommun @RoySocChem shorturl.at/AUoWM
July 4, 2025 at 12:02 PM
A Ca(I) synthon with bridging N2 is key to the synthesis of homometallic Ca peroxide and oxide complexes. In solution, the Ca oxide complex decomposes even at -80 C. It can only be prepared in the solid state. @ChemCommun @RoySocChem shorturl.at/AUoWM
Very happy to introduce BCB-Bx as an electrophilic bicyclobutane synthon!
Have a look at the preprint at @chemrxiv.org
chemrxiv.org/doi/full/10....
Have a look at the preprint at @chemrxiv.org
chemrxiv.org/doi/full/10....
June 19, 2026 at 7:50 AM
Very happy to introduce BCB-Bx as an electrophilic bicyclobutane synthon!
Have a look at the preprint at @chemrxiv.org
chemrxiv.org/doi/full/10....
Have a look at the preprint at @chemrxiv.org
chemrxiv.org/doi/full/10....
THIS CHALLENGING SYNTHESIS completes the (BDI)Ae-(benzene)-Ae(BDI) series (Ae = Mg, Ca, Sr, Ba) with Ba. We show trends in stability, structure, bonding and reactivity. Reacting like (BDI)Ba-Ba(BDI) this is the first Ba(I) synthon. shorturl.at/ZdToA @chemicalscience.rsc.org
September 4, 2025 at 11:00 AM
THIS CHALLENGING SYNTHESIS completes the (BDI)Ae-(benzene)-Ae(BDI) series (Ae = Mg, Ca, Sr, Ba) with Ba. We show trends in stability, structure, bonding and reactivity. Reacting like (BDI)Ba-Ba(BDI) this is the first Ba(I) synthon. shorturl.at/ZdToA @chemicalscience.rsc.org
Do you like bleeps? How about bloops? Join me at twitch.com/wokeassmessiah for my modular-centric SYNTHON! set ✨ Thanks to all the Golden Shrimp Guild organizers and perfomers for making each SYNTHON! such a special event 🦐
November 29, 2024 at 7:43 AM
Do you like bleeps? How about bloops? Join me at twitch.com/wokeassmessiah for my modular-centric SYNTHON! set ✨ Thanks to all the Golden Shrimp Guild organizers and perfomers for making each SYNTHON! such a special event 🦐
P4 reduction by low valent Mg(I) complexes and a Ca(I) synthon. The selectivity can be tuned with ligand bulk, metal choice and addition of dibora-anthracene (DBA). Details can be found in Chemical Science: pubs.rsc.org/en/content/a...
February 5, 2025 at 12:37 PM
P4 reduction by low valent Mg(I) complexes and a Ca(I) synthon. The selectivity can be tuned with ligand bulk, metal choice and addition of dibora-anthracene (DBA). Details can be found in Chemical Science: pubs.rsc.org/en/content/a...
New year, new arynes! Our goal was to provide easy access to our favorite synthon, getting rid of the barrier to its widespread adoption. Now you can make an aryne precursor in one pot from a carboxylic acid ($1.55/g) then derivatize it using SNAr. Bonus: just use blue light or heat to activate!
January 1, 2025 at 3:25 PM
New year, new arynes! Our goal was to provide easy access to our favorite synthon, getting rid of the barrier to its widespread adoption. Now you can make an aryne precursor in one pot from a carboxylic acid ($1.55/g) then derivatize it using SNAr. Bonus: just use blue light or heat to activate!
This week's #RDKit blog post, like last week's, looks at creating your own synthon spaces. Last week was BRICS, this week we use some combichem reactions:
greglandrum.github.io/rdkit-blog/p...
greglandrum.github.io/rdkit-blog/p...
Building synthon spaces with combinatorial reactions – RDKit blog
A frequently requested tutorial part 2
greglandrum.github.io
December 14, 2025 at 5:36 AM
This week's #RDKit blog post, like last week's, looks at creating your own synthon spaces. Last week was BRICS, this week we use some combichem reactions:
greglandrum.github.io/rdkit-blog/p...
greglandrum.github.io/rdkit-blog/p...
