1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)
October 16, 2025 at 6:54 PM
1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)
Are you going to #FOG2025? Meet us to learn about the integration of processes with PGSCatalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess
January 20, 2025 at 4:23 PM
Are you going to #FOG2025? Meet us to learn about the integration of processes with PGSCatalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess
Sumstats download: doi.org/10.6084/m9.f...
GWAS summary statistics for major depression (PGC MDD2025)
Genome-wide summary statistics of major depression from the Psychiatric Genomics Consortium (2025)Meta-analysed summary statistics for:Multi-ancestries, excluding 23andMe [DIV]European-ancestries, exc...
doi.org
January 14, 2025 at 4:28 PM
Sumstats download: doi.org/10.6084/m9.f...
Are you interested in GxE interaction #gwas?
Now, you can identify and filter them on our website!
Check the great review made by @genandgenes.bsky.social et al. at @johnshopkinssph.bsky.social
They also analysed the data we hosted and showed a lack of #SumStats available. tinyurl.com/bdfmsmtd
Now, you can identify and filter them on our website!
Check the great review made by @genandgenes.bsky.social et al. at @johnshopkinssph.bsky.social
They also analysed the data we hosted and showed a lack of #SumStats available. tinyurl.com/bdfmsmtd
February 13, 2025 at 7:29 PM
Are you interested in GxE interaction #gwas?
Now, you can identify and filter them on our website!
Check the great review made by @genandgenes.bsky.social et al. at @johnshopkinssph.bsky.social
They also analysed the data we hosted and showed a lack of #SumStats available. tinyurl.com/bdfmsmtd
Now, you can identify and filter them on our website!
Check the great review made by @genandgenes.bsky.social et al. at @johnshopkinssph.bsky.social
They also analysed the data we hosted and showed a lack of #SumStats available. tinyurl.com/bdfmsmtd
@jonicoleman.bsky.social I've just sent you an email about case-case ED sumstats, it may have landed in your spam! Thanks!
September 21, 2026 at 4:03 PM
@jonicoleman.bsky.social I've just sent you an email about case-case ED sumstats, it may have landed in your spam! Thanks!
*street fighter voice* "Round 2"
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
Super excited to see my first first-author paper on AJHG, in which we created FactorGo as a scalable tool to learn shared genetic components across traits using thousands of GWAS summary stats. Thanks to mentorship by Drs. @nmancuso.bsky.social and Steven Gazal. www.sciencedirect.com/science/arti...
A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits...
Genome-wide association studies (GWASs) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While …
www.sciencedirect.com
October 25, 2023 at 2:50 AM
*street fighter voice* "Round 2"
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
So happy to see Eleanor's work out in AJHG! Along with Steven Gazal, Eleanor developed a factor analysis model of GWAS sumstats to identify and characterize pleiotropy. 🧬🧬💻
🚨 IMPORTANT UPDATE 🚨
👩🏻💻👨🏻💻Work on #gwas?
📊Did you submit your #SumStats (bit.ly/38rNSjx) or are you planning to do so?
Now you can ALSO submit the top associations to be included in the GWAS Catalog!
Just follow the link in your submission confirmation email for more details!👇👇
👩🏻💻👨🏻💻Work on #gwas?
📊Did you submit your #SumStats (bit.ly/38rNSjx) or are you planning to do so?
Now you can ALSO submit the top associations to be included in the GWAS Catalog!
Just follow the link in your submission confirmation email for more details!👇👇
July 16, 2025 at 12:57 PM
🚨 IMPORTANT UPDATE 🚨
👩🏻💻👨🏻💻Work on #gwas?
📊Did you submit your #SumStats (bit.ly/38rNSjx) or are you planning to do so?
Now you can ALSO submit the top associations to be included in the GWAS Catalog!
Just follow the link in your submission confirmation email for more details!👇👇
👩🏻💻👨🏻💻Work on #gwas?
📊Did you submit your #SumStats (bit.ly/38rNSjx) or are you planning to do so?
Now you can ALSO submit the top associations to be included in the GWAS Catalog!
Just follow the link in your submission confirmation email for more details!👇👇
New preprint! www.medrxiv.org/content/10.1...
We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis.
@andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social
We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis.
@andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
www.medrxiv.org
December 6, 2024 at 12:50 AM
New preprint! www.medrxiv.org/content/10.1...
We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis.
@andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social
We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis.
@andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social
11/n For more on this #depression GWAS meta-analysis:
- Full paper: doi.org/10.1016/j.ce...
- Sumstats: doi.org/10.6084/m9.f...
- Full paper: doi.org/10.1016/j.ce...
- Sumstats: doi.org/10.6084/m9.f...
