Lupus in the News: A study of the two most common biologics for SLE, Benlysta (belimumab) and Saphnelo (anifrolumab), found that Saphnelo was associated with a significantly lower risk for cardiovascular disease events, like heart failure or stroke.
Link: https://ow.ly/OsL550ZYYYV~
Link: https://ow.ly/OsL550ZYYYV~
October 19, 2026 at 3:07 PM
Lupus in the News: A study of the two most common biologics for SLE, Benlysta (belimumab) and Saphnelo (anifrolumab), found that Saphnelo was associated with a significantly lower risk for cardiovascular disease events, like heart failure or stroke.
Link: https://ow.ly/OsL550ZYYYV~
Link: https://ow.ly/OsL550ZYYYV~
4/6 Parallel to that, a Phase 3 hypercholesterolaemia FDC (laroprovstat/rosuvastatin) entered recruitment, and a lupus-and-myopathy rollover study for anifrolumab (Saphnelo) is actively enrolling.
The prostate-cancer AZD9750 study remains active and closed to new recruitment.
The prostate-cancer AZD9750 study remains active and closed to new recruitment.
October 9, 2026 at 1:25 PM
4/6 Parallel to that, a Phase 3 hypercholesterolaemia FDC (laroprovstat/rosuvastatin) entered recruitment, and a lupus-and-myopathy rollover study for anifrolumab (Saphnelo) is actively enrolling.
The prostate-cancer AZD9750 study remains active and closed to new recruitment.
The prostate-cancer AZD9750 study remains active and closed to new recruitment.
I’m having my monthly IV infusion of Saphnelo for Lupus. Yeah? 😷🏥🩺⚕️
September 22, 2026 at 9:23 PM
I’m having my monthly IV infusion of Saphnelo for Lupus. Yeah? 😷🏥🩺⚕️
FDA Approves SAPHNELO Self-Administration for Treatment of Systemic Lupus Erythematosus.
Since #SLE´s been diagnosed in 08/02, 10 years after it´d broken out, I´ve always only taken cortisone, previously 100 mg/day, longtime dose 5 mg.
www.lupus.org/news/fda-app...
@lupus.org
Since #SLE´s been diagnosed in 08/02, 10 years after it´d broken out, I´ve always only taken cortisone, previously 100 mg/day, longtime dose 5 mg.
www.lupus.org/news/fda-app...
@lupus.org
May 17, 2026 at 10:34 AM
FDA Approves SAPHNELO Self-Administration for Treatment of Systemic Lupus Erythematosus.
Since #SLE´s been diagnosed in 08/02, 10 years after it´d broken out, I´ve always only taken cortisone, previously 100 mg/day, longtime dose 5 mg.
www.lupus.org/news/fda-app...
@lupus.org
Since #SLE´s been diagnosed in 08/02, 10 years after it´d broken out, I´ve always only taken cortisone, previously 100 mg/day, longtime dose 5 mg.
www.lupus.org/news/fda-app...
@lupus.org
New Analysis Finds SLE-DAS RI Effectively Measures Lupus Treatment Response.
Since #SLE was diagnosed in 08/02, about 10 years after it´d broken out, I´ve been taking cortisone only, started with 100 mg/day, longtime dose 5 mg/day.
www.lupus.org/news/new-ana...
@lupus.org
Since #SLE was diagnosed in 08/02, about 10 years after it´d broken out, I´ve been taking cortisone only, started with 100 mg/day, longtime dose 5 mg/day.
www.lupus.org/news/new-ana...
@lupus.org
New Analysis Finds SLE-DAS RI Effectively Measures Lupus Treatment Response
In a new analysis of Phase 2 and 3 anifrolumab (Saphnelo®) clinical trial data, researchers found that the SLE Disease Activity Score (SLE-DAS) Responder Index (RI) is a valid and sensitive tool to me...
www.lupus.org
April 26, 2026 at 3:53 AM
New Analysis Finds SLE-DAS RI Effectively Measures Lupus Treatment Response.
Since #SLE was diagnosed in 08/02, about 10 years after it´d broken out, I´ve been taking cortisone only, started with 100 mg/day, longtime dose 5 mg/day.
www.lupus.org/news/new-ana...
