This week’s new issue of #ScienceSignaling has arrived! https://scim.ag/48TEWoK
December 23, 2025 at 11:03 PM
This week’s new issue of #ScienceSignaling has arrived! https://scim.ag/48TEWoK
February 10, 2026 at 10:00 PM
Excited to share our latest work published in #ScienceSignaling! 🚀
www.science.org/doi/10.1126/...
(1/4)
www.science.org/doi/10.1126/...
(1/4)
Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling
Proteomic analyses offer insights into how KRAS inhibitors affect oncogenic KRAS signaling.
www.science.org
July 31, 2025 at 8:10 AM
Excited to share our latest work published in #ScienceSignaling! 🚀
www.science.org/doi/10.1126/...
(1/4)
www.science.org/doi/10.1126/...
(1/4)
Recent discoveries are reshaping how scientists understand the neuroscience and biology of drug addiction, according to a new #ScienceSignaling Review that discusses the latest findings, future research priorities, and emerging therapies. scim.ag/3DguvOY
The biology of addiction
Insights into the biology of addiction and their potential translation into advances in therapy are discussed.
scim.ag
March 5, 2025 at 7:00 PM
Recent discoveries are reshaping how scientists understand the neuroscience and biology of drug addiction, according to a new #ScienceSignaling Review that discusses the latest findings, future research priorities, and emerging therapies. scim.ag/3DguvOY
Scientists have identified how a #lncRNA named EPIC1 endows tumors with the ability to resist immunotherapies—and show that targeting the RNA in cells and mice can potentiate checkpoint blockade and slow tumor growth.
Learn more in #ScienceSignaling: https://scim.ag/45CokPp
Learn more in #ScienceSignaling: https://scim.ag/45CokPp
August 13, 2025 at 3:00 PM
Scientists have identified how a #lncRNA named EPIC1 endows tumors with the ability to resist immunotherapies—and show that targeting the RNA in cells and mice can potentiate checkpoint blockade and slow tumor growth.
Learn more in #ScienceSignaling: https://scim.ag/45CokPp
Learn more in #ScienceSignaling: https://scim.ag/45CokPp
New results in #ScienceSignaling reveal that the T cell adaptor protein PAG supports the function of #TCell immune synapses by connecting with actin, suggesting that it could offer a target to improve #immunotherapy in patients that show poor responses. https://scim.ag/3V1ilCa
PAG supports T cell immune synapse function by binding to actin
A plasma membrane adaptor protein supports cytotoxic T cell function by connecting with the actin network.
scim.ag
September 25, 2026 at 3:00 PM
New results in #ScienceSignaling reveal that the T cell adaptor protein PAG supports the function of #TCell immune synapses by connecting with actin, suggesting that it could offer a target to improve #immunotherapy in patients that show poor responses. https://scim.ag/3V1ilCa
The new issue of #ScienceSignaling is out!
Research reveals how Girdin binds to Dishevelled to promote the disassembly of cilia, experiments reveal how a T cell adaptor protein supports cytotoxic T cells by connecting with actin, and more. https://scim.ag/4dSEzN0
Research reveals how Girdin binds to Dishevelled to promote the disassembly of cilia, experiments reveal how a T cell adaptor protein supports cytotoxic T cells by connecting with actin, and more. https://scim.ag/4dSEzN0
September 22, 2026 at 9:00 PM
The new issue of #ScienceSignaling is out!
Research reveals how Girdin binds to Dishevelled to promote the disassembly of cilia, experiments reveal how a T cell adaptor protein supports cytotoxic T cells by connecting with actin, and more. https://scim.ag/4dSEzN0
Research reveals how Girdin binds to Dishevelled to promote the disassembly of cilia, experiments reveal how a T cell adaptor protein supports cytotoxic T cells by connecting with actin, and more. https://scim.ag/4dSEzN0
Harnessing antibodies found in patients with lupus, researchers test a new #cancer therapy that turns autoimmune responses against tumor cells in mice, suggesting similar approaches could be integrated into immunotherapy regimens.
