Excited to share our preprint studying the genetics of T cell receptors! bit.ly/tcrdiversity with @soumya-boston.bsky.social @broadinstitute.org 🧵
TCR germline diversity reveals evidence of natural selection on variable and joining alpha chain genes
T cell receptors (TCRs) orchestrate adaptive immunity, yet the complex, repetitive architecture of the TCR loci has impeded systematic characterization of human genetic variation in the genes encoding...
doi.org
August 29, 2025 at 6:15 PM
Excited to share our preprint studying the genetics of T cell receptors! bit.ly/tcrdiversity with @soumya-boston.bsky.social @broadinstitute.org 🧵
We are pleased to share our new publication linking TRAV1-2 negative MAIT cells, CD4 coexpression, and tuberculosis. A conserved innate-like T cell subset with more TCR diversity than previously appreciated. academic.oup.com/jimmunol/adv... #Immunology #maitcells #TCRdiversity
CD4+ mucosal-associated invariant T cells express highly diverse T cell receptors
Abstract. Mucosal-associated invariant T (MAIT) cells are highly conserved innate-like T cells in mammals recognized for their high baseline frequency in h
academic.oup.com
November 13, 2025 at 7:46 PM
We are pleased to share our new publication linking TRAV1-2 negative MAIT cells, CD4 coexpression, and tuberculosis. A conserved innate-like T cell subset with more TCR diversity than previously appreciated. academic.oup.com/jimmunol/adv... #Immunology #maitcells #TCRdiversity