#SimCells
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pnas.org
Researchers engineered nonreplicating “SimCells” that selectively bind to and inject toxic proteins into multidrug-resistant bacteria. SimCells can also convert aspirin into hydrogen peroxide, killing more than 97% of target bacteria. In PNAS: https://ow.ly/gsnn50YySHq
Design of the SimCell and mini-SimCell platform for treating bacterial antimicrobial resistance. Surface-displayed nanobodies are engineered to the outer membrane of SimCell and mini-SimCell using a modular surface display system to enable antigen recognition and selective binding to target pathogens.
March 26, 2026 at 4:01 PM
microbiotech.bsky.social
#MicroSky: ONE HEALTH: Fighting COVID-19 with engineered bacteria! SimCells & mini-SimCells displaying nanobodies effectively neutralize SARS-CoV-2 & its variants, offering a novel virus-blocking strategy. A promising step for future pandemic preparedness! doi.org/10.1111/1751...
April 3, 2025 at 11:01 AM
hamatsa50.bsky.social
This is impressive 🧪🧫 work both conceptually and technologically

Reprogrammed SimCells for antimicrobial therapy
www.pnas.org/doi/10.1073/...
April 2, 2026 at 1:30 PM
johnshirley2024.bsky.social
Sometimes there is good news.
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and anti...
phys.org
March 31, 2026 at 6:18 PM
sciencex.bsky.social
Engineered SimCells and mini-SimCells have demonstrated the ability to selectively target and eliminate multidrug-resistant bacteria, offering a modular approach to combating antimicrobial resistance. doi.org/hbvgs2
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work.
phys.org
March 31, 2026 at 6:00 PM
oxengsci.bsky.social
🧬 SimCells are engineered to destroy AMR bacteria without harming the microbiome. DPhil student Yun Dong’s work at Oxford, in Professor Wei Huang's lab, offers a smart, antibiotic-free solution - paving the way for future precision medicine.

🔗 #WorldMicrobiomeDay #AMR #OxfordEngineering
A scientific illustration showing the targeted action of engineered SimCells on harmful gut bacteria. On the left, a diagram of the human intestine highlights different microbial populations. A red target symbol focuses on a specific group of harmful pathogens. To the right, a sequence of annotated diagrams shows the construction of SimCells and Mini-SimCells, which are genome-free bacterial cells designed to selectively bind and destroy these pathogens. A photo of Yun Dong, a DPhil student in Professor Wei Huang’s group, appears in the top right corner. Caption notes that SimCells eliminate pathogens without disrupting the wider microbiome. Figure generated by BioRender.
June 27, 2025 at 10:48 AM
vivekmutalik.bsky.social
www.pnas.org/doi/full/10....

#microsky
Reprogrammed SimCells for antimicrobial therapy | PNAS
Antimicrobial resistance (AMR) is a critical global health challenge. In this study, we developed a platform based on chromosome-free and nonreplic...
www.pnas.org
March 31, 2026 at 3:59 PM
ibbtec.bsky.social
SEMINARS AT THE IBBTEC:
Professor Wei Huang (University of Oxford)
>> SYNTHETIC CELLS TO TREAT ANTIMICROBIAL-RESISTANT PATHOGENS AND CANCER
Tuesday, September 22
12 h
IBBTEC - PCTCAN - Santander

#IBBTEC #Seminar #AMR #SimCells #syntheticBiology
September 18, 2026 at 9:26 AM
servelan.newsie.social.ap.brid.gy
SimCells successfully target and kill drug-resistant bacteria

https://phys.org/news/2026-03-simcells-successfully-drug-resistant-bacteria.html
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and antimicrobial resistance (AMR) are a huge global health problem. So what do you do when your medicines are ineffective? The answer for some researchers is to build their own biological weapons. A team including experts from the University of Oxford in the UK has developed a way to create specialized cells that hunt down and kill drug-resistant germs.
phys.org
March 31, 2026 at 7:26 PM
kenneth-hansen.bsky.social
phys.org/news/2026-03...
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and anti...
phys.org
April 1, 2026 at 3:38 PM
falkenbeer.bsky.social
This is SO cool. Buttom up #SynBio in your favorite organism by taking the host genome out of the equation. Can't wait to see what kinds of crazy things people use #SimCells to in the future
https://www.pnas.org/content/early/2020/03/02/1918859117
April 14, 2025 at 10:45 AM
biorxiv-synthbio.bsky.social
Reprogrammed SimCells for Antimicrobial Therapy https://www.biorxiv.org/content/10.1101/2025.11.15.688600v1
November 16, 2025 at 3:02 AM
nachoquique.bsky.social
🇦🇷🔬 células zombis para la biología sintética www.pnas.org/doi/10.1073/...
Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology | PNAS
A type of chromosome-free cell called SimCells (simple cells) has been generated from Escherichia coli, Pseudomonas putida, and Ralstonia eutropha....
www.pnas.org
November 18, 2024 at 10:30 PM
microbesinfo.bsky.social
SimCells successfully target and kill #drug-resistant #bacteria ...

| #DrugResistance | #MicroSky | #antibiotics | #Superbugs | #AMR | Via @sciencex.bsky.social

phys.org/news/2026-03...
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and…
phys.org
April 2, 2026 at 1:04 PM
biorxivpreprint.bsky.social
Reprogrammed SimCells for Antimicrobial Therapy https://www.biorxiv.org/content/10.1101/2025.11.15.688600v1
November 16, 2025 at 3:02 AM
l2plabs.bsky.social
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and antimicrobial resistance (AMR) are a huge global health problem. So what do you do when your medicines are ineffective? The answer for some researchers is to build their own biological weapons. A team including experts from the University of Oxford in the UK has developed a way to create specialized cells that hunt down and kill drug-resistant germs.
dlvr.it
March 31, 2026 at 6:03 PM
thecakeisnotalie.bsky.social
phys.org/news/2026-03...
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and anti...
phys.org
April 5, 2026 at 7:20 AM
nealasher.bsky.social
phys.org/news/2026-03...
SimCells successfully target and kill drug-resistant bacteria
We are continually in an evolutionary arms race with bacteria. As we develop new antibiotics, they develop resistance, and so it goes on until some of our treatments no longer work. Superbugs and anti...
phys.org
April 1, 2026 at 4:50 AM