I hate TK2D. I hate TK2D.I hate TK2D. I hate TK2D. I hate TK2D. I hate TK2D. I hate TK2D. I hate TK2D.I hate TK2D.
Curse you Team Cherry for using abandonware in your game based off of a game that started development before the software is abandonware. (This is a joke, but fuck TK2D and abandonware)
Curse you Team Cherry for using abandonware in your game based off of a game that started development before the software is abandonware. (This is a joke, but fuck TK2D and abandonware)
July 22, 2026 at 1:50 AM
I hate TK2D. I hate TK2D.I hate TK2D. I hate TK2D. I hate TK2D. I hate TK2D. I hate TK2D. I hate TK2D.I hate TK2D.
Curse you Team Cherry for using abandonware in your game based off of a game that started development before the software is abandonware. (This is a joke, but fuck TK2D and abandonware)
Curse you Team Cherry for using abandonware in your game based off of a game that started development before the software is abandonware. (This is a joke, but fuck TK2D and abandonware)
#ACMGMtg26: Researchers noted that TK1 may partially compensate for #TK2 deficiency in vitro, although its contribution to #mtDNA maintenance in this system remains unclear. @theacmg.bsky.social
Read more: https://bit.ly/4t0VcLP
#RareDisease #TK2d #MedSky
Read more: https://bit.ly/4t0VcLP
#RareDisease #TK2d #MedSky
In Vitro Assays Fail to Detect mtDNA Depletion for Pathogenic Variants Found in TK2d Patients
Researchers developed an in vitro assay for TK2 variants, but mtDNA depletion was minimal, highlighting challenges in modeling TK2d.
bit.ly
March 19, 2026 at 7:37 PM
#ACMGMtg26: Researchers noted that TK1 may partially compensate for #TK2 deficiency in vitro, although its contribution to #mtDNA maintenance in this system remains unclear. @theacmg.bsky.social
Read more: https://bit.ly/4t0VcLP
#RareDisease #TK2d #MedSky
Read more: https://bit.ly/4t0VcLP
#RareDisease #TK2d #MedSky
Primary mitochondrial diseases (#PMDs), including thymidine kinase 2 deficiency (#TK2d), may be driven not only by bioenergetic failure but also by activation of innate immunity triggered by mitochondrial DNA release (#mtDNA).
Read here: https://bit.ly/4qlWwao
#RareDisease #MedSky
Read here: https://bit.ly/4qlWwao
#RareDisease #MedSky
Signaling Cascade Triggered by Circulating mtDNA May Contribute to Inflammation in TK2d
Primary mitochondrial diseases such as TK2d may involve not just energy failure, but also mtDNA-triggered immune activation.
bit.ly
February 6, 2026 at 10:14 PM
Primary mitochondrial diseases (#PMDs), including thymidine kinase 2 deficiency (#TK2d), may be driven not only by bioenergetic failure but also by activation of innate immunity triggered by mitochondrial DNA release (#mtDNA).
