A love story of misunderstandings and obsessive love between a husband who can't forget his dead wife and his reincarnated wife

にくけっと17にて頒布した花火と男主人公のイチャイチャ肥満化本です。 主人公に構って欲しい花火が自己肥育して、次第に食欲が抑えられなくなり...といった話になっています。 本編モノクロで27ページ、表紙など込みで全32Pとなります。 注意点として、スタレVer.4.0までのネタバレを含みます。

The cardiac conduction system (CCS) develops asymmetrically along the body axes. In heterotaxy syndrome — resulting from aberrant left-right axis formation — atrial and atrioventricular conduction defects can cause life-threatening arrhythmias. However, the developmental mechanisms regulating the atrioventricular conduction system (AVCS) disposition and integrity remain unclear. To investigate the etiology of AVCS malformations in laterality defects, we analyzed CCS development and function in mouse mutants for Cryptic and Lefty1, which are key regulators of Pitx2 in the left-right axis formation. Cryptic–/– embryos exhibited bilateral sinoatrial nodes and an ectopic anterior AV node and bundle accompanied by reduced Pitx2 expression. In contrast, Lefty1–/– embryos showed a hypoplastic sinoatrial node and AV node–bundle dissociation with ectopic Pitx2 expression. Single-cell transcriptomic analysis of Pitx2–/– hearts revealed expansion of AV node and bundle populations, consistent with a repressive role of Pitx2 in AVCS specification. Genetic lineage tracing indicated that Pitx2-expressing cells from the left lateral plate mesoderm populate cranioventral cardiac regions, where AVCS development is suppressed. Together, these findings clarify how global left-right axis information is locally integrated to shape AVCS disposition and integrity, providing a mechanistic model for AVCS abnormalities in laterality-associated congenital heart disease.

YouTube video by 汐瀬ゐを - Shiose Iwo

基本的にはゲームしたり適当に雑談してみたり、たまに歌ったりなんかして活動していく予定。 気を使わず楽しめたら何でもオールオッケー精神。 もし気に入ってもらえたらチャンネル登録してもらえると泣いて喜ぶ！