Input-tuned TLR8-dependent mechanism shaping differential immune programs towards archaea
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
November 3, 2026 at 1:22 AM
Input-tuned TLR8-dependent mechanism shaping differential immune programs towards archaea
www.nature.com/articles/s41... @natcomms.nature.com
www.nature.com/articles/s41... @natcomms.nature.com
TLR8 gain-of-function syndrome. New review from Hwi M. Gil and Megan A. Cooper @macattacklab.bsky.social @washumedicine.bsky.social:
rupress.org/jhi/article/...
#immunodeficiencies #InbornErrorsOfImmunity #TLR8
rupress.org/jhi/article/...
#immunodeficiencies #InbornErrorsOfImmunity #TLR8
October 29, 2026 at 3:04 PM
TLR8 gain-of-function syndrome. New review from Hwi M. Gil and Megan A. Cooper @macattacklab.bsky.social @washumedicine.bsky.social:
rupress.org/jhi/article/...
#immunodeficiencies #InbornErrorsOfImmunity #TLR8
rupress.org/jhi/article/...
#immunodeficiencies #InbornErrorsOfImmunity #TLR8
Authoritative review on a fascinating condition:
TLR8 gain-of-function syndrome rupress.org/jhi/article/...
TLR8 gain-of-function syndrome rupress.org/jhi/article/...
TLR8 gain-of-function syndrome
In this Review, Gil and Cooper review the molecular, immunologic, and clinical features of TLR8 gain-of-function syndrome. They review findings from patien
rupress.org
October 24, 2026 at 2:28 AM
Authoritative review on a fascinating condition:
TLR8 gain-of-function syndrome rupress.org/jhi/article/...
TLR8 gain-of-function syndrome rupress.org/jhi/article/...
Gil and Cooper @macattacklab.bsky.social review the molecular, immunologic, & clinical features of #TLR8 gain-of-function syndrome. They review findings from patients w/ mosaic & germline disease, and integrate knowledge of key structural components of the TLR8 protein. rupress.org/jhi/article/...
October 22, 2026 at 4:30 PM
Gil and Cooper @macattacklab.bsky.social review the molecular, immunologic, & clinical features of #TLR8 gain-of-function syndrome. They review findings from patients w/ mosaic & germline disease, and integrate knowledge of key structural components of the TLR8 protein. rupress.org/jhi/article/...
In @jhumimmunity.org, @macattacklab.bsky.social review the molecular, immunologic & clinical features of #TLR8 gain-of-function syndrome. They review findings from patients w/ mosaic & germline disease & integrate knowledge of key structural components of the TLR8 protein rupress.org/jhi/article/...
October 22, 2026 at 6:01 PM
In @jhumimmunity.org, @macattacklab.bsky.social review the molecular, immunologic & clinical features of #TLR8 gain-of-function syndrome. They review findings from patients w/ mosaic & germline disease & integrate knowledge of key structural components of the TLR8 protein rupress.org/jhi/article/...
In the 5 years since we first reported TLR8 GOF we have learned
-it is X-linked DOMINANT
-mosaic or germline variants with AA 432, an antagonist binding site, most commonly affected
-patients can be very sick, early recognition by deep sequencing and get them to HCT
-emerging spectrum of severity
-it is X-linked DOMINANT
-mosaic or germline variants with AA 432, an antagonist binding site, most commonly affected
-patients can be very sick, early recognition by deep sequencing and get them to HCT
-emerging spectrum of severity
In @jhumimmunity.org, @macattacklab.bsky.social review the molecular, immunologic & clinical features of #TLR8 gain-of-function syndrome. They review findings from patients w/ mosaic & germline disease & integrate knowledge of key structural components of the TLR8 protein rupress.org/jhi/article/...
October 23, 2026 at 12:12 AM
In the 5 years since we first reported TLR8 GOF we have learned
-it is X-linked DOMINANT
-mosaic or germline variants with AA 432, an antagonist binding site, most commonly affected
-patients can be very sick, early recognition by deep sequencing and get them to HCT
-emerging spectrum of severity
-it is X-linked DOMINANT
-mosaic or germline variants with AA 432, an antagonist binding site, most commonly affected
-patients can be very sick, early recognition by deep sequencing and get them to HCT
-emerging spectrum of severity
“GSK entered the year w a number of potential follow-ups to bepirovirsen in the works. But, w/ the TLR8 agonist GSK5251738 scrapped and GSK3965193’s future in doubt, the one significant candidate still in development appears to be the phase 2-stage hepatitis B virus-targeted siRNA drug GSK5637608”
Amid bepirovirsen triumph, GSK quietly scraps trial of next-gen hep B therapy
GSK’s hepatitis B credentials may be secured with Tuesday’s landmark FDA nod for its “functional cure” bepirovirsen, but the pharma has continued to tweak its strategy for next-gen candidates. | GSK m...
