What could you do with a Research Infrastructure award from the Massachusetts Life Sciences Center? 🤔 Earlier this year, Brandeis expanded their Light Microscopy Core Facility with a SmartSPIM light sheet microscope and SmartBatch+ active tissue processing system. @microscopyed.bsky.social
October 23, 2026 at 1:50 PM
What could you do with a Research Infrastructure award from the Massachusetts Life Sciences Center? 🤔 Earlier this year, Brandeis expanded their Light Microscopy Core Facility with a SmartSPIM light sheet microscope and SmartBatch+ active tissue processing system. @microscopyed.bsky.social
How does the cortex help regulate sleep & wakefulness? Researchers have ID'ed a sparse population of inhibitory neurons with unusually long axons, shown in this SmartSPIM video, which increase synchronization across multiple neocortical regions & promote sleep: bit.ly/47TH91Y #FluorescenceFriday
October 16, 2026 at 2:48 PM
How does the cortex help regulate sleep & wakefulness? Researchers have ID'ed a sparse population of inhibitory neurons with unusually long axons, shown in this SmartSPIM video, which increase synchronization across multiple neocortical regions & promote sleep: bit.ly/47TH91Y #FluorescenceFriday
This #FluorescenceFriday video from Dr. Kentaro Ishii shows mu-opioid receptor expressing cells (red) and c-FOS signal (green) in a mouse brain after exposure to acute morphine. Learn more about the science behind this SmartSPIM light sheet data in our upcoming webinar with Dr. Ishii: bit.ly/4ri944r
October 2, 2026 at 1:23 PM
This #FluorescenceFriday video from Dr. Kentaro Ishii shows mu-opioid receptor expressing cells (red) and c-FOS signal (green) in a mouse brain after exposure to acute morphine. Learn more about the science behind this SmartSPIM light sheet data in our upcoming webinar with Dr. Ishii: bit.ly/4ri944r
#SmartSPIM light sheet microscopy is coming to Barcelona! We can't wait to show you how easy it is to capture hi-res 3D data throughout your entire sample, like this intact mouse brain and spinal cord, mouse duodenum, and rat heart. #FluorescenceFriday @spaommeeting.bsky.social
September 25, 2026 at 1:48 PM
#SmartSPIM light sheet microscopy is coming to Barcelona! We can't wait to show you how easy it is to capture hi-res 3D data throughout your entire sample, like this intact mouse brain and spinal cord, mouse duodenum, and rat heart. #FluorescenceFriday @spaommeeting.bsky.social
They used a LifeCanvas tissue processing and #SmartSPIM imaging pipeline to map whole-brain distribution and projections of noradrenaline neurons in the locus coeruleus, a brain region that supplies this neurotransmitter to most of the CNS. (3/5)
September 18, 2026 at 6:11 PM
They used a LifeCanvas tissue processing and #SmartSPIM imaging pipeline to map whole-brain distribution and projections of noradrenaline neurons in the locus coeruleus, a brain region that supplies this neurotransmitter to most of the CNS. (3/5)
We're kicking off a new webinar series with Dr. Ken Ishii from the Stuber lab at the UWash NAPE Center! Join us 11/5 to learn how Dr. Ishii used LifeCanvas tools to create the first cellular-resolution whole-brain atlas of opioid administration and withdrawal states: bit.ly/4ri944r #SmartSPIM
September 17, 2026 at 1:33 PM
We're kicking off a new webinar series with Dr. Ken Ishii from the Stuber lab at the UWash NAPE Center! Join us 11/5 to learn how Dr. Ishii used LifeCanvas tools to create the first cellular-resolution whole-brain atlas of opioid administration and withdrawal states: bit.ly/4ri944r #SmartSPIM
0:20-0:35 - Mouse lumbar spinal cord imaged with SmartSPIM by Dr. Andrew Crowther (Virginia Commonwealth University).
0:36-0:48 - Mouse brains at different developmental stages, imaged with SmartSPIM by @ingvildeb.bsky.social (Penn State College of Medicine). @yongsookimlab.bsky.social (3/3)
0:36-0:48 - Mouse brains at different developmental stages, imaged with SmartSPIM by @ingvildeb.bsky.social (Penn State College of Medicine). @yongsookimlab.bsky.social (3/3)
September 11, 2026 at 2:32 PM
0:20-0:35 - Mouse lumbar spinal cord imaged with SmartSPIM by Dr. Andrew Crowther (Virginia Commonwealth University).
