By studying mice and cultured macrophages in the lab, a team has identified a previously unknown molecular brake on inflammation that may shield these cells from osmotic stress as they fight infections. #ScienceSignaling https://scim.ag/4zh5aLM
SNAT2-mediated amino acid import maintains osmotic balance to restrain macrophage metabolic reprogramming and inflammasome activation
A neutral amino acid transporter limits inflammatory activation of macrophages by buffering osmotic stress.
scim.ag
November 11, 2026 at 4:00 PM
By studying mice and cultured macrophages in the lab, a team has identified a previously unknown molecular brake on inflammation that may shield these cells from osmotic stress as they fight infections. #ScienceSignaling https://scim.ag/4zh5aLM
New work uncovers a surprising role for an amino acid transporter in restraining macrophage inflammation, researchers interrogate oncogenic G protein signaling in uveal melanoma cells, and more in this week’s new issue of in #ScienceSignaling. https://scim.ag/3UKDLne
November 10, 2026 at 10:00 PM
New work uncovers a surprising role for an amino acid transporter in restraining macrophage inflammation, researchers interrogate oncogenic G protein signaling in uveal melanoma cells, and more in this week’s new issue of in #ScienceSignaling. https://scim.ag/3UKDLne
Examining G protein–coupled receptor signaling in uveal melanoma cell lines, researchers have discovered a way to make these cells more sensitive to compounds that inhibit cancer-linked signaling pathways. #ScienceSignaling https://scim.ag/4sPXe2e
Gq-coupled GPCRs mediate the oncogenic activity of Gαq-Q209L/P mutants in uveal melanoma cells
Blocking a Gq-coupled GPCR sensitizes uveal melanoma cells to an inhibitor of constitutively active G proteins.
scim.ag
November 13, 2026 at 4:00 PM
Examining G protein–coupled receptor signaling in uveal melanoma cell lines, researchers have discovered a way to make these cells more sensitive to compounds that inhibit cancer-linked signaling pathways. #ScienceSignaling https://scim.ag/4sPXe2e
By studying G protein–coupled receptors in mouse hippocampal slices, scientists provide new evidence of unconventional receptor signaling that has implications for the function of synapses in the brain. #ScienceSignaling https://scim.ag/4ehCYAF
Gαq-coupled receptors activate cAMP signaling through Ca2+/calmodulin-stimulated adenylyl cyclases
Ca2+-dependent adenylyl cyclases in mouse brain hippocampal slices can be stimulated by Gαq-coupled GPCR signaling.
scim.ag
November 6, 2026 at 4:00 PM
By studying G protein–coupled receptors in mouse hippocampal slices, scientists provide new evidence of unconventional receptor signaling that has implications for the function of synapses in the brain. #ScienceSignaling https://scim.ag/4ehCYAF
New experiments in #ScienceSignaling present a rational cytokine-engineering strategy to activate immune signaling networks and provide clues about whether the cytokine IL-39 is found in the human body—a longstanding debate in immunology. https://scim.ag/3V8FhQ9
Subunit engineering enables the generation of human interleukin-39 as a proinflammatory cytokine
Rational design enables human cells to produce an inflammatory cytokine that may not be made naturally.
scim.ag
November 4, 2026 at 4:00 PM
New experiments in #ScienceSignaling present a rational cytokine-engineering strategy to activate immune signaling networks and provide clues about whether the cytokine IL-39 is found in the human body—a longstanding debate in immunology. https://scim.ag/3V8FhQ9
Don’t miss the new issue of #ScienceSignaling!
Discoveries about a cytokine’s long-debated origin yield a blueprint for rational cytokine engineering, new findings about unconventional GPCR signaling have implications for synaptic function, and more. https://scim.ag/4kwwxgU
Discoveries about a cytokine’s long-debated origin yield a blueprint for rational cytokine engineering, new findings about unconventional GPCR signaling have implications for synaptic function, and more. https://scim.ag/4kwwxgU
November 3, 2026 at 10:00 PM
Don’t miss the new issue of #ScienceSignaling!
Discoveries about a cytokine’s long-debated origin yield a blueprint for rational cytokine engineering, new findings about unconventional GPCR signaling have implications for synaptic function, and more. https://scim.ag/4kwwxgU
Discoveries about a cytokine’s long-debated origin yield a blueprint for rational cytokine engineering, new findings about unconventional GPCR signaling have implications for synaptic function, and more. https://scim.ag/4kwwxgU
New work in #ScienceSignaling shows how a mutant form of a protein named STAT3 causes a genetically dominant immunodeficiency, providing crucial insights into a signaling pathway critical for immune responses. https://scim.ag/4jJqzJk
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm
STAT3 with a patient-derived substitution causes immune dysfunction by sequestering wild-type STAT3.
scim.ag
October 30, 2026 at 3:00 PM
New work in #ScienceSignaling shows how a mutant form of a protein named STAT3 causes a genetically dominant immunodeficiency, providing crucial insights into a signaling pathway critical for immune responses. https://scim.ag/4jJqzJk
By studying sea slugs in the lab, researchers in #ScienceSignaling have determined how structural changes in molecules called transfer RNAs accompany behavioral habituation, an elemental form of learning. https://scim.ag/4BqCHFD
Neuronal tRNA modifications in Aplysia californica are repatterned during behavioral habituation
Synaptic plasticity in Aplysia is accompanied by dynamic modification of neuronal tRNAs.
scim.ag
October 28, 2026 at 4:25 PM
By studying sea slugs in the lab, researchers in #ScienceSignaling have determined how structural changes in molecules called transfer RNAs accompany behavioral habituation, an elemental form of learning. https://scim.ag/4BqCHFD
The new issue of #ScienceSignaling has arrived!