January 14, 2025 at 5:31 PM
11/n For more on this #depression GWAS meta-analysis:
- Full paper: doi.org/10.1016/j.ce...
- Sumstats: doi.org/10.6084/m9.f...
- Full paper: doi.org/10.1016/j.ce...
- Sumstats: doi.org/10.6084/m9.f...
At #fog2025 @markeffingham @ukbiobank.bsky.social is giving updates about #UKBiobank Did you know we are hosting more than 38K #gwas from UK Biobank lot of them with #SumStats? Access them through website and API, submit your data bit.ly/38rNSjx #openaccess
January 29, 2025 at 2:48 PM
At #fog2025 @markeffingham @ukbiobank.bsky.social is giving updates about #UKBiobank Did you know we are hosting more than 38K #gwas from UK Biobank lot of them with #SumStats? Access them through website and API, submit your data bit.ly/38rNSjx #openaccess
I appreciate that I am likely in the “big data, methodological problems, glam journals” camp form your perches, but I tend to seperate the observational analytical results (e.g. sumstats being generated etc) which are valuable, from their interpretation, which adds a layer of causal assumptions.
April 30, 2026 at 6:08 AM
I appreciate that I am likely in the “big data, methodological problems, glam journals” camp form your perches, but I tend to seperate the observational analytical results (e.g. sumstats being generated etc) which are valuable, from their interpretation, which adds a layer of causal assumptions.
Thanks Dirk! Looking forwards to you taking these sumstats and spinning whole new research tales with them.
May 20, 2025 at 9:48 PM
Thanks Dirk! Looking forwards to you taking these sumstats and spinning whole new research tales with them.
Hi Selim! Unfortunately, they're under embargo right now -- But, as soon the paper's published, we'll make all sumstats (and PGI weights) publicly available.
October 17, 2025 at 1:47 PM
Hi Selim! Unfortunately, they're under embargo right now -- But, as soon the paper's published, we'll make all sumstats (and PGI weights) publicly available.
It's truly a sad state of affairs when it takes longer to pull GWAS sumstats out of the AllofUs research platform than it takes to generate them.
January 12, 2026 at 11:44 PM
It's truly a sad state of affairs when it takes longer to pull GWAS sumstats out of the AllofUs research platform than it takes to generate them.
We also meta-analysed cohorts aggregated by phenotyping method (Clinical/Interview, Health Records, Symptom questionnaire, Self-report diagnosis).
Genetic correlations are what you'd expect but surprisingly little variant-level heterogeneity.
Genetic correlations are what you'd expect but surprisingly little variant-level heterogeneity.
January 14, 2025 at 4:50 PM
We also meta-analysed cohorts aggregated by phenotyping method (Clinical/Interview, Health Records, Symptom questionnaire, Self-report diagnosis).
Genetic correlations are what you'd expect but surprisingly little variant-level heterogeneity.
Genetic correlations are what you'd expect but surprisingly little variant-level heterogeneity.
a good workable rule is freeze the data you plan to release publically (sumstats for a meta, raw if you can etc) and build scripts that work from that point onward. I have sympathies for generating plots based on final frozen output that goes into tables/repo's...
March 24, 2026 at 6:41 PM
a good workable rule is freeze the data you plan to release publically (sumstats for a meta, raw if you can etc) and build scripts that work from that point onward. I have sympathies for generating plots based on final frozen output that goes into tables/repo's...
This work would not be possible without @jakobgrove.bsky.social, who generously shared the stratified ASD sumstats, and my amazing co-authors in the Badger lab: @lukas-schaffer.bsky.social, Jeremy Lawrence, Alex Sheppard, and @andrewgrotzinger.bsky.social. 🦡 🧬
May 8, 2026 at 10:35 PM
This work would not be possible without @jakobgrove.bsky.social, who generously shared the stratified ASD sumstats, and my amazing co-authors in the Badger lab: @lukas-schaffer.bsky.social, Jeremy Lawrence, Alex Sheppard, and @andrewgrotzinger.bsky.social. 🦡 🧬
I keep seeing people citing my paper in the opposite direction. The paper proves that local ancestry adjusted GWAS recovers ancestry specific effects under very restrictive conditions and show in both simulation and sumstats that the conditions doesn't hold.
August 11, 2026 at 10:08 AM
I keep seeing people citing my paper in the opposite direction. The paper proves that local ancestry adjusted GWAS recovers ancestry specific effects under very restrictive conditions and show in both simulation and sumstats that the conditions doesn't hold.
Hm, could we retrieve the P value from the beta, N and MAF? (I think we can, at least a way better approximation!). More important (IMO) Q is why they didn’t release the full sumstats? Or did they trough some other mechanism?
