Staphylococcus aureus is a major human pathogen causing extensive morbidity and mortality. In vitro and animal studies show that S aureus can invade and survive within host cells. Such intracellular r...

We describe FibriLysins, dual-action proteins that dismantle the fibrin structures encapsulating Staphylococcus aureus multicellular communities and kill the bacteria within. In a mouse model of devic...

Nature Microbiology, Published online: 30 October 2026; doi:10.1038/s41564-026-02512-2We describe FibriLysins, dual-action proteins that dismantle the fibrin structures encapsulating Staphylococcus aureus multicellular communities and kill the bacteria within. In a mouse model of device-associated infection, FibriLysins demonstrate higher antibacterial efficacy compared with the standard-of-care antibiotic vancomycin. These findings highlight the potential of FibriLysins to treat recalcitrant S. aureus infections.

Engineered FibriLysins dismantle fibrin-encapsulated Staphylococcus aureus communities and outperform vancomycin in a preclinical model of fracture-related infection.

Bullous impetigo is a superficial Staphylococcus aureus skin infection that predominantly affects young children and is rarely reported in a disseminated form in immunocompetent adults. We present an ...

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Using single-molecule physics and biochemical assays, Shaw, Hughes-Games and Torres Montaguth et al. reveal how the bacterial defense enzyme SauUSI repeatedly scans and makes multiple DNA breaks, efficiently fragmenting invading genetic material.