Check out this amazing paper from @samuelmaiwald.bsky.social! Congrats to all the authors 🎉
#TRIP12 #E3ligases #SchulmanLab
#TRIP12 #E3ligases #SchulmanLab
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology
Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...
www.nature.com
May 26, 2025 at 11:15 AM
Check out this amazing paper from @samuelmaiwald.bsky.social! Congrats to all the authors 🎉
#TRIP12 #E3ligases #SchulmanLab
#TRIP12 #E3ligases #SchulmanLab