Extracting information pan-repositories using structures or substructures have just become possible - see terrific thread by Yasin below.
Where has this molecule been detected before across samples, organisms, body parts, and environments?
With StructureMASST, you can explore this directly by entering a molecule name and running a search in your browser.
🔗 structure-masst.gnps2.org
📄 www.nature.com/articles/s41...
With StructureMASST, you can explore this directly by entering a molecule name and running a search in your browser.
🔗 structure-masst.gnps2.org
📄 www.nature.com/articles/s41...
Streamlit
structure-masst.gnps2.org
April 16, 2026 at 1:41 PM
Extracting information pan-repositories using structures or substructures have just become possible - see terrific thread by Yasin below.
This type of architecture already had a name, known specifically as "High-Tech", a machine aesthetic style that externalizes the mechanical services and substructures of a building.
calling it Anglofuturist Finance belies a conservative wet dream
calling it Anglofuturist Finance belies a conservative wet dream
May 27, 2026 at 6:00 AM
This type of architecture already had a name, known specifically as "High-Tech", a machine aesthetic style that externalizes the mechanical services and substructures of a building.
calling it Anglofuturist Finance belies a conservative wet dream
calling it Anglofuturist Finance belies a conservative wet dream
Nice catch, Bernd! I like the rough texture of the galaxy with all the detailed substructures 👍🧪🔭
NGC 2841 - The Tiger’s Eye Galaxy captured from my patio on five nights in February and March 😊🔭
It was shot on the EdgeHD 8 for a total integration time of 40 hours in LRGB and Ha to reveal the star forming regions.
#Astrophotography
@kat-astro-bot.bsky.social what do you see?
It was shot on the EdgeHD 8 for a total integration time of 40 hours in LRGB and Ha to reveal the star forming regions.
#Astrophotography
@kat-astro-bot.bsky.social what do you see?
March 15, 2026 at 7:06 PM
Nice catch, Bernd! I like the rough texture of the galaxy with all the detailed substructures 👍🧪🔭
We all know what will happen, these will all get handed out to vulture capitalists, who will offload responsibilities to 401K substructures.
When it all inevitably goes under, the vulture capitalists will liquidate everything, and leave the substructures with the bill.
When it all inevitably goes under, the vulture capitalists will liquidate everything, and leave the substructures with the bill.
October 31, 2025 at 7:04 AM
We all know what will happen, these will all get handed out to vulture capitalists, who will offload responsibilities to 401K substructures.
When it all inevitably goes under, the vulture capitalists will liquidate everything, and leave the substructures with the bill.
When it all inevitably goes under, the vulture capitalists will liquidate everything, and leave the substructures with the bill.
20 spectaculaire protoplanetaire schijven die zijn vastgelegd door ALMA 's eerste grote programma, bekend als het Disk Substructures at High Angular Resolution Project (DSHARP).
Releasedatum: 28 januari 2019
Releasedatum: 28 januari 2019
January 25, 2025 at 1:30 PM
20 spectaculaire protoplanetaire schijven die zijn vastgelegd door ALMA 's eerste grote programma, bekend als het Disk Substructures at High Angular Resolution Project (DSHARP).
Releasedatum: 28 januari 2019
Releasedatum: 28 januari 2019
Thanks for the shout out @meera-sundaram.bsky.social ! This was such a fun project! 101 knock-ins and counting and they all had such cool and unique localization pattern and substructures!
Up on biorxiv! The tour de force protein tagging atlas for the #Celegans cuticle #aECM - from Jordan Ward @gotworms.bsky.social and Andrew Chisholm labs. So many beautiful images of cuticle collagen substructures !! www.biorxiv.org/content/10.1...
Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging
Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in viv...
www.biorxiv.org
May 17, 2025 at 2:31 PM
Thanks for the shout out @meera-sundaram.bsky.social ! This was such a fun project! 101 knock-ins and counting and they all had such cool and unique localization pattern and substructures!