@lupus.org
Since #SLE was diagnosed in 08/02, about 10 years after it´d broken out, I´ve been taking cortisone only, started with 100 mg/day, longtime dose 5 mg/day.
www.lupus.org/news/new-ana...
@lupus.org
Phase III TULIP-SC trial of SAPHNELO® self-administration demonstrates reduction in systemic lupus erythematosus disease activity.
I take 5 mg cortisone the day and have been flare-free for 10+ years yet. (Fingers crossed)
www.lupus.org/news/phase-i...
@lupus.org
I take 5 mg cortisone the day and have been flare-free for 10+ years yet. (Fingers crossed)
www.lupus.org/news/phase-i...
@lupus.org
Phase III TULIP-SC trial of SAPHNELO® self-administration demonstrates reduction in systemic lupus erythematosus disease activity
AstraZeneca announced that the Phase III TULIP-SC trial of SAPHNELO (anifrolumab) for treatment of people with systemic lupus erythematosus met its primary endpoint.
www.lupus.org
October 6, 2025 at 2:44 PM
Phase III TULIP-SC trial of SAPHNELO® self-administration demonstrates reduction in systemic lupus erythematosus disease activity.
I take 5 mg cortisone the day and have been flare-free for 10+ years yet. (Fingers crossed)
www.lupus.org/news/phase-i...
@lupus.org
I take 5 mg cortisone the day and have been flare-free for 10+ years yet. (Fingers crossed)
www.lupus.org/news/phase-i...
@lupus.org
Saphnelo self-administration TULIP-SC Phase III trial meets primary endpoint in SLE | The Pharmaletter (lupus trial being reproducible is amazing)
Saphnelo self-administration TULIP-SC Phase III trial meets primary endpoint in SLE
Positive high-level results from a pre-specified interim analysis of the Phase III TULIP-SC trial in patients with systemic lupus erythematosus (SLE) showed that the subcutaneous (SC) administration…
www.thepharmaletter.com
September 21, 2025 at 1:53 PM
Saphnelo self-administration TULIP-SC Phase III trial meets primary endpoint in SLE | The Pharmaletter (lupus trial being reproducible is amazing)
😍GREAT NEWS!
@FDA approves self-injectable #Saphnelo
Pen for #SLE #lupus! Once-weekly dosing: 120 mg per dose.
www.astrazeneca.com/media-centre...
NOTE: This is NOT sponsored AstraZeneca
@FDA approves self-injectable #Saphnelo
Pen for #SLE #lupus! Once-weekly dosing: 120 mg per dose.
www.astrazeneca.com/media-centre...
NOTE: This is NOT sponsored AstraZeneca
April 27, 2026 at 7:36 PM
😍GREAT NEWS!
@FDA approves self-injectable #Saphnelo
Pen for #SLE #lupus! Once-weekly dosing: 120 mg per dose.
www.astrazeneca.com/media-centre...
NOTE: This is NOT sponsored AstraZeneca
@FDA approves self-injectable #Saphnelo
Pen for #SLE #lupus! Once-weekly dosing: 120 mg per dose.
www.astrazeneca.com/media-centre...
NOTE: This is NOT sponsored AstraZeneca
🫄Article by Dr. Siegel & Dr. Sammaritano supports #Benlysta & #Saphnelo in pregnancy.
www.lupusencyclopedia.com/successful-l...
I use biologics, such as Benlysta and Saphnelo, during pregnancy. I try to stop the biologic late in the 2nd trimester in order not to affect the newborn's immune system.
www.lupusencyclopedia.com/successful-l...
I use biologics, such as Benlysta and Saphnelo, during pregnancy. I try to stop the biologic late in the 2nd trimester in order not to affect the newborn's immune system.
How to have a successful pregnancy when you have lupus
Most patients with lupus can now have a successful pregnancy if they plan for it properly. My new blog post gives an easy-to-follow step-by-step list of recommendations. SHARE with everyone who may be...
www.lupusencyclopedia.com
April 13, 2026 at 8:48 PM
🫄Article by Dr. Siegel & Dr. Sammaritano supports #Benlysta & #Saphnelo in pregnancy.
www.lupusencyclopedia.com/successful-l...
