October 28, 2026 at 11:14 AM
Nuclear Functional Divergence and Genetic Basis of Cap Colour Variation Revealed by T2T Genomes of Two Compatible Monokaryons in Pholiota adiposa
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
Nuclear Functional Divergence and Genetic Basis of Cap Colour Variation Revealed by <fc>T2T</fc> Genomes of Two Compatible Monokaryons in <fi>Pholiota adiposa</fi>
T2T genomes of two compatible monokaryons reveal nuclear functional specialization and identify two candidate loci on chromosomes 6 and 12 associated with red cap colour in the edible mushroom Pholio...
enviromicro-journals.onlinelibrary.wiley.com
November 2, 2026 at 6:22 PM
Nuclear Functional Divergence and Genetic Basis of Cap Colour Variation Revealed by T2T Genomes of Two Compatible Monokaryons in Pholiota adiposa
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
🎙️NEW POD ALERT🎙️
Hello, Lovelies! Today we welcome broadcaster Toddy Tondera to the show! They & @wonderboyotm.bsky.social chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
Hello, Lovelies! Today we welcome broadcaster Toddy Tondera to the show! They & @wonderboyotm.bsky.social chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
October 30, 2026 at 5:26 PM
🎙️NEW POD ALERT🎙️
Hello, Lovelies! Today we welcome broadcaster Toddy Tondera to the show! They & @wonderboyotm.bsky.social chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
Hello, Lovelies! Today we welcome broadcaster Toddy Tondera to the show! They & @wonderboyotm.bsky.social chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
À la une | [Podcast] À Marseille, tous les visages de la colère sociale
➡️ https://l.marsactu.fr/T2t
➡️ https://l.marsactu.fr/T2t
October 28, 2026 at 6:15 AM
À la une | [Podcast] À Marseille, tous les visages de la colère sociale
➡️ https://l.marsactu.fr/T2t
➡️ https://l.marsactu.fr/T2t
🎙️NEW POD ALERT🎙️
Hello, Lovelies! Today @lgbtringpod.bsky.social welcomes broadcaster Toddy Tondera to the show! We chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
Hello, Lovelies! Today @lgbtringpod.bsky.social welcomes broadcaster Toddy Tondera to the show! We chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
October 30, 2026 at 5:26 PM
🎙️NEW POD ALERT🎙️
Hello, Lovelies! Today @lgbtringpod.bsky.social welcomes broadcaster Toddy Tondera to the show! We chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
Hello, Lovelies! Today @lgbtringpod.bsky.social welcomes broadcaster Toddy Tondera to the show! We chat 880 Wrestling, entering wrestling through T2T Brooklyn, a post-Enjoy Pittsburgh, Labor of Love, the comedy-to-wrestling pipeline & more!
🔗⬇️
速報オール4ヨシ！！
4T2Tと4Sを抜けコケなく決めただけでも
ここ最近とあなたの今のコンディションを考えたらよくやったよ……
ぶっちゃけFSより怖かったもの
4T2Tと4Sを抜けコケなく決めただけでも
ここ最近とあなたの今のコンディションを考えたらよくやったよ……
ぶっちゃけFSより怖かったもの
October 31, 2026 at 2:22 AM
速報オール4ヨシ！！
4T2Tと4Sを抜けコケなく決めただけでも
ここ最近とあなたの今のコンディションを考えたらよくやったよ……
ぶっちゃけFSより怖かったもの
4T2Tと4Sを抜けコケなく決めただけでも
ここ最近とあなたの今のコンディションを考えたらよくやったよ……
ぶっちゃけFSより怖かったもの
What can complete T2T genome assemblies reveal about the hidden architecture of our genomes?
Join us for a seminar by 𝐃𝐫 𝐊𝐚𝐭𝐞𝐫𝐲𝐧𝐚 𝐌𝐚𝐤𝐨𝐯𝐚, 𝐏𝐫𝐨𝐟𝐞𝐬𝐬𝐨𝐫 𝐚𝐭 𝐏𝐞𝐧𝐧 𝐒𝐭𝐚𝐭𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲, as she explores how non-B DNA structures influence genome function, evolution and disease.
