Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation https://www.biorxiv.org/content/10.64898/2026.09.24.754070v1
September 30, 2026 at 12:15 AM
Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation https://www.biorxiv.org/content/10.64898/2026.09.24.754070v1
Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation https://www.biorxiv.org/content/10.64898/2026.09.24.754070v1
September 30, 2026 at 12:15 AM
Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation https://www.biorxiv.org/content/10.64898/2026.09.24.754070v1
#Pericyte #Mechanobiology
Primary🐭cardiac pericyte (Ca2+) senses Compressive force (1 g/cm2 by calibrated weights on coverslip), via TRPM4 & TRPM7
TRPM4i, 9-phenanthrol, ⏬infarct size by 60% in🐭MI
@mishracbflab.bsky.social @physrep.bsky.social 2025
physoc.onlinelibrary.wiley.com/doi/10.14814...
Primary🐭cardiac pericyte (Ca2+) senses Compressive force (1 g/cm2 by calibrated weights on coverslip), via TRPM4 & TRPM7
TRPM4i, 9-phenanthrol, ⏬infarct size by 60% in🐭MI
@mishracbflab.bsky.social @physrep.bsky.social 2025
physoc.onlinelibrary.wiley.com/doi/10.14814...
June 21, 2025 at 11:55 AM
#Pericyte #Mechanobiology
Primary🐭cardiac pericyte (Ca2+) senses Compressive force (1 g/cm2 by calibrated weights on coverslip), via TRPM4 & TRPM7
TRPM4i, 9-phenanthrol, ⏬infarct size by 60% in🐭MI
@mishracbflab.bsky.social @physrep.bsky.social 2025
physoc.onlinelibrary.wiley.com/doi/10.14814...
Primary🐭cardiac pericyte (Ca2+) senses Compressive force (1 g/cm2 by calibrated weights on coverslip), via TRPM4 & TRPM7
TRPM4i, 9-phenanthrol, ⏬infarct size by 60% in🐭MI
@mishracbflab.bsky.social @physrep.bsky.social 2025
physoc.onlinelibrary.wiley.com/doi/10.14814...
Human CD4 T-cell activation relies on TRPM7, an ion channel regulating magnesium and calcium.
Blocking TRPM7 reduces activation, IL-2 secretion, and proliferation.
Findings suggest TRPM7 could be a drug target for T-cell-related diseases.
www.biorxiv.org/content/10.1...
Blocking TRPM7 reduces activation, IL-2 secretion, and proliferation.
Findings suggest TRPM7 could be a drug target for T-cell-related diseases.
www.biorxiv.org/content/10.1...
TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner
T lymphocyte activation is a crucial process in the regulation of innate and adaptive immune responses. The ion channel-kinase TRPM7 has previously been implicated in cellular Mg2+ homeostasis, prolif...
www.biorxiv.org
December 8, 2024 at 9:18 PM
Human CD4 T-cell activation relies on TRPM7, an ion channel regulating magnesium and calcium.
Blocking TRPM7 reduces activation, IL-2 secretion, and proliferation.
Findings suggest TRPM7 could be a drug target for T-cell-related diseases.
www.biorxiv.org/content/10.1...
Blocking TRPM7 reduces activation, IL-2 secretion, and proliferation.
Findings suggest TRPM7 could be a drug target for T-cell-related diseases.
www.biorxiv.org/content/10.1...
Protein TRPM7 Linked to Alzheimer’s Disease, Parkinson’s Disease and Stroke
www.thailandmedical.news/news/protein...
www.thailandmedical.news/news/protein...
Protein TRPM7 Linked to Alzheimer’s Disease, Parkinson’s Disease and Stroke - Thailand Medical News
www.thailandmedical.news
June 7, 2026 at 2:52 AM
Protein TRPM7 Linked to Alzheimer’s Disease, Parkinson’s Disease and Stroke
www.thailandmedical.news/news/protein...
www.thailandmedical.news/news/protein...
“Administration of CBDA and CBGA (10 mg/kg) improved the cognitive deficit induced by the β-amyloid peptide and restored the physiological expression of TRPM7, a receptor involved in neurodegenerative diseases.” The study below is intense, acidic cannabinoids are the way to go! #Cannabis #Weed #CBGa
June 27, 2025 at 2:04 PM
“Administration of CBDA and CBGA (10 mg/kg) improved the cognitive deficit induced by the β-amyloid peptide and restored the physiological expression of TRPM7, a receptor involved in neurodegenerative diseases.” The study below is intense, acidic cannabinoids are the way to go! #Cannabis #Weed #CBGa
More on #TRPM7 “Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases” doi.org/10.1111/imm.... free access.