www.fiercebiotech.com
October 21, 2026 at 4:56 PM
“GSK entered the year w a number of potential follow-ups to bepirovirsen in the works. But, w/ the TLR8 agonist GSK5251738 scrapped and GSK3965193’s future in doubt, the one significant candidate still in development appears to be the phase 2-stage hepatitis B virus-targeted siRNA drug GSK5637608”
Mosaic #TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy. New report from Jenny A. Patel, Megan A. Cooper @macattacklab.bsky.social, Ofer Zimmerman and colleagues @washumedicine.bsky.social:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
October 1, 2026 at 2:31 PM
Mosaic #TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy. New report from Jenny A. Patel, Megan A. Cooper @macattacklab.bsky.social, Ofer Zimmerman and colleagues @washumedicine.bsky.social:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
When is SEGA gonna add this masterpiece to one of the arcades in Yakuza?
www.youtube.com/watch?v=Tlr8...
www.youtube.com/watch?v=Tlr8...
テディボーイブルース [AC] 1985 セガ アーケード
YouTube video by ゲーセンYOUGO / Arcade YOUGO
www.youtube.com
September 30, 2026 at 6:31 PM
When is SEGA gonna add this masterpiece to one of the arcades in Yakuza?
www.youtube.com/watch?v=Tlr8...
www.youtube.com/watch?v=Tlr8...
A pleasure to work with Ofer Zimmerman & @washumedicine.bsky.social heme to make the diagnosis in this adult woman who had symptoms for two decades. TLR8 GOF is X linked DOMINANT -males & females. Our original cohorts were younger (I’m a pediatrician!) there are more older adults out there
Patel, @macattacklab.bsky.social, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...
September 24, 2026 at 11:14 PM
A pleasure to work with Ofer Zimmerman & @washumedicine.bsky.social heme to make the diagnosis in this adult woman who had symptoms for two decades. TLR8 GOF is X linked DOMINANT -males & females. Our original cohorts were younger (I’m a pediatrician!) there are more older adults out there
Mosaic TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy rupress.org/jhi/article/...
Mosaic TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy
Patel et al. describe an elderly woman with severe chronic neutropenia caused by mosaic TLR8 gain-of-function. The report broadens a primarily pediatric, m
rupress.org
September 24, 2026 at 2:47 PM
Mosaic TLR8 gain-of-function in an elderly female treated with JAK inhibitor and adjunctive therapy rupress.org/jhi/article/...
Patel, @macattacklab.bsky.social, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...
September 24, 2026 at 4:00 PM
Patel, @macattacklab.bsky.social, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...
In @jhumimmunity.org, Patel, Cooper, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...
September 24, 2026 at 4:00 PM
In @jhumimmunity.org, Patel, Cooper, Zimmerman et al. describe an elderly woman w/ severe chronic #neutropenia caused by mosaic #TLR8 GOF, broadening a primarily pediatric, male disease spectrum & highlighting somatic mosaicism as an important diagnostic consideration rupress.org/jhi/article/...
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus | Nature Reviews Rheumatology https://buff.ly/3CmxswA Incomplete X chromosomal inactivation of TLR7, TLR8 and CD40L might further contribute to such a positive feedforward loop
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus - Nature Reviews Rheumatology
BCR-independent memory B cell reactivation via TLR7 or TLR8 activation, type I interferon production, immune complex formation and T helper cell signalling is central in SLE pathogenesis. Dörner and…
buff.ly
November 12, 2024 at 2:53 PM
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus | Nature Reviews Rheumatology https://buff.ly/3CmxswA Incomplete X chromosomal inactivation of TLR7, TLR8 and CD40L might further contribute to such a positive feedforward loop
Sequencing has aided in the discovery of mutations in inborn errors of immunity, but their clinical relevance is often unclear
Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....
Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....
March 2, 2026 at 9:01 PM
Sequencing has aided in the discovery of mutations in inborn errors of immunity, but their clinical relevance is often unclear
Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....
Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....
en el citoplasma (compartimento interior de la célula) como TLR3, TLR8 o TLR13 que reconocen fragmentos comunes en muchos patógenos. El ejemplo para entender cómo actúan estos receptores podrían ser las alarmas caseras que detectan movimiento. En un hogar hay...
4/n
4/n
November 21, 2024 at 12:48 PM
en el citoplasma (compartimento interior de la célula) como TLR3, TLR8 o TLR13 que reconocen fragmentos comunes en muchos patógenos. El ejemplo para entender cómo actúan estos receptores podrían ser las alarmas caseras que detectan movimiento. En un hogar hay...
4/n
4/n
www.nature.com/articles/s41...
“During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chaperone protein UNC93B1. All variants increased TLR7 and TLR8 signalling and caused systemic lupus erythematosus “
#SLE #lupus #TLR
“During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chaperone protein UNC93B1. All variants increased TLR7 and TLR8 signalling and caused systemic lupus erythematosus “
#SLE #lupus #TLR
The emergence of SLE-causing UNC93B1 variants in 2024 - Nature Reviews Rheumatology
During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chaperone protein UNC93B1. All variants increased TLR7 and TLR8 signalling and cau...
www.nature.com
November 21, 2024 at 9:34 AM
www.nature.com/articles/s41...