#ASTAR
#GIS
#GISSpeakerSeries
Join us for a seminar by 𝐃𝐫 𝐊𝐚𝐭𝐞𝐫𝐲𝐧𝐚 𝐌𝐚𝐤𝐨𝐯𝐚, 𝐏𝐫𝐨𝐟𝐞𝐬𝐬𝐨𝐫 𝐚𝐭 𝐏𝐞𝐧𝐧 𝐒𝐭𝐚𝐭𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲, as she explores how non-B DNA structures influence genome function, evolution and disease.
#ASTAR
#GIS
#GISSpeakerSeries
October 29, 2026 at 8:30 AM
What can complete T2T genome assemblies reveal about the hidden architecture of our genomes?
Join us for a seminar by 𝐃𝐫 𝐊𝐚𝐭𝐞𝐫𝐲𝐧𝐚 𝐌𝐚𝐤𝐨𝐯𝐚, 𝐏𝐫𝐨𝐟𝐞𝐬𝐬𝐨𝐫 𝐚𝐭 𝐏𝐞𝐧𝐧 𝐒𝐭𝐚𝐭𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲, as she explores how non-B DNA structures influence genome function, evolution and disease.
#ASTAR
#GIS
#GISSpeakerSeries
Join us for a seminar by 𝐃𝐫 𝐊𝐚𝐭𝐞𝐫𝐲𝐧𝐚 𝐌𝐚𝐤𝐨𝐯𝐚, 𝐏𝐫𝐨𝐟𝐞𝐬𝐬𝐨𝐫 𝐚𝐭 𝐏𝐞𝐧𝐧 𝐒𝐭𝐚𝐭𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲, as she explores how non-B DNA structures influence genome function, evolution and disease.
#ASTAR
#GIS
#GISSpeakerSeries
T2T By LingOrm 💜
THE WORLD BETWEEN LINGORM D1
THE WORLD BETWEEN LINGORM D1
October 24, 2026 at 1:59 PM
T2T By LingOrm 💜
THE WORLD BETWEEN LINGORM D1
THE WORLD BETWEEN LINGORM D1
The new rat genome annotations for GRCr8 (strain: BN/NHsdMcwi) and the T2T assembly SHRSP_T2T (strain: SHRSP/BbbUtx) are now integrated into RGD! 🐀
Explore the annotations here: rgd.mcw.edu/rgdweb/jbrow...
Explore the annotations here: rgd.mcw.edu/rgdweb/jbrow...
October 27, 2026 at 3:26 PM
The new rat genome annotations for GRCr8 (strain: BN/NHsdMcwi) and the T2T assembly SHRSP_T2T (strain: SHRSP/BbbUtx) are now integrated into RGD! 🐀
Explore the annotations here: rgd.mcw.edu/rgdweb/jbrow...
Explore the annotations here: rgd.mcw.edu/rgdweb/jbrow...
Some mobile elements are still jumping!
New Mobile Element Insertions tracks show polymorphic Alu, L1 and SVA sites on hg38, hg19 and T2T-CHM13, from long reads, short-read cohorts and 32 published studies.
Look at our news for more: bit.ly/GBmeiRelease
New Mobile Element Insertions tracks show polymorphic Alu, L1 and SVA sites on hg38, hg19 and T2T-CHM13, from long reads, short-read cohorts and 32 published studies.
Look at our news for more: bit.ly/GBmeiRelease
October 23, 2026 at 6:15 PM
Some mobile elements are still jumping!
New Mobile Element Insertions tracks show polymorphic Alu, L1 and SVA sites on hg38, hg19 and T2T-CHM13, from long reads, short-read cohorts and 32 published studies.
Look at our news for more: bit.ly/GBmeiRelease
New Mobile Element Insertions tracks show polymorphic Alu, L1 and SVA sites on hg38, hg19 and T2T-CHM13, from long reads, short-read cohorts and 32 published studies.
Look at our news for more: bit.ly/GBmeiRelease
SETDB1 knockdown + long-read RNA-seq on a T2T mouse genome: young LTR retroelements (ERVK/ERV1) selectively wake up, while LINE/L1 follow a different epigenetic logic than HUSH/MORC2/DNMT silencing. @bkcenik.bsky.social @vram142.bsky.social doi.org/10.1073/pnas...