January 31, 2025 at 8:28 PM
Hm, could we retrieve the P value from the beta, N and MAF? (I think we can, at least a way better approximation!). More important (IMO) Q is why they didn’t release the full sumstats? Or did they trough some other mechanism?
It is #WorldCancerDay and you can access ~ 2500 #gwas linked to cancer, with close to 1,100 of them with #SumStats. THANKS for helping us to increase the data available following #FAIRprinciples. Share your data bit.ly/38rNSjx #OpenAccess
February 4, 2025 at 8:54 AM
It is #WorldCancerDay and you can access ~ 2500 #gwas linked to cancer, with close to 1,100 of them with #SumStats. THANKS for helping us to increase the data available following #FAIRprinciples. Share your data bit.ly/38rNSjx #OpenAccess
🧵 Polygenic scores in hypertrophic cardiomyopathy
📎 Paper: www.nature.com/articles/s41... in @naturegenet.bsky.social
We created PGS using sumstats from our linked GWAS study www.nature.com/articles/s41..., evaluating it across a range of clinical settings in several cohorts. 1/n
📎 Paper: www.nature.com/articles/s41... in @naturegenet.bsky.social
We created PGS using sumstats from our linked GWAS study www.nature.com/articles/s41..., evaluating it across a range of clinical settings in several cohorts. 1/n
February 18, 2025 at 3:21 PM
🧵 Polygenic scores in hypertrophic cardiomyopathy
📎 Paper: www.nature.com/articles/s41... in @naturegenet.bsky.social
We created PGS using sumstats from our linked GWAS study www.nature.com/articles/s41..., evaluating it across a range of clinical settings in several cohorts. 1/n
📎 Paper: www.nature.com/articles/s41... in @naturegenet.bsky.social
We created PGS using sumstats from our linked GWAS study www.nature.com/articles/s41..., evaluating it across a range of clinical settings in several cohorts. 1/n
Yes!!! I think of these chills as a potentially universal biological component of openness to experience (From the preprint you all cited back in the day, now much more polished in published form). Once the GWAS is published so we can share the sumstats publicly, I'd love to see what you all find!
February 19, 2026 at 8:08 PM
Yes!!! I think of these chills as a potentially universal biological component of openness to experience (From the preprint you all cited back in the day, now much more polished in published form). Once the GWAS is published so we can share the sumstats publicly, I'd love to see what you all find!
So…you want more flavours? Sumstats for the PGC MDD2025 meta-analysis now also available as daner and GWAS-SSF, to ease the way in getting them hooked into your analyses. (GWAS-VCF next? 👀)
figshare.com/articles/dat...
figshare.com/articles/dat...
February 17, 2025 at 4:18 PM
So…you want more flavours? Sumstats for the PGC MDD2025 meta-analysis now also available as daner and GWAS-SSF, to ease the way in getting them hooked into your analyses. (GWAS-VCF next? 👀)
figshare.com/articles/dat...
figshare.com/articles/dat...
Yeah I considered emailing UK biobank, can’t find a project NR, I figure it’s either entirely fake, or the author found some sumstats…
January 27, 2026 at 8:43 PM
Yeah I considered emailing UK biobank, can’t find a project NR, I figure it’s either entirely fake, or the author found some sumstats…
Per the readme, "Variants with a p-value of zero actually had a p-value that exceeded the number of significant digits possible in R (p<1E-321) but can be recalculated using the effect size and standard error provided."
Guess it affected more than just the sumstats 😬
Guess it affected more than just the sumstats 😬
Aargh. The curse of the underflow p value strikes the MVP study.
In picking the lead snps the authors (inadvertantly) picked the first SNP with an underflow pvalue. This can be up to 500kb from the true lead snp.
All the strong pvalues listed from verma et al in @gwascatalog.bsky.social are suspect
In picking the lead snps the authors (inadvertantly) picked the first SNP with an underflow pvalue. This can be up to 500kb from the true lead snp.
All the strong pvalues listed from verma et al in @gwascatalog.bsky.social are suspect
See now this is what I'm talking about. A massive study (MVP) with 80,000 GWAS associations and the 1,000 most significant are corrupted because the authors didn't provide their actual p-values.
www.ebi.ac.uk/gwas/publica...
Don't do this
www.ebi.ac.uk/gwas/publica...
Don't do this
February 11, 2025 at 4:37 PM
Per the readme, "Variants with a p-value of zero actually had a p-value that exceeded the number of significant digits possible in R (p<1E-321) but can be recalculated using the effect size and standard error provided."
Guess it affected more than just the sumstats 😬
Guess it affected more than just the sumstats 😬