u know what they say. tgfb (thank god for bush)
August 7, 2026 at 3:38 AM
u know what they say. tgfb (thank god for bush)
OMG ITS STILL MONDAY!!
TGFB
Thank God For Beauty 🫶🏻
🔥 Marina 🔥
TGFB
Thank God For Beauty 🫶🏻
🔥 Marina 🔥
February 25, 2025 at 3:47 AM
OMG ITS STILL MONDAY!!
TGFB
Thank God For Beauty 🫶🏻
🔥 Marina 🔥
TGFB
Thank God For Beauty 🫶🏻
🔥 Marina 🔥
Sculpture of TGFb for Joan Massague. Commissioned by past and current Massague lab members. The base shows waves eroding a rocky shore on one side, the other side has wings and a wave breaking offshore. This symbolizes the dual roles of TGFb as both a growth suppressor and promoter.
October 25, 2023 at 4:36 PM
Sculpture of TGFb for Joan Massague. Commissioned by past and current Massague lab members. The base shows waves eroding a rocky shore on one side, the other side has wings and a wave breaking offshore. This symbolizes the dual roles of TGFb as both a growth suppressor and promoter.
TW- age gap, implied non con/sex work
more Sharkteeth Fanart for @fastpuck.bsky.social ❤️
(Skelter x Miles) 👀🥲🫠🤍
Theme Song: www.youtube.com/watch?v=TgFb...
#deaddovedonoteat #comics #fanart #webcomics #proshipsky #art #Sharkteeth #indiecomics #darkstories #queerart #indieartists
more Sharkteeth Fanart for @fastpuck.bsky.social ❤️
(Skelter x Miles) 👀🥲🫠🤍
Theme Song: www.youtube.com/watch?v=TgFb...
#deaddovedonoteat #comics #fanart #webcomics #proshipsky #art #Sharkteeth #indiecomics #darkstories #queerart #indieartists
December 15, 2025 at 1:59 AM
TW- age gap, implied non con/sex work
more Sharkteeth Fanart for @fastpuck.bsky.social ❤️
(Skelter x Miles) 👀🥲🫠🤍
Theme Song: www.youtube.com/watch?v=TgFb...
#deaddovedonoteat #comics #fanart #webcomics #proshipsky #art #Sharkteeth #indiecomics #darkstories #queerart #indieartists
more Sharkteeth Fanart for @fastpuck.bsky.social ❤️
(Skelter x Miles) 👀🥲🫠🤍
Theme Song: www.youtube.com/watch?v=TgFb...
#deaddovedonoteat #comics #fanart #webcomics #proshipsky #art #Sharkteeth #indiecomics #darkstories #queerart #indieartists
Who is the lord of the genes?
A. KRAS
B. MYC
C. P53
D. TGFB
E. Irrelevant. The TME rules them all!
A. KRAS
B. MYC
C. P53
D. TGFB
E. Irrelevant. The TME rules them all!
December 13, 2024 at 11:50 PM
Who is the lord of the genes?
A. KRAS
B. MYC
C. P53
D. TGFB
E. Irrelevant. The TME rules them all!
A. KRAS
B. MYC
C. P53
D. TGFB
E. Irrelevant. The TME rules them all!
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes
Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.
www.science.org
April 27, 2025 at 2:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A 🐭 without Furin in T cells develops a spontaneous autoimmune disease with colitis and autoantibodies. This is likely because Furin in Tregs is necessary to activate TGFb, but also Furin-/- Tcons are less suppressable.
#throwbayfriday 🧪⑂
Pesu et al 2008 www.nature.com/articles/nat...
#throwbayfriday 🧪⑂
Pesu et al 2008 www.nature.com/articles/nat...
June 13, 2025 at 10:19 PM
A 🐭 without Furin in T cells develops a spontaneous autoimmune disease with colitis and autoantibodies. This is likely because Furin in Tregs is necessary to activate TGFb, but also Furin-/- Tcons are less suppressable.
#throwbayfriday 🧪⑂
Pesu et al 2008 www.nature.com/articles/nat...
#throwbayfriday 🧪⑂
Pesu et al 2008 www.nature.com/articles/nat...
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
December 25, 2024 at 11:53 AM
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
MAGA Regret: Trump Voters Beg LIBERALS for HELP as Reality Hits!
YouTube video by JRM REACTS
www.youtube.com
March 22, 2025 at 12:43 AM
Holy shit I had no idea that was you. I mostly knew you from TGFB though tbf. (If you still remember that place lmao)
September 26, 2026 at 2:51 AM
Holy shit I had no idea that was you. I mostly knew you from TGFB though tbf. (If you still remember that place lmao)
TGFB
Thank God for Bluesky
Thank God for Bluesky
April 19, 2023 at 3:27 AM
TGFB
Thank God for Bluesky
Thank God for Bluesky
Oh also--and @gateskp.bsky.social points this out--you are so familiar with your own work that it feels so obvious that anybody looking at the graph knows what you are showing.
"As you can see, TGFb increases blah..." but it's not always obvious... So what are the x and y axes, what was done, etc
"As you can see, TGFb increases blah..." but it's not always obvious... So what are the x and y axes, what was done, etc
May 18, 2024 at 8:59 PM
Oh also--and @gateskp.bsky.social points this out--you are so familiar with your own work that it feels so obvious that anybody looking at the graph knows what you are showing.
