#ScienceReview!
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In a new #ScienceReview, researchers provide a critical evaluation of research linking glymphatic dysfunction with Alzheimer’s disease. scim.ag/4lG54a0
Figure showing a schematic of the glymphatic system in health and Alzheimer's disease.
July 11, 2025 at 2:07 PM
science.org
It has long been recognized that millions of women, especially younger women, are disproportionately affected by pain disorders.

In a new #ScienceReview, researchers synthesize recent advances in understanding these conditions. https://scim.ag/3TFlxTo
Sex-specific mechanisms of chronic pain
For decades, we have known that women, especially younger women, are disproportionately affected by pain disorders, including irritable bowel syndrome, endometriosis, menstrual migraines, fibromyalgia...
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October 7, 2026 at 7:45 PM
science.org
In a new #ScienceReview, researchers highlight recent advances in the design, characterization, modeling, and fundamental understanding of porosity that have enabled breakthroughs across the landscape of energy technologies. https://scim.ag/3LkoODa
November 4, 2025 at 8:31 PM
science.org
A new #ScienceReview details the consequences of the loss of Earth’s old, wise, and large animal species. scim.ag/4h71fsm
Loss of Earth’s old, wise, and large animals
Earth’s old animals are in decline. Despite this, emerging research is revealing the vital contributions of older individuals to cultural transmission, population dynamics, and ecosystem processes and...
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January 7, 2025 at 2:20 PM
science.org
Antarctic ice plays a crucial role in regulating Earth’s climate, global sea levels, ocean circulation, and planetary reflectivity.

Learn more in this 2025 #ScienceReview: https://scim.ag/493YlDy #ScienceMagArchives
Antarctica in 2025: Drivers of deep uncertainty in projected ice loss
Antarctica is a vital component of Earth’s climate system, influencing global sea level, ocean circulation, and planetary albedo. Major knowledge gaps in critical processes—spanning the atmosphere, oc...
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January 1, 2026 at 9:57 PM
science.org
A new #ScienceReview shows how the ecological concept of plant-soil feedback can be used to restore the capacity of agricultural soils to provide nutrients, suppress pathogens, and enhance crop resilience sustainably. scim.ag/45dhSOu
Steering plant-soil feedback for sustainable agriculture
The challenge of producing food at low monetary cost comes with high environmental impacts as yield maximization by excessive fertilization and chemical pest control drive farmers away from using the ...
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July 30, 2025 at 3:12 PM
science.org
Researchers in a new #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. scim.ag/4ln58Le
A figure showing the characteristics of human immune cells of both the adaptive and innate branches of the immune system and their responsiveness to sex steroid hormones.
August 13, 2025 at 4:20 PM
science.org
A new #ScienceReview takes a look at the contribution of neuroinflammation during the course of a range of neurologic disorders, including multiple sclerosis, stroke, Alzheimer's disease, and Parkinson's disease. scim.ag/44wDXIH
Neuroinflammation across neurological diseases
The brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details diff...
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June 24, 2025 at 7:53 PM
science.org
In a 2020 #ScienceReview, researchers investigated how systematic racist practices such as residential segregation have led to an unequal distribution of “nature” within cities.

Learn more on #WorldHabitatDay: https://scim.ag/3KQnEir
The ecological and evolutionary consequences of systemic racism in urban environments
Cities create challenging environments for many nonhuman species, and the presence of nonhumans in cities influences the health and well-being of the humans with which they share the environment. Dist...
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October 6, 2025 at 7:17 PM
science.org
The production and accumulation of aberrant proteins can have serious pathological consequences.

In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B
Systems-level organization of extracellular proteostasis
One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...
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April 1, 2026 at 7:24 PM
science.org
Natural hazards such as earthquakes, fires, and floods can dramatically affect human life and infrastructure.

In a recent #ScienceReview, researchers argue the need for a unified, interdisciplinary approach to studying cascading land surface hazards. scim.ag/4kbWn60
A photograph and a schematic illustration of how the interaction of Earth systems through surface process controls the emergence and persistence of cascading hazards.
July 14, 2025 at 6:56 PM
science.org
In a new #ScienceReview, researchers argue that menopause research needs a major rethink, shifting from a one-size-fits-all view of the transition to a precision medicine approach that accounts for differences in symptoms, timing, genetics and hormone treatments. https://scim.ag/4hAtykK
Reframing menopause and menopause hormone therapy as opportunities for healthy aging
Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...
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October 2, 2026 at 7:42 PM
science.org
A 2024 #ScienceReview highlights the growing recognition of the complex cognitive capacities of #rats and its implications for how they are treated in scientific contexts. https://scim.ag/49byOse #ScienceMagArchives
The complex affective and cognitive capacities of rats
For several decades, although studies of rat physiology and behavior have abounded, research on rat emotions has been limited in scope to fear, anxiety, and pain. Converging evidence for the capacity ...
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October 25, 2025 at 7:59 PM
science.org
Recent studies have revealed the synchronization of neuromodulators including norepinephrine, serotonin, acetylcholine, dopamine, and histamine during sleep.