Read here: https://bit.ly/4qlWwao
#RareDisease #MedSky
Read here: https://bit.ly/4qlWwao
#RareDisease #MedSky
“Espero con este fármaco poder hacer las actividades del día a día”. Sergio y Sofía sufren una enfermedad ultrarrara que afecta a una persona de cada millón. Solo hay 250 enfermos en todo el mundo, pero España es el país donde más casos hay diagnosticados
El enigma de la enfermedad ultrarrara que abunda en España
La neuróloga del Hospital 12 de Octubre Cristina Domínguez impulsa un ensayo clínico que permita recibir tratamiento a decenas de pacientes adultos de TK2d en nuestro país, donde más casos se han detectado en todo el mundo
dozz.es
February 26, 2025 at 10:11 AM
“Espero con este fármaco poder hacer las actividades del día a día”. Sergio y Sofía sufren una enfermedad ultrarrara que afecta a una persona de cada millón. Solo hay 250 enfermos en todo el mundo, pero España es el país donde más casos hay diagnosticados
Catch up on the latest news from the Child Neurology Society (CNS), including a webinar, residency application updates, and a new Mission Partner supporting education in epilepsy and TK2d. Swipe through for details and click the link below to learn more: https://ow.ly/rJAt50YPw43
April 27, 2026 at 1:01 PM
Catch up on the latest news from the Child Neurology Society (CNS), including a webinar, residency application updates, and a new Mission Partner supporting education in epilepsy and TK2d. Swipe through for details and click the link below to learn more: https://ow.ly/rJAt50YPw43
Exactly! For HK, TC uses a sprite animation library called tk2d that allows them to specify a fixed framerate for each animation individually
This, theoretically, should help guarantee a consistent experience, but bc of jank you might see diferences between higher and lower fps
This, theoretically, should help guarantee a consistent experience, but bc of jank you might see diferences between higher and lower fps
September 9, 2025 at 5:34 AM
Exactly! For HK, TC uses a sprite animation library called tk2d that allows them to specify a fixed framerate for each animation individually
This, theoretically, should help guarantee a consistent experience, but bc of jank you might see diferences between higher and lower fps
This, theoretically, should help guarantee a consistent experience, but bc of jank you might see diferences between higher and lower fps
#MitoAwarenessWeek highlights mitochondrial diseases like #TK2d. Delays in diagnosis due to limited knowledge & similarities with other myopathies can impact outcomes for the TK2d community. UCB is committed to increasing education for accurate diagnoses. More about TK2d: www.ucb.com/solutions/di...
September 15, 2025 at 8:34 AM
#MitoAwarenessWeek highlights mitochondrial diseases like #TK2d. Delays in diagnosis due to limited knowledge & similarities with other myopathies can impact outcomes for the TK2d community. UCB is committed to increasing education for accurate diagnoses. More about TK2d: www.ucb.com/solutions/di...
We're excited to announce our partnership with UCB to accelerate research and diagnosis for thymidine kinase 2 deficiency (TK2d)—a devastating but underdiagnosed rare mitochondrial disease. Read the #pressrelease ➡️ www.genomenon.com/news-press-e...
July 10, 2025 at 1:20 PM
We're excited to announce our partnership with UCB to accelerate research and diagnosis for thymidine kinase 2 deficiency (TK2d)—a devastating but underdiagnosed rare mitochondrial disease. Read the #pressrelease ➡️ www.genomenon.com/news-press-e...
UCB is a Diamond Partner at #Euromit2026 💎
We look forward to discussing the latest advancements in thymidine kinase 2 deficiency (TK2d) with the mitochondrial community and sharing our commitment to optimize TK2d management.
Meet us at Euromit2026! 🤝
#mitochondrialdisease #TK2d #raredisease #UCB
We look forward to discussing the latest advancements in thymidine kinase 2 deficiency (TK2d) with the mitochondrial community and sharing our commitment to optimize TK2d management.
Meet us at Euromit2026! 🤝
#mitochondrialdisease #TK2d #raredisease #UCB
February 16, 2026 at 8:03 AM
UCB is a Diamond Partner at #Euromit2026 💎
We look forward to discussing the latest advancements in thymidine kinase 2 deficiency (TK2d) with the mitochondrial community and sharing our commitment to optimize TK2d management.
Meet us at Euromit2026! 🤝
#mitochondrialdisease #TK2d #raredisease #UCB
We look forward to discussing the latest advancements in thymidine kinase 2 deficiency (TK2d) with the mitochondrial community and sharing our commitment to optimize TK2d management.
Meet us at Euromit2026! 🤝
#mitochondrialdisease #TK2d #raredisease #UCB
UCB Unveils Groundbreaking TK2d Research at Upcoming UMDF Conference in 2025#United_States#St._Louis#UCB#Thymidine_Kinase#UMDF
UCB Unveils Groundbreaking TK2d Research at Upcoming UMDF Conference in 2025
UCB prepares to showcase innovative research on thymidine kinase 2 deficiency (TK2d) at the 2025 UMDF Conference, emphasizing patient experiences.
third-news.com
June 20, 2025 at 11:21 AM
UCB Unveils Groundbreaking TK2d Research at Upcoming UMDF Conference in 2025#United_States#St._Louis#UCB#Thymidine_Kinase#UMDF
From thymidine kinase 2 deficiency (TK2d) recognition to management
Diagnosis pathways are rarely linear and shaped by key clinical decisions.
