#Senescence🦴
#Senescence🦴

p21Cip1- versus p16Ink4a-mediated senescence in radiation-induced #Osteoporosis

Ablating p21+ cells partially rescues
#BoneMineralDensity
#MineralAppositionRate
Trabecular architecture
#BoneMarrowAdiposity
in irradiated🐭🦴

#AgingCell 2022
onlinelibrary.wiley.com/doi/10.1111/...
October 9, 2025 at 7:07 PM
🦴 Back pain often comes from worn-out discs in your spine.

Scientists found that a protein called PDGF can help slow down the ageing of these disc cells. This could lead to new treatments that stop back pain before it gets worse.
🔗
Targeting cellular senescence for better disc health
The growth factor PDGF can halt cell ageing in intervertebral disc cells and may, in the future, be used to help stop the progression of degenerative disc disease.
buff.ly
July 17, 2025 at 1:44 PM
🦴 New research sheds light on how the protein CHMP5 helps regulate bone formation by influencing cellular senescence via the endolysosomal-mitochondrial pathway. Could this be a target for age-related skeletal disorders?
buff.ly/ATVeWMw
July 1, 2025 at 3:11 PM