0:36-0:48 - Mouse brains at different developmental stages, imaged with SmartSPIM by @ingvildeb.bsky.social (Penn State College of Medicine). @yongsookimlab.bsky.social (3/3)
0:36-0:48 - Mouse brains at different developmental stages, imaged with SmartSPIM by @ingvildeb.bsky.social (Penn State College of Medicine). @yongsookimlab.bsky.social (3/3)
0:00-0:19 - Mouse bladder imaged with SmartSPIM by
Dr. Zhen Wang (Brian S. Kim's lab, Icahn School of Medicine at Mount Sinai). Read Dr. Wang's latest preprint on interorgan neuroimmune circuitry: researchsquare.com/article/rs-6...
(2/3)
Dr. Zhen Wang (Brian S. Kim's lab, Icahn School of Medicine at Mount Sinai). Read Dr. Wang's latest preprint on interorgan neuroimmune circuitry: researchsquare.com/article/rs-6...
(2/3)
An interorgan neuroimmune circuit promotes visceral hypersensitivity
Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis...
researchsquare.com
September 11, 2026 at 2:29 PM
0:00-0:19 - Mouse bladder imaged with SmartSPIM by
Dr. Zhen Wang (Brian S. Kim's lab, Icahn School of Medicine at Mount Sinai). Read Dr. Wang's latest preprint on interorgan neuroimmune circuitry: researchsquare.com/article/rs-6...
(2/3)
Dr. Zhen Wang (Brian S. Kim's lab, Icahn School of Medicine at Mount Sinai). Read Dr. Wang's latest preprint on interorgan neuroimmune circuitry: researchsquare.com/article/rs-6...
(2/3)
For #WorldAlzheimersMonth, we’re highlighting a breakthrough 2026 study that shows the power of tissue clearing and SmartSPIM light sheet microscopy to improve preclinical models: www.nature.com/articles/s41...
@davidashbrook.bsky.social
@davidashbrook.bsky.social
September 4, 2026 at 5:06 PM
For #WorldAlzheimersMonth, we’re highlighting a breakthrough 2026 study that shows the power of tissue clearing and SmartSPIM light sheet microscopy to improve preclinical models: www.nature.com/articles/s41...
@davidashbrook.bsky.social
@davidashbrook.bsky.social
How does the brain control limb movement? In a new paper, Julia Kaiser et al. investigate the development of different populations of neurons that project to the brain stem and spinal cord, seen in this SmartSPIM video. Read the open access study: bit.ly/4y5YIH9 #FluorescenceFriday
August 28, 2026 at 1:36 PM
How does the brain control limb movement? In a new paper, Julia Kaiser et al. investigate the development of different populations of neurons that project to the brain stem and spinal cord, seen in this SmartSPIM video. Read the open access study: bit.ly/4y5YIH9 #FluorescenceFriday
🧪 At LM IMG, we offer top-tier systems & expert support, including:
🔹 FCS, STED Xtend, Navigator + AIVIA (Leica Stellaris 8)
🔹 Evident SpinSR & scanR AI modules
🔹 LifeCanvas SmartSPIM + SmartBatch+ for whole-organism clearing & imaging
🔹 FCS, STED Xtend, Navigator + AIVIA (Leica Stellaris 8)
🔹 Evident SpinSR & scanR AI modules
🔹 LifeCanvas SmartSPIM + SmartBatch+ for whole-organism clearing & imaging
March 26, 2025 at 9:33 AM
🧪 At LM IMG, we offer top-tier systems & expert support, including:
🔹 FCS, STED Xtend, Navigator + AIVIA (Leica Stellaris 8)
🔹 Evident SpinSR & scanR AI modules
🔹 LifeCanvas SmartSPIM + SmartBatch+ for whole-organism clearing & imaging
🔹 FCS, STED Xtend, Navigator + AIVIA (Leica Stellaris 8)
🔹 Evident SpinSR & scanR AI modules
🔹 LifeCanvas SmartSPIM + SmartBatch+ for whole-organism clearing & imaging
Up in Acadia at the @mdibiolab.bsky.social for #LSFM25! Here's a cleared whole mouse head on the SmartSPIM, 3.6X objective for #3DThursday.