"As you can see, TGFb increases blah..." but it's not always obvious... So what are the x and y axes, what was done, etc
"As you can see, TGFb increases blah..." but it's not always obvious... So what are the x and y axes, what was done, etc
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular
mechanisms guiding their sustained functional adaptation remain unclear. Kolter and
Döring et al. show that local i...
www.cell.com
October 16, 2025 at 9:00 AM
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
December 27, 2024 at 12:09 PM
#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30
Angiogenic niche comprising #EndothelialCell Fibroblast Mφ
Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB
#CellStemCell 2024
www.cell.com/cell-stem-ce...
The only lung person presenting to some of the greats of the TGFb signalling world 🌍
TGFbeta driven remodelling and fibrosis across lung diseases, from airways to alveoli, and from babies to diseases of advanced age 😎
TGFbeta driven remodelling and fibrosis across lung diseases, from airways to alveoli, and from babies to diseases of advanced age 😎
October 24, 2025 at 11:01 AM
The only lung person presenting to some of the greats of the TGFb signalling world 🌍
TGFbeta driven remodelling and fibrosis across lung diseases, from airways to alveoli, and from babies to diseases of advanced age 😎
TGFbeta driven remodelling and fibrosis across lung diseases, from airways to alveoli, and from babies to diseases of advanced age 😎
Yup.
Highlights how extremely difficult and unpredictable it is getting anything from bench to bedside. Even the most exciting, robust and replicated research discoveries like AVB6’s role in activating TGFb.
I still hope it happens.
Highlights how extremely difficult and unpredictable it is getting anything from bench to bedside. Even the most exciting, robust and replicated research discoveries like AVB6’s role in activating TGFb.
I still hope it happens.
February 13, 2025 at 6:41 PM
Yup.
Highlights how extremely difficult and unpredictable it is getting anything from bench to bedside. Even the most exciting, robust and replicated research discoveries like AVB6’s role in activating TGFb.
I still hope it happens.
Highlights how extremely difficult and unpredictable it is getting anything from bench to bedside. Even the most exciting, robust and replicated research discoveries like AVB6’s role in activating TGFb.
I still hope it happens.
TGFB (Thank God for Birria)
August 12, 2023 at 12:50 AM
TGFB (Thank God for Birria)
Russian drones strike Ukrainian city of Odesa, underlining challenges for even limited truce
www.youtube.com/watch?v=TgFb...
www.youtube.com/watch?v=TgFb...
MAGA Regret: Trump Voters Beg LIBERALS for HELP as Reality Hits!
YouTube video by JRM REACTS
www.youtube.com
March 21, 2025 at 6:57 PM
Russian drones strike Ukrainian city of Odesa, underlining challenges for even limited truce
www.youtube.com/watch?v=TgFb...
www.youtube.com/watch?v=TgFb...
#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...
Redirecting
doi.org
October 18, 2025 at 7:33 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...
We identify a mechanism for clonal expansion of MDS through local immunosuppressive effects of MDS mutant cells through secretion of TGFb, as well as cell intrinsic effects as mutant cells themselves have dampened recognition of TGFb (gorgeous art by @DrawImpacts):
May 12, 2026 at 11:41 AM
We identify a mechanism for clonal expansion of MDS through local immunosuppressive effects of MDS mutant cells through secretion of TGFb, as well as cell intrinsic effects as mutant cells themselves have dampened recognition of TGFb (gorgeous art by @DrawImpacts):
#WeekendRead! #MetabolismPower! @fendtlab.bsky.social &co show @ Nature that pulmonary aspartate favors lung metastases via CREB & DOHH dependent hypusination of the alternative translation factor eIF5A, driving TGFb & collagen deposition! www.nature.com/articles/s41...
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
www.nature.com
January 5, 2025 at 3:43 PM
#WeekendRead! #MetabolismPower! @fendtlab.bsky.social &co show @ Nature that pulmonary aspartate favors lung metastases via CREB & DOHH dependent hypusination of the alternative translation factor eIF5A, driving TGFb & collagen deposition! www.nature.com/articles/s41...
IL-17REL is increased under inflammatory conditions, such as during colitis, induced by TGFb. It functions as a soluble decoy receptor, capturing IL-17A, F and C.
3/5
3/5
January 6, 2026 at 11:17 AM
IL-17REL is increased under inflammatory conditions, such as during colitis, induced by TGFb. It functions as a soluble decoy receptor, capturing IL-17A, F and C.
3/5
3/5
#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!
Matrix-producing neutrophils populate and shield the skin - Nature
A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.
www.nature.com
March 19, 2025 at 7:36 PM
#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!
Not using an adjuvant during the i.n. booster is possible due to the previously generated memory CD4 T cells, which are critical to differentiate memory B cells (from local lymph nodes) into IgA producing plasma cells, using CD40 and TGFb.
4/6
4/6
May 14, 2025 at 10:11 AM
Not using an adjuvant during the i.n. booster is possible due to the previously generated memory CD4 T cells, which are critical to differentiate memory B cells (from local lymph nodes) into IgA producing plasma cells, using CD40 and TGFb.
4/6
4/6
