CADASIL 3D Vessel-on-Chip models the effects of NOTCH3 R182C on Vasculopathy
AIM Biotech with primary or hiPSC-derived Smooth Muscle Cells

⏫SMC arborization surrounding endothelial tubes
⏫SMC NOTCH3-ECD, PDGFRβ, Contractile proteins, Ca2+ activity

#StemCellRep 2026
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#hiPSC-derived Cardiac #Pericyte

SMAD3 (likely not SMAD2/4, even not TGFβ-dependent SMAD3 phosphorylation) gatekeeps the lineage fate of #hiPSC-#Epicardium

siRNA SMAD3 (+TGFβi)➡️
⏫#Pericyte-like differentiation from hiPSC-Epicardium
Altered Pericrine

#StemCellRep 2024
www.cell.com/stem-cell-re...