"Revolutionary change always involves the complete alteration of the structure of property relations and the institutional substructures that support them. It leads from hierarchy to mass society."
September 22, 2025 at 4:15 AM
"Revolutionary change always involves the complete alteration of the structure of property relations and the institutional substructures that support them. It leads from hierarchy to mass society."
You know DC is actually a swamp, those heavy tanks are going to do a significant amount of damage to the roads and substructures in DC. They'll be repairing it for years.
Not to mention it's an embarrassment, and a threat to our entire nation from the person sitting in its highest office.
Not to mention it's an embarrassment, and a threat to our entire nation from the person sitting in its highest office.
June 11, 2025 at 9:56 PM
You know DC is actually a swamp, those heavy tanks are going to do a significant amount of damage to the roads and substructures in DC. They'll be repairing it for years.
Not to mention it's an embarrassment, and a threat to our entire nation from the person sitting in its highest office.
Not to mention it's an embarrassment, and a threat to our entire nation from the person sitting in its highest office.
blue MAGA and red MAGA are two clusters heavily interwoven into the rest of the network , but weakly with each other . This gives the nodes these substructures the impression that they are enemies , even though they are related cousins .
March 30, 2024 at 5:23 PM
blue MAGA and red MAGA are two clusters heavily interwoven into the rest of the network , but weakly with each other . This gives the nodes these substructures the impression that they are enemies , even though they are related cousins .
#RNA #Virology 🧪
Check out our latest paper! We discovered why inserts in RNA viruses are unstable. RNA viruses have substructures with very specific thermodynamic properties. Hairpin inserts that have the same properties are also stable. So simple yet so profound!
journals.asm.org/doi/10.1128/...
Check out our latest paper! We discovered why inserts in RNA viruses are unstable. RNA viruses have substructures with very specific thermodynamic properties. Hairpin inserts that have the same properties are also stable. So simple yet so profound!
journals.asm.org/doi/10.1128/...
Hairpin inserts in viral genomes are stable when they conform to the thermodynamic properties of viral RNA substructures | Journal of Virology
Plus-strand RNA plant viruses are used as tools to introduce small interfering RNAs
(siRNAs) into laboratory plants to target and silence genes. However, virus-induced
gene silencing (VIGS) vectors en...
journals.asm.org
March 22, 2025 at 11:27 PM
#RNA #Virology 🧪
Check out our latest paper! We discovered why inserts in RNA viruses are unstable. RNA viruses have substructures with very specific thermodynamic properties. Hairpin inserts that have the same properties are also stable. So simple yet so profound!
journals.asm.org/doi/10.1128/...
Check out our latest paper! We discovered why inserts in RNA viruses are unstable. RNA viruses have substructures with very specific thermodynamic properties. Hairpin inserts that have the same properties are also stable. So simple yet so profound!
journals.asm.org/doi/10.1128/...
...other half, a decent amount of that must be substructures (foundations, basements, etc.). From that, am I wrong to conclude that the story of concrete emissions is as much about cars as about buildings? open.spotify.com/episode/6gev...
294: Beyond Operational Carbon: Rethinking Cement, Steel, and Embodied Carbon
Passive House Podcast · Episode
open.spotify.com
July 2, 2026 at 1:05 AM
...other half, a decent amount of that must be substructures (foundations, basements, etc.). From that, am I wrong to conclude that the story of concrete emissions is as much about cars as about buildings? open.spotify.com/episode/6gev...
Dit "Large Program" van ALMA, bekend als Disk Substructures at High Angular Resolution Project (DSHARP), heeft verbluffende, hoge-resolutie beelden opgeleverd van 20 nabijgelegen protoplanetaire schijven.
Een platte wolk van stof en gas die rond een jonge ster draait.
Een platte wolk van stof en gas die rond een jonge ster draait.