Learn more in #ScienceSignaling: scim.ag/3FXZQGX
Learn more in #ScienceSignaling: scim.ag/3FXZQGX
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
scim.ag
March 28, 2025 at 5:24 PM
Harnessing antibodies found in patients with lupus, researchers test a new #cancer therapy that turns autoimmune responses against tumor cells in mice, suggesting similar approaches could be integrated into immunotherapy regimens.
Learn more in #ScienceSignaling: scim.ag/3FXZQGX
Learn more in #ScienceSignaling: scim.ag/3FXZQGX
This week’s new issue of #ScienceSignaling has arrived!
A new study defines the regulation of a receptor that’s central to allergic inflammation, scientists map out the landscape of cancer-linked KRAS signaling, and more. scim.ag/4oaphXx
A new study defines the regulation of a receptor that’s central to allergic inflammation, scientists map out the landscape of cancer-linked KRAS signaling, and more. scim.ag/4oaphXx
July 29, 2025 at 9:35 PM
This week’s new issue of #ScienceSignaling has arrived!
A new study defines the regulation of a receptor that’s central to allergic inflammation, scientists map out the landscape of cancer-linked KRAS signaling, and more. scim.ag/4oaphXx
A new study defines the regulation of a receptor that’s central to allergic inflammation, scientists map out the landscape of cancer-linked KRAS signaling, and more. scim.ag/4oaphXx
A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
scim.ag
May 26, 2025 at 5:04 PM
A new #ScienceSignaling study interrogates crosstalk between mechanical and biochemical signals in epithelial cells, illustrating how mechanical stretching activates a kinase that regulates cell growth, migration, and differentiation.
The new issue of #ScienceSignaling is out now!
This week, scientists discover how tumor-derived vesicles reprogram pain-sensing neurons to dampen anti-tumor immunity in mice. scim.ag/41tgLsR
This week, scientists discover how tumor-derived vesicles reprogram pain-sensing neurons to dampen anti-tumor immunity in mice. scim.ag/41tgLsR
August 5, 2025 at 9:04 PM
The new issue of #ScienceSignaling is out now!
This week, scientists discover how tumor-derived vesicles reprogram pain-sensing neurons to dampen anti-tumor immunity in mice. scim.ag/41tgLsR
This week, scientists discover how tumor-derived vesicles reprogram pain-sensing neurons to dampen anti-tumor immunity in mice. scim.ag/41tgLsR
September 8, 2026 at 9:00 PM
The B vitamin known as #biotin can protect flies and human neurons from the devastating neurodegenerative effects of #manganese toxicity, which is a major environmental hazard for welders and industrial workers.
Learn more in #ScienceSignaling: scim.ag/3XeMMTG
Learn more in #ScienceSignaling: scim.ag/3XeMMTG
Biotin mitigates the development of manganese-induced, Parkinson’s disease–related neurotoxicity in Drosophila and human neurons
A diet rich in biotin blocks metal-induced neurotoxicity and parkinsonism in flies.
scim.ag
February 26, 2025 at 3:18 PM
The B vitamin known as #biotin can protect flies and human neurons from the devastating neurodegenerative effects of #manganese toxicity, which is a major environmental hazard for welders and industrial workers.
Learn more in #ScienceSignaling: scim.ag/3XeMMTG
Learn more in #ScienceSignaling: scim.ag/3XeMMTG
A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw
August 19, 2025 at 9:00 PM
A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw
New work in #ScienceSignaling expands scientific knowledge of the small proteins that coordinate stress responses in bacteria, such as #Ecoli, and suggests that cellular stress networks are more interconnected than was previously thought. https://scim.ag/3HTeuRc
August 27, 2025 at 3:00 PM
New work in #ScienceSignaling expands scientific knowledge of the small proteins that coordinate stress responses in bacteria, such as #Ecoli, and suggests that cellular stress networks are more interconnected than was previously thought. https://scim.ag/3HTeuRc
August 25, 2026 at 9:00 PM
In a new #ScienceSignaling paper, scientists have found that the notorious pathogen C. difficile, the cause of many hospital-acquired infections, can detoxify bacitracin to colonize the gut. https://scim.ag/4cC5bBw
September 9, 2026 at 3:33 PM
In a new #ScienceSignaling paper, scientists have found that the notorious pathogen C. difficile, the cause of many hospital-acquired infections, can detoxify bacitracin to colonize the gut. https://scim.ag/4cC5bBw
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179
The structure of the orphan GPCR GPR179 bound to the extracellular matrix component pikachurin is solved.