At #Euromit2026, UCB joins scientific exchange on TK2d, through sessions, exhibition, and a symposium on the journey from recognition to disease management.💬
Diagnosis pathways are rarely linear and shaped by key clinical decisions.
At #Euromit2026, UCB joins scientific exchange on TK2d, through sessions, exhibition, and a symposium on the journey from recognition to disease management.💬
May 6, 2026 at 9:44 AM
From thymidine kinase 2 deficiency (TK2d) recognition to management
Diagnosis pathways are rarely linear and shaped by key clinical decisions.
At #Euromit2026, UCB joins scientific exchange on TK2d, through sessions, exhibition, and a symposium on the journey from recognition to disease management.💬
Diagnosis pathways are rarely linear and shaped by key clinical decisions.
At #Euromit2026, UCB joins scientific exchange on TK2d, through sessions, exhibition, and a symposium on the journey from recognition to disease management.💬
How are thymidine kinase 2 deficiency (TK2d) care strategies evolving? Michio Hirano shares the latest updates on managing TK2d, from early symptom care to emerging disease-modifying therapies, in this accredited on-demand symposium from #EPNS2025 #MedSky #NeuroSky
ow.ly/sagZ50X3w58
ow.ly/sagZ50X3w58
September 29, 2025 at 3:39 PM
How are thymidine kinase 2 deficiency (TK2d) care strategies evolving? Michio Hirano shares the latest updates on managing TK2d, from early symptom care to emerging disease-modifying therapies, in this accredited on-demand symposium from #EPNS2025 #MedSky #NeuroSky
ow.ly/sagZ50X3w58
ow.ly/sagZ50X3w58
What's new in TK2d? Watch this accredited symposium recording from #EPNS2025 for the latest insights from Cristina Domínguez González, Caterina Garone, and Michio Hirano on early detection and emerging therapies for TK2d. Visit Medthority today to earn your #CME credit
#MedEd
ow.ly/I4l250WwNtj
#MedEd
ow.ly/I4l250WwNtj
July 29, 2025 at 3:04 PM
What's new in TK2d? Watch this accredited symposium recording from #EPNS2025 for the latest insights from Cristina Domínguez González, Caterina Garone, and Michio Hirano on early detection and emerging therapies for TK2d. Visit Medthority today to earn your #CME credit
#MedEd
ow.ly/I4l250WwNtj
#MedEd
ow.ly/I4l250WwNtj
#MDAConference: Thymidine kinase 2 deficiency (#TK2d) is an ultrarare but measurable genetic disease worldwide, according to estimates set to be presented at the 2026 @mda.org Clinical and Scientific Conference.
Read more: https://bit.ly/4riZuNa
#RareDisease #MedSky
Read more: https://bit.ly/4riZuNa
#RareDisease #MedSky
Analysis Estimates Global TK2d Prevalence, Identifying Population-Specific Differences
TK2d is an ultrarare but measurable genetic disease worldwide, with an estimated prevalence of up to 2.82 per million pregnancies.
bit.ly
March 9, 2026 at 4:47 PM
#MDAConference: Thymidine kinase 2 deficiency (#TK2d) is an ultrarare but measurable genetic disease worldwide, according to estimates set to be presented at the 2026 @mda.org Clinical and Scientific Conference.
Read more: https://bit.ly/4riZuNa
#RareDisease #MedSky
Read more: https://bit.ly/4riZuNa
#RareDisease #MedSky
Thymidine Kinase 2 Deficiency (TK2d) is a rare mitochondrial disorder causing progressive muscle weakness and respiratory failure in children and adults.
Learn more: https://dub.sh/TK2d
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
Learn more: https://dub.sh/TK2d
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
August 10, 2026 at 2:00 PM
Thymidine Kinase 2 Deficiency (TK2d) is a rare mitochondrial disorder causing progressive muscle weakness and respiratory failure in children and adults.
Learn more: https://dub.sh/TK2d
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
Learn more: https://dub.sh/TK2d
You may be rare, but you're not alone!