🔎 @jtakatoh.bsky.social, now at @stonybrooku.bsky.social
🔬 LifeCanvas Technologies, lifecanvastech.com/products/sma...
🥽 syGlass.io
@lsfm-na.bsky.social
🔎 @jtakatoh.bsky.social, now at @stonybrooku.bsky.social
🔬 LifeCanvas Technologies, lifecanvastech.com/products/sma...
🥽 syGlass.io
@lsfm-na.bsky.social
June 5, 2025 at 12:54 PM
Up in Acadia at the @mdibiolab.bsky.social for #LSFM25! Here's a cleared whole mouse head on the SmartSPIM, 3.6X objective for #3DThursday.
🔎 @jtakatoh.bsky.social, now at @stonybrooku.bsky.social
🔬 LifeCanvas Technologies, lifecanvastech.com/products/sma...
🥽 syGlass.io
@lsfm-na.bsky.social
🔎 @jtakatoh.bsky.social, now at @stonybrooku.bsky.social
🔬 LifeCanvas Technologies, lifecanvastech.com/products/sma...
🥽 syGlass.io
@lsfm-na.bsky.social
Hi Julia! My lab uses the smartSPIM from Life Canvas Technologies (Boston, Massachusetts) for imaging. This was cleared using their SMARTBATCH+
January 18, 2025 at 4:33 PM
Hi Julia! My lab uses the smartSPIM from Life Canvas Technologies (Boston, Massachusetts) for imaging. This was cleared using their SMARTBATCH+
Lightsheet microscopy is unparalleled in its ability to resolve whole circuits in the mouse brain. Michelle Bedebaugh let me image one of her Rabies MC3R Cre samples with the 15X objective on my smartSPIM and we are very happy with the results. 🧪
December 4, 2024 at 2:02 AM
Lightsheet microscopy is unparalleled in its ability to resolve whole circuits in the mouse brain. Michelle Bedebaugh let me image one of her Rabies MC3R Cre samples with the 15X objective on my smartSPIM and we are very happy with the results. 🧪
Sorry for the lack of details. This was taken on a Life Canvas smartSPIM with a 4x objective and a rolling shutter. The sample is a transgenic mouse whose details I don’t have with me now.
November 21, 2024 at 2:30 PM
Sorry for the lack of details. This was taken on a Life Canvas smartSPIM with a 4x objective and a rolling shutter. The sample is a transgenic mouse whose details I don’t have with me now.
This was labeled using Life Canvas’ new RADIANT SMARTBATCH+ devices and imaged on a modified smartSPIM at 4x and 15X.
November 20, 2024 at 2:32 PM
This was labeled using Life Canvas’ new RADIANT SMARTBATCH+ devices and imaged on a modified smartSPIM at 4x and 15X.
#MicroscopyMonday Axons and apical dendrites go in CA1 of mouse Hippocampus. Raw image was acquired w\ a LifeCanvas SmartSPIM light-sheet 🔬 and deconvolved and depth-colored in 3D.
Thanks Matthias Klumpp, @uniheidelberg.bsky.social for joining the previous Image Contest!
Join: svi.nl/ImageContest
Thanks Matthias Klumpp, @uniheidelberg.bsky.social for joining the previous Image Contest!
Join: svi.nl/ImageContest
November 24, 2025 at 10:47 AM
#MicroscopyMonday Axons and apical dendrites go in CA1 of mouse Hippocampus. Raw image was acquired w\ a LifeCanvas SmartSPIM light-sheet 🔬 and deconvolved and depth-colored in 3D.
Thanks Matthias Klumpp, @uniheidelberg.bsky.social for joining the previous Image Contest!
Join: svi.nl/ImageContest
Thanks Matthias Klumpp, @uniheidelberg.bsky.social for joining the previous Image Contest!
Join: svi.nl/ImageContest
Clip from her talk: AAVretro-ArgiNLS-DIO-oScarlet in red, AAV-ArgiNLS-GFP in green (both in the NAc) of a vlgut2-Cre transgenic. Imaged at 1.6x with a SmartSPIM LSFM. Rendered with Arivis.
