Background: HIV pre-exposure prophylaxis (PrEP) is underused by cis- and transgender women despite a significant HIV burden. Smartphone technologies are promising tools to support HIV prevention but have yet to be assessed in women. Objective: We conducted a 12-month feasibility study to assess the use and acceptability of a mobile phone app, SmartPrEP, designed to support PrEP adherence and HIV self- and partner-testing among women living in an area of elevated HIV burden in New York City. Methods: Nonpregnant adult cisgender and transgender women who met US PrEP eligibility criteria and...

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