October 24, 2026 at 1:55 AM
SETDB1 knockdown + long-read RNA-seq on a T2T mouse genome: young LTR retroelements (ERVK/ERV1) selectively wake up, while LINE/L1 follow a different epigenetic logic than HUSH/MORC2/DNMT silencing. @bkcenik.bsky.social @vram142.bsky.social doi.org/10.1073/pnas...
I can find two official animations, a2a_soc_foosballTable_T_highFive and t2t_friendly_T_highFive_succeed
My sims didn't do first one after playing foosball, and if I pose them it looks more like a fist bump anyway
What's the interaction for the other one? It says t2t, but I've seen non-teens do it
My sims didn't do first one after playing foosball, and if I pose them it looks more like a fist bump anyway
What's the interaction for the other one? It says t2t, but I've seen non-teens do it
October 22, 2026 at 3:07 PM
I can find two official animations, a2a_soc_foosballTable_T_highFive and t2t_friendly_T_highFive_succeed
My sims didn't do first one after playing foosball, and if I pose them it looks more like a fist bump anyway
What's the interaction for the other one? It says t2t, but I've seen non-teens do it
My sims didn't do first one after playing foosball, and if I pose them it looks more like a fist bump anyway
What's the interaction for the other one? It says t2t, but I've seen non-teens do it
Very interesting review on variant calling from long-read data!
On a personal side, I am glad to be part of the cited authors describing the relevance of T2T-CHM13 for variant calling 🧬
On a personal side, I am glad to be part of the cited authors describing the relevance of T2T-CHM13 for variant calling 🧬
New online! Small variant calling in the era of long-read sequencing
Small variant calling in the era of long-read sequencing
Nature Reviews Genetics, Published online: 20 October 2026; doi:10.1038/s41576-026-01020-7Long-read sequencing is expanding the scope of small-variant detection, enabling analysis of genomic regions that were previously difficult to interrogate. In this Review, the authors examine approaches for long-read small-variant calling across sequencing platforms and applications, highlighting advances in deep learning, assembly-based and pangenome-based methods, benchmarking strategies and future challenges.
dlvr.it
October 21, 2026 at 2:18 PM
Very interesting review on variant calling from long-read data!
On a personal side, I am glad to be part of the cited authors describing the relevance of T2T-CHM13 for variant calling 🧬
On a personal side, I am glad to be part of the cited authors describing the relevance of T2T-CHM13 for variant calling 🧬
Depends on what you mean by "high-quality"! Certainly T2T is not necessarily required (but they certainly give me more faith), Fig S1 shows inference on the high-coverage 1KGP samples aligned to the T2T HG002, though they look indistinguishable when aligned to GRCh38. In the original preprint we...
October 20, 2026 at 9:06 PM
Depends on what you mean by "high-quality"! Certainly T2T is not necessarily required (but they certainly give me more faith), Fig S1 shows inference on the high-coverage 1KGP samples aligned to the T2T HG002, though they look indistinguishable when aligned to GRCh38. In the original preprint we...
Near-T2T diploid assembly of a melanoma donor: ~16% of somatic variants sit outside GRCh38; satellites sink UV mutations, and somatic epimutations outpace SNVs in reshaping regulation. @mrvollger.bsky.social @eichlerlab.bsky.social doi.org/10.1016/j.ce...
October 22, 2026 at 2:02 AM
Near-T2T diploid assembly of a melanoma donor: ~16% of somatic variants sit outside GRCh38; satellites sink UV mutations, and somatic epimutations outpace SNVs in reshaping regulation. @mrvollger.bsky.social @eichlerlab.bsky.social doi.org/10.1016/j.ce...
which we hope (a) increases confidence in the signal and (b) introduces to the community an appropriate and robust variant-calling pipeline for this sort of analysis on T2T data. 9/n
October 20, 2026 at 8:32 AM
which we hope (a) increases confidence in the signal and (b) introduces to the community an appropriate and robust variant-calling pipeline for this sort of analysis on T2T data. 9/n
So glad to see this work published, especially since we preprinted it 2 years ago🥲. Then, the great-ape data we used was 10+ years out of date. We then made the decision to redo all analysis using the new and high-quality T2T data...8/n
October 20, 2026 at 8:32 AM
So glad to see this work published, especially since we preprinted it 2 years ago🥲. Then, the great-ape data we used was 10+ years out of date. We then made the decision to redo all analysis using the new and high-quality T2T data...8/n
The Indian Council of Agricultural Research (#ICAR) will showcase landmark scientific achievements—including the world’s first two genome-edited rice varieties and India’s first telomere-to-telomere (T2T) reference genome of pigeonpea
October 20, 2026 at 6:36 AM
The Indian Council of Agricultural Research (#ICAR) will showcase landmark scientific achievements—including the world’s first two genome-edited rice varieties and India’s first telomere-to-telomere (T2T) reference genome of pigeonpea
using new and high-quality telomere-to-telomere sequences for a human, bonobo, chimpanzee, gorilla, and two orangutans (as well as three 1000 Genome Project (1KGP) humans aligned to the human T2T assembly). 3/n
October 20, 2026 at 8:30 AM
using new and high-quality telomere-to-telomere sequences for a human, bonobo, chimpanzee, gorilla, and two orangutans (as well as three 1000 Genome Project (1KGP) humans aligned to the human T2T assembly). 3/n
October 15, 2026 at 7:46 AM
the T2T stare of desired friendship between customer (me) and employee (she)
October 14, 2026 at 6:22 PM
the T2T stare of desired friendship between customer (me) and employee (she)
Why T2T?
2026-10-13
programmingsimplicity.substack.com
October 14, 2026 at 2:04 PM
Our gratitude to those who created several public resources that were absolutely essential for this work, including the HPRC assemblies, T2T consortium, 1KG, MAGE, ONT Vienna, AoU, and more.
Please let us know if you have feedback!
Please let us know if you have feedback!
October 14, 2026 at 11:59 PM
Our gratitude to those who created several public resources that were absolutely essential for this work, including the HPRC assemblies, T2T consortium, 1KG, MAGE, ONT Vienna, AoU, and more.
Please let us know if you have feedback!
Please let us know if you have feedback!
Interviewer: Can you explain this gap in your CV?
Genomicist: I tried to save money by skipping HiC scaffolding, but T2T assemblies are really overrated for most use cases anyway
Genomicist: I tried to save money by skipping HiC scaffolding, but T2T assemblies are really overrated for most use cases anyway
Interviewer: Can you explain this gap in your CV?
Scientist: I made it in TeX and can't figure out how to remove the gap but I also don't want to get yelled at if I post a question on stackexchange, so I have instead decided to appreciate the gap, which is still there
Scientist: I made it in TeX and can't figure out how to remove the gap but I also don't want to get yelled at if I post a question on stackexchange, so I have instead decided to appreciate the gap, which is still there
Interviewer: Can you explain this gap in your résumé?
John Cage:
John Cage:
October 12, 2026 at 11:38 AM
Interviewer: Can you explain this gap in your CV?
Genomicist: I tried to save money by skipping HiC scaffolding, but T2T assemblies are really overrated for most use cases anyway
Genomicist: I tried to save money by skipping HiC scaffolding, but T2T assemblies are really overrated for most use cases anyway
The rapid radiation of cichlid fishes of Lake Malawi is also famous for their vibrant colors. But they also hide incredible beauty inside.
We uncovered a centromeric structure in cichlids, unreported in large eukaryotes, similar to regional centromeres of S. pombe. (1/5)🧵
doi.org/10.1007/s105...
We uncovered a centromeric structure in cichlids, unreported in large eukaryotes, similar to regional centromeres of S. pombe. (1/5)🧵
doi.org/10.1007/s105...
Near-complete genomes for nine haplochromine cichlid fishes reveal a novel centromeric satellite structure organised around a pair of inverted elements - Chromosome Research
The haplochromine cichlid fishes of Lake Malawi form one of the most dramatic examples of recent rapid radiation in vertebrates. Here we describe nine new diploid telomere-to-telomere (T2T) genome seq...
link.springer.com
October 12, 2026 at 8:21 PM
The rapid radiation of cichlid fishes of Lake Malawi is also famous for their vibrant colors. But they also hide incredible beauty inside.
We uncovered a centromeric structure in cichlids, unreported in large eukaryotes, similar to regional centromeres of S. pombe. (1/5)🧵
doi.org/10.1007/s105...
We uncovered a centromeric structure in cichlids, unreported in large eukaryotes, similar to regional centromeres of S. pombe. (1/5)🧵
doi.org/10.1007/s105...