“A growing body of evidence highlights the critical role of TRPM7 in autoimmue diseases, including #rheumatoidarthritis, #MultipleSclerosis and #diabetes.”
“A growing body of evidence highlights the critical role of TRPM7 in autoimmue diseases, including #rheumatoidarthritis, #MultipleSclerosis and #diabetes.”
January 18, 2025 at 7:12 PM
More on #TRPM7 “Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases” doi.org/10.1111/imm.... free access.
“A growing body of evidence highlights the critical role of TRPM7 in autoimmue diseases, including #rheumatoidarthritis, #MultipleSclerosis and #diabetes.”
“A growing body of evidence highlights the critical role of TRPM7 in autoimmue diseases, including #rheumatoidarthritis, #MultipleSclerosis and #diabetes.”
Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7
Important, if it can be therapeutically targeted.: TRPM7 is important for cell entry for several viruses.
www.nature.com/artic...
1/4
Important, if it can be therapeutically targeted.: TRPM7 is important for cell entry for several viruses.
www.nature.com/artic...
1/4
Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7
Nature Communications - The TRPM7 channel enables endosomal acidification, which is vital for the entry of many enveloped viruses. Here, the authors show that loss of TRPM7 protects cells from...
www.nature.com
October 1, 2024 at 9:48 PM
Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7
Important, if it can be therapeutically targeted.: TRPM7 is important for cell entry for several viruses.
www.nature.com/artic...
1/4
Important, if it can be therapeutically targeted.: TRPM7 is important for cell entry for several viruses.
www.nature.com/artic...
1/4
“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial
Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice.…
www.sciencedirect.com
November 16, 2025 at 5:08 PM
“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Loss of TRPM7 kinase function impairs mTOR signaling, leading to reduced α-cell proliferation and glucagon secretion @MolMetab www.sciencedirect.com/science/arti...
TRPM7 Kinase Regulates α-Cell Proliferation and Glucagon Production in Mice
Glucagon is essential for maintaining glucose homeostasis, yet the molecular mechanisms governing α-cell function remain incompletely understood. Tran…
www.sciencedirect.com
January 10, 2026 at 2:28 AM
Loss of TRPM7 kinase function impairs mTOR signaling, leading to reduced α-cell proliferation and glucagon secretion @MolMetab www.sciencedirect.com/science/arti...
TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner https://www.biorxiv.org/content/10.1101/2024.12.04.626765v1
December 8, 2024 at 1:15 AM
TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner https://www.biorxiv.org/content/10.1101/2024.12.04.626765v1
Magnezyum takviyelerinin bağırsak bakterilerini güçlendirebileceğini ve böylece bağırsak kanseri gelişimini önleyebileceğini öne sürdüler.
Ancak genlerine ve cinsiyetlerine bağlı olarak yalnızca bazı kişilerde. Özellikle kadınlarda ve belirli TRPM7 gen varyantlarına sahip olmayan kişilerde.
Ancak genlerine ve cinsiyetlerine bağlı olarak yalnızca bazı kişilerde. Özellikle kadınlarda ve belirli TRPM7 gen varyantlarına sahip olmayan kişilerde.
Study shows magnesium inhibits colorectal cancer carcinogenesis by increasing vitamin D-synthesizing bacteria
Study shows that a magnesium supplement increases gut bacteria that have been shown to synthesize vitamin D and inhibit colorectal cancer carcinogenesis.
news.vumc.org
September 21, 2025 at 9:39 AM
Magnezyum takviyelerinin bağırsak bakterilerini güçlendirebileceğini ve böylece bağırsak kanseri gelişimini önleyebileceğini öne sürdüler.
Ancak genlerine ve cinsiyetlerine bağlı olarak yalnızca bazı kişilerde. Özellikle kadınlarda ve belirli TRPM7 gen varyantlarına sahip olmayan kişilerde.
Ancak genlerine ve cinsiyetlerine bağlı olarak yalnızca bazı kişilerde. Özellikle kadınlarda ve belirli TRPM7 gen varyantlarına sahip olmayan kişilerde.
Happy to share that our seminal work on waixenicin A derivatization is now covered by a provisional patent:
“Waixenicin A Derivatives as Neuroprotective Agents against Hypoxic Ischemic Brain Injury Through TRPM7 Blockade.”
“Waixenicin A Derivatives as Neuroprotective Agents against Hypoxic Ischemic Brain Injury Through TRPM7 Blockade.”
January 17, 2026 at 6:29 AM
Happy to share that our seminal work on waixenicin A derivatization is now covered by a provisional patent:
“Waixenicin A Derivatives as Neuroprotective Agents against Hypoxic Ischemic Brain Injury Through TRPM7 Blockade.”