March 11, 2025 at 7:55 PM
Dit "Large Program" van ALMA, bekend als Disk Substructures at High Angular Resolution Project (DSHARP), heeft verbluffende, hoge-resolutie beelden opgeleverd van 20 nabijgelegen protoplanetaire schijven.
Een platte wolk van stof en gas die rond een jonge ster draait.
Een platte wolk van stof en gas die rond een jonge ster draait.
DC is swamp land. They’ll need to put in reinforcement substructures to change the slope and then put in the helipad.
Don’t make me come down there. Their contractors should know this.
Don’t make me come down there. Their contractors should know this.
August 4, 2026 at 8:35 PM
DC is swamp land. They’ll need to put in reinforcement substructures to change the slope and then put in the helipad.
Don’t make me come down there. Their contractors should know this.
Don’t make me come down there. Their contractors should know this.
essential thread for understanding the religious substructures of Christian nationalism 🧵🧵🧵
So as a religious person I have 0 issue with actually enforcing the rules on 501c3s, particularly religious ones, and I think we should do it.
But I think describing the base of Christian Nationalist support for Trump as being churches misunderstands how conservative Christianity works.
But I think describing the base of Christian Nationalist support for Trump as being churches misunderstands how conservative Christianity works.
It is time for Democrats to go on the attack, and take away tax-exempt status for every church that unabashedly campaigned for Trump. Take off the gloves, start to destroy the opposing institutions that fund the fascist movement.
April 16, 2025 at 2:10 AM
essential thread for understanding the religious substructures of Christian nationalism 🧵🧵🧵
📢Lisa Hamada and colleagues present TDiMS, a molecular descriptor that summarizes the enumerated pairwise topological distances between molecular substructures, capturing nonlocal interactions. www.nature.com/articles/s43... 🔓 #chemsky
Revisiting molecular descriptors with TDiMS for interpretable intramolecular interactions based on substructure pairs - Nature Computational Science
A descriptor, TDiMS, is developed to summarize the enumerated pairwise topological distances between molecular substructures and identify interpretable molecular features for materials discovery.
www.nature.com
September 21, 2026 at 4:56 PM
📢Lisa Hamada and colleagues present TDiMS, a molecular descriptor that summarizes the enumerated pairwise topological distances between molecular substructures, capturing nonlocal interactions. www.nature.com/articles/s43... 🔓 #chemsky
Deeper Beneath The Finger
There is a strange break between these two levels. We transition from the strange temple/structures of the Reverie Collective to something much older-a set of secret substructures that still have working elevators between them.
dysonlogos.blog/2025/03/14/d...
There is a strange break between these two levels. We transition from the strange temple/structures of the Reverie Collective to something much older-a set of secret substructures that still have working elevators between them.
dysonlogos.blog/2025/03/14/d...
March 14, 2025 at 3:44 PM
Deeper Beneath The Finger
There is a strange break between these two levels. We transition from the strange temple/structures of the Reverie Collective to something much older-a set of secret substructures that still have working elevators between them.
dysonlogos.blog/2025/03/14/d...
There is a strange break between these two levels. We transition from the strange temple/structures of the Reverie Collective to something much older-a set of secret substructures that still have working elevators between them.
dysonlogos.blog/2025/03/14/d...
we face many questions when it comes to planet formation. when do planets form? how do planets form? do planets have a standard evolutionary path? are disk substructures caused by planets? do the planets like me? do they like me so so so so much?
October 25, 2023 at 1:18 PM
we face many questions when it comes to planet formation. when do planets form? how do planets form? do planets have a standard evolutionary path? are disk substructures caused by planets? do the planets like me? do they like me so so so so much?
This might be the best paper on applying sparse autoencoders to protein language models. The authors identify how neural networks trained on amino acid sequences "discover" different features, some specific to individual protein families, other for substructures
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 10, 2025 at 12:15 PM
This might be the best paper on applying sparse autoencoders to protein language models. The authors identify how neural networks trained on amino acid sequences "discover" different features, some specific to individual protein families, other for substructures
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
While my nascent lab group was working toward experimentally determining the structure, I had time to think about what it might look like, I examined known structures of some metalloproteins and discovered some recurring substructures that shared characteristics with zinc finger sequences.