#rareDisease #rareDiseaseAwareness
#DGUOK, a mitochondrial disorder similar to #TK2d, reprograms hepatocellular metabolism and triggers innate immune signaling through a purine-dependent mechanism, leading to metabolic and immunological changes. Study in @biorxivpreprint.bsky.social
Read more: https://bit.ly/3MwjLjG
Read more: https://bit.ly/3MwjLjG
Study Finds Link Between Deoxyguanosine Kinase Deficiency and Immune Activation in Liver
Research shows DGUOK deficiency, a mitochondrial disorder like TK2d, reprograms hepatocellular metabolism and triggers innate immune signaling in the liver.
bit.ly
December 10, 2025 at 4:45 PM
#DGUOK, a mitochondrial disorder similar to #TK2d, reprograms hepatocellular metabolism and triggers innate immune signaling through a purine-dependent mechanism, leading to metabolic and immunological changes. Study in @biorxivpreprint.bsky.social
Read more: https://bit.ly/3MwjLjG
Read more: https://bit.ly/3MwjLjG
A case involving a patient with a novel homozygous #POLG mutation, an important differential diagnosis for thymidine kinase 2 deficiency (#TK2d). Published in Acta Neurologica Belgica.
Read more: https://bit.ly/47V8qkp
#RareDisease #ThymidineKinase2Deficiency #MedSky #Neurology
Read more: https://bit.ly/47V8qkp
#RareDisease #ThymidineKinase2Deficiency #MedSky #Neurology
Case Report: Novel Homozygous POLG Mutation
A case report describes a novel homozygous POLG mutation, an important differential diagnosis for thymidine kinase 2 deficiency (TK2d).
bit.ly
November 11, 2025 at 4:53 PM
A case involving a patient with a novel homozygous #POLG mutation, an important differential diagnosis for thymidine kinase 2 deficiency (#TK2d). Published in Acta Neurologica Belgica.
Read more: https://bit.ly/47V8qkp
#RareDisease #ThymidineKinase2Deficiency #MedSky #Neurology
Read more: https://bit.ly/47V8qkp
#RareDisease #ThymidineKinase2Deficiency #MedSky #Neurology
Stay up to date with the latest insights on #TK2d diagnosis from #EPNS2025, from clinical signs and symptoms to key differential biomarkers. Watch now to earn #CME credit, free and on demand #MedSky
ow.ly/8HOF50WNzRv
ow.ly/8HOF50WNzRv
August 28, 2025 at 2:20 PM
Stay up to date with the latest insights on #TK2d diagnosis from #EPNS2025, from clinical signs and symptoms to key differential biomarkers. Watch now to earn #CME credit, free and on demand #MedSky
ow.ly/8HOF50WNzRv
ow.ly/8HOF50WNzRv
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
November 10, 2025 at 1:38 PM
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
This is not saying it was easy- our half broken version of TK2D AssetRipper produces from the built game does NOT like it, and is throwing a MASSIVE hissy fit and being a PITA to get it to work lol.
August 5, 2026 at 3:33 AM
This is not saying it was easy- our half broken version of TK2D AssetRipper produces from the built game does NOT like it, and is throwing a MASSIVE hissy fit and being a PITA to get it to work lol.
Looking for #ICNMD2026 updates? Register to receive the on-demand recording of our EBAC‑accredited symposium on advancing TK2d management, with Caterina Garone, Yolanda Cámara, and Cristina Domínguez González discussing emerging evidence and real‑world practice
https://ow.ly/Cp3q50ZlAjx
https://ow.ly/Cp3q50ZlAjx
July 8, 2026 at 4:01 PM
Looking for #ICNMD2026 updates? Register to receive the on-demand recording of our EBAC‑accredited symposium on advancing TK2d management, with Caterina Garone, Yolanda Cámara, and Cristina Domínguez González discussing emerging evidence and real‑world practice
https://ow.ly/Cp3q50ZlAjx
https://ow.ly/Cp3q50ZlAjx
No es magia, son tus impuestos.
El enigma de la enfermedad ultrarrara que abunda en España
La neuróloga del Hospital 12 de Octubre Cristina Domínguez impulsa un ensayo clínico que permita recibir tratamiento a decenas de pacientes adultos de TK2d en nuestro país, donde más casos se han dete...
elpais.com
February 26, 2025 at 8:29 AM
No es magia, son tus impuestos.