A new #ScienceReview explores what potential role the synchronization of these oscillations may play in health. https://scim.ag/3PEGdsW
The oscillatory biology of sleep: Linkage to dementia
During wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity into a coordinated brain rhythm. During sleep, the ma...
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May 28, 2026 at 9:03 PM
science.org
Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases.

Learn more: https://scim.ag/4ln58Le
Sex differences in tissue-specific immunity and immunology
Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...
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September 14, 2025 at 8:18 PM
science.org
In a new #ScienceReview, researchers look at recent developments in the field of complex frequency excitations in photonics and in other fields of physics governed by wave equations. scim.ag/4l9MxU1
Complex-frequency excitations in photonics and wave physics
Closed, lossless optical cavities are characterized by a Hamiltonian that obeys Hermiticity, resulting in strictly real-valued resonance frequencies. By contrast, non-Hermitian wave systems are charac...
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April 3, 2025 at 4:24 PM
science.org
In a #ScienceReview from earlier this year, researchers provide a critical evaluation of research linking glymphatic dysfunction with Alzheimer’s disease.

Learn more: https://scim.ag/4qhg28c
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal
Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function ...
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December 25, 2025 at 2:24 PM
science.org
Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases.

Learn more: https://scim.ag/48YKHAe
Sex differences in tissue-specific immunity and immunology
Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...
scim.ag
December 24, 2025 at 8:44 PM
science.org
In the 20 years since the term “microplastics” was first coined, a growing body of research has consistently shown how pervasive and problematic the pollutants have become.

A recent #ScienceReview provides an overview and the progress made in understanding #microplastics.
Twenty years of microplastic pollution research—what have we learned?
Twenty years after the first publication that used the term microplastic, we review current understanding, refine definitions, and consider future prospects. Microplastics arise from multiple sources, including tires, textiles, cosmetics, paint, and the...
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December 20, 2024 at 3:07 PM
science.org
Natural hazards such as earthquakes, fires, and floods can dramatically affect human life and infrastructure.

In a new #ScienceReview, researchers argue the need for a unified, interdisciplinary approach to studying cascading land surface hazards. scim.ag/4kbWn60
A photograph and a schematic illustration of how the interaction of Earth systems through surface process controls the emergence and persistence of cascading hazards.
June 30, 2025 at 4:09 PM
science.org
Continuous protein monitoring is an emerging area in clinical monitoring strategies.

A new #ScienceReview looks at how this approach has transformative potential for preventive health care. https://scim.ag/4nnXlyB
Schematics of clinical integration of continuous biomolecular monitoring across the spectrum of preventative health care and challenges to integration and data handling in care settings.
September 29, 2025 at 7:18 PM
science.org
In a new #ScienceReview, researchers examine the evidence for how global diets have changed and strategies that could transition food systems toward a healthier future.

Learn more on #WorldHealthDay: https://scim.ag/4siRJaH
Strategies for achieving healthy, sustainable, and equitable dietary transitions
The industrialization of global food systems has led to dietary changes that harm both health and the environment. If global food systems are to meet the needs of a growing population for healthy, env...
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April 7, 2026 at 1:23 PM
science.org
In a new #ScienceReview, researchers discuss the latest understanding of secondary organic aerosol formation in urban China, providing a framework for identifying knowledge gaps and guiding future research into haze chemistry and pollution control strategies. https://scim.ag/3HCgNrX
The air quality in Shanghai has been substantially improved over the past decade. Left: the medium-level haze event in 2013, right: the air is much more clear in 2025, although there is still air pollution.
September 1, 2025 at 12:49 PM
science.org
In a new #ScienceReview, researchers discuss a variety of methods to reimagine human-centric drug development.

Learn more: https://scim.ag/42ow8Tv
Reimagining human-centric drug development with new approach methodologies
Despite unprecedented technological progress, most drug candidates continue to fail in clinical trials, reflecting a persistent gap between preclinical models and human biology. New approach methodolo...
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April 24, 2026 at 7:42 PM
science.org
A new #ScienceReview provides a preview of what the Arctic region may look like in a warmer world. https://scim.ag/41rrYuF
Impacts of global warming on (A) marine ecosystem functioning and fisheries, (B) large marine mammals, (C) local transportation, and (D) infrastructure. Colors indicate risk level as a function of global warming: white, undetectable; yellow, moderate; red, high; purple, very high. Black bar indicates 2.7°C. Confidence in assessment of risk transitions by warming levels is indicated by the number of dots shown, from three (high) to one (low). No dots indicate confidence could not be assessed or a risk transition threshold was not met.
February 22, 2025 at 3:07 PM