#SpliceSwitching
Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids
Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages
Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.
academic.oup.com
November 29, 2025 at 8:37 PM
🎉🎉 Congrats! 🥳

If you're interested in unveiling the NATURA way, you can find the plasmids here: www.addgene.org/browse/artic...
February 6, 2025 at 7:45 PM