I use biologics, such as Benlysta and Saphnelo, during pregnancy. I try to stop the biologic late in the 2nd trimester in order not to affect the newborn's immune system.
www.lupusencyclopedia.com/successful-l...
I use biologics, such as Benlysta and Saphnelo, during pregnancy. I try to stop the biologic late in the 2nd trimester in order not to affect the newborn's immune system.
SC #Saphnelo meets its primary endpoint. How exciting for patients who find IV infusions too time consuming and difficult! I hope it is approved and available for my patients quickly!
www.astrazeneca-us.com/media/press-...
www.astrazeneca-us.com/media/press-...
SAPHNELO self-administration TULIP-SC Phase III trial meets primary endpoint in patients with systemic lupus erythematosus based on an interim analysis
www.astrazeneca-us.com
September 18, 2025 at 12:34 AM
SC #Saphnelo meets its primary endpoint. How exciting for patients who find IV infusions too time consuming and difficult! I hope it is approved and available for my patients quickly!
www.astrazeneca-us.com/media/press-...
www.astrazeneca-us.com/media/press-...
You're not subtle, Saphnelo and Benlysta ads. I know my lupus is not being adequately controlled with standard therapy. I think about it constantly.
November 17, 2024 at 7:32 PM
You're not subtle, Saphnelo and Benlysta ads. I know my lupus is not being adequately controlled with standard therapy. I think about it constantly.
Infusion #3 at new infusion center. Took almestica am hour to get started. hopefully it doesn't always take this long. Follow-up with my doctor is on Monday so we will see if we will continue.
#midwesterngirlonthebelt #saphnelo #lupuswarrior #lupusawareness #ivegotthis #lupus
#midwesterngirlonthebelt #saphnelo #lupuswarrior #lupusawareness #ivegotthis #lupus
January 22, 2025 at 7:58 PM
Infusion #3 at new infusion center. Took almestica am hour to get started. hopefully it doesn't always take this long. Follow-up with my doctor is on Monday so we will see if we will continue.
#midwesterngirlonthebelt #saphnelo #lupuswarrior #lupusawareness #ivegotthis #lupus
#midwesterngirlonthebelt #saphnelo #lupuswarrior #lupusawareness #ivegotthis #lupus
Shingles vaccine was a pre requisite for my lupus treatment with Saphnelo. I’m very thankful to have had that vaccine.
January 22, 2026 at 1:09 AM
Shingles vaccine was a pre requisite for my lupus treatment with Saphnelo. I’m very thankful to have had that vaccine.
I had zero problems with the shingles vaccine. After I finished getting it I found out the vaccine was a prerequisite to being treated with Saphnelo for lupus. So, that was great among its many benefits.
December 9, 2025 at 5:55 AM
I had zero problems with the shingles vaccine. After I finished getting it I found out the vaccine was a prerequisite to being treated with Saphnelo for lupus. So, that was great among its many benefits.
delirious on my Saphnelo infusion and educating my husband on the difference between babygirl and daddy
November 15, 2025 at 9:02 AM
delirious on my Saphnelo infusion and educating my husband on the difference between babygirl and daddy
yeeeeeep. it’s also worth mentioning that the majority of patients are using speciality pharmacies for very immunosuppressive drugs to treat conditions like lupus. any virus, but esp COVID, is especially harmful to me while on Saphnelo.
the sparkling ✨cognitive dissonance✨
the sparkling ✨cognitive dissonance✨
January 29, 2025 at 10:34 PM
yeeeeeep. it’s also worth mentioning that the majority of patients are using speciality pharmacies for very immunosuppressive drugs to treat conditions like lupus. any virus, but esp COVID, is especially harmful to me while on Saphnelo.