28/41
28/41
November 8, 2025 at 1:58 PM
While my nascent lab group was working toward experimentally determining the structure, I had time to think about what it might look like, I examined known structures of some metalloproteins and discovered some recurring substructures that shared characteristics with zinc finger sequences.
28/41
28/41
Folddisco is now published!! Try out searching specific substructures (e.g. motif, pocket, interface) of your interest🪩
Does your designed active site already exist in nature? Is an uncharacterized protein hiding a catalytic site or a pocket? Folddisco answers both, searching millions of structures for a 3D motif in seconds.
@natbiotech.nature.com 🧬
📄 www.nature.com/articles/s41...
🧵1/7👇
@natbiotech.nature.com 🧬
📄 www.nature.com/articles/s41...
🧵1/7👇
Structural motif search across the protein universe with Folddisco - Nature Biotechnology
Folddisco enables protein structural motif search in million scale databases.
www.nature.com
June 6, 2026 at 4:48 PM
Folddisco is now published!! Try out searching specific substructures (e.g. motif, pocket, interface) of your interest🪩
She isn't quiet a hero, but she is about the best you can get in the lower substructures of Nilspeir.
February 8, 2025 at 4:13 PM
She isn't quiet a hero, but she is about the best you can get in the lower substructures of Nilspeir.
Very proud of PhD student Thomas Tomlinson, who's awesome paper is out on the arXiv today, on bar-induced substructures in stellar haloes 🤩🔭 #astrosci
arxiv.org/abs/2601.14409
arxiv.org/abs/2601.14409
January 22, 2026 at 11:35 AM
Very proud of PhD student Thomas Tomlinson, who's awesome paper is out on the arXiv today, on bar-induced substructures in stellar haloes 🤩🔭 #astrosci
arxiv.org/abs/2601.14409
arxiv.org/abs/2601.14409
The Piazza dell' Anfiteatro in Lucca, Italy, preserves the shape of the city's Roman amphitheatre. The houses incorporate the substructures of the seating of the amphitheatre.
March 2, 2025 at 1:34 PM
The Piazza dell' Anfiteatro in Lucca, Italy, preserves the shape of the city's Roman amphitheatre. The houses incorporate the substructures of the seating of the amphitheatre.
Happy to share our article on the PROTAC-Splitter, an ML framework for automated identification of PROTAC substructures, is now finally online in Journal of Cheminformatics! rdcu.be/e4Ulj 🤩
Work led by our amazing senior PhD student Stefano, together with collaborators at AstraZeneca. #chemsky
Work led by our amazing senior PhD student Stefano, together with collaborators at AstraZeneca. #chemsky
PROTAC-Splitter: a machine learning framework for automated identification of PROTAC substructures
rdcu.be
February 20, 2026 at 2:42 PM
Happy to share our article on the PROTAC-Splitter, an ML framework for automated identification of PROTAC substructures, is now finally online in Journal of Cheminformatics! rdcu.be/e4Ulj 🤩
Work led by our amazing senior PhD student Stefano, together with collaborators at AstraZeneca. #chemsky
Work led by our amazing senior PhD student Stefano, together with collaborators at AstraZeneca. #chemsky
This is the thing that always frustrates me so much, is that people don’t realize that all of our systems are composed of individual actors with agency, at every level. Not just the people, but the substructures. I know it’s frustrating to hear “Manchin” for the fiftieth time but it’s just the truth
“The Dems” is always a cohesive unit that can do anything and decides as a unit not to.
November 17, 2023 at 6:20 PM
This is the thing that always frustrates me so much, is that people don’t realize that all of our systems are composed of individual actors with agency, at every level. Not just the people, but the substructures. I know it’s frustrating to hear “Manchin” for the fiftieth time but it’s just the truth