The humble sea slug reveals how transfer RNAs become modified during behavioral habituation and learning, new work shows how a mutant form of STAT3 causes a genetically dominant immunodeficiency, and more. https://scim.ag/4ily0Eo
The humble sea slug reveals how transfer RNAs become modified during behavioral habituation and learning, new work shows how a mutant form of STAT3 causes a genetically dominant immunodeficiency, and more. https://scim.ag/4ily0Eo
October 27, 2026 at 9:00 PM
The new issue of #ScienceSignaling has arrived!
The humble sea slug reveals how transfer RNAs become modified during behavioral habituation and learning, new work shows how a mutant form of STAT3 causes a genetically dominant immunodeficiency, and more. https://scim.ag/4ily0Eo
The humble sea slug reveals how transfer RNAs become modified during behavioral habituation and learning, new work shows how a mutant form of STAT3 causes a genetically dominant immunodeficiency, and more. https://scim.ag/4ily0Eo
A new slate of optogenetic tools enables scientists to finely control G protein signaling in excitable cells—providing a flexible method that might also be used therapeutically for disorders that disrupt the excitability of cells. #ScienceSignaling https://scim.ag/4z2tPV2
Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression
Optogenetically coupling GIRK channel activation to an opsin switches G protein signaling.
scim.ag
October 23, 2026 at 3:00 PM
A new slate of optogenetic tools enables scientists to finely control G protein signaling in excitable cells—providing a flexible method that might also be used therapeutically for disorders that disrupt the excitability of cells. #ScienceSignaling https://scim.ag/4z2tPV2
Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment. #ScienceSignaling https://scim.ag/4jxuatU
A PRMT5-ANGPTL4 axis in brain endothelial cells regulates cerebellar inhibitory synaptogenesis and motor coordination
Vascular PRMT5 restricts inhibitory input to the cerebellum to support fine motor coordination.
scim.ag
October 22, 2026 at 4:30 PM
Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment. #ScienceSignaling https://scim.ag/4jxuatU
New work involving mice and patient cells reveals the mechanisms behind how neutrophils drive a rare group of autoinflammatory disorders called CAPS—and uncovers a potential new therapeutic target. #ScienceSignaling https://scim.ag/4zCDwcO
Clusters of GSDMD and GSDME mediate neutrophil pyroptosis in cryopyrin-associated periodic syndrome
Gasdermins D and E cooperatively promote pyroptosis in a neutrophil-driven autoinflammation syndrome.
scim.ag
October 21, 2026 at 10:32 PM
New work involving mice and patient cells reveals the mechanisms behind how neutrophils drive a rare group of autoinflammatory disorders called CAPS—and uncovers a potential new therapeutic target. #ScienceSignaling https://scim.ag/4zCDwcO
Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment.
See more in #ScienceSignaling: scim.ag/4BmvHcU
See more in #ScienceSignaling: scim.ag/4BmvHcU
A PRMT5-ANGPTL4 axis in brain endothelial cells regulates cerebellar inhibitory synaptogenesis and motor coordination
Vascular PRMT5 restricts inhibitory input to the cerebellum to support fine motor coordination.
scim.ag
October 22, 2026 at 2:38 PM
Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment.
See more in #ScienceSignaling: scim.ag/4BmvHcU
See more in #ScienceSignaling: scim.ag/4BmvHcU
Scientists uncover a surprising connection between the brain’s maze of blood vessels and fine motor control in the cerebellum, new tools provide scientists with an optogenetic means to control G protein signaling, and more this week in #ScienceSignaling. https://scim.ag/4jQ6Mbp
October 20, 2026 at 9:00 PM
Scientists uncover a surprising connection between the brain’s maze of blood vessels and fine motor control in the cerebellum, new tools provide scientists with an optogenetic means to control G protein signaling, and more this week in #ScienceSignaling. https://scim.ag/4jQ6Mbp
This week in #ScienceSignaling, scientists show that intracellular changes to receptor conformation alter how activating molecules bind to a biologically important GPCR from outside the cell through an “inside out” mechanism. https://scim.ag/3TXDs8e
Inside-out allosteric regulation of ligand binding and activation of the atypical chemokine receptor ACKR3
The effect of chemokines on ACKR3 is altered by the equilibrium between active and inactive receptor states.
scim.ag
October 19, 2026 at 3:00 PM
This week in #ScienceSignaling, scientists show that intracellular changes to receptor conformation alter how activating molecules bind to a biologically important GPCR from outside the cell through an “inside out” mechanism. https://scim.ag/3TXDs8e
This week’s new issue of #ScienceSignaling has arrived!
Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more. https://scim.ag/4ijhKon
Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more. https://scim.ag/4ijhKon
October 13, 2026 at 9:00 PM
This week’s new issue of #ScienceSignaling has arrived!
Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more. https://scim.ag/4ijhKon
Researchers discover how the inflammatory death of neutrophils drives a rare group of autoinflammatory disorders, a new study uncovers an “inside out” regulatory mechanism for a GPCR, and more. https://scim.ag/4ijhKon
Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. #ScienceSignaling https://scim.ag/4zj9pqt
The Gα-interacting protein RGS4 in dorsal root ganglia maintains molecular and behavioral maladaptations in murine pain models
A G protein regulator weakens inhibitory signaling after nerve injury.
scim.ag
October 9, 2026 at 3:00 PM
Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. #ScienceSignaling https://scim.ag/4zj9pqt
A preclinical #ScienceSignaling analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to oxphos curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions. https://scim.ag/4yzeCub
Metabolic reprogramming of pathogenic CD4+ T helper cells attenuates inflammatory bowel disease in mice
The kinase GSK3β drives the metabolism supporting the inflammatory function of pathogenic TH1 cells.
scim.ag
October 7, 2026 at 3:00 PM
A preclinical #ScienceSignaling analysis of T helper 1 cells shows that shifting their metabolism from glycolysis to oxphos curtails their role in inflammatory bowel disease and identifies a potential therapeutic target for these conditions. https://scim.ag/4yzeCub
Scientists target a G protein regulator to combat neuropathic pain, a study in mice shows how metabolically reprograming disease-linked T cells can calm inflammation in inflammatory bowel disease, and more in the new issue of #ScienceSignaling. https://scim.ag/4AS62bx
October 6, 2026 at 9:00 PM
Scientists target a G protein regulator to combat neuropathic pain, a study in mice shows how metabolically reprograming disease-linked T cells can calm inflammation in inflammatory bowel disease, and more in the new issue of #ScienceSignaling. https://scim.ag/4AS62bx
Researchers have constructed a map of how light remodels patterns in a process called phosphorylation in the eye of the fruit fly, illuminating the core #biochemistry that enables these flies to adapt to oscillating light and dim conditions. #ScienceSignaling https://scim.ag/4jmYN5a
Light-induced remodeling of the Drosophila phosphoproteome regulates visual adaptation through the Trp channel
A phosphorylation site in Trp is identified that enables Drosophila to respond to oscillating light.
scim.ag
October 2, 2026 at 3:00 PM
Researchers have constructed a map of how light remodels patterns in a process called phosphorylation in the eye of the fruit fly, illuminating the core #biochemistry that enables these flies to adapt to oscillating light and dim conditions. #ScienceSignaling https://scim.ag/4jmYN5a
A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology. https://scim.ag/4dCF2ms
S1P mimics phosphorylation to mediate PDK1-independent activation of aPKC with an opposing downstream effect
A bioactive lipid activates aPKC like phosphorylation does but switches the effect of aPKC on apoptosis.
scim.ag
September 30, 2026 at 3:00 PM
A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology. https://scim.ag/4dCF2ms
A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling.
scim.ag/4xTKRTQ
scim.ag/4xTKRTQ
Contents | Science Signaling 19, 957
scim.ag
September 30, 2026 at 4:47 PM
A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling.
scim.ag/4xTKRTQ
scim.ag/4xTKRTQ
A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology.
Learn more: scim.ag/3Vjodqq
Learn more: scim.ag/3Vjodqq
S1P mimics phosphorylation to mediate PDK1-independent activation of aPKC with an opposing downstream effect
A bioactive lipid activates aPKC like phosphorylation does but switches the effect of aPKC on apoptosis.
scim.ag
September 30, 2026 at 4:47 PM
A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology.
Learn more: scim.ag/3Vjodqq
Learn more: scim.ag/3Vjodqq
A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling. https://scim.ag/3VdwiwU
September 29, 2026 at 9:00 PM
A biochemical deep dive deciphers how the same enzyme has contrasting effects on cancer growth, researchers build a global map of how light remodels phosphorylation in the eye of the fruit fly, and more in the new issue of #ScienceSignaling. https://scim.ag/3VdwiwU
New results in #ScienceSignaling reveal that the T cell adaptor protein PAG supports the function of #TCell immune synapses by connecting with actin, suggesting that it could offer a target to improve #immunotherapy in patients that show poor responses. https://scim.ag/3V1ilCa
PAG supports T cell immune synapse function by binding to actin
A plasma membrane adaptor protein supports cytotoxic T cell function by connecting with the actin network.
scim.ag
September 25, 2026 at 3:00 PM
New results in #ScienceSignaling reveal that the T cell adaptor protein PAG supports the function of #TCell immune synapses by connecting with actin, suggesting that it could offer a target to improve #immunotherapy in patients that show poor responses. https://scim.ag/3V1ilCa