“Waixenicin A Derivatives as Neuroprotective Agents against Hypoxic Ischemic Brain Injury Through TRPM7 Blockade.”
"Nous émettons l’ hypothèse que le Cd2+ (cadmium) pourrait induire la surexpression de la protéine TRPM7 et l’activation des CSP (cellules stellaires pancréatiques), favorisant ainsi le risque d’ adénocarcinome canalaire pancréatique."
June 7, 2025 at 10:17 AM
"Nous émettons l’ hypothèse que le Cd2+ (cadmium) pourrait induire la surexpression de la protéine TRPM7 et l’activation des CSP (cellules stellaires pancréatiques), favorisant ainsi le risque d’ adénocarcinome canalaire pancréatique."
Mg2+ influx mediated by TRPM7 triggers the initiation of muscle stem cell activation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mg2+ influx mediated by TRPM7 triggers the initiation of muscle stem cell activation
Mg2+ permeation via the TRPM7 ion channel acts as a primary trigger for muscle stem cell activation and muscle regeneration.
www.science.org
April 5, 2025 at 5:50 AM
Mg2+ influx mediated by TRPM7 triggers the initiation of muscle stem cell activation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7 - Nature Communications
The TRPM7 channel enables endosomal acidification, which is vital for the entry of many enveloped viruses. Here, the authors show that loss of TRPM7 protects cells from various pandemic-threat viruses...
www.nature.com
October 1, 2024 at 4:18 PM
Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner https://www.biorxiv.org/content/10.1101/2024.12.04.626765v1
December 8, 2024 at 1:15 AM
TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner https://www.biorxiv.org/content/10.1101/2024.12.04.626765v1
The authors included RRIDs in their paper! We value the author's support of reproducibility. #STMpublishing #RRID #OpenScience
The Association of Gut Microbiota With TRPM7 Genotype, Colorectal Polyps, and Magnesium
doi.org
February 1, 2026 at 8:03 AM
The authors included RRIDs in their paper! We value the author's support of reproducibility. #STMpublishing #RRID #OpenScience
Arijit Roy et al. found that diet-induced #obesity in mice increases #carotid body chemosensitivity via the leptin-TRPM7 pathway 🫀🫁
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
September 19, 2025 at 11:01 AM
Arijit Roy et al. found that diet-induced #obesity in mice increases #carotid body chemosensitivity via the leptin-TRPM7 pathway 🫀🫁
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #methodsmatter #reproducibility #accelerateopenscience
The cytoplasmic domains of the CNNM family of transmembrane proteins modulate the ion channel-kinase TRPM7
doi.org
October 26, 2025 at 7:00 AM
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #methodsmatter #reproducibility #accelerateopenscience
Seriously - THANK YOU for the dialogue today. Searching “renal” finally sent me in the right direction to determine the WHY. Part kidney, part intestinal tract - TRPM6.
January 18, 2025 at 7:32 PM
Seriously - THANK YOU for the dialogue today. Searching “renal” finally sent me in the right direction to determine the WHY. Part kidney, part intestinal tract - TRPM6.
For #MS #MultipleSclerosis, we are often told to avoid boosting the immune system using #zinc. BUT see my recent post discusses affect of #TRPM7 on zinc #homeostasis. This morning another gene variant affecting zinc levels and contributing to #autoimmune disease. Screen shot from article. 🧵
January 27, 2025 at 12:55 PM
For #MS #MultipleSclerosis, we are often told to avoid boosting the immune system using #zinc. BUT see my recent post discusses affect of #TRPM7 on zinc #homeostasis. This morning another gene variant affecting zinc levels and contributing to #autoimmune disease. Screen shot from article. 🧵
RRIDs were included in this Cell Death & Disease paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #OpenScience #methodsmatter
The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition
doi.org
May 26, 2025 at 7:01 AM
RRIDs were included in this Cell Death & Disease paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #OpenScience #methodsmatter
https://gregory-ms.com/articles/43566/
Novel TRPM7 inhibitors with potent anti-inflammatory effects <em>in vivo</em>
#MSchat #Neurology #MultipleSclerosis
Novel TRPM7 inhibitors with potent anti-inflammatory effects <em>in vivo</em>
#MSchat #Neurology #MultipleSclerosis
September 5, 2023 at 2:32 PM
https://gregory-ms.com/articles/43566/
Novel TRPM7 inhibitors with potent anti-inflammatory effects <em>in vivo</em>
#MSchat #Neurology #MultipleSclerosis
Novel TRPM7 inhibitors with potent anti-inflammatory effects <em>in vivo</em>
#MSchat #Neurology #MultipleSclerosis
Authors used PC12 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice
www.biorxiv.org
March 11, 2026 at 12:00 PM
Authors used PC12 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #RRID