scim.ag
February 27, 2025 at 5:25 PM
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
A new study could inform regenerative therapies for salivary glands after radiotherapy, a computational platform offers a deeper look at protein binding interfaces, and more in this week’s issue of #ScienceSignaling. https://scim.ag/4ran6VE
November 18, 2025 at 10:00 PM
A new study could inform regenerative therapies for salivary glands after radiotherapy, a computational platform offers a deeper look at protein binding interfaces, and more in this week’s issue of #ScienceSignaling. https://scim.ag/4ran6VE
In a new #ScienceSignaling study, researchers introduce extracellular #TurboID, a refinement of the popular proteomics tool that interrogates #ProteinProteinInteractions on the exterior cell membrane, and characterize interactions between #EGFR and #LDLR. scim.ag/3DgfJr9
Extracellular proximal interaction profiling by cell surface–targeted TurboID reveals LDLR as a partner of liganded EGFR
A modified form of TurboID identifies extracellular interactions between transmembrane proteins.
www.science.org
December 13, 2024 at 5:22 PM
In a new #ScienceSignaling study, researchers introduce extracellular #TurboID, a refinement of the popular proteomics tool that interrogates #ProteinProteinInteractions on the exterior cell membrane, and characterize interactions between #EGFR and #LDLR. scim.ag/3DgfJr9
June 30, 2026 at 9:00 PM
This week’s new issue of #ScienceSignaling has arrived! https://scim.ag/4ah1ctN
December 16, 2025 at 10:19 PM
This week’s new issue of #ScienceSignaling has arrived! https://scim.ag/4ah1ctN
A preclinical study interrogates how a cytokine cocktail can invigorate cancer-fighting natural killer cells, new experiments reveal how the oncogenicity of RAS is a family affair, and more in the new issue of #ScienceSignaling. https://scim.ag/4n2QPwW
September 16, 2025 at 9:00 PM
A preclinical study interrogates how a cytokine cocktail can invigorate cancer-fighting natural killer cells, new experiments reveal how the oncogenicity of RAS is a family affair, and more in the new issue of #ScienceSignaling. https://scim.ag/4n2QPwW
This week’s new issue of #ScienceSignaling is out!
A long noncoding RNA offers a potential target in triple-negative breast cancer, mutual information uncovers pathways that underlie heterogeneity in pancreatic cancer, and more. https://scim.ag/45uRxLR
A long noncoding RNA offers a potential target in triple-negative breast cancer, mutual information uncovers pathways that underlie heterogeneity in pancreatic cancer, and more. https://scim.ag/45uRxLR
August 12, 2025 at 9:00 PM
This week’s new issue of #ScienceSignaling is out!
A long noncoding RNA offers a potential target in triple-negative breast cancer, mutual information uncovers pathways that underlie heterogeneity in pancreatic cancer, and more. https://scim.ag/45uRxLR
A long noncoding RNA offers a potential target in triple-negative breast cancer, mutual information uncovers pathways that underlie heterogeneity in pancreatic cancer, and more. https://scim.ag/45uRxLR
Using advanced protein tagging techniques, researchers have made new discoveries about the assorted members of a protein #interactome that guides signaling in cells in the #lymphatic system, which could inform novel therapeutics. #ScienceSignaling https://scim.ag/4hqlbJo
September 16, 2026 at 3:00 PM
Using advanced protein tagging techniques, researchers have made new discoveries about the assorted members of a protein #interactome that guides signaling in cells in the #lymphatic system, which could inform novel therapeutics. #ScienceSignaling https://scim.ag/4hqlbJo