This is the native (non stained) signal following SHIELD clearing.
Constructs at www.addgene.org/Sam_Golden/
This is the native (non stained) signal following SHIELD clearing.
Constructs at www.addgene.org/Sam_Golden/
December 12, 2024 at 11:49 PM
Clip from her talk: AAVretro-ArgiNLS-DIO-oScarlet in red, AAV-ArgiNLS-GFP in green (both in the NAc) of a vlgut2-Cre transgenic. Imaged at 1.6x with a SmartSPIM LSFM. Rendered with Arivis.
This is the native (non stained) signal following SHIELD clearing.
Constructs at www.addgene.org/Sam_Golden/
This is the native (non stained) signal following SHIELD clearing.
Constructs at www.addgene.org/Sam_Golden/
#flourescent(almost)friday
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
December 5, 2024 at 6:50 PM
#flourescent(almost)friday
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
First data set collected at #Sample2Image #EMBO by @lifecanvastech.bsky.social SmartSPIM team rocking Oeiras PT
July 5, 2026 at 10:38 AM
First data set collected at #Sample2Image #EMBO by @lifecanvastech.bsky.social SmartSPIM team rocking Oeiras PT
I cleared this brain last year with the @lifecanvastech.bsky.social SmartBatch and imaged with their SmartSPIM and I am pretty proud of it. As a computational guy, I was low key shocked that it came out as well as it did on the first try bc I forgot how to pipette
January 29, 2026 at 5:20 PM
I cleared this brain last year with the @lifecanvastech.bsky.social SmartBatch and imaged with their SmartSPIM and I am pretty proud of it. As a computational guy, I was low key shocked that it came out as well as it did on the first try bc I forgot how to pipette
aind-smartspim-operator-utils 0.0.3
Generated from aind-library-template
Author: Allen Institute for Neural Dynamics
Generated from aind-library-template
Author: Allen Institute for Neural Dynamics
August 21, 2025 at 2:00 AM
aind-smartspim-operator-utils 0.0.3
Generated from aind-library-template
Author: Allen Institute for Neural Dynamics
Generated from aind-library-template
Author: Allen Institute for Neural Dynamics
How did vertebrates evolve kidneys? Pascal Schmidt et al. used #SmartSPIM light sheet microscopy to visualize kidney development in the catshark by mapping expression of the early pronephric marker gene PAX2, revealing a somitic origin: www.science.org/doi/full/10....
Unraveling the origin of the vertebrate kidney: Emergence from a somitic compartment
The pronephros evolves from a somitic compartment in early vertebrates.
www.science.org
July 8, 2026 at 2:39 PM
How did vertebrates evolve kidneys? Pascal Schmidt et al. used #SmartSPIM light sheet microscopy to visualize kidney development in the catshark by mapping expression of the early pronephric marker gene PAX2, revealing a somitic origin: www.science.org/doi/full/10....
📽️ SYFP2 expression data from Dr. Tanya Daigle & Emily Kussick, imaged with #SmartSPIM!
Spinal motor neurons in dazzling detail. ✨🧠
Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of spinal cord neurons. In diseases like #ALS, they are selectively damaged, making them of special interest to neuroscientists.
🔗 https://bit.ly/4anj19z
#SciShots
Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of spinal cord neurons. In diseases like #ALS, they are selectively damaged, making them of special interest to neuroscientists.
🔗 https://bit.ly/4anj19z
#SciShots
June 11, 2026 at 8:48 PM
📽️ SYFP2 expression data from Dr. Tanya Daigle & Emily Kussick, imaged with #SmartSPIM!
Yehui Sun & Yu-Chung Pien et al. screened LNPs using human iPSC-derived cardiomyocytes, then used Clear+ tissue clearing with #SmartSPIM lightsheet microscopy to characterize biodistribution of their lead candidate throughout the whole mouse heart. (2/3)
June 5, 2026 at 1:53 PM
Yehui Sun & Yu-Chung Pien et al. screened LNPs using human iPSC-derived cardiomyocytes, then used Clear+ tissue clearing with #SmartSPIM lightsheet microscopy to characterize biodistribution of their lead candidate throughout the whole mouse heart. (2/3)