“During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chaperone protein UNC93B1. All variants increased TLR7 and TLR8 signalling and caused systemic lupus erythematosus “
#SLE #lupus #TLR
“During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chaperone protein UNC93B1. All variants increased TLR7 and TLR8 signalling and caused systemic lupus erythematosus “
#SLE #lupus #TLR
Since officials #Rheumatology accounts are not here yet, I will start posting papers that I liked recently.
Can’t miss #lupus 🦋💙
👉Memory B cells are hyporesponsive to BCR stimulation in lupus but can be activated upon TLR engagement and interaction with T cells.
www.nature.com/articles/s41...
Can’t miss #lupus 🦋💙
👉Memory B cells are hyporesponsive to BCR stimulation in lupus but can be activated upon TLR engagement and interaction with T cells.
www.nature.com/articles/s41...
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus - Nature Reviews Rheumatology
BCR-independent memory B cell reactivation via TLR7 or TLR8 activation, type I interferon production, immune complex formation and T helper cell signalling is central in SLE pathogenesis. Dörner and L...
www.nature.com
November 11, 2024 at 1:22 PM
Since officials #Rheumatology accounts are not here yet, I will start posting papers that I liked recently.
Can’t miss #lupus 🦋💙
👉Memory B cells are hyporesponsive to BCR stimulation in lupus but can be activated upon TLR engagement and interaction with T cells.
www.nature.com/articles/s41...
Can’t miss #lupus 🦋💙
👉Memory B cells are hyporesponsive to BCR stimulation in lupus but can be activated upon TLR engagement and interaction with T cells.
www.nature.com/articles/s41...
New approaches to research into systemic sclerosis
TLR8 influences the production of disease-related cytokines
Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the l...
weiterlesen
TLR8 influences the production of disease-related cytokines
Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the l...
weiterlesen
September 23, 2024 at 12:31 PM
New approaches to research into systemic sclerosis
TLR8 influences the production of disease-related cytokines
Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the l...
weiterlesen
TLR8 influences the production of disease-related cytokines
Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the l...
weiterlesen
Neue Ansätze zur Erforschung der systemischen Sklerose
TLR8 beeinflusst Bildung von krankheitsrelevanten Zytokinen
Die systemische Sklerose ist eine Autoimmunerkrankung, die vor allem Entzündungen der Haut, sowie innerer Organe wie Lunge und...
weiterlesen
TLR8 beeinflusst Bildung von krankheitsrelevanten Zytokinen
Die systemische Sklerose ist eine Autoimmunerkrankung, die vor allem Entzündungen der Haut, sowie innerer Organe wie Lunge und...
weiterlesen
September 23, 2024 at 12:15 PM
Neue Ansätze zur Erforschung der systemischen Sklerose
TLR8 beeinflusst Bildung von krankheitsrelevanten Zytokinen
Die systemische Sklerose ist eine Autoimmunerkrankung, die vor allem Entzündungen der Haut, sowie innerer Organe wie Lunge und...
weiterlesen
TLR8 beeinflusst Bildung von krankheitsrelevanten Zytokinen
Die systemische Sklerose ist eine Autoimmunerkrankung, die vor allem Entzündungen der Haut, sowie innerer Organe wie Lunge und...
weiterlesen
Printing my photo as a #cyanotype on kodak film packaging.
I don’t print my own work enough, and Cyanotypes are such a fun way to do so!
#kodak #35mmfilm #alternativeprintingprocess #streetphotography
www.instagram.com/reel/DZ-Tlr8...
I don’t print my own work enough, and Cyanotypes are such a fun way to do so!
#kodak #35mmfilm #alternativeprintingprocess #streetphotography
www.instagram.com/reel/DZ-Tlr8...
Instagram
Create an account or log in to Instagram - Share what you're into with the people who get you.
www.instagram.com
June 29, 2026 at 6:40 PM
Printing my photo as a #cyanotype on kodak film packaging.
I don’t print my own work enough, and Cyanotypes are such a fun way to do so!
#kodak #35mmfilm #alternativeprintingprocess #streetphotography
www.instagram.com/reel/DZ-Tlr8...
I don’t print my own work enough, and Cyanotypes are such a fun way to do so!
#kodak #35mmfilm #alternativeprintingprocess #streetphotography
www.instagram.com/reel/DZ-Tlr8...
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
June 10, 2026 at 11:58 AM
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
June 10, 2026 at 11:51 AM
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
June 10, 2026 at 11:47 AM
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,
June 10, 2026 at 11:47 AM
[2/3] application for ACT201 injection has been accepted. ACT201 injection is an innovative antisense oligonucleotide (ASO) drug that has the characteristics of significantly improving RNase H-mediated antiviral activity, moderately increasing human TLR8 (hTLR8) agonist activity,