the sparkling ✨cognitive dissonance✨
the sparkling ✨cognitive dissonance✨
Just finished my second Saphnelo infusion. Any other Lupus folks here have success with it? I’m running out of options and really hoping this one works. 🤞🏻
November 23, 2024 at 5:58 AM
Just finished my second Saphnelo infusion. Any other Lupus folks here have success with it? I’m running out of options and really hoping this one works. 🤞🏻
Characteristics and clinical outcomes of patients with systemic lupus erythematosus initiating anifrolumab in a real-world setting in Spain (AZAHAR study): an observational study protocol lupus.bmj.com/content/12/1... #hvhebron #reu [Text complet]
Characteristics and clinical outcomes of patients with systemic lupus erythematosus initiating anifrolumab in a real-world setting in Spain (AZAHAR study): an observational study protocol
Introduction Anifrolumab (Saphnelo) is approved for adult patients with moderate-severe systemic lupus erythematosus (SLE). Considering its commercialisation in Spain in 2023, observational studies de...
lupus.bmj.com
February 13, 2025 at 3:13 PM
Characteristics and clinical outcomes of patients with systemic lupus erythematosus initiating anifrolumab in a real-world setting in Spain (AZAHAR study): an observational study protocol lupus.bmj.com/content/12/1... #hvhebron #reu [Text complet]
ooo an existing one or new new new? i think i remember hearing some talk of success with saphnelo but
July 23, 2026 at 10:29 PM
ooo an existing one or new new new? i think i remember hearing some talk of success with saphnelo but
Note to self, don't try to be clever and schedule both a follow up with your GP and your monthly Saphnelo on the same day, 'cause both involve needles and right arm pokes hurt more. :( #ItsAlwaysLupus #ItsNotLupus #AutoimmuneDisease
January 5, 2026 at 6:27 PM
Note to self, don't try to be clever and schedule both a follow up with your GP and your monthly Saphnelo on the same day, 'cause both involve needles and right arm pokes hurt more. :( #ItsAlwaysLupus #ItsNotLupus #AutoimmuneDisease
New research finds Saphnelo may help restore overall immune health in people with moderate-to-severe systemic #lupus erythematosus. Read the study: buff.ly/aAhNNpE
June 29, 2026 at 6:00 PM
New research finds Saphnelo may help restore overall immune health in people with moderate-to-severe systemic #lupus erythematosus. Read the study: buff.ly/aAhNNpE
BREAKING NEWS: The @FDA.gov has approved SAPHNELO self-administration for the treatment of people living with moderately to severely active autoantibody-positive systemic lupus erythematosus who are receiving standard therapy. Read the announcement: buff.ly/SJlJCts
FDA Approves SAPHNELO Self-Administration for Treatment of Systemic Lupus Erythematosus
The U.S. Food & Drug Administration (FDA) has granted approval for subcutaneous administration of anifrolumab (SAPHNELO) for treatment of people living with moderately to severely active…
www.lupus.org
April 27, 2026 at 8:49 PM
BREAKING NEWS: The @FDA.gov has approved SAPHNELO self-administration for the treatment of people living with moderately to severely active autoantibody-positive systemic lupus erythematosus who are receiving standard therapy. Read the announcement: buff.ly/SJlJCts
A new analysis of anifrolumab (Saphnelo®) clinical trials shows the SLE-DAS Responder Index is a reliable way to measure meaningful improvement in people living with lupus. Read the study: buff.ly/BN2FgX2
New Analysis Finds SLE-DAS RI Effectively Measures Lupus Treatment Response
In a new analysis of Phase 2 and 3 anifrolumab (Saphnelo®) clinical trial data, researchers found that the SLE Disease Activity Score (SLE-DAS) Responder Index (RI) is a valid and sensitive tool to…
www.lupus.org
April 24, 2026 at 4:50 PM
A new analysis of anifrolumab (Saphnelo®) clinical trials shows the SLE-DAS Responder Index is a reliable way to measure meaningful improvement in people living with lupus. Read the study: buff.ly/BN2FgX2
UPDATE: The @fda.gov issued a Complete Response Letter to AstraZeneca requesting additional information for the self-administered subcutaneous version of Saphnelo. Read the announcement:
Update: Self-administered Saphnelo remains under FDA review in the U.S.
The U.S. Food and Drug Administration (FDA) issued a complete response letter requesting additional information from AstraZeneca regarding the Biologics License Application (BLA) for subcutaneous…
buff.ly
February 3, 2026 at 10:30 PM
UPDATE: The @fda.gov issued a Complete Response Letter to AstraZeneca requesting additional information for the self-administered subcutaneous version of Saphnelo. Read the announcement: