#TAFRO
Primary adrenal insufficiency and autoimmune thyroiditis in an adolescent with Castleman-TAFRO syndrome. Read more in #JCEM Case Reports: https://bit.ly/4nUCoMK #CastlemanDisease #TAFRO #primaryadrenalinsufficiency @endocrinesociety.bsky.social
Primary adrenal insufficiency and autoimmune thyroiditis in an adolescent with Castleman-TAFRO syndrome
Abstract. The idiopathic multicentric Castleman disease (CD)–TAFRO variant (iMCD-TAFRO) is a rare, clinically aggressive lymphoproliferative disorder chara
bit.ly
June 12, 2026 at 8:35 PM
原因不明の高熱が続いた母、入院して検査するも分からんまま1カ月経った時にTAFRO症候群(症例がめちゃくちゃ少ない上に効く薬が個人差あり過ぎて治療がかなり難しい奇病で亡くなる率も高い)か悪性リンパ腫の2択で悪性リンパ腫のステージ4だったんですけど、奇病よりは効く薬分かってるしだいぶマシ判定で、副作用も無くひとまず治療終えて寛解したので本当に良かったどす
May 26, 2025 at 9:33 AM
Japan Links Surge in Deadly TAFRO Syndrome to Moderna’s mRNA ‘Vaccine’
slaynews.com/news/japan-l...
Japan Links Surge in Deadly TAFRO Syndrome to Moderna's mRNA 'Vaccine' - Slay News
A groundbreaking study from Japan has drawn a concerning connection between Moderna's Covid mRNA "vaccine" and surges in the once-rare, life-threatening condition known as TAFRO syndrome.
slaynews.com
July 26, 2025 at 8:04 PM
Castleman disease (CD) is a rare, non-clonal lymphoproliferative disorder w/ systemic sxs & maybe linked w/ herpesvirus 8, POEMS or TAFRO syndrome. Mimickers include lymphoma, sarcoma, IgG4-RD, Infections (EBV, HHV8, HIV, CMV, TB), Autoimmune Dz (RA, SLE, Stills) buff.ly/9CShm3t
April 25, 2025 at 9:15 AM
おはこんです🌤️
本日は大晦日
今日で2024年も終了です
去年の難病TAFRO症候群発病に比べ、今年は後遺症&謎の合併症に苦しむ程度で済んでいるので良しとします!(๑˃̵ᴗ˂̵)و ヨシ!
手足の痛みや痺れで思い通りに積みプラを崩せ無かった事もあり、ほとんどドールに走った1年でした…σ(^_^;
来年はお迎えしたうちのこ達と穏やかに過ごすと共に、生きている内に果たさなければならない積みプラ崩しに励もうと思っています
本年新たにお会いできた皆様方、以前よりお付き合い頂いている皆様方、ありがとうございましたm(_ _)m
来年も何卒宜しくお願い致します!ヨロ \(>▽<)/ シク!
December 31, 2024 at 3:02 AM
Do you know the difference between unicentric and multicentric Castleman disease?
New editorial doi.org/10.5114/reum...
highlights key diagnostic and treatment insights — including the role of IL-6, the TAFRO variant, and promising outcomes with siltuximab in idiopathic MCD.
July 27, 2025 at 6:55 PM
Also shows the huge role of #Pathology #LabMedicine in the diagnosis of these “zebra” cases! ☺️🙌
January 11, 2026 at 6:29 PM
Paciente há 7 meses com todas as bizarrices do mundo e sem diagnóstico aí a Hemato lançou um “síndrome de Tafro” e o nosso chefe da nefro “nossa como não pensamos nisso antes??!!”
a man is making a funny face and asking does this exist .
ALT: a man is making a funny face and asking does this exist .
media.tenor.com
September 12, 2024 at 8:31 PM
iMCD 兩個亞型的血小板方向相反
iMCD-TAFRO:血小板「低下」,伴全身水腫腹水、發燒、骨髓 reticulin 纖維化、腎功能異常、器官腫大,病程急重。
iMCD-NOS:血小板反而「上升」,伴多株性高球蛋白血症,病程較緩。
記法:大類看範圍,多中心看病因。
#血液專科
https://hema-2026.hsiehting.com/q/110-031
August 4, 2026 at 6:19 AM
MCD 依亞型分流治療
HHV-8 相關:一線 rituximab;有嚴重全身症狀或器官功能障礙時加 etoposide。
POEMS-MCD:走標準 myeloma 誘導治療,並考慮 auto-HSCT 鞏固。
iMCD-TAFRO:因為病程急重,要給靜脈類固醇加抗 IL-6 治療。
#血液專科
https://hema-2026.hsiehting.com/q/112-034
August 3, 2026 at 4:31 PM
iMCD-TAFRO 的字母意義
T:Thrombocytopenia,血小板「減少」不是增多
A:Anasarca,全身水腫、腹水
F:Fever
R:Reticulin fibrosis/Renal dysfunction
O:Organomegaly
它是急性、嚴重、類似 HLH 或敗血症的細胞激素風暴,預後差,不是 indolent。
#血液專科
https://hema-2026.hsiehting.com/q/114-021
August 3, 2026 at 8:08 AM
Castleman 病的分類
Unicentric CD 對比 Multicentric CD。
MCD 再分三類:HHV-8 陽性 MCD、MCD-POEMS、idiopathic MCD。
iMCD 又分 TAFRO、IPL(idiopathic plasmacytic lymphadenopathy)與 NOS。
診斷 iMCD 必須排除自體免疫疾病、惡性淋巴增生疾病與 HHV-8 感染。
#血液專科
https://hema-2026.hsiehting.com/q/114-021
August 3, 2026 at 8:09 AM
Robin Williams of UofM Masonic Children's Hospital describes the medical mystery of a 15-year-old who became critically ill when he was admitted into a PICU and what it took to diagnose him with the ultra-rare disease TAFRO. @globalgenes.bsky.social #RARECast

globalgenes.org/raredaily/so...
Sometimes the Hoofbeats Do Belong to Zebras
Robin Williams, assistant professor of pediatric hematology/oncology at the University of Minnesota Masonic Children's Hospital, describes the case of Avion, a 15-year-old who became critically ill wh...
globalgenes.org
September 5, 2025 at 4:37 PM
Las Blancas Podcast: 7-Star Attack, 3-Star Defence
Hosts Yash and Kanita discuss Real Madrid’s 7-3 derby win and Olga to PSG rumors. On this episode of Las Blancas Podcast, hosts Yash Thakur and Kanita Tafro discuss Real Madrid’s 7-3 win in a derby against **Madrid CFF**. **Talking points:** * The fluctuation of the scoreline and dominance * A fun fact about the 10+ goals games in Liga F * Defensive issues - the setup and the performance of the CBs * Angeldahl’s performance and role in the club and country * An issue in the broadcast that no one complained about * The issue with the midfield setup - forcing Toletti deep * **Olga** **Carmona** will leave Real Madrid for Paris Saint-Germain? ## **WATCH THE EPIDOSE ON YOUTUBE:** * * * Managing Madrid is a hub for all Madridistas with updated news, op-eds, tactical analyses, artwork, and of course, podcasts. It also serves as a means for **Real Madrid** fans to connect and discuss the team. We would like your support so that we can continue to produce podcasts for you. The site is run by a small team that works tirelessly around the clock to make it into what it is today. Your contributions will allow us to continue to have a real and full-time presence in keeping this website, and its podcasts, going. * * * **Hosts this week** : Yash Thakur (**@Odriozolite**) Kanita Tafro (**@KaniFroh**) Las Blancas (**@Las_Blancas**)
www.managingmadrid.com
May 3, 2025 at 12:55 PM
Las Blancas Podcast: Beating Betis... Again
Hosts Yash and Kanita discuss Real Madrid’s goleada against Real Betis. On this episode of Las Blancas Podcast, hosts Yash Thakur and Kanita Tafro discuss Real Madrid’s 5-1 win over Real Betis in Liga F. **Talking points:** * Real Madrid’s goals - a quick overview * Caroline Weir stepping up instead of Olga for the penalty - Is it a sign? * Misa’s mistakes leading to conceding Zouhir’s goal * Addressing the Merle Frohms to Real Madrid rumor * The perfect time to incorporate the academy more * What happens with Carla at the season’s end? * Shei hasn’t started for 3 games straight * Match MVP ## **VIDEO** * * * Managing Madrid is a hub for all Madridistas with updated news, op-eds, tactical analyses, artwork, and of course, podcasts. It also serves as a means for **Real Madrid** fans to connect and discuss the team. We would like your support so that we can continue to produce podcasts for you. The site is run by a small team that works tirelessly around the clock to make it into what it is today. Your contributions will allow us to continue to have a real and full-time presence in keeping this website, and its podcasts, going. * * * **Hosts this week** : Yash Thakur (**@Odriozolite**) Kanita Tafro (**@KaniFroh**) Las Blancas (**@Las_Blancas**)
www.managingmadrid.com
April 22, 2025 at 6:51 AM
Las Blancas Podcast: Toril’s No-Show at the Carpet
Hosts Yash and Kanita are joined by Hridyam and Freddie discuss Real Madrid’s 3-0 loss to Arsenal. On this episode of Las Blancas Podcast hosts Yash Thakur and Kanita Tafro are joined by Hridyam Arora and Freddie Cardy to discuss Real Madrid’s 3-0 loss against **Arsenal** in the second leg of UEFA Women’s Champions League quarterfinals. **Talking points:** * The atmosphere leading up to the game and on the Emirates Stadium * Renée Slegers changing up the lineup from the first leg * Would a back 5 have been helpful to Las Blancas? * El Clásico affecting the players’ mentality for this game * Alberto Toril’s laid back approach and late subs * How Arsenal neutralized Las Blancas * Van Domselaar saving Arsenal’s tie in the first half * Preview: Arsenal vs Olympique Lyonnais semifinal tie * Real Madrid players not thanking travelling fans after the final whistle ## **VIDEO** * * * Managing Madrid is a hub for all Madridistas with updated news, op-eds, tactical analyses, artwork, and of course, podcasts. It also serves as a means for **Real Madrid** fans to connect and discuss the team. We would like your support so that we can continue to produce podcasts for you. The site is run by a small team that works tirelessly around the clock to make it into what it is today. Your contributions will allow us to continue to have a real and full-time presence in keeping this website, and its podcasts, going. * * * **Hosts this week** : Yash Thakur (**@Odriozolite**) Kanita Tafro (**@KaniFroh**) Hridyam Arora (**@hridarora**) Freddie Cardy (**@CardyFreddie**) Las Blancas (**@Las_Blancas**)
www.managingmadrid.com
March 29, 2025 at 6:02 PM
Las Blancas Podcast: The Pitch, the Goals, and the Win
Hosts Yash and Kanita are joined by Freddie Cardy from The Gooner Fanzine to discuss Real Madrid’s 20 win over Arsenal On this episode of Las Blancas Podcast, hosts Yash Thakur and Kanita Tafro are joined by Arsenal Women expert and journalist Freddie Cardy from The Gooner Fanzine to discuss Real Madrid’s 2-0 win over **Arsenal** in the first leg of the UEFA Women’s Champions League quarterfinals. **Talking points:** * The state of the pitch * Should this tie have been played at Santiago Bernabéu? * Lineups - the situation with the #10 at Arsenal * The game state * How the second goal came to be - escaping Arsenal’s midfield * The explanation of Arsenal’s set-piece problems * Melanie Leupolz injury update * Renée Slegers’s tenure at Arsenal Women * The controversy with Rosa Kafaji and the management of young talent * Second leg predictions * Who’s more likely to win if it comes to extra time? * Freddie takes the stage ## **VIDEO** * * * Managing Madrid is a hub for all Madridistas with updated news, op-eds, tactical analyses, artwork, and of course, podcasts. It also serves as a means for **Real Madrid** fans to connect and discuss the team. We would like your support so that we can continue to produce podcasts for you. The site is run by a small team that works tirelessly around the clock to make it into what it is today. Your contributions will allow us to continue to have a real and full-time presence in keeping this website, and its podcasts, going. * * * **Hosts this week** : Yash Thakur (**@Odriozolite**) Kanita Tafro (**@KaniFroh**) Freddie Cardy (**@CardyFreddie**) Las Blancas (**@Las_Blancas**)
www.managingmadrid.com
March 20, 2025 at 5:42 PM
Las Blancas Podcast: Captain Athenea
Hosts Yash and Kanita discuss Real Madrid’s win over Sevilla. On this episode of Las Blancas Podcast, hosts Yash Thakur and Kanita Tafro discuss Real Madrid’s 0-4 win over Sevilla on matchday 21 of Liga F. **Talking points:** * Linda Caicedo’s continued absence from the squad * Why was Alberto Toril absent from the bench? * Heavy rotation in the lineup * Lakrar finally getting rest and Antonia starting as CB * Alba Redondo’s positioning in her two goals * Athenea’s brilliant debut as captain * Difference between the left and right-hand side * The box shape in the midfield * Sandie Toletti’s performance (visual) * Elsa Santos debuts for the first team * Was it a red card for Sullastres? * The quality of Liga F (discussion) * * * Managing Madrid is a hub for all Madridistas with updated news, op-eds, tactical analyses, artwork, and of course, podcasts. It also serves as a means for **Real Madrid** fans to connect and discuss the team. We would like your support so that we can continue to produce podcasts for you. The site is run by a small team that works tirelessly around the clock to make it into what it is today. Your contributions will allow us to continue to have a real and full-time presence in keeping this website, and its podcasts, going. * * * **Hosts this week** : Yash Thakur (**@Odriozolite**) Kanita Tafro (**@KaniFroh**) Las Blancas (**@Las_Blancas**)
www.managingmadrid.com
March 12, 2025 at 12:58 AM