I'm live at Synthon: Voice-off on Twitch now! www.twitch.tv/w_mrx/
November 26, 2023 at 7:25 PM
I'm live at Synthon: Voice-off on Twitch now! www.twitch.tv/w_mrx/
It's finally working! SynthOn going to be getting some short pre-rendered animated cut scenes that play when you win/loose a battle!
Clickteam Fusion is a bit limited with traditional movie formats, so had to improv using active objects. Here are some teaser screens!
#GameDev #MadeWithFusion
Clickteam Fusion is a bit limited with traditional movie formats, so had to improv using active objects. Here are some teaser screens!
#GameDev #MadeWithFusion
May 21, 2025 at 5:40 PM
It's finally working! SynthOn going to be getting some short pre-rendered animated cut scenes that play when you win/loose a battle!
Clickteam Fusion is a bit limited with traditional movie formats, so had to improv using active objects. Here are some teaser screens!
#GameDev #MadeWithFusion
Clickteam Fusion is a bit limited with traditional movie formats, so had to improv using active objects. Here are some teaser screens!
#GameDev #MadeWithFusion
Our new preprint introduces a new approach for controlling the helicity and handedness of polyaromatics using a helical cyclophane synthon: isobenzofuranophane.
We demonstrate the applicability by remotely controlling the handedness and pitch of [5]helicenes. go.shr.lc/44yCyln
#PiSky
We demonstrate the applicability by remotely controlling the handedness and pitch of [5]helicenes. go.shr.lc/44yCyln
#PiSky
May 12, 2025 at 7:23 AM
Our new preprint introduces a new approach for controlling the helicity and handedness of polyaromatics using a helical cyclophane synthon: isobenzofuranophane.
We demonstrate the applicability by remotely controlling the handedness and pitch of [5]helicenes. go.shr.lc/44yCyln
#PiSky
We demonstrate the applicability by remotely controlling the handedness and pitch of [5]helicenes. go.shr.lc/44yCyln
#PiSky
A chill Sunday soundtrack: here are two hours of spacy 808 live jams and improvisations. #music https://www.youtube.com/watch?v=vhyrGtYTfwM
Mr. X Live at SYNTHON! OPERATION 808, 8.08.24 // @GSGlive // Berlin School, Kosmische Musik, Ambient
www.youtube.com
November 24, 2024 at 12:45 PM
A chill Sunday soundtrack: here are two hours of spacy 808 live jams and improvisations. #music https://www.youtube.com/watch?v=vhyrGtYTfwM
MaLiCeCoLtRaNe is now streaming Music on Twitch: https://twitch.tv/malicecoltrane
SYNTHON: 6th anniversary – June 20, 2026 – presented by the Golden Shrimp Guild – https://gsg.live/synthon – coming up next: @n_eonvoid !
#synth #synthsky #music #twitch #GSGLive
SYNTHON: 6th anniversary – June 20, 2026 – presented by the Golden Shrimp Guild – https://gsg.live/synthon – coming up next: @n_eonvoid !
#synth #synthsky #music #twitch #GSGLive
June 21, 2026 at 3:28 AM
MaLiCeCoLtRaNe is now streaming Music on Twitch: https://twitch.tv/malicecoltrane
SYNTHON: 6th anniversary – June 20, 2026 – presented by the Golden Shrimp Guild – https://gsg.live/synthon – coming up next: @n_eonvoid !
#synth #synthsky #music #twitch #GSGLive
SYNTHON: 6th anniversary – June 20, 2026 – presented by the Golden Shrimp Guild – https://gsg.live/synthon – coming up next: @n_eonvoid !
#synth #synthsky #music #twitch #GSGLive
By the way, want to hear some really cool modular synth stuff?
TotoRobyn is streaming and sounds like it's gonna start ambient that'll go over into faster paced stuff
TotoRobyn is streaming and sounds like it's gonna start ambient that'll go over into faster paced stuff
TotoRobyn - Twitch
SYNTHON - 6 YR Celebration! // !charity // next up @chawo
www.twitch.tv
June 21, 2026 at 3:34 PM
By the way, want to hear some really cool modular synth stuff?
TotoRobyn is streaming and sounds like it's gonna start ambient that'll go over into faster paced stuff
TotoRobyn is streaming and sounds like it's gonna start ambient that'll go over into faster paced stuff